Article
Endocrinology & Metabolism
Ying Sun, Lei Zhao, Di Teng, Xiaoguang Shi, Yongze Li, Zhongyan Shan, Weiping Teng
Summary: Postprandial glucose dips are closely associated with metabolic disorders, metabolic syndrome, related component diseases, and cardiovascular disease risk. Glucose dips may serve as an indicator of underlying metabolic abnormalities.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Sergio Montserrat-de la Paz, Maria del Carmen Naranjo, Sergio Lopez, Maria del Carmen Millan-Linares, Antonio Rivas -Dominguez, Sara Maria Jaramillo-Carmona, Rocio Abia, Francisco J. G. Muriana, Beatriz Bermudez
Summary: This study aimed to investigate the effects of combining immediate-release niacin with different fats (butter, olive oil enriched in monounsaturated fatty acids, and olive oil supplemented with eicosapentaenoic and docosahexaenoic acids) on postprandial inflammation in individuals with metabolic syndrome.
CLINICAL NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Laura Alvarez-Jimenez, Alfonso Moreno-Cabanas, Miguel Ramirez-Jimenez, Felix Morales-Palomo, Juan F. Ortega, Ricardo Mora-Rodriguez
Summary: The study showed that hypercholesteraemic individuals with metabolic syndrome did not benefit from exercise in reducing postprandial triglyceridaemia, but chronic statin medication could lower triglyceride levels after a fat meal, reducing cardiovascular risk.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Li Chen, Shiqi Zhang, Xiaowei Sun, Joshua D. McDonald, Richard S. Bruno, Jiangjiang Zhu
Summary: This study investigated the differential plasma lipidomic responses to non-fat or full-fat milk ingestion during postprandial hyperglycemia and found that dairy milk, especially non-fat milk, protected against lipid changes induced by glucose ingestion. Co-ingestion of dairy milk with glucose significantly altered lipid profiles, with full-fat milk more substantially modulating lipid profiles, suggesting dairy milk-mediated lipid modulation may be an effective dietary approach to reduce the risk of metabolic diseases among those with prediabetes.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Bergmann, Anna Stefanska, Magdalena Krintus, Lukasz Szternel, Mauro Panteghini, Grazyna Sypniewska
Summary: This study assessed the association between fasting and postprandial liver enzyme levels with MetS and elevated HbA1c in children aged 9-11. The results showed that postprandial GGT changes predicted the occurrence of MetS, while postprandial ALT changes predicted prediabetes in prepubertal children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Sylvain Raimbault, Guillaume Monneret, Morgane Gossez, Fabienne Venet, Alexandre Belot, Franck Zekre, Solene Remy, Etienne Javouhey
Summary: In this study, the researchers examined the use of monocyte human leucocyte antigen (mHLA)-DR as a potential diagnostic marker for secondary HLH (sHLH). They found that levels of mHLA-DR were significantly higher in patients with sHLH compared to healthy children and those with septic shock. Additionally, mHLA-DR levels decreased after treatment initiation. The findings suggest that elevated mHLA-DR could aid in the diagnosis of sHLH and distinguish it from septic shock.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Christoph Stenzel, Nina Dalkner, Human -Friedrich Unterrainer, Armin Birner, Susanne A. Bengesser, Frederike T. Fellendorf, Andreas Fink, Eva Fleischmann, Melanie Lenger, Alexander Maget, Martina Platzer, Robert Queissner, Elena Schonthaler, Adelina Tmava-Berisha, Eva Z. Reininghaus
Summary: The prevalence of metabolic syndrome and overweight/obesity is increased in bipolar disorder (BD) compared to the general population and is related to suicidality. This study found that there is a difference in suicidal ideation based on body mass index (BMI) categories, but no association between suicide attempts and metabolic syndrome or serum lipid levels in individuals with BD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Nutrition & Dietetics
Mariana Duarte Bona, Carlos Henrique de Medeiros Torres, Severina Carla Vieira Cunha Lima, Ana Heloneida de Araujo Morais, Aldo Angelo Moreira Lima, Bruna Leal Lima Maciel
Summary: This systematic review assessed the association between obesity with or without MetS and alteration of intestinal barrier permeability in humans. A total of eight studies were included and categorized as moderate to high quality. The findings suggested that impaired intestinal barrier permeability was positively associated with obesity with MetS. However, the evidence quality was assessed to be very low to low according to the GRADE framework.
Article
Nutrition & Dietetics
Aimee L. Dordevic, Susan L. Coort, Chris T. Evelo, Chiara Murgia, Andrew J. Sinclair, Maxine P. Bonham, Amy E. Larsen, Petra Gran, David Cameron-Smith
Summary: In middle-aged males with MetS, a widespread suppression of the subcutaneous adipose tissue nutrient responsive gene expression suggests an inflexibility in the transcriptomic responsiveness to both high-fat meals.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Juan Carlos Sanchez-Delgado, Daniel D. Cohen, Paul A. Camacho-Lopez, Javier Carreno-Robayo, Alvaro Castaneda-Hernandez, Daniel Garcia-Gonzalez, Daniel Martinez-Bello, Gustavo Aroca-Martinez, Gianfranco Parati, Patricio Lopez-Jaramillo
Summary: The association between handgrip strength (HGS) and arterial stiffness parameters in individuals with Metabolic Syndrome (MetS) is not well defined. This study found that lower HGS is associated with an increased risk of cardiometabolic diseases, and higher HGS asymmetry may be associated with greater vascular resistance.
Article
Genetics & Heredity
Sanghoo Lee, Seol-A Kim, Yejin Kim, Juhoon Kim, Gayeon Hong, Jeonghoon Hong, Kyeonghwan Choi, Chun-Sick Eom, Saeyun Baik, Mi-Kyeong Lee, Kyoung-Ryul Lee
Summary: Metabolic syndrome is a complex metabolic disorder, and increased plasma ceramides are associated with this condition. This study identified novel genetic factors related to increased plasma ceramides in individuals with metabolic syndrome.
Article
Medicine, Research & Experimental
Jason D. Simmons, Phu T. Van, Catherine M. Stein, Violet Chihota, Thobani Ntshiqa, Pholo Maenetje, Glenna J. Peterson, Anthony Reynolds, Penelope Benchek, Kavindhran Velen, Katherine L. Fielding, Alison D. Grant, Andrew D. Graustein, Felicia K. Nguyen, Chetan Seshadri, Raphael Gottardo, Harriet Mayanja-Kizza, Robert S. Wallis, Gavin Churchyard, W. Henry Boom, Thomas R. Hawn
Summary: RNAseq analysis revealed distinct differences in carbon metabolism, free fatty acid responses, and genetic variations between individuals with latent tuberculosis infection and those who resist tuberculosis infection, suggesting that immunometabolic pathways play a role in TST/IGRA conversion.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Genetics & Heredity
Lavanya Jain, Lindsay M. Oberman, Laura Beamer, Lauren Cascio, Melanie May, Sujata Srikanth, Cindy Skinner, Kelly Jones, Bridgette Allen, Curtis Rogers, Katy Phelan, Walter E. Kaufmann, Barbara DuPont, Sara M. Sarasua, Luigi Boccuto
Summary: This study investigated the prevalence of seizures and their association with genetic and metabolic features in Phelan-McDermid syndrome (PMS) patients. Results showed that individuals with pathogenic SHANK3 mutations had the highest prevalence of seizures, and the gene TBC1D22A in the 22q13.31 region was significantly associated with seizure prevalence. Additionally, a distinct metabolic profile was identified for PMS patients with seizures, indicating a disrupted utilization of main energy sources.
Article
Medicine, General & Internal
Ming-Chuan Lee, Yu-Tsang Wang, Yu-Ju Li, Ching-Yi Tsai, Su-Te Chen, Wun-Jyun Jhuang, Meng-Chi Chang, Mei-Yu Chien, Hsiang -Chun Lee
Summary: The study found that AF risk in patients with MetS phenotypes can be reflected by QTc quartiles.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Yannik Bernd Schoenknecht, Silke Crommen, Birgit Stoffel-Wagner, Martin Coenen, Rolf Fimmers, Peter Stehle, Alfredo Ramirez, Sarah Egert
Summary: In this study, it was found that APOE E4 carriers exhibit increased postprandial inflammation, as indicated by a higher postprandial IL-6 increase compared to non-carriers. Other parameters of metabolism did not show significant differences, suggesting a specific impact of the APOE genotype on postprandial inflammatory response.
Article
Cardiac & Cardiovascular Systems
Amit Saha, Kershaw Patel, Colby Ayers, Christie M. Ballantyne, Adolfo Correa, Christopher Defilippi, Michael E. Hall, Robert J. Mentz, Stephen L. Seliger, Wondwosen Yimer, Javed Butler, Jarett D. Berry, James A. De Lemos, Ambarish Pandey
Summary: Among Black adults, persistent or worsening levels of cardiac troponin I (hs-cTnI) are associated with an increased risk of heart failure (HF). Participants with incident, stable or improved, or worsened hs-cTnI elevation had higher HF risk compared to those without elevated hs-cTnI.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Miller, Deepak L. Bhatt, Ph Gabriel Steg, Eliot A. Brinton, Terry A. Jacobson, Lixia Jiao, Jean-Claude Tardif, Christie M. Ballantyne, Matthew Budoff, R. Preston Mason
Summary: The study found that the use of IPE can reduce the risk of cardiovascular disease in smokers to the level observed in non-smokers.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Peripheral Vascular Disease
Matthew F. Blum, Jingsha Chen, Aditya Surapaneni, Stephen T. Turner, Christie M. Ballantyne, Paul A. Welling, Anna Koettgen, Josef Coresh, Deidra C. Crews, Morgan E. Grams
Summary: This study investigated the association of renin with adverse kidney outcomes and compared different measurement strategies. The results showed that renin levels measured by SomaScan modified nucleotide aptamer assay were predictive of chronic kidney disease, end-stage kidney disease, and mortality. The SomaScan measurement was moderately correlated with plasma renin activity and highly correlated with renin level from Olink.
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Article
Urology & Nephrology
Donghai Wen, Linda Zhou, Zihe Zheng, Aditya Surapaneni, Christie M. Ballantyne, Ron C. Hoogeveen, Michael G. Shlipak, Sushrut S. Waikar, Ramachandran S. Vasan, Paul L. Kimmel, Ruth F. Dubin, Rajat Deo, Harold I. Feldman, Peter Ganz, Josef Coresh, Morgan E. Grams, Eugene P. Rhee
Summary: Testican-2, a protein released into circulation by the kidneys, is positively correlated with eGFR and eGFR slope. However, it is unknown whether higher testican-2 levels are associated with lower risk of ESKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Medical Laboratory Technology
Seyedmohammad Saadatagah, Christie M. Ballantyne
Summary: Age is a crucial risk factor for cardiovascular disease, as genetic mutations occur with aging, leading to somatic mosaicism. Clonal hematopoiesis resulting from somatic mutations, known as CHIP, has been associated with an increased risk of cardiovascular disease. Recent advances in exome-sequencing projects have enabled the study of CHIP frequency, gene-specific analyses, and potential therapeutic implications for preventing cardiovascular disease.
TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Jarett D. Berry, Haiying Chen, Vijay Nambi, Walter T. Ambrosius, Simon B. Ascher, Michael G. Shlipak, Joachim H. Ix, Rajesh Gupta, Anthony Killeen, Robert D. Toto, Dalane W. Kitzman, Christie M. Ballantyne, James A. de Lemos
Summary: This study aimed to investigate the effects of intensive systolic blood pressure lowering on hs-cTnT and NT-proBNP levels. The results showed that intensive SBP lowering increased hs-cTnT levels, mediated by the effect on reduced kidney filtration, while NT-proBNP levels decreased, explained by the decrease in SBP. These findings highlight the importance of noncardiac factors influencing cardiac biomarker variation and raise questions about the potential role of hs-cTnT as a surrogate marker for heart failure or death in SBP-lowering studies.
Article
Medical Laboratory Technology
Mary R. Rooney, Jingsha Chen, Christie M. Ballantyne, Ron C. Hoogeveen, Olive Tang, Morgan E. Grams, Adrienne Tin, Chiadi E. Ndumele, Faiez Zannad, David J. Couper, Weihong Tang, Elizabeth Selvin, Josef Coresh
Summary: Comparisons of highly multiplexed aptamer-based and proximity-extension immunoassays revealed variations in protein measurements. Furthermore, comparisons between SomaScan and targeted immunoassays showed varying degrees of correlation for different proteins. These findings highlight the importance of considering measurement techniques in protein quantification studies.
CLINICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Anandita Agarwala, Elena Deych, Laney K. Jones, Amy C. Sturm, Karen Aspry, Zahid Ahmad, Christie M. Ballantyne, Anne C. Goldberg
Summary: This study retrospectively examined the burden and risk factors of premature ASCVD in men and women with FH. The results showed a high prevalence of premature ASCVD in both genders, and significant differences were observed in predictive factors and lipid treatment outcomes for women with premature ASCVD.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mini G. Varughese, Matthew R. Deshotels, Lilei Zhang, Christie M. Ballantyne
Summary: A 20-year-old male presented with severe elevation in low-density lipoprotein cholesterol (LDL-C) and was initially tested negative for familial hypercholesterolemia. Further genetic testing revealed homozygous variants in the ALB gene, indicating congenital analbuminemia (CAA) as the cause of severe hyperlipidemia. CAA is a rare autosomal recessive disorder with a frequency of about 1:1,000,000. Pathological variants in the ALB gene disrupt albumin synthesis and can lead to gross hyperlipidemia and hypercholesterolemia. Early diagnosis through genetic examination is crucial for initiating lipid-lowering treatments and preventing premature coronary artery disease.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Biochemical Research Methods
Bruno Bohn, Pamela L. Lutsey, Weihong Tang, James S. Pankow, Faye L. Norby, Bing Yu, Christie M. Ballantyne, Eric A. Whitsel, Kunihiro Matsushita, Ryan T. Demmer
Summary: This study compared the proteome of statin users and nonusers and found differences in proteins unrelated to lipid metabolism. Further investigation into these differences may help elucidate the pleiotropic effects of statins.
JOURNAL OF PROTEOMICS
(2023)
Correction
Biochemistry & Molecular Biology
Michael R. Duggan, Lauren Butler, Zhongsheng Peng, Gulzar N. Daya, Abhay Moghekar, Yang An, Stephen R. Rapp, Kathleen M. Hayden, Aladdin H. Shadyab, Ginny Natale, Longjian Liu, Linda Snetselaar, Ruin Moaddel, Casey M. Rebholz, Kevin Sullivan, Christie M. Ballantyne, Susan M. Resnick, Luigi Ferrucci, Keenan A. Walker
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Robert S. Rosenson, Daniel Gaudet, Christie M. Ballantyne, Seth J. Baum, Jean Bergeron, Erin E. Kershaw, Patrick M. Moriarty, Paolo Rubba, David C. Whitcomb, Poulabi Banerjee, Andrew Gewitz, Claudia Gonzaga-Jauregui, Jennifer McGinniss, Manish P. Ponda, Robert Pordy, Jian Zhao, Daniel J. Rader
Summary: Severe hypertriglyceridemia (sHTG) is a known risk factor for acute pancreatitis. Current therapies for sHTG are often insufficient, and this phase 2 trial evaluated the use of evinacumab in patients with sHTG. Although evinacumab showed some effectiveness in reducing triglyceride levels, it did not meet the primary endpoint. However, the safety profile and lipid changes observed support further evaluation in larger trials.
Article
Cardiac & Cardiovascular Systems
Xiaoming Jia, Leo Buckley, Caroline Sun, Mahmoud Al Rifai, Bing Yu, Vijay Nambi, Salim S. Virani, Elizabeth Selvin, Kunihiro Matsushita, Ron C. Hoogeveen, Josef Coresh, Amil M. Shah, Christie M. Ballantyne
Summary: Higher levels of interleukin-6 and interleukin-18 in older adults are associated with an increased risk of global cardiovascular disease (including coronary heart disease, stroke, and heart failure) and death. The association between interleukin-6 and global cardiovascular disease is stronger than that for interleukin-18, and remains significant even after adjustments for other biomarkers.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lena Mathews, Xiao Hu, Ning Ding, Junichi Ishigami, Mahmoud Al Rifai, Ron C. C. Hoogeveen, Josef Coresh, Christie M. M. Ballantyne, Elizabeth Selvin, Kunihiro Matsushita
Summary: A study on 9205 participants from the ARIC study found that higher levels of GDF15 protein were associated with bleeding events and improved the prediction of bleeding risk in individuals without cardiovascular disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Salim S. Virani, Karen Aspry, Dave L. Dixon, Keith C. Ferdinand, Paul A. Heidenreich, Elizabeth J. Jackson, Terry A. Jacobson, Janice L. McAlister, David R. Neff, Martha Gulati, Christie M. Ballantyne
Summary: Despite the established role of LDL-C as a major risk factor for CVD, national quality assurance metrics no longer include LDL-C measurement as a required performance metric. This article reviews the history of LDL-C as a quality and performance metric and presents rationales for re-establishing LDL-C measurement to improve cholesterol control and reduce CVD morbidity and mortality, healthcare disparities, and costs.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)