Article
Biochemistry & Molecular Biology
Jufen Liu, Huijing Wang, Cuiting Huang
Summary: This study found that Exendin-4 has a protective effect in inhibiting the progression of DR, and it may exert its effect by regulating the expression of TGFB2.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Neurosciences
Adriana M. Zago, Fabiano B. Carvalho, Francine L. Rahmeier, Marta Santin, Giuliano R. Guimaraes, Jessie M. Gutierres, Marilda da C. Fernandes
Summary: This study investigated the neuroprotective effects of EXE-4 on memory and hippocampal neuronal populations in SDAT rats. The results showed that EXE-4 protected against memory impairment and neuronal death, while promoting cell proliferation in the hippocampus.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Saumik Biswas, Ali Coyle, Shali Chen, Miso Gostimir, John Gonder, Subrata Chakrabarti
Summary: With the increasing incidence of diabetes worldwide, diabetic retinopathy (DR) has become one of the leading causes of blindness in the working age population. Recent research has shown that long noncoding RNAs (lncRNAs) play a significant role in the development of DR. A serum-based PCR test using 9 lncRNAs has been developed as a potential diagnostic and prognostic tool for DR.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyehun Choi, Michael R. Miller, Hong-Ngan Nguyen, Victoria E. Surratt, Stephen R. Koch, Ryan J. Stark, Fred S. Lamb
Summary: TNF alpha activates NADPH oxidase 1, which produces extracellular superoxide anion. The secreted protein ecSOD converts superoxide anion to hydrogen peroxide, playing a role in TNF alpha signaling in vascular smooth muscle cells. Knockdown of ecSOD suppresses downstream TNF alpha signals and reduces expression of TNF alpha receptors.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Yiwei Wu, Haidong Zou
Summary: Diabetic retinopathy is a significant complication of diabetes that can result in blindness. Mitochondria, the energy-producing organelles, play a crucial role in cellular metabolism and function. Under high glucose conditions, metabolic changes and epigenetic alterations in mitochondria-related genes can cause mitochondrial dysfunction and apoptosis. Additionally, mitophagy and mitochondrial dynamics also adaptively change. These mechanisms are likely to contribute to the development and progression of diabetic retinopathy and provide insights for its prevention and treatment.
Review
Cell Biology
Renu. A. A. Kowluru
Summary: Diabetic retinopathy is a complex disease with a multifactorial and unknown molecular pathogenesis. High blood glucose induces oxidative stress and inflammation in the retina, which can form a positive loop. Furthermore, diabetes can also lead to epigenetic modifications that affect genes associated with oxidative stress and inflammation. Understanding the cross-talk between oxidative stress, inflammation, and epigenetics may contribute to the development of novel strategies for treating diabetic retinopathy.
Article
Biochemistry & Molecular Biology
Peipei Tu, Bin Huang, Minggang Li, Yaofang Zhang, Shixiang Bao, Na Tu, Yanan Yang, Jingtao Lu
Summary: Type 2 diabetes (T2D) is a complex systemic disease that might benefit from treatment with exendin-4, as shown in this study on C57BL/6 J mice. The study investigated epigenetic alterations in pancreatic tissues of diabetic mice and demonstrated an improvement in T2D progression with exendin-4 treatment through modulation of histone acetylation and methylation patterns. Understanding these epigenetic changes may lead to novel therapeutic approaches for T2D.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Endocrinology & Metabolism
Renu A. Kowluru
Summary: Diabetic retinopathy is a devastating complication of diabetes, and long noncoding RNAs have been found to play a crucial role in its development by altering the expression of genes involved in maintaining mitochondrial homeostasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Ophthalmology
Saumik Biswas, Biao Feng, Shali Chen, Jieting Liu, Erfan Aref-Eshghi, John Gonder, Vy Ngo, Bekim Sadikovic, Subrata Chakrabarti
Summary: The study reveals that HOTAIR is upregulated in high glucose conditions, promoting angiogenesis, oxidative damage, and mitochondrial aberrations. Patients with proliferative DR and diabetic animal models show increased HOTAIR expression, and knocking down HOTAIR protects against glucose-induced damage in the retina. Mechanistically, HOTAIR exerts its effects by preventing oxidative stress and modulating epigenetic pathways involving histone methylation, histone acetylation, DNA methylation, and transcription factors.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ayaka Yoshinaga, Nobuhiro Kajihara, Daisuke Kukidome, Hiroyuki Motoshima, Takeshi Matsumura, Takeshi Nishikawa, Eiichi Araki
Summary: Hypoglycemia induces mitochondrial ROS production through fatty acid oxidation and leads to increased vascular permeability in retinal endothelial cells. Blocking fatty acid oxidation reduces mtROS production and prevents hypoglycemia-induced vascular permeability in the retina.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Alessia Parascandolo, Mikko O. Laukkanen
Summary: Superoxide dismutase (SOD) family isoenzymes, including SOD1, SOD2, and SOD3, synthesize hydrogen peroxide (H2O2) to regulate signal transduction. The cellular response to SOD3 is dose-dependent, with high concentrations reducing cell survival.
Review
Biochemistry & Molecular Biology
Brianne R. O'Leary, Rory S. Carroll, Garett J. Steers, Jennifer Hrabe, Frederick E. Domann, Joseph J. Cullen
Summary: Reactive oxygen species are essential components in cell signaling and immune responses, but an imbalance can lead to oxidative stress. Cancer cells show increased oxidative stress and decreased expression of extracellular superoxide dismutase, an antioxidant enzyme that plays a role in maintaining redox balance and protecting against oxidative damage. Understanding the role of EcSOD in cancer could have potential implications for detection, prognosis, and treatment of malignancies.
Article
Medicine, General & Internal
Haiqing Li, Wei Hong, Zixiong Zeng, Shan Gong, Fan Wu, Zihui Wang, Heshen Tian, Juan Cheng, Ruiting Sun, Mi Gao, Chunxiao Liang, Weitao Cao, Guoping Hu, Yuqun Li, Liping Wei, Yumin Zhou, Pixin Ran
Summary: The study investigated the association between serum ecSOD activity and 1-year all-cause mortality in acute exacerbations of COPD (AECOPD) patients. The findings suggest that lower ecSOD activity is a strong independent predictor of 1-year all-cause mortality in AECOPD patients.
FRONTIERS IN MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Daiyong Chao, Qing Dong, Zhixuan Yu, Desheng Qi, Minghua Li, Lili Xu, Ling Liu, Youxing Fang, Shaojun Dong
Summary: This study presents an effective antioxidative system for diabetic chronic wound healing by integrating a metal organic framework (MOF) nanozyme with antioxidant enzyme-like activity with a hydrogel (Gel), which can modulate the oxidative stress microenvironment and transition from the inflammation phase to the proliferation phase, comparable to a widely used clinical drug.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Hongyu Fu, Huiqiang Liu
Summary: This study found that TLR4 can serve as an independent target for treating diabetic retinopathy, and the absence of TLR4 can significantly improve the manifestations of diabetic retinopathy.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Health Care Sciences & Services
Saki Harada, Akio Suzuki, Shohei Nishida, Ryo Kobayashi, Sayuri Tamai, Keisuke Kumada, Nobuo Murakami, Yoshinori Itoh
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2017)
Article
Geriatrics & Gerontology
Shohei Nishida, Yuichi Hayashi, Akio Suzuki, Ryo Kobayashi, Takashi Inuzuka, Yoshinori Itoh
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2018)
Article
Medicine, General & Internal
Yuichi Hayashi, Hideaki Shibata, Takuya Kudo, Shohei Nishida, Rie Ishikawa, Chie Moriya, Akio Suzuki, Akio Kimura, Takashi Inuzuka
Article
Chemistry, Organic
Tsuyoshi Miura, Shohei Nishida, Akira Masuda, Norihiro Tada, Akichika Itoh
TETRAHEDRON LETTERS
(2011)
Article
Chemistry, Inorganic & Nuclear
Tsuyoshi Miura, Akira Masuda, Mariko Ina, Kosuke Nakashima, Shohei Nishida, Norihiro Tada, Akichika Itoh
TETRAHEDRON-ASYMMETRY
(2011)
Article
Endocrinology & Metabolism
Yukio Horikawa, Akio Suzuki, Mayumi Enya, Ken-ichi Hashimoto, Shohei Nishida, Ryo Kobayashi, Tetsuya Ohashi, Futoshi Yamazaki, Rieko Totani, Hiroshi Kobayashi, Mayumi Yamamoto, Yoshinori Itoh, Jun Takeda
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2020)
Article
Oncology
Kazuyo Shimada, Shiori Hasegawa, Satoshi Nakao, Ririka Mukai, Kiyoka Matsumoto, Mizuki Tanaka, Hiroaki Uranishi, Mayuko Masuta, Shohei Nishida, Shinya Shimizu, Yuichi Hayashi, Mitsuhiro Nakamura, Akio Suzuki
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Shinya Shimizu, Yuichi Hayashi, Shohei Nishida, Hironori Fujii, Mitsuhiro Nakamura, Nobuaki Yoshikura, Akihito Nagano, Junichi Kitagawa, Nobuhiro Kanemura, Kosuke Mizutani, Ryo Kobayashi, Takuma Ishihara, Hideki Hayashi, Takayoshi Shimohata, Tadashi Sugiyama, Akio Suzuki
Summary: The study identified that the ALBI score may be a useful biomarker for predicting neuropsychiatric symptoms in patients receiving ifosfamide-based chemotherapy. Additionally, there were correlations between the predicted risk of neuropsychiatric symptoms and ifosfamide dose per cycle and creatinine clearance. Serum albumin and total bilirubin were not significant risk factors for neuropsychiatric symptoms.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Keiko Suzuki, Hironori Fujii, Tomoyo Yamauchi, Hiroko Kato-Hayashi, Masashi Ishihara, Hirotoshi Iihara, Chiemi Hirose, Shohei Nishida, Miyui Funato, Ryo Kobayashi, Koji Yasuda, Yoko Ino, Hirofumi Tamaki, Shuji Yamashita, Kazuhiro Iguchi, Yoshihiro Noguchi, Hitomi Teramachi, Jun Takada, Masaya Kubota, Takashi Ibuka, Hiroshi Araki, Masahito Shimizu, Akio Suzuki
Summary: Frequently skipping meals and using multiple dose regimens are associated with decreased adherence to oral 5-ASA therapy. Patients who skip meals can improve adherence to oral 5-ASA therapy by adopting a once-daily dosing regimen.
JOURNAL OF PHARMACY PRACTICE AND RESEARCH
(2021)
Review
Endocrinology & Metabolism
Shohei Nishida, Takehiro Kato, Yuichi Hayashi, Shoya Yamada, Hironori Fujii, Michi Yamada, Nao Asai, Shinya Shimizu, Takashi Niwa, Hirotoshi Iihara, Sodai Kubota, Mayu Sakai, Yoshihiro Takahashi, Ken Takao, Masami Mizuno, Takuo Hirota, Ryo Kobayashi, Yukio Horikawa, Daisuke Yabe, Akio Suzuki
Summary: The aim of this study was to evaluate the usefulness of pharmacist check followed by a multidisciplinary team review in diabetic patients with polypharmacy. The study found that the combination of pharmacist check and multidisciplinary team review successfully reduced the use of inappropriate or potentially inappropriate medications in diabetic patients.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Chemistry, Medicinal
S. Nishida, Y. Hayashi, K. Hirai, A. Takekoshi, Y. Yamada, R. Kobayashi, S. Shimizu, T. Niwa, H. Hayashi, T. Shimohata, T. Sugiyama, A. Suzuki
Article
Endocrinology & Metabolism
Yukio Horikawa, Akio Suzuki, Ken-ichi Hashimoto, Mayumi Enya, Shohei Nishida, Ryo Kobayashi, Tetsuya Ohashi, Futoshi Yamazaki, Rieko Totani, Hiroshi Kobayashi, Mayumi Yamamoto, Yoshinori Itoh, Jun Takeda
DIABETOLOGY INTERNATIONAL
(2019)