Article
Multidisciplinary Sciences
Annika F. Barber, Shi Yi Fong, Anna Kolesnik, Michael Fetchko, Amita Sehgal
Summary: Regulation of circadian behavior and physiology by the Drosophila brain clock requires communication from central clock neurons to downstream output regions. Morning and evening clock neurons have time-of-day-dependent connectivity to the pars intercerebralis, which is regulated by specific peptides and fast neurotransmitters. This study provides insights into mechanisms by which clock neurons signal to nonclock cells to drive rhythms of behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Sabrina Klemz, Thomas Wallach, Sandra Korge, Mechthild Rosing, Roman Klemz, Bert Maier, Nicholas C. Fiorenza, Irem Kaymak, Anna K. Fritzsche, Erik D. Herzog, Ralf Stanewsky, Achim Kramer
Summary: In organisms with circadian clocks, the post-translational modifications of clock proteins, particularly phosphorylation, play a crucial role in controlling circadian rhythms. Protein phosphatase 4 (PPP4) and its regulatory subunit PPP4R2 have been identified as critical components in mammals and Drosophila, affecting the circadian system by regulating phosphorylation and transactivation activity of CLOCK/BMAL1.
GENES & DEVELOPMENT
(2021)
Article
Multidisciplinary Sciences
Hyun Woong Roh, Su Jung Choi, Hyunjin Jo, Dongyeop Kim, Jung-gu Choi, Sang Joon Son, Eun Yeon Joo
Summary: This study examined the associations between actigraphy-derived parameters and clinical symptoms and PSG results in patients with chronic insomnia. The findings showed significant correlations between certain rest-activity patterns and circadian phase parameters with insomnia severity and PSG outcomes, suggesting their potential clinical implications for PSG interpretation and insomnia pathophysiology assessment.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Keren Levy, Yoav Wegrzyn, Ronny Efronny, Anat Barnea, Amir Ayali
Summary: The study reveals that ecologically relevant ALAN intensities can affect cricket behavioral patterns, potentially leading to individual level decoupling of locomotion and stridulation behaviors, as well as loss of synchronization at the population level.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Mireia Vaca-Dempere, Arun Kumar, Valentina Sica, Pura Munoz-Canoves
Summary: Circadian rhythms play a crucial role in regulating skeletal muscle growth, maintenance, and metabolic functions. However, there is still much unknown about the functions, regulatory mechanisms, and interactions of the skeletal muscle molecular clock with other tissues.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Chemistry, Medicinal
Yong Uk Jeong, Hyo-Eon Jin, Hye Young Lim, Goyeong Choi, Hansol Joo, Bohun Kang, Ga-Hyun Lee, Kwang-Hyeon Liu, Han-Joo Maeng, Sooyoung Chung, Gi Hoon Son, Jong-Wha Jung
Summary: Non-ethoxypropanoic acid-type inhibitors were developed as potent enhancers of E-box-mediated transcription, showing promising metabolic and pharmacokinetic profiles. These inhibitors directly bound to both CRY1 and 2, and exhibited significant effects on molecular circadian rhythmicity as circadian clock-enhancers.
Article
Biochemistry & Molecular Biology
Ludovic Bellier, Anais Llorens, Deborah T. Marciano, Aysegul Gunduz, Gerwin Schalk, Peter Brunner, Robert T. Knight
Summary: This study analyzed the neural dynamics of music perception by reconstructing a recognizable song from direct neural recordings of 29 patients. The results showed the involvement of specific brain regions and response patterns in music perception and suggested the potential application of music in brain-computer interface technology.
Review
Andrology
Wei-Zhen Zhu, Qi-Ying He, De-Chao Feng, Qiang Wei, Lu Yang
Summary: The circadian clock is associated with better adaptation to changes in the external environment. Disruption of the circadian rhythm plays a critical role in the tumorigenesis of many cancers, including prostate cancer. Integrating the circadian rhythm into PCa research can provide a deeper understanding of PCa mechanisms and offer new treatment options for patients with PCa.
ASIAN JOURNAL OF ANDROLOGY
(2023)
Review
Neurosciences
Jennifer W. Mitchell, Martha U. Gillette
Summary: The neurovascular system is crucial for regulating the movement of substances in and out of the brain tissue and maintaining brain health. The development of an intrinsic circadian clock allows the neurovascular unit to anticipate rhythmic changes in brain activity and physiology, which in turn affects neurovascular physiology.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Physiology
Olga Kuldavletova, Deborah C. Navarro Morales, Gaelle Quarck, Pierre Denise, Gilles Clement
Summary: We conducted a study on astronauts to explore the changes in duration judgment before, during, and after their stays on board the International Space Station. Results showed that astronauts had longer reaction times during spaceflight compared to preflight and control participants. Additionally, time intervals were under-produced during counting aloud tasks and under-reproduced during concurrent reading tasks. These alterations in time perception during spaceflight could be attributed to changes in vestibular inputs and difficulties in attention and working memory.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Psychology, Clinical
Jeong-Won Choi, Gi-Eun Lee, Jang-Han Lee
Summary: This study aimed to investigate the effects of emotional state on time perception in patients with depression and whether induced emotional states could alter time perception. Results showed that clinically depressed patients perceived time passing more slowly, especially in negative-low arousal conditions, compared to non-depressed individuals. Emotional states with combined valence and arousal factors were found to influence time perception in patients with depression, suggesting that changing the emotional state by considering valence and arousal is crucial to improve time perception distortion in depressive patients.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2021)
Article
Pharmacology & Pharmacy
Narin Ozturk, Dilek Ozturk Civelek, Serap Sancar, Engin Kaptan, Zeliha Pala Kara, Alper Okyar
Summary: The study revealed dosing-time dependent testicular toxicity of everolimus in mice, with greater severity when administered at early rest-span (daytime-ZT1) compared to early activity-span (nighttime-ZT13). These findings support the concept of everolimus chronotherapy for minimizing reproductive toxicity and increasing the tolerability of everolimus, providing a clinical advantage.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Physiology
Sebastian Rock, Frans Rodenburg, Marcel J. M. Schaaf, Christian Tudorache
Summary: Research on stress coping style in animal welfare has gained momentum in recent years. This study analyzed the light dark challenge behavioral assay in zebrafish larvae and found that behavioral responses are robust and can be generalized for the light and dark phases. The hatching time may determine the behavioral phenotype of an individual.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Psychology, Multidisciplinary
Alessia Tonelli, Claudia Lunghi, Monica Gori
Summary: This study found that moderate physical activity affects time perception, leading to a consistent overestimation of durations in the range of milliseconds. Spatial perception, on the other hand, was unaffected by physical activity. The results of this study are important for understanding the impact of exercise on cognitive functions.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Hospitality, Leisure, Sport & Tourism
Zohreh Korani, Fatemeh Sam
Summary: This study aims to explore the factors influencing visitors' perception of time at two cultural heritage sites. The findings indicate that environmental variables and specific dates play a significant role in shaping visitors' time perception. Through interviews and narrative stories, researchers gained in-depth understanding of visitors' perception of time and identified four core categories. The study highlights the importance of rhythm, speed of time, sense of change, and cultural norms in shaping visitors' perception of time.
CURRENT ISSUES IN TOURISM
(2023)
Article
Mathematics
A. A. Firsova, E. L. Makarova
Summary: This paper demonstrates the application of cognitive modeling methods to study the functioning problems of semi-structured complex economic systems, specifically focusing on the structural stability between knowledge-intensive sectors and regional economy using cognitive analysis. The research results can be utilized in decision-making processes to develop strategies and policies for the balanced development of knowledge-intensive markets and socio-economic systems.
IZVESTIYA OF SARATOV UNIVERSITY MATHEMATICS MECHANICS INFORMATICS
(2022)
Article
Mathematics
Galina Chernyshova, Irina Veshneva, Anna Firsova, Elena L. Makarova, Elena A. Makarova
Summary: Research on competitiveness at the meso level is important due to the contemporary views of regions as essential elements of the economic space. This article proposes a novel method for quantitatively assessing regional competitiveness risks, using both fixed-point risk assessment and scenario-based predictive analysis. A web application has been developed to assess the risks of Russian regions' competitiveness, providing multi-criteria decision-making methods and visualizing results.
Article
Mathematics
Anna Firsova, Galina Gorelova, Elena L. Makarova, Elena A. Makarova, Galina Chernyshova
Summary: This article presents the study results of sustainable development in a region using cognitive simulation methods and proposes recommendations for the region's further development.
Article
Education & Educational Research
Elena A. Makarova, Elena L. Makarova
Summary: This study aims to prove the negative impact of cyber-victimization on psychosomatic health and concludes that young victims may face social and psychological problems in the future due to this. Cyberbullying has become an increasing problem due to the widespread dissemination of information and digitalization, leading to concerns from researchers, parents, teachers, and psychologists.
INTERNATIONAL JOURNAL OF COGNITIVE RESEARCH IN SCIENCE ENGINEERING AND EDUCATION-IJCRSEE
(2023)
Article
Education & Educational Research
Elena A. Makarova, Elena L. Makarova, Irina A. Egorova
Summary: The research aims to analyze the main economic trends in modern student exchange programs and discuss how to increase educational services export by promoting various student exchange models.
INTERNATIONAL JOURNAL OF COGNITIVE RESEARCH IN SCIENCE ENGINEERING AND EDUCATION-IJCRSEE
(2021)
Article
Communication
Elena A. Makarova, Elena L. Makarova, Sergei Maximets
MEDIA EDUCATION-MEDIAOBRAZOVANIE
(2020)
Proceedings Paper
Optics
Iakov Korovin, Maxim Khisamutdinov
TWELFTH INTERNATIONAL CONFERENCE ON MACHINE VISION (ICMV 2019)
(2020)
Article
Humanities, Multidisciplinary
Elena A. Makarova, Elena L. Makarova, Tatyana Korsakova
TARIH KULTUR VE SANAT ARASTIRMALARI DERGISI-JOURNAL OF HISTORY CULTURE AND ART RESEARCH
(2019)