Journal
JOURNAL OF KIDNEY CANCER AND VHL
Volume 9, Issue 1, Pages 51-54Publisher
CODON PUBLICATIONS
DOI: 10.15586/jkcvhl.v9i1.216
Keywords
kidney; immunohistochemistry; leiomyosarcoma; Nephrology
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Renal leiomyosarcoma is a rare and poor prognosis malignant tumor, mainly derived from smooth muscle. This article reports a case of renal leiomyosarcoma and reviews the related literature. The identification of renal leiomyosarcoma is based on immunohistochemistry.
Renal sarcomas are very rare malignant tumours with a very poor prognosis. Renal leiomyosarcoma, a malignant tumour of smooth muscle origin, is the most common histological type. The article reports a case of leiomyosarcoma of renal location, with a review of the literature. A 38-year-old female patient, with no previous pathological history, consulted the nephrology department of the Teaching Hospital of Lome for abdominal pain that had been present for 4 years. Histology showed a tumour proliferation of fasciculated architecture, made of spindle cells arranged in long bundles, with cytonuclear atypia and cytoarchitectural abnormalities. Immunohistochemical examination showed positive staining for smooth muscle actin, h-caldesmone, desmin and CD34 and negative for pancytokeratin (AE1/AE3), myogenin and PS100. Renal leiomyosarcoma is an exceptional malignancy. It remains the most common renal sarcoma, the differential diagnosis of which is based on immunohistochemical findings.
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