Article
Biochemical Research Methods
Simone Hintze, Youssef Sameh Bahgat Hannalla, Sylvie Guinchard, Daniel Hunkeler, Gaetan Glauser
Summary: Pesticide metabolites are often detected in groundwater at concentrations higher than their parent pesticides, with some metabolites frequently appearing at elevated levels. Developing methods to measure these metabolites in soil and the unsaturated zone is crucial for estimating their impact on groundwater concentrations post-ban.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Environmental Sciences
Cuifang Zhang, Zhuang Wang, Sheng Liu, Huihua Tan, Dongqiang Zeng, Xuesheng Li
Summary: A novel and accurate liquid chromatography-tandem mass spectrometry method was developed to determine persistent herbicides and their metabolites in fresh fish tissues. The method was validated according to Codex guidelines and successfully applied to analyze the concentrations of target chemicals in fish samples collected from markets in Nanning City, Guangxi Province, China. This study also identified DEA and DIA concentrations in fish liver for the first time.
Article
Environmental Sciences
Lifei He, Falin He, Song Yang, Yangyang Gao, Beixing Li, Feng Liu, Wei Mu
Summary: An efficient method was established for simultaneously determining PYR and its metabolite BF 500-3 in cucumber fruits, leaves, and soil matrices, showing that PYR quickly dissipates in cucumber fields and does not exceed the maximum residue limit in cucumber fruits at the recommended application rate of 150 g a.i. ha(-1) in China.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Agronomy
Petros Tsiantas, Evangelia N. Tzanetou, Helen Karasali, Konstantinos M. Kasiotis
Summary: Soil is a major recipient of contaminants, including organochlorine pesticides, despite being banned in the EU. A GC-MS/MS method was developed and applied to soil samples, revealing the presence of dieldrin. The subsequent health risk assessment showed negligible non-carcinogenic risk and tolerable carcinogenic risk, indicating the importance of continuous monitoring for persistent chemical residues in soil.
Article
Environmental Sciences
Margaret L. Eng, Chunyan Hao, Christena Watts, Fengrong Sun, Christy A. Morrissey
Summary: The study utilized sensitive analytical methods to measure the effects of two field-realistic concentrations of neonicotinoid insecticides on red-winged blackbirds. Imidacloprid was rapidly absorbed and metabolized within 48 hours, with the most significant decrease in parent IMI observed at 6 hours post-exposure. 5-OH-IMI was identified as a persistent marker of exposure at 48 hours.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Agriculture, Multidisciplinary
Tzu-Hsuen Yuan, Meng-Ting Yu, Yoshinori Ikenaka, Yi-Hsuan Chen, Shoji F. Nakayama, Chang-Chuan Chan
Summary: Neonicotinoids and their metabolites were detected in Taiwanese tea leaves, with different tea species and harvest seasons influencing the levels of these pesticides. The government should monitor the use of neonicotinoids to ensure food safety.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Agriculture, Multidisciplinary
Feng Xu, Gongming Du, Duo Xu, Liuyang Chen, Xinxin Zha, Zhenyu Guo
Summary: The optimized QuEChERS method combined with UPLC-MS/MS analysis was established for the simultaneous determination of flonicamid, dinotefuran and its metabolites in peach trees. The potential dietary intake risk of the flonicamid-dinotefuran mixture on peach trees was found to be negligible.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Environmental Sciences
Hua Zhang, Kairui Zhu, Jiang Du, Maota Ou, Junlong Hou, Desheng Wang, Jing Wang, Wencai Zhang, Guodong Sun
Summary: This study investigated the concentrations of NEOs and their metabolites in serum samples collected from an elderly population in China. Results showed widespread detection of NEOs and their metabolites, with males having higher concentrations than females. Associations between NEO concentrations and osteoporosis indicate a potential correlation with increased odds of prevalent OP.
ENVIRONMENTAL RESEARCH
(2022)
Article
Chemistry, Analytical
Sonja A. Wrobel, Daniel Bury, Vladimir N. Belov, Jan M. Klenk, Bernhard Hauer, Heiko Hayen, Anderson J. Martino-Andrade, Holger M. Koch, Thomas Bruening, Heiko U. Kaefferlein
Summary: We have developed a specific and robust analytical method to analyze the most important neonicotinoids and their metabolites in human urine. The method was successfully validated and applied to quantify these compounds in individuals from the general population in Germany and pregnant women from Brazil with no known occupational exposures to neonicotinoids.
ANALYTICA CHIMICA ACTA
(2023)
Article
Environmental Sciences
Zhi-Feng Chen, Ying-Tao Tang, Xiao-Liang Liao, Jie-Ru Jiang, Zenghua Qi, Zongwei Cai
Summary: This study developed a rapid, easy, cheap, effective, rugged, and safe method for determining the content of organophosphate flame retardants (OPFRs) and their metabolites in urine. By monitoring specific substances in urine, human exposure to OPFRs can be traced. Additionally, the study revealed that an important OPFR is predominantly present in its conjugated form in urine.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Applied
Huiyu Zhao, Zhenni Zhao, Xue Li, Shanshan Di, Peipei Qi, Zhiwei Wang, Jiao Wang, Pei Tian, Hao Xu, Xinquan Wang
Summary: A modified QuEChERS LC-MS/MS method was developed for analyzing 107 pesticides in animal lipids. The challenges of cleaning up high fat matrices were addressed by optimizing adsorbents and using low temperature assistance. The method was validated and showed good linearity, low LOQs, and precision and accuracy. It was successfully applied to various animal lipids with satisfactory recoveries and RSDs.
Article
Chemistry, Analytical
Shaodong Pan, Xianpeng Song, Dan Wang, Yajie Ma, Xiangliang Ren, Hongyan Hu, Yongpan Shan, Xiaoyan Ma, Junyu Luo, Changcai Wu, Yan Ma, Jinjie Cui
Summary: Neonicotinoids, including thiacloprid, have been banned in the European Union due to concerns about their impact on the environment. A new analytical method using QuEChERS-HPLC-MS/MS was developed to effectively determine thiacloprid and its metabolites in vegetables and flowers. The method demonstrated good linearity, low limits of quantitation and detection, and satisfactory recovery and precision.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Wei Zuo, Zhi Wu, Huan Xiong, Huyi Zhou, Chengqiu Wang, Jing Li
Summary: A fast and sensitive method for simultaneously detecting the nematicide fluensulfone and its two major metabolites in different types of agricultural soils was established using ultra-high performance liquid chromatography-tandem mass spectrometry. The method demonstrated high recoveries and precision, with an overall average recovery range of 73.1%-113.9% and relative standard deviations of less than 12.7%. The method was successfully applied to examine the degradation of the nematicide and the formation of its metabolites in three different types of soil, indicating its efficacy in studying the environmental behavior of the nematicide in agricultural soil.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Applied
Shuhui Li, Ziwei Meng, Yang Liu, Dan Liu, Zhiyi Xu
Summary: A rapid method was developed to analyze pinoxaden and its metabolite M4 in wheat, and wheat samples from 12 cities in China were examined. The results showed that the residues of pinoxaden and M4 in wheat were acceptable.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Environmental Sciences
Vahideh Mahdavi, Mir-Ebrahim Solhi Heris, Mehdi Dastranj, Mahdi Moridi Farimani, Zahra Eslami, Hassan Y. Aboul-Enein
Summary: The study evaluated pesticide residues in soil samples from different areas in the North of Iran, finding the presence of malathion, propargite, and butachlor. Malathion and propargite were most frequently observed in forestal and residential areas. The research provides valuable information for monitoring pesticide presence in soils and conducting more precise risk assessment studies.
WATER AIR AND SOIL POLLUTION
(2021)
Article
Chemistry, Applied
Yasmin M. Shaalan, H. Handoussa, R. A. Youness, R. A. Assal, A. H. El-Khatib, M. W. Linscheid, H. M. El Tayebi, A. I. Abdelaziz
NATURAL PRODUCT RESEARCH
(2018)
Review
Spectroscopy
Michael W. Linscheid
MASS SPECTROMETRY REVIEWS
(2019)
Article
Biochemical Research Methods
Sabrina Trog, Ahmed H. El-Khatib, Sebastian Beck, Marcus R. Makowski, Norbert Jakubowski, Michael W. Linscheid
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Hesham El-Askary, Heba Handoussa, Farid Badria, Ahmed H. El-Khatib, Abdulrhman Alsayari, Michael W. Linscheid, Amira Abdel Motaal
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2019)
Article
Chemistry, Analytical
David Benda, Sebastian Beck, Michael W. Linscheid
Article
Biochemical Research Methods
Stefanie Ickert, Timm Schwaar, Andreas Springer, Marko Grabarics, Jens Riedel, Sebastian Beck, Kevin Pagel, Michael W. Linscheid
JOURNAL OF MASS SPECTROMETRY
(2019)
Article
Food Science & Technology
Reham Wagdy, Reham M. Abdelkader, Ahmed H. El-Khatib, Michael W. Linscheid, Nabila Hamdi, Heba Handoussa
JOURNAL OF FOOD SCIENCE
(2019)
Article
Biochemical Research Methods
Pablo Lores Lareo, Michael W. Linscheid, Oliver Seitz
JOURNAL OF MASS SPECTROMETRY
(2019)
Article
Chemistry, Analytical
Noha F. El Azab, Said F. Hotar, Yossra A. Trabik
Summary: Sensitive, simple and rapid bioanalytical method for the simultaneous determination of 13 PAHs in rat plasma was established using QuEChERS as a preliminary step and GC-MS for identification. The method was fully validated and successfully applied to a minor toxicokinetic study in rats.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2022)
Article
Spectroscopy
Sarah H. Abdelaal, Noha F. El Azab, Said A. Hassan, Amira M. El-Kosasy
Summary: The study proposes a native spectrofluorimetric quality control assay of raspberry ketone, overcoming the limitations of conventional excitation/ emission spectra. The method shows a linear relationship and high sensitivity in aqueous medium. The proposal is simple, eco-friendly, and cost-effective, suitable for routine quality control practices especially in developing countries.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Noha F. El Azab, Amr M. Mahmoud, Yossra A. Trabik
Summary: In this study, a disposable electrochemical sensor was developed for the determination of Levofloxacin in human plasma. The sensor's performance was enhanced by modifying the pencil graphite electrode with Au-NPs and molecularly imprinted copolymer. The sensor showed a linear response and low detection limit, with the benefits of selectivity, repeatability, and low manufacturing cost.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Noha F. El Azab
Summary: In this study, a LC-MS/MS approach was developed to detect and quantify certain COVID-19 candidate drugs in rat plasma. The method was validated according to US FDA criteria and showed satisfactory recoveries, low detection limits, and good precision and accuracy.
MICROCHEMICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Noha F. F. El-Azab, Sarah H. H. Abdelaal, Said A. A. Hassan, Amira M. M. El-Kosasy
Summary: A simple HPLC/PDA method was developed for quantitation of seven popular slimming ingredients. The method showed efficient separation and baseline-separated symmetric peaks without the need for gradient programs or modified phases. Method validation was conducted, and the linear calibration curves and low LOD values indicated the reliability of the method. Mislabeling actions were observed in some tested products, highlighting the importance of accurate labeling in dietary supplements.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Analytical
Noha F. F. El Azab, Faizah A. Binjubair, Sara T. Al-Rashood, Sherif Okeil, Noha M. El Zahar
Summary: Neoadjuvant treatment has been proven to be a viable option for locally advanced breast cancer patients. This article presents the development of a unique bioanalytical method using UPLC-MS/MS for the concurrent estimation of neoadjuvant treatments in rat plasma. The method showed good linearity, low detection limits, and high precision.
Article
Chemistry, Analytical
Doaa M. Mustafa, Nancy Magdy, Noha F. El Azab
Summary: The study focused on the development of a stability-indicating HPLC-DAD technique for Vericiguat (VER) analysis. VER was found to be sensitive to alkaline, oxidative and thermal degradation. The analysis method was validated to be specific, fast, simple, precise and accurate for routine analysis and quality control of VER in its pharmaceutical formulation. The technique was also used to investigate the kinetics of alkaline, oxidative and dry heat degradation.