Article
Environmental Sciences
Kumari Vandana Singh, Rakesh Arya, Jay Prakash Nirala, Debasis Sahu, Ranjan Kumar Nanda, Paulraj Rajamani
Summary: This study reveals the deregulation of hippocampus proteome upon exposure to mobile phone radiation, which may influence the healthy functioning of the brain.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Omur Gulsum Deniz, Suleyman Kaplan
Summary: This study investigated the effects of EMF from mobile phones on the hippocampus, with findings suggesting that a 900 MHz EMF can lead to detrimental changes in the brain. The protective effect of Momordica charantia (MC) was shown to be more potent than other antioxidant substances.
JOURNAL OF CHEMICAL NEUROANATOMY
(2022)
Article
Biochemistry & Molecular Biology
Abdalla Ahmed Eldaw Elamin, Omur Gulsum Deniz, Suleyman Kaplan
Summary: This study investigated the potential effects of electromagnetic field emitted by mobile phones on hippocampal pyramidal neurons and the role of curcumin, Garcinia kola, and Gum Arabic in reducing these effects. The results showed that exposure to the electromagnetic field caused severe alterations in the number and structure of hippocampal pyramidal neurons. Curcumin and Garcinia kola exhibited a protective effect against these deleterious effects, while Gum Arabic did not provide any protection.
JOURNAL OF CHEMICAL NEUROANATOMY
(2022)
Article
Multidisciplinary Sciences
Mariam Salameh, Sukaina Zeitoun-Ghandour, Lina Sabra, Ahmad Daher, Mahmoud Khalil, Wissam H. Joumaa
Summary: This study investigated the effects of continuous 24-hour exposure to mobile communication electromagnetic fields on oxidative stress, apoptosis, and inflammation in the liver of rat fetuses. The results showed that exposure to electromagnetic radiation increased oxidative stress, apoptosis, and inflammation, but before a sensitive developmental stage, the mother may provide protection for the embryos.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Kristina A. Simeone, Julianne C. Wilke, Stephanie A. Matthews, Timothy A. Simeone, Jong M. Rho
Summary: The study provides evidence that metabolic therapies like the ketogenic diet may have a protective effect on reducing cell loss in the hippocampus of epileptic mice. This protection may involve mechanisms beyond just reducing seizure activity and could play a role in promoting or restoring hippocampal morphological integrity.
Article
Neurosciences
Danielle Guez-Barber, Lorianna M. Colon, Dana Raphael, Max A. Wragan, Sanghee Yun, Amelia J. Eisch
Summary: Microglia are immune cells in the brain that play a supportive role in brain function and response to disease and injury. Sex differences in microglia have been observed in early life stages in rodents. However, the sex differences in the dentate gyrus (DG) at the P10 stage have not been assessed, providing a baseline for interpreting microglia changes after injury.
NEUROSCIENCE LETTERS
(2023)
Article
Environmental Sciences
Ranjeet Kumar, Pravin S. Deshmukh, Sonal Sharma, Basu Dev Banerjee
Summary: This study evaluated the dose-dependent and frequency-dependent epigenetic modulation in the hippocampus of Wistar rats exposed to RF-MW at different frequencies and absorption rates for varying durations. The results showed significant alterations in global DNA and histone methylation in the hippocampus with increasing frequency and duration of microwave exposure, indicating a potential impact on gene expression.
ENVIRONMENTAL RESEARCH
(2021)
Article
Neurosciences
Kiymet Kuebra Tufekci, Elfide Gizem Bakirhan, Funda Terzi
Summary: This study investigated the effects of maternal obesity on the hippocampus of male rat offspring and the potential neuroprotective effects of N-acetylcysteine (NAC). The results showed that maternal obesity led to decreased hippocampal volume and NPY1R expression, and the offspring displayed increased anxiety and reduced social interaction. NAC was found to attenuate these effects.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Yaroslav Kolinko, Lucie Marsalova, Stephanie Proskauer Pena, Milena Kralickova, Peter R. Mouton
Summary: Microcirculatory factors are important in Aβ-related neuropathology in AD. This study quantified and compared microvessel parameters in hippocampal subregions of Tg AD model rats. Results showed disruptions in microvascular structure in Tg rats, suggesting potential for novel AD therapeutic strategies.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biology
Imam Hasan, Mir Rubayet Jahan, Md Nabiul Islam, Mohammad Rafiqul Islam
Summary: The study showed that 2400MHz RF-EMR cell phone radiation affects the structural integrity of the hippocampus in mice, leading to behavioral changes such as anxiety. This highlights the potential long-term detrimental effects of exposure to RF-EMR.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Naserddine Hamadi, Omur Gulsum Deniz, Ahlam Said Abi Issa, Azim Ullah Shamsul Islam, Naheed Amir, Saeed Tariq Minhas, Nather Madjid, Fatima Khelifi-Touhami, Suleyman Kaplan, Abdu Adem
Summary: The development of animal models to study cell death in the brain is a delicate task. One of the models, that was discovered in the late eighties, is the induction of neurodegeneration through glucocorticoid withdrawal by adrenalectomy in albino rats. In this study, the impact of short-term adrenalectomy on hippocampal neuronal populations in Wistar rats was investigated using stereological technique and ultrastructural examination. The levels of insulin-like growth factor-1 (IGF-1) and beta-nerve growth factor (beta-NGF) were measured to understand the underlying mechanisms of degeneration in these neurons. The cognitive behavior of Wistar rats after short-term adrenalectomy was also examined.
Article
Cell Biology
Mohammad Alipour, Mina Kamkar Asl, Elnaz Khordad, Fatemeh Alipour, Amir Raoofi, Alireza Ebrahimzadeh-bideskan, Vahid Ebrahimi
Summary: Etomidate may have neurodegenerative effects in rat hippocampus, increasing the number of apoptotic cells and dark neurons in different regions of the hippocampus.
Article
Environmental Sciences
Keiko Yamazaki, Atsuko Ikeda-Araki, Chihiro Miyashita, Naomi Tamura, Toshio Yoshikawa, Takashi Hikage, Manabu Omiya, Masahiro Mizuta, Miwa Ikuyo, Kazuhiro Tobita, Teruo Onishi, Masao Taki, Soichi Watanabe, Reiko Kishi
Summary: This study examined children's exposure to radiofrequency electromagnetic fields (RF-EMF) in Japan and found that it was lower than in Europe. The most significant contributor to total exposure was the downlink signals from mobile phone base stations, while Wireless LAN and digital TV had minimal impact. Urban residence was consistently associated with increased exposure in four frequency bands. There was also a link between RF-EMF exposure and inattention/hyperactivity symptoms in children.
ENVIRONMENTAL RESEARCH
(2023)
Article
Anatomy & Morphology
J. Sadeghinezhad, I Amrein
Summary: This study used design-based stereological methods to describe the morphometrical features of the hippocampus structures in rats following oxaliplatin (OX) treatment. The results showed that OX treatment induced a decrease in hippocampal volume without neuronal loss, which could help clarify the mechanism by which OX affects cognition and improve preventive treatment strategies.
FOLIA MORPHOLOGICA
(2021)
Article
Environmental Sciences
Isabel Lopez, Nazario Felix, Marco Rivera, Adrian Alonso, Ceferino Maestu
Summary: The study found a significant relationship between health indicators such as headaches, dizziness, and sleep duration among residents exposed to electromagnetic radiation from mobile phone base stations. Additionally, the percentage of cancer cases in the study population was ten times higher than that of the total Spanish population.
ENVIRONMENTAL RESEARCH
(2021)
Article
Surgery
Ilke Onur Kazaz, Selim Demir, Gokcen Kerimoglu, Fatih Colak, Nihal Turkmen Alemdar, Ahmet Ugur Akman, Ozan Can Cekuc, Ahmet Mentese
Summary: The study demonstrated that chrysin may prevent testicular torsion/detorsion injury by inhibiting endoplasmic reticulum stress, showing potential as a therapeutic approach. However, more comprehensive studies are needed to understand the underlying mechanisms.
JOURNAL OF INVESTIGATIVE SURGERY
(2022)
Article
Surgery
Selim Demir, Ilke Onur Kazaz, Gokcen Kerimoglu, Elif Ayazoglu Demir, Fatih Colak, Sedanur Yilmaz, Ahmet Mentese
Summary: In this study, the effects of astaxanthin on testicular torsion/detorsion damage in rats were investigated in terms of oxidative stress and endoplasmic reticulum stress. Astaxanthin administration significantly reduced the damage induced by T/D, indicating a potential protective role through its antioxidant activity. Further studies are needed to elucidate the underlying mechanisms.
JOURNAL OF INVESTIGATIVE SURGERY
(2022)
Article
Pediatrics
Ilke Onur Kazaz, Selim Demir, Gokcen Kerimoglu, Fatih Colak, Nihal Turkmen Alemdar, Sedanur Yilmaz Dogan, Serdar Bostan, Ahmet Mentese
Summary: Chlorogenic acid (CGA) can inhibit testicular damage caused by ischemia-reperfusion and may serve as a potential treatment for testicular torsion.
JOURNAL OF PEDIATRIC UROLOGY
(2022)
Article
Medicine, Research & Experimental
Seckin Engin, Elif Nur Barut, Yesim Kaya Yasar, Aysun Celik Soysal, Tugba Arici, Gokcen Kerimoglu, Mine Kadioglu, Sena F. Sezen
Summary: Trimetazidine (TMZ) exerts protective effects in cyclophosphamide (CP)-induced cystitis through inhibiting TLR4/ NF Kappa B signaling. TMZ improves histological disturbances and contraction abnormalities in the bladder by enhancing antioxidant capacity and suppressing inflammation, as indicated by decreased TNF-alpha and IL-1 beta levels. However, TMZ also enhances the cytotoxicity of CP when combined.
Article
Medicine, General & Internal
Sila Ozlem Sener, Merve Badem, Ufuk Ozgen, Nuriye Korkmaz, Seyda Kanbolat, Gokcen Kerimoglu, Rezzan Aliyazicioglu, Engin Yenilmez, Esen Sezen Karaoglan
Summary: This study evaluated the antidiabetic and antioxidant effects of Lysimachia verticillaris extract and its isolated compounds in rats with STZ-induced type 1 diabetes. The results showed that the extract and compounds reduced blood glucose levels and increased insulin and antioxidant enzyme levels. Quercetin 3-O-beta-glucopyranoside exhibited the strongest antidiabetic effect. These findings suggest that Lysimachia verticillaris and its compounds could be potential sources of herbal medicine for treating diabetes.
Article
Environmental Sciences
Kubra Koc, Nihal Simsek Ozek, Ferhunde Aysin, Ozlem Demir, Asli Yilmaz, Mehmet Yilmaz, Fatime Geyikoglu, Huseyin Serkan Erol
Summary: This study investigates the protective role of Hispidulin on acute respiratory distress syndrome (ARDS) in rats. Rats were divided into three groups: control, ARDS, ARDS+ Hispidulin. The ARDS models were established by injecting rats with oleic acid. Hispidulin treatment resulted in a significant decrease in inflammatory cytokine levels, apoptosis, and ACE activity, suggesting a protective effect against ARDS.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Fisheries
Osman Sabri Kesbic, Umit Acar, Beste Demirci, Funda Terzi, Rifat Tezel, Ali Turker, Kenan Gullu, Hueseyin Serkan Erol
Summary: The study aimed to determine the potential use of poppy seed oil as a main lipid source in common carp diets. Five different experimental diets with various proportions of fish oil and poppy seed oil were provided to common carp for 90 days. The results showed that feeding carp with diets consisting completely of poppy seed oil resulted in significantly greater growth and feed utilization performance, without negative effects on hematological or liver pathology.
AQUACULTURE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Funda Terzi, Beste Demirci, Umit Acar, Suleyman Yuksel, Cagatay Salum, Huseyin Serkan Erol, Osman Sabri Kesbic
Summary: The study aimed to investigate the effect of grape seed extract (GSE) on liver damage in rainbow trout caused by dietary oxidized fish oil. The results showed that supplementation of 0.1% GSE had a significant ameliorative role in these adverse effects.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Immunology
Pinar Bayram, Selina Aksak Karamese, Bengul Ozdemir, Cagatay Salum, Huseyin Serkan Erol, Murat Karamese
Summary: This study investigated the protective and therapeutic effects of baicalein and naringin in a rat model of sepsis. Both pre- and post-application of these flavonoids showed beneficial effects by regulating oxidative stress and suppressing inflammation.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2023)
Article
Cell Biology
Pinar Bayram, Selina Aksak Karamese, Huseyin Serkan Erol, Bengul Ozdemir, Erdem Toktay, Cagatay Salum
Summary: The main hypothesis of this study is that paeoniflorin can inhibit cellular processes such as oxidative stress and inflammation. The protective effects of paeoniflorin on rat model of ovarian ischemia-reperfusion injury were investigated by measuring oxidative stress and inflammatory process parameters. The results suggest that paeoniflorin has a potential dose-dependent protective effect on ovarian ischemia-reperfusion injury, as it improved related parameters and reduced pro-inflammatory cytokines.
JOURNAL OF HISTOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Mohammad Alhilal, Huseyin Serkan Erol, Serkan Yildirim, Ahmet Cakir, Murat Koc, Demet Celebi, Mesut Bunyami Halici
Summary: This study aimed to investigate the effects of flavonoid osajin (OSJ) on liver damage caused by sepsis. The results showed that sepsis induced elevated lipid peroxidation level and catalase activity and decreased glutathione level and superoxide dismutase activity in hepatic tissues. However, administration of OSJ significantly reduced lipid peroxidation level and increased glutathione level and superoxide dismutase activity. Furthermore, OSJ also reduced the expression of interleukin-33 and caspase-3 and improved histopathological integrity. In conclusion, OSJ has a hepatoprotective effect against sepsis-induced liver injury.
JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Busra Dincer, Irfan Cinar, Huseyin Serkan Erol, Beste Demirci, Funda Terzi
Summary: This study compared the effects of Gossypin and the therapeutically used drug Dexamethasone on an oleic acid-induced acute lung injury model. The results showed that Gossypin pretreatment attenuated inflammation and oxidative stress, and had similar therapeutic effects as Dexamethasone.
JOURNAL OF MOLECULAR RECOGNITION
(2023)
Article
Pharmacology & Pharmacy
Ibrahim Turan, Deniz Canbolat, Selim Demir, Gokcen Kerimoglu, Fatih Colak, Nihal Turkmen Alemdar, Ahmet Mentese, Yueksel Aliyazicioglu
Summary: This study evaluated for the first time the protective effect of dimethyl sulfoxide (DMSO) extract of Primula vulgaris leaf (PVE) against cisplatin (CDDP)-induced nephrotoxicity in rats. The results showed that PVE exhibited strong protective effects through its anti-apoptotic, antioxidant, and anti-inflammatory activities against nephrotoxicity and oxidative damage caused by CDDP.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Andrology
Selim Demir, Ilke Onur Kazaz, Gokcen Kerimoglu, Elif Ayazoglu Demir, Fatih Colak, Ayse Firuze Biyik, Yasin Cansever, Ahmet Mentese
Summary: This study evaluated the effect of ethanolic extract of Turkish propolis (EEP) on testicular ischemia/reperfusion (I/R) damage in rats for the first time. The results showed that EEP prevented I/R-induced testicular damage through its antioxidant activity. More comprehensive studies are needed to understand the underlying mechanisms.
REVISTA INTERNACIONAL DE ANDROLOGIA
(2023)
Article
Urology & Nephrology
Gokcen Kerimoglu, Tugba Arici, Ayse Firuze Biyik, Ali Kulaber, Nihal Tuerkmen Alemdar, Selim Demir, Yueksel Aliyazicioglu, Engin Yenilmez
Summary: The purpose of this study was to investigate the potential protective effects of Pterostilbene (Pte) against CYP-induced nephrotoxicity and cystitis in rats. The results showed that Pte could reduce oxidative stress and apoptosis in kidney and bladder tissues caused by CYP, as well as ameliorate histopathological damage.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)