Article
Biochemistry & Molecular Biology
Rita Hargitai, David Kis, Eszter Persa, Tunde Szatmari, Geza Safrany, Katalin Lumniczky
Summary: The study shows that extracellular vesicles (EVs) from irradiated mice can affect the redox status and expression of radiation-response genes in bystander mice. Irradiation with 2 Gy leads to increased lipid peroxidation and altered gene expression. EVs cause decreased expression of antioxidant enzyme genes and iNOS2 in bystander mice.
Article
Environmental Sciences
Xiaole Wang, Jingwen Zhang, Chengbo Lu, Yu Liu, Xiao Yang, Kaixuan Hou, Zhongkun Du, Bing Li, Albert Juhasz, Lusheng Zhu
Summary: This study evaluated the toxicity of environmentally relevant concentrations of pyroxsulam to zebrafish embryos and adults, providing valuable data for assessing its effects on aquatic ecosystems.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Neza Brezovec, Katja Perdan-Pirkmajer, Blaz Burja, Ziga Rotar, Josko Osredkar, Snezna Sodin-Semrl, Katja Lakota, Sasa Cucnik
Summary: The balance between reactive oxygen species and antioxidant defense is disrupted in oxidative stress. This study examined the oxidative balance in systemic sclerosis (SSc) patients and healthy controls, and found high levels of reactive oxidative metabolites (ROMs) in both groups. However, SSc patients had significantly higher total antioxidant capacity (TAC) and oxidative stress index, indicating an increased antioxidant capacity. Although there was no difference in lipid peroxidation or oxidative DNA damage, SSc patients had more leukocyte DNA breaks, especially those treated with immunosuppressives.
Article
Environmental Sciences
Ryan S. Babadi, Anne M. Riederer, Paul D. Sampson, Sheela Sathyanarayana, Terrance J. Kavanagh, Jennifer E. Krenz, Syam S. Andra, Seunghee Kim-Schulze, Karen L. Jansen, Elizabeth Torres, Adriana Perez, Lisa R. Younglove, Maria I. Tchong-French, Catherine J. Karr
Summary: Studies show a positive relationship between phthalate exposure and oxidative stress in children with asthma, indicating a potential adverse impact on asthma morbidity. Further research is needed to confirm these findings and better understand the role of phthalates in childhood asthma.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Critical Care Medicine
Wei Liu, Linling Yu, Min Zhou, Zi Ye, Ruyi Liang, Qiyou Tan, Jiahao Song, Jixuan Ma, Dongming Wang, Bin Wang, Weihong Chen
Summary: This study found an association between propylene oxide (PO) exposure and lung function decline among community residents. The potential mediating mechanism involves oxidative DNA damage and protein carbonylation. Urinary 2HPMA was used as a biomarker for internal exposure to PO.
Article
Biochemistry & Molecular Biology
Axel Guilbaud, Farzan Ghanegolmohammadi, Yijun Wang, Jiapeng Leng, Alexander Kreymerman, Jacqueline Gamboa Varela, Jessica Garbern, Hannah Elwell, Fang Cao, Elisabeth M. Ricci-Blair, Cui Liang, Seetharamsing Balamkundu, Charles Vidoudez, Michael S. Demott, Kenneth Bedi, Kenneth B. Margulies, David A. Bennett, Abraham A. Palmer, Amanda Barkley-Levenson, Richard T. Lee, Peter C. Dedon
Summary: DNA damage is a major cause of genomic instability in various diseases. Traditional analytical methods provide limited insight into the spectrum of DNA lesions in living organisms. In this study, untargeted chromatography-coupled tandem mass spectrometry (LC-MS/MS) was used to explore the landscape of DNA modifications in rat and human tissues. A total of 114 potential DNA adducts were identified in heart, liver, brain, and kidney tissues of rats, and 111 in human heart and brain tissues using the LC-MS/MS approach. Subsequent targeted analysis revealed species, tissue, age, and sex biases in the DNA adducts. This study demonstrates the potential of adductomics in discovering disease-driving DNA adducts and provides a valuable resource for characterizing new forms of DNA damage and developing biomarkers for aging and disease.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Nutrition & Dietetics
Daniela Martini, Raul Dominguez-Perles, Alice Rosi, Michele Tassotti, Donato Angelino, Sonia Medina, Cristian Ricci, Alexandre Guy, Camille Oger, Letizia Gigliotti, Thierry Durand, Mirko Marino, Hans Gottfried-Genieser, Marisa Porrini, Monica Antonini, Alessandra Dei Cas, Riccardo C. Bonadonna, Federico Ferreres, Francesca Scazzina, Furio Brighenti, Patrizia Riso, Cristian Del Bo, Pedro Mena, Angel Gil-Izquierdo, Daniele Del Rio
Summary: The study investigated the effect of consuming different doses of coffee or cocoa-based products containing coffee on markers of DNA damage and lipid peroxidation in young healthy volunteers for one month. Overall, the results showed that consumption of these products did not significantly affect oxidative stress markers, except for a time effect on DNA strand breaks and some markers of lipid peroxidation. Further studies are needed to better explain the findings and understand the impact of different dosages on specific target groups.
Article
Agricultural Engineering
Muhammad Ahmad, Ejaz Ahmad Waraich, Usman Zulfiqar, Aman Ullah, Muhammad Farooq
Summary: This study demonstrated that the application of thiourea can improve heat tolerance in camelina, increase seed yield, and protect plants from oxidative damage. Additionally, thiourea application was more effective at the reproductive stage, and genotype 618 showed higher tolerance to heat stress compared to genotype 611.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Nutrition & Dietetics
Malgorzata M. Brzoska, Magdalena Kozlowska, Joanna Rogalska, Malgorzata Galazyn-Sidorczuk, Alicja Roszczenko, Nazar M. Smereczanski
Summary: This research showed that increasing zinc intake can alleviate oxidative stress and damage caused by cadmium in the brain. The interaction between zinc and cadmium can effectively prevent the imbalance in oxidative/antioxidative status and protect against injury to cellular macromolecules in the nervous system.
Article
Nanoscience & Nanotechnology
Xueyan Hu, Xinyue Wang, Qiqi Liu, Jin Wu, Haoqi Zhang, Anila Khalique, Zhiyuan Sun, Rui Chen, Jing Wei, Hongbo Li, Deling Kong, Jie Zhuang, Xiyun Yan, Xinglu Huang
Summary: The fully synthetic cell system, integrating biomimetic nanozymes into giant unilamellar vesicles, successfully mimics intracellular oxidative stress pathways and induces tumor cell death by sensing and responding to external chemical signals.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Medicine, Research & Experimental
Uttpal Anand, Protha Biswas, Vinay Kumar, Durga Ray, Puja Ray, Verity I. P. Loake, Ramesh Kandimalla, Anupama Chaudhary, Birbal Singh, Nanda Kishore Routhu, Zhe-Sheng Chen, Jaroslaw Prockow, Abhijit Dey
Summary: Radiation has deleterious effects on cells and tissues, but certain plants and natural compounds, such as Podophyllum hexandrum, have radioprotective abilities. Studies have shown that Podophyllum and its constituents protect various biological systems and induce DNA repair, apoptosis inhibition, and free radical scavenging.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cell Biology
Puneet Kaur, Umesh Rai, Rajeev Singh
Summary: During modern era, various electronic devices using radiofrequency waves have become essential in our daily lives. The increasing risk of male infertility is a growing concern, as excessive exposure to non-ionizing radiation may cause genetic health effects on the male reproductive system. Studies on the genotoxic effects of radiofrequency (RF) waves have shown contradictory results regarding their impact on humans and animals. This review focuses on the genomic impact of RF-EMF on male infertility, discussing the potential damage to DNA, chromosomal aberrations, micronuclei formation, and oxidative stress caused by RF radiation exposure.
Article
Cell Biology
Giulia Leanza, Caterina Conte, Francesca Cannata, Camilla Isgro, Alessandra Piccoli, Rocky Strollo, Carlo Cosimo Quattrocchi, Rocco Papalia, Vincenzo Denaro, Mauro Maccarrone, Nicola Napoli, Anna Maria Sardanelli
Summary: In this study, the oxidative stress states were compared between postmenopausal women with and without obesity. The results showed that women with obesity had doubled levels of oxidative stress markers compared to women of normal weight. The severity of oxidative stress was correlated with body mass index, visceral fat mass, and trunk fat percentage, but not with fasting glucose levels. These findings suggest that obesity and visceral fat increase oxidative stress in postmenopausal women, potentially increasing the risks of cardiometabolic and cancer diseases.
Review
Health Care Sciences & Services
Xinxi Cao, Yangyang Cheng, Chenjie Xu, Yabing Hou, Hongxi Yang, Shu Li, Ying Gao, Peng Jia, Yaogang Wang
Summary: Improper use of mobile phones increases the risk of accidents and chronic disorders. This study found that long-term use of mobile phones is associated with higher accident risk and various health issues such as neoplasms, eye diseases, mental health disorders, and headaches. Proper and reasonable use of mobile phones is essential for minimizing these risks.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jan Stepniak, Aleksandra Rynkowska, Malgorzata Karbownik-Lewinska
Summary: Iron is essential for many organs but its overload can be toxic. Excessive iron absorption and deposition can lead to diseases like hemochromatosis. This study found that the thyroid is less sensitive to oxidative effects caused by Fenton reaction substrates and melatonin has the same protective effects in different tissues.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Environmental Sciences
Aysel Caglan Gunal, Secil Kayiran Tunca, Pinar Arslan, Goktug Gul, Aylin Sepici Dincel
Summary: Permethrin has acute and sublethal effects on narrow-clawed crayfish, causing changes in various organs and hemolymph biochemical parameters. This synthetic pyrethroid pesticide poses a potential threat to biodiversity and freshwater ecosystems.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Erdal Ergunol, Rabia Semsi, Aylin Sepici Dincel
Summary: This study investigated the history of dentistry and medical ethics course at Cyprus Health and Social Sciences University, finding that students performed well in midterm and final exams. The success of students suggests the value of teaching this course in the dental curriculum.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2022)
Article
Biochemistry & Molecular Biology
Rabia Semsi, Umut Kokbas, Burak Arslan, Erdal Ergunol, Levent Kayrin, Aylin Sepici Dincel
Summary: The study compared salivary cortisol and amylase levels measured by three different analytical methods to discuss stress level alterations in samples. The biosensor method showed good correlation with ELISA in determining salivary cortisol levels and could be offered as an alternative to ELISA due to its effectiveness, cost-efficiency, speed, and specificity.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Biochemical Research Methods
Burcu Eser, Rabia Tural, Aysel Caglan Gunal, Aylin Sepici Dincel
Summary: Bisphenol A is a high-production-volume industrial chemical with endocrine disruptor effects. This study analyzed BPA exposure in zebrafish at different doses and durations, using an HPLC method to detect BPA levels. The findings suggested significant effects of dose and time on zebrafish, and highlighted the feasibility of using HPLC to measure BPA levels.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Medicine, Research & Experimental
Burak Arslan, Goekce Ayhan Arslan, Asli Tuncer, Rana Karabudak, Aylin Sepici Dincel
Summary: This study compared CSF NfL levels in different CNS diseases groups, finding the highest levels in the NDCNS group and a strong positive correlation between T2 lesion number and CSF NfL level in the MS group. It also concluded that SIMOA is the most reliable method for serum NfL determination.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Ebru Menekse, Sezai Aydin, Oguz Ugur Aydin, Duygu Sahin, Gulcin Akca, Abdullah Eroglu, Aylin Sepici Dincel, Yesim Ozkan, Mete Dolapci
Summary: This study aimed to investigate the presence of indoleamine-2,3-dioxygenase and bacterial translocation after the administration of 3-aminobenzamide and infliximab in the TNBS model of rat colitis. The results showed that infliximab treatment can decrease bacterial translocation by altering the expression of indoleamine-2,3-dioxygenase compared with 3-aminobenzamide treatment. Combined treatments provide different approaches for new molecules related to indoleamine-2,3-dioxygenase.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2022)
Article
Medicine, General & Internal
Burcu Eser, Duygu Tecer, Aylin S. Dincel
Summary: The study compared the levels of MMP-9 and MMP-13 in pSS, PsA, RA, and healthy control groups, showing no significant differences between the groups in terms of these two indicators, but a negative correlation between MMP-9 and MMP-13 in the pSS group was observed.
ROMANIAN JOURNAL OF MILITARY MEDICINE
(2022)
Article
Green & Sustainable Science & Technology
Aysel Caglan Gunal, Pinar Arslan, Nagehan Ipicuruk, Rabia Tural, Aylin Sepici Dincel
Summary: This study aimed to investigate the effects of copper pyrithione (CPT), zinc pyrithione (ZPT), and their mixtures on histological changes in zebrafish tissues and the vitellogenin hormone. The results showed that these substances not only caused histopathological changes but also affected the vitellogenin hormone levels, indicating their role as endocrine disrupting compounds.
ENERGY ECOLOGY AND ENVIRONMENT
(2022)
Article
Ecology
Nesli Belek, Belda Erkmen, Aylin Sepici Dincel, Aysel Caglan Gunal
Summary: This study investigated the toxic effects of sublethal concentrations of PFOS on narrow-clawed crayfish. The results showed that PFOS exposure led to a decrease in total haemocyte counts and an increase in haemolymph total antioxidant status. Histopathological alterations were observed in hepatopancreas and gill tissues. The findings highlight the importance of understanding the early toxicological effects of PFOS on freshwater ecosystems, and suggest that A. leptodactylus is a reliable model for studying histopathological alterations and enzyme activities in toxicology studies.
Article
Biology
Yusuf Kucukbagriacik, Mohammadreza Dastouri, Elcin Ozgur-Buyukatalay, Ozen Akarca Dizakar, Korkut Yegin
Summary: This study aimed to investigate whether exposure to non-ionizing radiofrequency fields could induce an adaptive response in adult mice and to uncover the underlying molecular mechanisms. The findings of the study suggest that exposure to 900 MHz GSM signal can trigger an adaptive response in the RB group. The increase in reactive oxygen species (ROS) may play a crucial role in triggering this response, along with the increase in the expression of genes involved in the DNA repair mechanism. The study highlights the protective reaction against bleomycin induced by RF radiation and the role of minimal oxidative stress in enabling the survival of cells through an adaptive response.
ELECTROMAGNETIC BIOLOGY AND MEDICINE
(2022)
Article
Veterinary Sciences
Gozde Yucel-Tenekeci, Aylin Sepici-Dincel, Ibrahim Ayhan Ozkul
Summary: This study investigated the pathomorphological lesions occurring in the ovaries of water buffaloes sent to slaughterhouses. The study found that follicular cysts and luteal cysts were the main problems, and other issues such as cyst extension and ovarian inflammation were also observed. The hormonal levels in water buffalo ovaries were found to be abnormal, which may threaten their reproductive performance.
ACTA SCIENTIAE VETERINARIAE
(2022)
Meeting Abstract
Geriatrics & Gerontology
E. Atmaca, V. E. Dincel, O. Ozbas, A. Sepici Dincel
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Medicine, General & Internal
Ozgul Ozgan Celikel, Filiz Yildirim, Zuhal Yildirim, Sevgi Ayhan, Aylin Sepici Dincel
Summary: This study investigated the relationship between fasting blood sugar, lipid profile, bone mineral density (BMD) values, and antioxidant enzyme activities in postmenopausal women. The results showed that increased age, duration of menopause, and oxidative stress, as well as decreased antioxidant enzyme activity, were associated with increased osteoporosis.
GAZI MEDICAL JOURNAL
(2022)
Meeting Abstract
Endocrinology & Metabolism
A. Sepici Dincel, E. Ergunol, R. Orkun, D. Dayanir, O. Ekim, U. Altay, I. A. Ozkul
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Otorhinolaryngology
Mehmet Duzlu, Ayse Iriz, Suleyman Cebeci, Rabia Semsi, Muammer Melih Sahin, Aylin Sepici Dincel
Summary: The study aimed to investigate the relationship between oxidative stress and obstructive sleep apnea (OSA), finding that only gal-1 levels were significantly decreased in patients with OSA, suggesting it may serve as a novel biomarker for OSA. No statistically significant difference was found in the serum levels of PON1, ARES, and oxidized LDL in patients with OSA.
