Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 37, Issue 3, Pages 902-913Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X16647737
Keywords
Brain imaging; cerebral blood flow; cerebral hemodynamics; magnetic resonance imaging; near-infrared spectroscopy
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Funding
- Dutch Technology Foundation STW
- applied science division of NOW
- Technology Program of the Ministry of Economic Affairs
- ZonMW Electromagnetic Fields and Health program
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Although near-infrared spectroscopy is increasingly being used to monitor cerebral oxygenation in neonates, it has a limited penetration depth. The T-2-prepared Blood Imaging of Oxygen Saturation (T-2-BIOS) magnetic resonance sequence provides an oxygen saturation estimate on a voxel-by-voxel basis, without needing a respiratory calibration experiment. In 15 neonates, oxygen saturation measured by T-2-prepared blood imaging of oxygen saturation and near-infrared spectroscopy were compared. In addition, these measures were compared to cerebral blood flow and venous oxygen saturation in the sagittal sinus. A strong linear relation was found between the oxygen saturation measured by magnetic resonance imaging and the oxygen saturation measured by near-infrared spectroscopy (R-2=0.64, p < 0.001). Strong linear correlations were found between near-infrared spectroscopy oxygen saturation, and magnetic resonance imaging measures of frontal cerebral blood flow, whole brain cerebral blood flow and venous oxygen saturation in the sagittal sinus (R-2=0.71, 0.50, 0.65; p < 0.01). The oxygen saturation obtained by T-2-prepared blood imaging of oxygen saturation correlated with venous oxygen saturation in the sagittal sinus (R-2=0.49, p=0.023), but no significant correlations could be demonstrated with frontal and whole brain cerebral blood flow. These results suggest that measuring oxygen saturation by T-2-prepared blood imaging of oxygen saturation is feasible, even in neonates. Strong correlations between the various methods work as a cross validation for near-infrared spectroscopy and T-2-prepared blood imaging of oxygen saturation, confirming the validity of using of these techniques for determining cerebral oxygenation.
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