Low-Dose Farnesyltransferase Inhibitor Suppresses HIF-1α and Snail Expression in Triple-Negative Breast Cancer MDA-MB-231 Cells In Vitro

Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/β-catenin signaling pathway

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Snail Is a Direct Target of Hypoxia-inducible Factor 1α (HIF1α) in Hypoxia-induced Endothelial to Mesenchymal Transition of Human Coronary Endothelial Cells

(2015) Xingbo Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Protein Farnesylation in Burn-Induced Metabolic Derangements and Insulin Resistance in Mouse Skeletal Muscle

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P2Y2R activation by nucleotides released from the highly metastatic breast cancer cell contributes to pre-metastatic niche formation by mediating lysyl oxidase secretion, collagen crosslinking, and monocyte recruitment

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Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

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Meaningful prevention of breast cancer metastasis: candidate therapeutics, preclinical validation, and clinical trial concerns

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Phase II/III trial of a pre-transplant farnesyl transferase inhibitor in juvenile myelomonocytic leukemia: A report from the Children's Oncology Group

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Autocrine signaling via release of ATP and activation of P2X7 receptor influences motile activity of human lung cancer cells

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Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65

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The impact of KRAS mutations on VEGF-A production and tumour vascular network

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Phase I–II study of the farnesyl transferase inhibitor tipifarnib plus sequential weekly paclitaxel and doxorubicin–cyclophosphamide in HER2/neu-negative inflammatory carcinoma and non-inflammatory estrogen receptor-positive breast carcinoma

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The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

ATP citrate lyase knockdown impacts cancer stem cells in vitro

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A phase II trial of capecitabine in combination with the farnesyltransferase inhibitor tipifarnib in patients with anthracycline-treated and taxane-resistant metastatic breast cancer: an Eastern Cooperative Oncology Group Study (E1103)

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Overexpression of galectin-3 enhances migration of colon cancer cells related to activation of the K-Ras–Raf–Erk1/2 pathway

(2012) Keng-Liang Wu et al.   JOURNAL OF GASTROENTEROLOGY

Snail1 induces epithelial-to-mesenchymal transition and tumor initiating stem cell characteristics

(2011) Hien Dang et al.   BMC CANCER

Hallmarks of Cancer: The Next Generation

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Circulating Cell-Free DNA in Plasma of Never Smokers with Advanced Lung Adenocarcinoma Receiving Gefitinib or Standard Chemotherapy as First-Line Therapy

(2011) Y. J. Lee et al.   CLINICAL CANCER RESEARCH

Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB2 Transgenic Mice

(2011) M. E. Balasis et al.   CLINICAL CANCER RESEARCH

A phase 1-2 study of a farnesyltransferase inhibitor, tipifarnib, combined with idarubicin and cytarabine for patients with newly diagnosed acute myeloid leukemia and high-risk myelodysplastic syndrome

(2010) Elias Jabbour et al.   CANCER

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Suppression of farnesyltransferase activity in acute myeloid leukemia and myelodysplastic syndrome: current understanding and recommended use of tipifarnib

(2010) Pearlie K Epling-Burnette et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists

(2010) Sunil Badve et al.   MODERN PATHOLOGY

Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer

(2010) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic KRAS and BRAF Differentially Regulate Hypoxia-Inducible Factor-1  and -2  in Colon Cancer

(2009) H. Kikuchi et al.   CANCER RESEARCH

Metastasis: a therapeutic target for cancer

(2008) Patricia S Steeg et al.   Nature clinical practice. Oncology