Journal
ACS APPLIED NANO MATERIALS
Volume 5, Issue 4, Pages 5387-5397Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsanm.2c00368
Keywords
porous silicon nanoparticles; indocyanine green; photodynamic therapy; glioblastoma multiforme; targeting peptide
Funding
- Basic Science Research Program through the National Research Foundation (NRF) of Korea - Ministry of Education [2018-R1A6A1A03025124]
- Bio & Medical Technology Development Program of the NRF of Korea - Ministry of Science ICT [2022-M3A9H1014157, 2021-M3A9I5030523]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI21C0239]
- KIST institutional project [2E31502]
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This study developed a novel nanoformulation to enhance the efficacy of photodynamic therapy for glioblastoma, with significant targeting ability and excellent biocompatibility.
Photodynamic therapy (PDT) is a clinically approved minimally invasive therapy for malignant diseases. Indocyanine green (ICG) is a prominent photosensitive agent for PDT, but it has intrinsic drawbacks such as aggregation, instability, and photolytic degradation. Although numerous nanoparticle-based approaches have been studied to overcome such issues, there are still limitations such as potential immunogenicity and unprecise and inefficient delivery to the tumor. In this study, we disclosed a nanoformulation (SIWV-pSiNP(ICG)), SIWV peptide-functionalized glioblastoma (GBM) homing, and ICGincorporated porous silicon nanoparticles (pSiNPs). The nanoformulation demonstrated an enhanced photodynamic property under NIR light irradiation with improved stability of the incorporated ICG. The SIWV-pSiNP(ICG) also showed significant targeting ability to the GBM cells with nontoxicity and laser-triggered ROS generation in situ. As a result, the SIWV-pSiNP(ICG) showed superior therapeutic efficacy (anticancer efficiency) with excellent biocompatibility in the GBM xenograft mice. This work presents a novel and efficient strategy to enhance PDT efficacy for the targeted GBM therapy.
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