Molecular insights into cell toxicity of a novel familial amyloidogenic variant of β2-microglobulin

Polymorphism of hen egg white lysozyme amyloid fibrils influences the cytotoxicity in LLC-PK1 epithelial kidney cells

(2014) Maria-Magdalena Mocanu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Cholesterol Drives Aβ(1–42) Interaction with Lipid Rafts in Model Membranes

(2014) Silvia Seghezza et al.   LANGMUIR

Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes

(2014) Soyon Hong et al.   NEURON

Partitioning and confinement of GM1 ganglioside induced by amyloid aggregates

(2013) Martino Calamai et al.   FEBS LETTERS

Structure, Folding Dynamics, and Amyloidogenesis of D76N β2-Microglobulin

(2013) P. Patrizia Mangione et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Both the cis-trans equilibrium and isomerization dynamics of a single proline amide modulate  2-microglobulin amyloid assembly

(2013) V. Y. Torbeev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Measurement of the Mechanical Properties of Lipid Phases in Supported Bilayers

(2012) Laura Picas et al.   BIOPHYSICAL JOURNAL

Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers

(2012) E. Evangelisti et al.   JOURNAL OF CELL SCIENCE

Hereditary Systemic Amyloidosis Due to Asp76Asn Variant β2-Microglobulin

(2012) Sophie Valleix et al.   NEW ENGLAND JOURNAL OF MEDICINE

Direct three-dimensional visualization of membrane disruption by amyloid fibrils

(2012) L. Milanesi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoscale structural and mechanical effects of beta-amyloid (1–42) on polymer cushioned membranes: A combined study by neutron reflectometry and AFM Force Spectroscopy

(2011) Silvia Dante et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Toxic effects of amyloid fibrils on cell membranes: the importance of ganglioside GM1

(2011) Monica Bucciantini et al.   FASEB JOURNAL

Understanding the complex mechanisms of β2-microglobulin amyloid assembly

(2011) Timo Eichner et al.   FEBS Journal

Sequence Determinants of Compaction in Intrinsically Disordered Proteins

(2010) Joseph A. Marsh et al.   BIOPHYSICAL JOURNAL

Effect of Tetracyclines on the Dynamics of Formation and Destructuration of β2-Microglobulin Amyloid Fibrils

(2010) Sofia Giorgetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metal binding sheds light on mechanisms of amyloid assembly

(2010) Matthew F. Calabrese et al.   Prion

Fibril fragmentation in amyloid assembly and cytotoxicity

(2010) Wei-Feng Xue et al.   Prion

Ganglioside-induced amyloid formation by human islet amyloid polypeptide in lipid rafts

(2009) Masaki Wakabayashi et al.   FEBS LETTERS

Fibril Fragmentation Enhances Amyloid Cytotoxicity

(2009) Wei-Feng Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Generic Mechanism of β2-Microglobulin Amyloid Assembly at Neutral pH Involving a Specific Proline Switch

(2009) Timo Eichner et al.   JOURNAL OF MOLECULAR BIOLOGY

A regulatable switch mediates self-association in an immunoglobulin fold

(2008) Matthew F Calabrese et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

 2-Microglobulin is potentially neurotoxic, but the blood brain barrier is likely to protect the brain from its toxicity

(2008) S. Giorgetti et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Plasma membranes are poised for activation of raft phase coalescence at physiological temperature

(2008) D. Lingwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA