Article
Immunology
Xin Hua, Qi-Wei Zhu, Yi-Nuan Zhang, Lu Cao, Meng-Di Wang, Yun-Sheng Gao, Jia-Yi Chen
Summary: This study investigated the prognostic value and biological features of ovarian aging in breast cancer through genetic analysis. An eight-gene signature based on ovarian aging was established and validated, and it accurately predicted clinical outcomes and drug sensitivity of breast cancer patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Xiao-Wei Fu, Chun-Qing Song
Summary: The study revealed that the pyroptosis-related gene signature comprised of GSDME, GPX4, and SCAF11 can serve as an independent prognostic factor for HCC patients, providing further evidence for more clinical and functional studies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Cong Luo, Wenrui Ye, Jiao Hu, Belaydi Othmane, Huihuang Li, Jinbo Chen, Xiongbing Zu
Summary: The study revealed that poliovirus receptor (PVR) was overexpressed and associated with poor prognosis in bladder cancer. A risk signature and nomogram model based on PVR-related genes could predict patient prognosis and therapeutic efficacy, and were also correlated with immune infiltration in bladder cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sha Cao, Cheng Chen, Dezhi Gu, Zhengdong Wang, Guanghui Xu
Summary: The study aimed to establish an oxidative stress-related signature to predict the clinical outcomes and therapeutic responses of colorectal cancer patients. By analyzing the transcriptome profiles and clinical features of patients, a reliable signature was constructed and validated for its superior performance in predicting survival rates and correlation with clinicopathological features. Additionally, the signature was found to be associated with antitumor immunity, drug sensitivity, and CRC-related pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Haoxiang Zheng, Weihan Luo, Yuqing Li, Guoyu Peng, Dewang Zhou, Dongdong Tang, Jiwen Cheng, Song Wu
Summary: The study established a new prognostic signature consisting of seven IRGs, which could effectively predict the prognosis of patients with BLCA and reveal the relationship between immune features in BLCA and different risk scores. The study also provided a possible indicator for targeted therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Cong Luo, Zhixiong Liu, Wenrui Ye, Fangkun Liu
Summary: This study identified immune infiltrates associated with overall survival in lower grade glioma patients and obtained 44 hub genes to construct an immune infiltration-related signature. The signature showed potential as a prognostic biomarker for glioma patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Wei Lu, Changwei Yin, Tianqi Zhang, Yihua Wu, Shengyun Huang
Summary: This study developed an oxidative stress-related prognostic signature based on mRNA expression data of OSCC patients, which was proven to be an independent predictor for patients' prognosis and immune status. It was also found that patients with high-risk scores may benefit more from immune checkpoint therapy, and the risk score was associated with the tumor microenvironment and chemotherapy sensitivity.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Lianmin Luo, Fenghua Li, Binbin Gong, Ping Xi, Wenjie Xie
Summary: This study established a prognostic model based on cellular senescence-related genes in bladder cancer (BCa), which showed reliable predictive power for patient survival. Functional analysis revealed differences in immune-related pathways activity and immune cell infiltration between the two risk groups.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zili Lin, Ziyi Wu, Yuhao Yuan, Wei Zhong, Wei Luo
Summary: This study reveals the crucial role of m7G-related genes in the pathogenesis of osteosarcoma (OS) and establishes a comprehensive risk model incorporating eight signatures. The study also identifies AZD2014 as a potential therapeutic candidate for OS and confirms CYFIP1 and EIF4A1 as independent prognostic risk factors.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Lan Mu, Ke Ding, Ranran Tu, Wei Yang
Summary: The study identified 4 immune infiltrating cells related to the prognosis of early-stage LUAD and established a novel 5 immune-related lncRNA signature for predicting patients' prognosis, showing promising potential for accurate prognosis prediction in early-stage LUAD patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Xi Chen, Chunyan Liao, Xiong Zou, Bei Zhang, Zengnan Mo
Summary: This study aimed to develop a signature of cancer-associated fibroblasts (CAFs)-related genes (CRGs) to predict the survival outcomes and treatment response of bladder cancer (BLCA). Weighted gene co-expression network analysis was utilized to uncover CAFs-associated hub genes, and a risk model for survival prognosis was constructed using LASSO-Cox regression. The findings suggest that the CRG signature offers new avenues for the prognosis evaluation and development of personalized treatment strategies for BLCA.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Jiao-chen Luan, Teng-yue Zeng, Qi-jie Zhang, De-run Xia, Rong Cong, Liang-yu Yao, Le-bin Song, Xiang Zhou, Xuan Zhou, Xiang Chen, Jia-dong Xia, Ning-hong Song
Summary: This study identified prognostic ferroptosis-associated genes in bladder urothelial carcinoma and established a novel gene signature that accurately predicts patient prognosis. The research also found significant differences in immune cell infiltration and immune-related pathways between two risk groups, providing new insights for bladder cancer treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Zhenhua Chen, Yi Zhang, Sujuan Feng, Jiaqi Yuan, Dongliang Shi, Yong Wang, Yongdong Li, Jun Dong
Summary: FOXD3-AS1 is a potential target for tumor prediction and treatment in glioma patients, and its high expression is associated with poor prognosis and survival outcome. It is closely related to immune cell infiltration and response to oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Jing Liu, Tongyu Liu, Chuanhao Zhang, Jiabei He, Dong Zhou, Zhe Wang, Ruoyu Wang
Summary: This study demonstrates that EIF2S2 is highly expressed in hepatocellular carcinoma (HCC) and is associated with poor prognosis. EIF2S2 expression is closely related to immune infiltration and immune checkpoints, and may play a potential regulatory role in predicting drug sensitivity.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Zixuan Zhong, Minxuan Xu, Jun Tan
Summary: This study explores the prognostic role of oxidative stress-related long non-coding RNAs (lncRNAs) in hepatocellular carcinoma (HCC). By analyzing gene expression data from The Cancer Genome Atlas (TCGA) database, a four-DElncRNA signature was constructed and shown to be a robust independent prognostic factor for overall survival. The signature was also found to regulate HCC progression and chemotherapeutic response, and was associated with immune cell infiltration. HCC patients in the high-risk group were more sensitive to conventional chemotherapeutic drugs. This study deepens our understanding of DElncRNA in HCC and provides a theoretical foundation for chemotherapy selection.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)