Article
Infectious Diseases
Chang-Sheng Xia, Minghua Zhan, Yudong Liu, Zhi-Hong Yue, Ying Song, Feifei Zhang, Hui Wang
Summary: This study assessed the levels of protective antibodies in SARS survivors with and without the COVID-19 vaccine, and found that SARS survivors have protective antibodies against SARS-CoV-2 even without vaccination, and generate a stronger antibody response after vaccination compared to controls.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Immunology
Hailong Qi, Zhongjie Sun, Yanling Yao, Ligong Chen, Xuncheng Su
Summary: This study presents a targeted strategy for improved COVID-19 vaccine design using type 1 conventional dendritic (cDC1) cells. By fusing the S protein with the Xcl1 gene, the expressed S protein can be delivered to cDC1 cells, resulting in stronger immune responses and neutralizing activity against SARS-CoV-2 in a mouse model. These findings suggest that Xcl1 serves as a potential molecular adjuvant for SARS-CoV-2 vaccines.
Article
Medicine, Research & Experimental
Riccardo Levi, Elena Azzolini, Chiara Pozzi, Leonardo Ubaldi, Michele Lagioia, Alberto Mantovani, Maria Rescigno
Summary: A study showed that individuals with prior exposure to SARS-CoV-2 had a significant increase in antibody response within 5 to 18 days after receiving the Pfizer/BioNTech vaccine. Symptomatic individuals reached a high titer of antibodies with just one dose, suggesting that a second dose may not be necessary.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Immunology
Jang Hyun Park, Heung Kyu Lee
Summary: The development of COVID-19 vaccines includes various types such as subunit vaccines, inactivated vaccines, and nucleic acid vaccines, but currently only intramuscular vaccination is available. Research suggests that mucosal vaccination may enhance local immune responses, but the lack of understanding of mucosal immunity combined with the urgent need for a COVID-19 vaccine has resulted in the limited delivery options available at present.
Article
Immunology
Chomchanat Tubjaroen, Sittichoke Prachuapthunyachart, Nattakoon Potjalongsilp, Pimpayao Sodsai, Nattiya Hirankarn, Peera Jaru-Ampornpan, Voranush Chongsrisawat
Summary: This study evaluated the humoral immune response in liver transplant recipients and obese adolescents after receiving the BNT162b2 vaccine. The results suggest the need for a booster vaccination for groups with a lower immunogenic response.
Article
Immunology
Yudi Xie, Lei Liu, Jue Wang, Yaqiong Zheng, Chen Luo, Wenxu Ni, Zhihang He, Xin Zhao, Yan Liu, Yingyu He, Shangen Zheng, Ling Li, Zhong Liu
Summary: Among the 64 plasma samples of COVID-19 convalescents, whether vaccinated or not, Omicron (B.1.1.529) escaped the neutralizing antibodies, with a significantly decreased neutralization activity compared to WT. And two-dose of the vaccine could significantly raise the average neutralization of Omicron in convalescent individuals.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemical Research Methods
Shokouh Rezaei, Yahya Sefidbakht, Vuk Uskokovic
Summary: Immunoinformatics plays a crucial role in the development of vaccines and drugs for combating SARS-CoV-2 by extracting meaningful connections from COVID-19 patient data to design effective preventive measures.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Immunology
Negar Firouzabadi, Parisa Ghasemiyeh, Fatemeh Moradishooli, Soliman Mohammadi-Samani
Summary: It has been over three years since the emergence of COVID-19, resulting in millions of deaths. Mass vaccination is the most effective approach to control the infection, and various vaccine platforms have been developed and approved. Despite the decline in transmission and severity of COVID-19 after global vaccination, the emergence of the Omicron variant has raised concerns about vaccine effectiveness. This review focuses on the efficacy and safety of COVID-19 vaccines against SARS-CoV-2 variants, discussing available vaccines and characteristics of different variants, particularly the Omicron variant.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Kiana Shahzamani, Fatemeh Mahmoudian, Shahrzad Ahangarzadeh, Mohammad Mehdi Ranjbar, Leila Beikmohammadi, Samira Bahrami, Elmira Mohammadi, Sahar Esfandyari, Abbas Alibakhshi, Shaghayegh Haghjooy Javanmard
Summary: During the COVID-19 pandemic, the development and application of vaccines have become crucial in combating the spread of the virus, with effective vaccines playing a significant role in reducing the burden and transmission of the disease. While some vaccines have been released ahead of schedule, potential side effects must also be carefully considered.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Ananda M. Rodilla, Sooyun Tavolacci, Jazz Cagan, Tanay Shah, Sandeep Mittan, Philip C. Mack, Fred R. Hirsch
Summary: Compared to the general population, lung cancer patients have a higher risk of severe COVID-19 and associated mortality. Despite being prioritized for vaccination, clinical trials did not include these patients, raising concerns about vaccine efficacy and immune response. Recent investigations have focused on the humoral responses of lung cancer patients to COVID-19 vaccination.
Article
Immunology
David R. Boulware, Thomas A. Murray, Jennifer L. Proper, Christopher J. Tignanelli, John B. Buse, David M. Liebovitz, Jacinda M. Nicklas, Kenneth Cohen, Michael A. Puskarich, Hrishikesh K. Belani, Lianne K. Siegel, Nichole R. Klatt, David J. Odde, Amy B. Karger, Nicholas E. Ingraham, Katrina M. Hartman, Via Rao, Aubrey A. Hagen, Barkha Patel, Sarah L. Fenno, Nandini Avula, Neha Reddy, Spencer M. Erickson, Sarah Lindberg, Regina Fricton, Samuel Lee, Adnin Zaman, Hanna G. Saveraid, Walker J. Tordsen, Matthew F. Pullen, Nancy E. Sherwood, Jared D. Huling, Carolyn T. Bramante
Summary: SARS-CoV-2 vaccine-boosted participants experienced the least severe symptoms during COVID-19, and their symptoms improved the fastest over time. Vaccination against SARS-CoV-2 was found to be associated with reduced symptom severity in a sample of low to moderate risk adults enrolled in an outpatient COVID-19 treatment trial. Booster shots further reduced symptom severity.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Kathryn Macrae, Catherine Yuqing Gong, Prameet Sheth, Jorge Martinez-Cajas, Yanping Gong
Summary: This study aimed to evaluate the antibody responses post three doses of COVID-19 vaccination in the Canadian population. The results showed that most vaccines were effective in producing robust antibody responses, and the more doses were given, the higher the serological response. However, a significant number of participants had lower antibody levels compared to the average levels prior to breakthrough infections, indicating the need for additional vaccination to ensure immunity against SARS-CoV-2.
Review
Biochemistry & Molecular Biology
Hadis Fathizadeh, Saman Afshar, Mahmood Reza Masoudi, Pourya Gholizadeh, Mohammad Asgharzadeh, Khudaverdi Ganbarov, Sukran Kose, Mehdi Yousefi, Hossein Samadi Kafil
Summary: The development of COVID-19 vaccines is aimed at preventing the spread of the disease globally, with some vaccines showing high levels of safety and protection. However, comparing different vaccines is not easy without a unified standard for measuring neutralization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Pravas Kumar Baral, Jiang Yin, Michael N. G. James
Summary: Researchers worldwide are working on developing prophylactic and therapeutic interventions to combat the COVID-19 crisis, with a focus on antibody-based therapies targeting the viral spike protein, particularly monoclonal antibodies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Microbiology
Michael T. Hawkes, Michael F. Good
Summary: According to a mathematical epidemiological model, childhood vaccination against COVID-19 can have modest public health benefits, including reducing child morbidity and mortality and decreasing adult cases, hospitalizations, and mortality. However, the ethical considerations and global social justice, especially in terms of prioritizing children in high-income settings over vulnerable adults in low-income settings, should also be taken into account.
Article
Virology
Gonzalo Moratorio, Gonzalo Obal, Ana Dubra, Agustin Correa, Sergio Bianchi, Alejandro Buschiazzo, Juan Cristina, Otto Pritsch
ARCHIVES OF VIROLOGY
(2010)
Article
Hematology
Natalia Rego, Sergio Bianchi, Pilar Moreno, Helena Persson, Anders Kvist, Alvaro Pena, Pablo Oppezzo, Hugo Naya, Carlos Rovira, Guillermo Dighiero, Otto Pritsch
BRITISH JOURNAL OF HAEMATOLOGY
(2012)
Letter
Oncology
P. Moreno, C. Abreu, M. Borge, F. Palacios, P. Morande, M. Pegazzano, S. Bianchi, Al Landoni, R. Agrelo, M. Giordano, G. Dighiero, R. Gamberale, P. Oppezzo
Article
Oncology
Sergio Bianchi, Pilar Moreno, Ana Ines Landoni, Hugo Naya, Pablo Oppezzo, Guillermo Dighiero, Raul Gabus, Otto Pritsch
LEUKEMIA & LYMPHOMA
(2010)
Letter
Gastroenterology & Hepatology
Jimena Prieto, Florencia Rammauro, Martin Lopez, Romina Rey, Ana Fernandez, Sergio Bianchi, Solange Gerona, Julio Medina, Otto Pritsch
LIVER TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Mariana Seija, Florencia Rammauro, Jose Santiago, Natalia Orihuela, Catherine Zulberti, Danilo Machado, Cecilia Recalde, Javier Noboa, Victoria Frantchez, Rossana Astesiano, Federico Yandian, Ana Guerisoli, Alvaro Morra, Daniela Cassinelli, Cecilia Coelho, Belen de Aramburu, Paulina Gonzalez-Severgnini, Romina Moreno, Aldana Pippolo, Gabriela Lopez, Monica Lemos, Lorena Somariva, Eliana Lopez, Soledad Fumero, Carla Orihuela, Rosalia Rodriguez, Gonzalo Acuna, Victoria Rabaza, Nancy Perg, Rossana Cordero, Cristina Reisfeld, Paula Olivera, Paola Montero, Cecilia Nogueira, Catheryn Nalerio, Sergio Orihuela, Lilian Curi, Ema Burgstaller, Oscar Noboa, Otto Pritsch, Marcelo Nin, Sergio Bianchi
Summary: The antibody response against SARS-CoV-2 after vaccination is weak in kidney transplant patients, especially those who received inactivated virus-based vaccines. Strategies are needed to improve the immunogenicity in this population.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Multidisciplinary Sciences
Martin Flo, Federico Carrion, Natalia Olivero-Deibe, Sergio Bianchi, Madelon Portela, Florencia Rammauro, Beatriz Alvarez, Otto Pritsch
Summary: The study successfully expressed and characterized the retropepsin of Bovine leukemia virus, shedding light on its activity and kinetic properties. The findings contribute to a better understanding of the infection process of this virus and may have implications for the study of other viral proteases.
Article
Immunology
Florencia Rammauro, Federico Carrion, Natalia Olivero-Deibe, Martin Flo, Ana Ferreira, Otto Pritsch, Sergio Bianchi
Summary: Heterologous prime-boost vaccination with CoronaVac and BNT162b2 led to a significant increase in serum anti-RBD specific antibody levels followed by a decrease. However, these levels remained higher than those in individuals vaccinated only with CoronaVac. Serum IgG levels were correlated with antibody binding, blocking RBD-ACE2 interaction, and Fc-effector mechanisms. This study provides insights into the humoral immune response to heterologous vaccination and the scheduling of future vaccine boosters.
Meeting Abstract
Surgery
M. Seija, F. Rammauro, J. Santiago, N. Orihuela, C. Zulberti, D. Machado, C. Recalde, J. Noboa, R. Astesiano, F. Yandian, A. Guerisoli, A. Morra, D. Cassinelli, A. Pippolo, B. De Aramburu, C. Coelho, P. Gonzalez, R. Romero, R. Rodriguez-Teja, G. Acuna, V. Rabaza, N. Perg, R. Cordero, S. Orihuela, L. Curi, E. Burgstaller, O. Noboa, O. Pritsch, M. Nin, S. Bianchi
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Bruno Balduini, Carmela Priore, Cristian Acosta, Emilio Salazar, Facundo Rodriguez, Sergio Bianchi, Otto Pritsch
ANALES DE LA FACULTAD DE MEDICINA-UNIVERSIDAD DE LA REPUBLICA URUGUAY
(2017)
Article
Veterinary Sciences
Gonzalo Moratorio, Sabrina Fischer, Sergio Bianchi, Lorena Tome, Gonzalo Rama, Gonzalo Obal, Federico Carrion, Otto Pritsch, Juan Cristina
VETERINARY RESEARCH
(2013)
Meeting Abstract
Immunology
G. Moratorio, A. Dubra, G. Obal, J. L. Santos, J. Cristina, O. Pritsch, S. Bianchi
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2009)
Meeting Abstract
Hematology
Raul Gabus, Otto Pritsch, Ana I. Landoni, Sergio Bianchi, Cecilia Canessa, Adriana Tiscornia, Gabriel Borelli, Faride Uturbey, Juan Enrique Bodega
