GEF-H1 is necessary for neutrophil shear stress–induced migration during inflammation

Could pharmacological curtailment of the RhoA/Rho-kinase pathway reverse the endothelial barrier dysfunction associated with Ebola virus infection?

(2015) Shahram Eisa-Beygi et al.   ANTIVIRAL RESEARCH

Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin  3 1-dependent

(2014) Y. V. Lerman et al.   BLOOD

Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1

(2014) David Meiri et al.   Nature Communications

GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses

(2013) Hao-Sen Chiang et al.   NATURE IMMUNOLOGY

Low-Level Shear Stress Induces Human Mesenchymal Stem Cell Migration Through the SDF-1/CXCR4 Axis Via MAPK Signaling Pathways

(2013) Lin Yuan et al.   STEM CELLS AND DEVELOPMENT

The 3BP2 Adapter Protein Is Required for Chemoattractant-Mediated Neutrophil Activation

(2012) G. Chen et al.   JOURNAL OF IMMUNOLOGY

Microtubules regulate GEF-H1 in response to extracellular matrix stiffness

(2012) Jessica N. Heck et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanistic Insight into the Microtubule and Actin Cytoskeleton Coupling through Dynein-Dependent RhoGEF Inhibition

(2012) David Meiri et al.   MOLECULAR CELL

Polarity-regulating Kinase Partitioning-defective 1b (PAR1b) Phosphorylates Guanine Nucleotide Exchange Factor H1 (GEF-H1) to Regulate RhoA-dependent Actin Cytoskeletal Reorganization

(2011) Yukie Yamahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

(2011) Jean-Cheng Kuo et al.   NATURE CELL BIOLOGY

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Mechanotransduction by GEF-H1 as a novel mechanism of ventilator-induced vascular endothelial permeability

(2010) Anna A. Birukova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mesenchymal Stem Cells Reduce Inflammation while Enhancing Bacterial Clearance and Improving Survival in Sepsis

(2010) Shirley H. J. Mei et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Endothelial LSP1 is involved in endothelial dome formation, minimizing vascular permeability changes during neutrophil transmigration in vivo

(2010) B. Petri et al.   BLOOD

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration

(2010) Sarah J. Heasman et al.   JOURNAL OF CELL BIOLOGY

The RhoA Activator GEF-H1/Lfc Is a Transforming Growth Factor-β Target Gene and Effector That Regulates α-Smooth Muscle Actin Expression and Cell Migration

(2010) Anna Tsapara et al.   MOLECULAR BIOLOGY OF THE CELL

GEF-H1 Mediates Tumor Necrosis Factor-α-induced Rho Activation and Myosin Phosphorylation

(2009) Eli Kakiashvili et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vav1 Is Essential for Mechanotactic Crawling and Migration of Neutrophils out of the Inflamed Microvasculature

(2009) M. Phillipson et al.   JOURNAL OF IMMUNOLOGY

Modulation of Rho Guanine Exchange Factor Lfc Activity by Protein Kinase A-Mediated Phosphorylation

(2009) D. Meiri et al.   MOLECULAR AND CELLULAR BIOLOGY

Guanine Nucleotide Exchange Factor-H1 Regulates Cell Migration via Localized Activation of RhoA at the Leading Edge

(2009) Perihan Nalbant et al.   MOLECULAR BIOLOGY OF THE CELL

Flotillins Interact with PSGL-1 in Neutrophils and, upon Stimulation, Rapidly Organize into Membrane Domains Subsequently Accumulating in the Uropod

(2009) Jérémie Rossy et al.   PLoS One

Hemodynamic Regulation of Inflammation at the Endothelial–Neutrophil Interface

(2008) Julie Y. Ji et al.   ANNALS OF BIOMEDICAL ENGINEERING

ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA

(2008) Shuh-hei Fujishiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells

(2008) Ronen Alon et al.   CURRENT OPINION IN CELL BIOLOGY

GEF-H1 Couples Nocodazole-induced Microtubule Disassembly to Cell Contractility via RhoA

(2008) Yuan-Chen Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Rapid leukocyte migration by integrin-independent flowing and squeezing

(2008) Tim Lämmermann et al.   NATURE