Article
Cardiac & Cardiovascular Systems
Mats C. H. Lassen, Kristoffer Grundtvig Skaarup, Jannie N. Lind, Alia S. Alhakak, Morten Sengelov, Anne B. Nielsen, Jakob O. Simonsen, Niklas D. Johansen, Filip S. Davidovski, Jacob Christensen, Henning Bundgaard, Christian Hassager, Reza Jabbari, Jorn Carlsen, Ole Kirk, Matias G. Lindholm, Ole P. Kristiansen, Olav W. Nielsen, Charlotte S. Ulrik, Pradeesh Sivapalan, Gunnar Gislason, Rasmus Mogelvang, Gorm B. Jensen, Peter Schnohr, Peter Sogaard, Scott D. Solomon, Kasper Iversen, Jens U. S. Jensen, Morten Schou, Tor Biering-Sorensen
Summary: This study showed that right ventricular function tends to recover following COVID-19, while left ventricular function does not significantly improve post-recovery. Recovered COVID-19 patients have lower cardiac function measures compared to matched controls, indicating that both left and right ventricular function remain impaired.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jeffrey P. Kanne, Brent P. Little, Jefree J. Schulte, Adina Haramati, Linda B. Haramati
Summary: In the 3rd year of the SARS-CoV-2 pandemic, it has been found that about one-third of patients with moderate-to-severe pneumonia, especially those who required intensive care or mechanical ventilation, have residual abnormalities in their lungs one year after initial presentation. These abnormalities range from parenchymal bands to bronchial dilation to fibrosis. The long-term pulmonary vascular sequelae are not well understood, but there seems to be a persistent increased risk of venothromboembolic events in a small group of patients. The histologic abnormalities associated with SARS-CoV-2 infection are similar to those seen in patients with acute lung injury from other causes.
Article
Transplantation
Mohammad Atiquzzaman, Jordyn R. Thompson, Selena Shao, Ognjenka Djurdjev, Micheli Bevilacqua, Michelle M. Y. Wong, Adeera Levin, Peter C. Birks
Summary: We investigated the effect of Post-Acute COVID Syndrome on kidney function among patients in post-COVID recovery clinics in British Columbia, Canada. The study found that patients with long-COVID experienced a significant decline in estimated glomerular filtration rate (eGFR) within 1 year from the infection date. Close monitoring of kidney function is necessary for patients with persistent COVID-19 symptoms.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Virology
Mohammad Zarei, Deepanwita Bose, Masoud Nouri-Vaskeh, Vida Tajiknia, Ramin Zand, Mehdi Ghasemi
Summary: As the understanding of COVID-19's pathophysiology and clinical manifestations improves, it is important to acknowledge the long-term impact on different organ systems. Clinicians should provide patients with expectations of long-term effects post COVID-19 recovery, and understand the risk factors and signs and symptoms for proper follow-up and management.
REVIEWS IN MEDICAL VIROLOGY
(2022)
Article
Gastroenterology & Hepatology
Rithvik Golla, Sudheer Vuyyuru, Bhaskar Kante, Peeyush Kumar, David Mathew Thomas, Govind Makharia, Saurabh Kedia, Vineet Ahuja
Summary: This study examined the frequency, spectrum, and risk factors of post infection functional gastrointestinal disorders/disorders of gut-brain interaction (PI-FGID/DGBI) after COVID-19. The results showed a significantly higher number of PI-FGID/DGBI cases in COVID-19 patients compared to healthy controls at 3 and 6 months of follow-up. These findings are important for understanding and managing the long-term effects of COVID-19.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Ting-Yu Lin, Yun-Hsuan Yeh, Li-Wen Chen, Chao-Neng Cheng, Chen Chang, Jun-Neng Roan, Ching-Fen Shen
Summary: This article reports a rare but potentially fatal case of hemophagocytic lymphohistiocytosis in a 14-year-old adolescent after receiving the BNT162b2 mRNA COVID-19 vaccine. The case suggests that immune activation after COVID-19 vaccination may interfere with the adequate immune response to certain infectious pathogens, resulting in a hyperinflammatory syndrome.
Article
Pediatrics
Madeleine D. Burns, Yannic C. Bartsch, Jameson P. Davis, Brittany P. Boribong, Maggie Loiselle, Jaewon Kang, Abigail S. Kane, Andrea G. Edlow, Alessio Fasano, Galit Alter, Lael M. Yonker
Summary: By studying blood samples from children with COVID-19 and MIS-C, it was found that the immune profile of children continues to develop after acute illness, and the antibody response also changes over time.
PEDIATRIC RESEARCH
(2023)
Review
Multidisciplinary Sciences
Ali Jafar, Andrea Lasso, Risa Shorr, Brian Hutton, Shaun Kilty
Summary: Loss of smell is a common symptom associated with COVID-19 infection, with most patients recovering their sense of smell within 30 days. Patients with severe initial olfactory loss have lower recovery rates. Additional trials on olfactory retraining and steroid therapy are ongoing.
Review
Immunology
Miao Yu, Shuang Nie, Yue Qiao, Ying Ma
Summary: This study retrospectively analyzed reported Guillain-Barre syndrome (GBS) cases occurring after COVID-19 vaccination. The analysis revealed that GBS mostly occurred after the first dose of the vaccination (90%), particularly with DNA vaccines (63%). It was more common in middle-aged and elderly individuals (mean age: 54.5 years) and in men (60%). The mean time from vaccination to onset was 12.3 days. Monitoring for GBS following vaccination is recommended to establish the true incidence and association between GBS and COVID-19 vaccination.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sophie C. Queler, Alexander J. Towbin, Carlo Milani, Jeremy Whang, Darryl B. Sneag
Summary: This article describes two cases of PTS symptoms following COVID-19 vaccination, confirmed by neuroimaging. Further research is needed to understand the association between vaccination and PTS, but MR neurography can be used for diagnosis.
Article
Medicine, General & Internal
Indre Bileviciute-Ljungar, Jan-Rickard Norrefalk, Kristian Borg
Summary: A significant number of post-COVID-19 syndrome sufferers experience pain, highlighting the urgent need for pain management.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Respiratory System
Thomas Sonnweber, Sabina Sahanic, Alex Pizzini, Anna Luger, Christoph Schwabl, Bettina Sonnweber, Katharina Kurz, Sabine Koppelstatter, David Haschka, Verena Petzer, Anna Boehm, Magdalena Aichner, Piotr Tymoszuk, Daniela Lener, Markus Theurl, Almut Lorsbach-Koehler, Amra Tancevski, Anna Schapfl, Marc Schaber, Richard Hilbe, Manfred Nairz, Bernhard Puchner, Doris Huettenberger, Christoph Tschurtschenthaler, Malte Asshoff, Andreas Peer, Frank Hartig, Romuald Bellmann, Michael Joannidis, Can Gollmann-Tepekoylu, Johannes Holfeld, Gudrun Feuchtner, Alexander Egger, Gregor Hoermann, Andrea Schroll, Gernot Fritsche, Sophie Wildner, Rosa Bellmann-Weiler, Rudolf Kirchmair, Raimund Helbok, Helmut Prosch, Dietmar Rieder, Zlatko Trajanoski, Florian Kronenberg, Ewald Woell, Gunter Weiss, Gerlig Widmann, Judith Loeffler-Ragg, Ivan Tancevski
Summary: A study found that some COVID-19 patients still experienced persistent symptoms and lung function impairment 100 days after the onset of the disease, but there was significant improvement in symptoms and cardiopulmonary status over time.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Yi-Ping Gao, Wei Zhou, Pei-Na Huang, Hong-Yun Liu, Xiao-Jun Bi, Ying Zhu, Jie Sun, Qiao-Ying Tang, Li Li, Jun Zhang, Rui-Ying Sun, Xue-Qing Cheng, Ya-Ni Liu, You-Bin Deng
Summary: This study found no significant cardiac structural and functional abnormalities in COVID-19 survivors 327 days after recovery, including patients with myocardial injury at admission.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Urology & Nephrology
Larissa Lebedev, Marina Sapojnikov, Alexander Wechsler, Ronen Varadi-Levi, Doron Zamir, Ana Tobar, Nomy Levin-Iaina, Shlomo Fytlovich, Yoram Yagil
Summary: A 50-year-old man developed minimal change disease (MCD) with nephrotic syndrome and acute kidney injury (AKI) shortly after receiving his first dose of the Pfizer-BioNTech COVID-19 vaccine. Treatment with prednisone was initiated and kidney function gradually improved, eventually returning to normal. While the association between the vaccine and MCD is temporal and by exclusion, further reports are needed to evaluate the true incidence of this potential vaccine side effect.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Immunology
Po-Jui Chen, Yi-Sheng Chang, Chen-Chee Lim, Yu-Kuei Lee
Summary: We report a case of branch retinal artery occlusion and Susac syndrome following COVID-19 vaccination, which may be caused by endotheliopathy resulting from molecular mimicry of the vaccine. Further research is needed to confirm this relationship.
Article
Radiology, Nuclear Medicine & Medical Imaging
Wenjun Wang, Juan Diego Sanchez-Heredia, Rie Beck Olin, Esben Sovso Szocska Hansen, Christoffer Laustsen, Vitaliy Zhurbenko, Jan Henrik Ardenkjaer-Larsen
Summary: This article introduces a novel 14-channel receive-only array for C-13 human head imaging at 3 T that achieves higher SNR by operating at cryogenic temperature cooled by liquid nitrogen. The array is cooled using cryostats and circuits are adapted to the low temperature environment. Imaging results show significant SNR improvement at cryogenic temperature compared to room temperature. The cryogenic coil array is suitable for scenarios that require high SNR deep in a head and decent SNR on the periphery.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Biophysics
Camilla W. Rasmussen, Nikolaj Bogh, Sabrina K. Bech, Thomas H. Thorsen, Esben S. S. Hansen, Lotte B. Bertelsen, Christoffer Laustsen
Summary: Chronic kidney disease has significant implications for health and mortality, and there is a need for a noninvasive method to assess kidney fibrosis. This study explores the potential of a multiparametric MRI protocol, including sodium imaging, in assessing fibrosis. The results suggest that sodium imaging can partially predict fibrosis but its application in kidney disease remains uncertain.
NMR IN BIOMEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Christine Gyldenkerne, Michael Maeng, Lars Kjoller-Hansen, Akiko Maehara, Zhipeng Zhou, Ori Ben-Yehuda, Hans Erik Botker, Thomas Engstrom, Mitsuaki Matsumura, Gary S. Mintz, Ole Froebert, Jonas Persson, Rune Wiseth, Alf I. Larsen, Lisette O. Jensen, Jan E. Nordrehaug, Oyvind Bleie, Elmir Omerovic, Claes Held, Stefan K. James, Ziad A. Ali, Hans C. Rosen, Gregg W. Stone, David Erlinge
Summary: Patients with diabetes have a higher risk of major adverse cardiac events due to both treated culprit lesions and untreated nonculprit lesions. However, this study did not identify diabetes-related high-risk plaque characteristics using multimodality imaging.
Article
Cardiac & Cardiovascular Systems
Martin Bodtker Mortensen, Omar Dzaye, Hans Erik Botker, Jesper Moller Jensen, Michael Maeng, Jacob Fog Bentzon, Helle Kanstrup, Henrik Toft Sorensen, Jonathon Leipsic, Ron Blankstein, Khurram Nasir, Michael J. Blaha, Bjarne Linde Norgaard
Summary: Low-density lipoprotein cholesterol (LDL-C) is associated with atherosclerotic cardiovascular disease (ASCVD), but its association with ASCVD risk is modified by the presence of coronary artery calcification (CAC). This study found that LDL-C is only associated with ASCVD events in patients with CAC, and not in those without CAC. This information is valuable for individualized risk assessment among middle-aged people with or without coronary atherosclerosis.
Article
Clinical Neurology
Jane Agergaard, Benjamin Yamin Ali Khan, Thomas Engell-Sorensen, Berit Schiottz-Christensen, Lars ostergaard, Eva K. Hejbol, Henrik D. Schroder, Henning Andersen, Jakob Udby Blicher, Thomas Holm Pedersen, Thomas Harbo, Hatice Tankisi, M. U. L. T. I. C. O. V. Consortium MULTICOV Consortium
Summary: This study examined 84 patients with long COVID using qEMG and sfEMG, and performed muscle biopsies in a subset of patients. The results showed that the mean MUP duration was decreased in >= 1 muscles in 52% of the patients, and the mean jitter was increased in 17% of the patients in the tibialis anterior and 25% in the extensor digitorum communis. Muscle biopsies revealed damage of terminal nerves and motor endplate with abundant basal lamina material. These findings suggest a muscle pathophysiology behind fatigue in long COVID.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Immunology
Maarten van Wijhe, Kamille Fogh, Steen Ethelberg, Kasper Karmark Iversen, Henrik Nielsen, Lars Ostergaard, Berit Andersen, Henning Bundgaard, Charlotte S. Jorgensen, Bibi F. Ss Scharff, Svend Ellermann-Eriksen, Isik S. Johansen, Anders Fomsgaard, Tyra Grove Krause, Lothar Wiese, Thea K. Fischer, Kare Molbak, Thomas Benfield, Fredrik Folke, Freddy Lippert, Sisse R. Ostrowski, Anders Koch, Christian Erikstrup, Anne-Marie Vangsted, Anna Irene Vedel Sorensen, Henrik Ullum, Robert Leo Skov, Lone Simonsen, Susanne Dam Nielsen
Summary: This study assessed the burden of long COVID among nonhospitalized adults with PCR-confirmed SARS-CoV-2 infection. The results showed that 25 out of 100 cases reported at least one long-COVID symptom. Infected individuals had worse general health, higher odds of various symptoms, particularly loss of taste and smell, and significantly reduced physical and mental health. Female sex and severity of infection were identified as major risk factors for long COVID.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Microbiology
Kamille Fogh, Alexandra R. R. Eriksen, Tine Graakjaer Larsen, Rasmus B. Hasselbalch, Henning Bundgaard, Bibi F. S. S. Scharff, Susanne D. Nielsen, Charlotte S. Jorgensen, Christian Erikstrup, Lars ostergaard, Svend Ellermann-Eriksen, Berit Andersen, Henrik Nielsen, Isik S. Johansen, Lothar Wiese, Lotte Hindhede, Susan Mikkelsen, Susanne G. Saekmose, Bitten Aagaard, Dorte K. Holm, Lene Harritshoj, Lone Simonsen, Thea K. Fischer, Fredrik Folke, Freddy Lippert, Sisse R. Ostrowski, Thomas Benfield, Kare Molbak, Steen Ethelberg, Anders Koch, Anne-Marie Vangsted, Tyra Grove Krause, Anders Fomsgaard, Henrik Ullum, Robert Skov, Kasper Iversen
Summary: This study investigated the immunity against COVID-19, risk factors, and behavior among employees in day care facilities and preschools (DCS) in Denmark. The study found that DCS staff had a higher risk of exposure within their own household than at their workplace. The study also found that most employees expressed fear of contracting COVID-19 and there was limited use of personal protective equipment at work.
MICROBIOLOGY SPECTRUM
(2023)
Article
Physiology
Jakob Wang, Anna-Maria Godsk Mogensen, Frederik Thybo, Magnus Brandbyge, Jonas Brorson, Gerrit van Hall, Jakob Agergaard, Frank Vincenzo de Paoli, Benjamin F. Miller, Hans Erik Botker, Jean Farup, Kristian Vissing
Summary: This study found that low-load blood flow-restricted resistance exercise (BFRRE) is effective in promoting muscle hypertrophy and improving muscle function in older individuals. However, its impact on age-related skeletal muscle decay at a cellular level is still unclear. BFRRE resulted in significant increases in muscle fiber morphology, integrated muscle protein synthesis, and muscle functional capacity without changes in muscle stem cells (MuSCs) and myonuclear content.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Uffe Kjaergaard, Nikolaj Bogh, Esben Sovso Szocska Hansen, Rasmus Stilling Tougaard, Lotte Bonde Bertelsen, Rolf F. Schulte, Christoffer Laustsen
Summary: This study assessed the metabolic alterations following subclinical focal ischemia-reperfusion injury with hyperpolarized [1-C-13]pyruvate MRI in a porcine model. The results showed restricted diffusion and decreased perfusion in the injured areas compared to the contralateral kidney. The metabolic assessment revealed an increased lactate/pyruvate ratio in the injured areas.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Steffen Sejersen, Camilla W. Rasmussen, Nikolaj Bogh, Uffe Kjaergaard, Esben S. S. Hansen, Rolf F. Schulte, Christoffer Laustsen
Summary: This study proposes a simple method of using the (13)CO(2) content in the expired air to normalize the hyperpolarized [1-C-13]pyruvate MRI images, overcoming the non-quantitative limitation of the method for image comparison across time and individuals. Experimental results with a porcine model demonstrate that normalizing the metabolic signal using the (13)CO(2) content in expired air can significantly reduce variation in metabolic sensitive pathways and improve the specificity of the method.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Clinical Neurology
Jacob Bodilsen, Laerke Storgaard Duerlund, Theis Mariager, Christian Thomas Brandt, Lothar Wiese, Pelle Trier Petersen, Lykke Larsen, Birgitte Ronde Hansen, Lars Haukali Omland, Malte Mose Tetens, Rasmus Langelund Jorgensen, Steffen Leth, Henrik Nielsen
Summary: This study examined risk factors and prognosis of epilepsy among survivors of brain abscess and found that important risk factors for epilepsy include seizures during brain abscess, neurosurgery, alcoholism, frontal lobe abscess, and stroke. Epilepsy is also associated with increased mortality.
Article
Immunology
Cecilie V. Vollmond, Malte M. Tetens, Fie W. Paulsen, Jan Gerstoft, Gitte Kronborg, Isik S. Johansen, Carsten S. Larsen, Lothar Wiese, Michael Dalager-Pedersen, Steffen Leth, Preben B. Mortensen, Anne-Mette Lebech, Niels Obel, Lars H. Omland
Summary: In this nationwide, population-based, matched cohort study in Denmark, we found that people with HIV have an increased risk of depression, receipt of antidepressants, treatment with electroconvulsive therapy, and suicide compared to the general population. This risk decreases after 2 years but remains higher than the general population. Familial factors are unlikely to explain this risk.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Virology
Kristoffer Skaalum Hansen, Sofie Eg Jorgensen, Morten Kelder Skouboe, Jane Agergaard, Berit Schiottz-Christensen, Line Khalidan Vibholm, Martin Tolstrup, Lars Ostergaard, Steffen Leth, Trine H. Mogensen
Summary: Long COVID is an emerging global health concern, and its underlying mechanism and pathophysiology are still unclear. This study found that autoantibodies against type 1 interferons in patients with Long COVID do not contribute to the symptoms.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nichlas Vous Christensen, Michael Vaeggemose, Nikolaj Bogh, Esben S. S. Hansen, Jonas L. Olesen, Yaewon Kim, Daniel B. Vigneron, Jeremy W. Gordon, Sune N. Jespersen, Christoffer Laustsen
Summary: In this study, a novel denoising method was compared to the current state-of-the-art denoising method, and it was found that the new method performed slightly better in noise removal. The results showed that this new method is widely applicable to different data sources and is the preferred denoising method for x-nuclei imaging improvements.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jesper D. Gunst, Jesper F. Hojen, Marie H. Pahus, Miriam Rosas-Umbert, Birgitte Stiksrud, James H. Mcmahon, Paul W. Denton, Henrik Nielsen, Isik S. Johansen, Thomas Benfield, Steffen Leth, Jan Gerstoft, Lars Ostergaard, Mariane H. Schleimann, Rikke Olesen, Henrik Stovring, Line Vibholm, Nina Weis, Anne M. Dyrhol-Riise, Karen B. H. Pedersen, Jillian S. Y. Lau, Dennis C. Copertino, Noemi Linden, Tan T. Huynh, Victor Ramos, R. Brad Jones, Sharon R. Lewin, Martin Tolstrup, Thomas A. Rasmussen, Michel C. Nussenzweig, Marina Caskey, Dag Henrik Reikvam, Ole S. Sogaard
Summary: In people with HIV-1 undergoing antiretroviral treatment interruption, combining lefitolimod with broadly neutralizing antibodies (bNAbs) did not delay viral rebound beyond that achieved with bNAbs alone, raising the question of how to optimize combination immunotherapy to control HIV-1.
