Journal
PHARMACEUTICALS
Volume 15, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/ph15050518
Keywords
V/Q PET/CT; [Ga-68]Ga-MAA; Ga-68-labelled carbon nanoparticles
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Lung ventilation/perfusion (V/Q) positron emission tomography-computed tomography (PET/CT) is a promising imaging modality for assessing regional lung function. This article discusses the challenges and optimization processes involved in transitioning from technetium-99m (Tc-99m) to gallium-68 (Ga-68) labeled radiopharmaceuticals for V/Q PET/CT.
Lung ventilation/perfusion (V/Q) positron emission tomography-computed tomography (PET/CT) is a promising imaging modality for regional lung function assessment. The same carrier molecules as a conventional V/Q scan (i.e., carbon nanoparticles for ventilation and macro aggregated albumin particles for perfusion) are used, but they are labeled with gallium-68 (Ga-68) instead of technetium-99m (Tc-99m). For both radiopharmaceuticals, various production processes have been proposed. This article discusses the challenges associated with the transition from Tc-99m- to Ga-68-labelled radiopharmaceuticals. The various production and optimization processes for both radiopharmaceuticals are reviewed and discussed for optimal clinical use.
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