Ultrarare Loss-of-Function Mutations in the Genes Encoding the Ionotropic Glutamate Receptors of Kainate Subtypes Associated with Schizophrenia Disrupt the Interaction with PSD95

Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations

(2021) Elliott Rees et al.   Nature Communications

Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders

(2021) Jacob R. Stolz et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Multiple Rare Risk Coding Variants in Postsynaptic Density-Related Genes Associated With Schizophrenia Susceptibility

(2020) Tsung-Ming Hu et al.   Frontiers in Genetics

Functional analyses and effect of DNA methylation on the EGR1 gene in patients with schizophrenia

(2019) Tsung-Ming Hu et al.   PSYCHIATRY RESEARCH

Synapse Pathology in Schizophrenia: A Meta-analysis of Postsynaptic Elements in Postmortem Brain Studies

(2019) Amber Berdenis van Berlekom et al.   SCHIZOPHRENIA BULLETIN

Damaging coding variants within kainate receptor channel genes are enriched in individuals with schizophrenia, autism and intellectual disabilities

(2019) Maria Koromina et al.   Scientific Reports

Increased Grik4 Gene Dosage Causes Imbalanced Circuit Output and Human Disease-Related Behaviors

(2018) Vineet Arora et al.   Cell Reports

No association of GRIK4 polymorphisms with schizophrenia in the Chinese Han population

(2017) Decheng Ren et al.   PSYCHIATRIC GENETICS

Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia

(2016) Giulio Genovese et al.   NATURE NEUROSCIENCE

PSD-95 regulates synaptic kainate receptors at mouse hippocampal mossy fiber-CA3 synapses

(2016) Etsuko Suzuki et al.   NEUROSCIENCE RESEARCH

Genetic assessment of additional endophenotypes from the Consortium on the Genetics of Schizophrenia Family Study

(2016) Tiffany A. Greenwood et al.   SCHIZOPHRENIA RESEARCH

Resequencing and Association Analysis of Six PSD-95-Related Genes as Possible Susceptibility Genes for Schizophrenia and Autism Spectrum Disorders

(2016) Jingrui Xing et al.   Scientific Reports

Expanding the spectrum of Grik2 mutations: intellectual disability, behavioural disorder, epilepsy and dystonia

(2014) M. Córdoba et al.   CLINICAL GENETICS

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

1p34.3 deletion involvingGRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay

(2013) Toshiki Takenouchi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

(2013) S Hong Lee et al.   NATURE GENETICS

The GluK4 kainate receptor subunit regulates memory, mood, and excitotoxic neurodegeneration

(2013) E.R. Lowry et al.   NEUROSCIENCE

Interaction of neurodevelopmental pathways and synaptic plasticity in mental retardation, autism spectrum disorder and schizophrenia: Implications for psychiatry

(2013) Robert Waltereit et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Evaluation of copy number variations reveals novel candidate genes in autism spectrum disorder-associated pathways

(2012) Anthony J. Griswold et al.   HUMAN MOLECULAR GENETICS

Association study of GRIK1 gene polymorphisms in schizophrenia: case-control and family-based studies

(2012) Yuko Hirata et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder

(2011) Jillian P. Casey et al.   HUMAN GENETICS

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

(2011) G Kirov et al.   MOLECULAR PSYCHIATRY

Genomic Analysis of Mental Illness

(2010) Jon McClellan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Molecular Cloning, Expression, and Pharmacological Characterization of humEAA1, a Human Kainate Receptor Subunit

(2010) Rajender K. Kamboj et al.   JOURNAL OF NEUROCHEMISTRY

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Correction: Genetic and Functional Analysis of the DLG4 Gene Encoding the Post-Synaptic Density Protein 95 in Schizophrenia

(2010) Min-Chih Cheng et al.   PLoS One

De novo mutations in the gene encoding the synaptic scaffolding proteinSHANK3in patients ascertained for schizophrenia

(2010) Julie Gauthier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

(2009) Shaun M. Purcell et al.   NATURE

The Neurodevelopmental Hypothesis of Schizophrenia, Revisited

(2009) S. H. Fatemi et al.   SCHIZOPHRENIA BULLETIN

A nomenclature for ligand-gated ion channels

(2008) Graham L. Collingridge et al.   NEUROPHARMACOLOGY

No genetic association between polymorphisms in the kainate-type glutamate receptor gene, GRIK4, and schizophrenia in the Chinese population

(2008) Zhiqiang Li et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A possible association between schizophrenia and GRIK3 polymorphisms in a multicenter sample of Scandinavian origin (SCOPE)

(2008) S. Djurovic et al.   SCHIZOPHRENIA RESEARCH