Journal
JOURNAL OF FUNGI
Volume 8, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/jof8050492
Keywords
Boeremia exigua; Fritillaria hupehensis; eremophilanes; boeremialanes; anti-inflammatory; NO production inhibition
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Funding
- National Natural Science Foundation of China [31870513]
- Fundamental Research Funds for the Central Universities, South-Central MinZu University [CZD21003]
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Four new eremophilane-type sesquiterpenes were isolated from an endophytic fungus Boeremia exigua isolated from Fritillaria hupehensis. Among them, Boeremialane D showed potent inhibition of nitric oxide production in lipopolysaccharide-treated macrophages.
Four new eremophilane-type sesquiterpenes, boeremialanes A-D (1-4) were obtained from solid substrate cultures of Boeremia exigua (Didymellaceae), an endophytic fungus isolated from Fritillaria hupehensis (Liliaceae). Boeremialanes A-C (1-3) are highly oxygenated eremophilanes with a benzoate unit attached at the C-13 position and are rarely found in nature. Their structures and absolute configurations were determined by extensive spectroscopic methods, electronic circular dichroism (ECD), and nuclear magnetic resonance (NMR) calculations with DP4+ analysis. Boeremialane D (4) potently inhibited nitric oxide production in lipopolysaccharide-treated RAW264.7 macrophages with an IC50 of 8.62 mu M and was more potent than the positive control, pyrrolidinedithiocarbamate (IC50 = 23.1 mu M).
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