Review
Nutrition & Dietetics
Vugar Azizov, Mario M. Zaiss
Summary: Alcohol consumption can increase the risk of various diseases, but may also reduce the risk of autoimmune diseases. Alcohol affects intestinal barrier integrity and the microbiome, potentially contributing to the development of rheumatoid arthritis.
Article
Rheumatology
Achilleas Floudas, Conor M. Smith, Orla Tynan, Nuno Neto, Vinod Krishna, Sarah M. Wade, Megan Hanlon, Clare Cunningham, Viviana Marzaioli, Mary Canavan, Jean M. Fletcher, Ronan H. Mullan, Suzanne Cole, Ling-Yang Hao, Michael G. Monaghan, Sunil Nagpal, Douglas J. Veale, Ursula Fearon
Summary: This study provides a global transcriptomic analysis of the synovial joints in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), revealing the immune-stromal cell interactions in synovial inflammation. The findings highlight the differential transcription profiles and interactions between cell subsets in RA and PsA, suggesting potential targets for targeted therapeutic intervention in these diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Zhen-Yi Long, Yi-Feng Zhou, Hao Yuan, Ya-Meng Peng, Si-Xian Wu, Fang Peng
Summary: The study revealed that the levels of IgG4 and IL-21 in the serum increased with disease progression in collagen-induced arthritis (CIA) rats, and the expression of IgG4 and IL-21 receptors in the ankle joint was significantly higher in the CIA model group. These proteins were closely related to the pathological score, indicating that IL-21 may promote rheumatoid arthritis development by regulating IgG4 content.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Allergy
Maria Sokolova, Georg Schett, Ulrike Steffen
Summary: Autoantibodies such as rheumatoid factor (RF) and antibodies against citrullinated proteins (ACPA) are key markers of rheumatoid arthritis (RA) and can impact disease course and progression. The identification of new autoantibodies and advancements in diagnostic techniques have led to a decrease in the seronegative patient population. Autoantibodies not only play a role in the pathogenesis of RA but also directly influence disease progression and radiographic outcomes.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Article
Rheumatology
Maria Sokolova, Melanie Hagen, Holger Bang, Georg Schett, Juergen Rech, Ulrike Steffen
Summary: This study suggests that IgA ACPA, combined with IgG ACPA, is a risk factor for flare in RA. In patients who remain in remission, levels of IgA2 ACPA and the proportion of IgA2 in ACPA significantly decline, and this is associated with flare severity.
Article
Biochemistry & Molecular Biology
Katarina Barbaric Starcevic, Nina Lukac, Mislav Jelic, Alan Sucur, Danka Grcevic, Natasa Kovacic
Summary: This study analyzed the cellular composition of synovial tissue from RA and control patients and found higher proportions of lymphocytes and myeloid cells in RA synovial tissue compared to controls. Additionally, there was a decrease in the proportion of CD200(+)CD105(-) cells and an increase in CD200(-)CD105(+) cells in RA synovial tissue. These cell populations were associated with inflammatory activity and could differentiate between RA and control patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chihiro Kaneko, Tetsuo Kobayashi, Satoshi Ito, Noriko Sugita, Akira Murasawa, Hajime Ishikawa, Koichi Tabeta
Summary: The study found a positive correlation between periodontitis severity, anti-agalactosyl IgG titer, and rheumatoid arthritis disease activity in patients with RA. Supragingival scaling was shown to decrease the anti-agalactosyl IgG titer in these patients.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Review
Immunology
Ziqiang Shuai, Shuang Zheng, Kang Wang, Jian Wang, Patrick S. C. Leung, Bin Xu
Summary: Researchers are actively exploring new approaches to treat rheumatoid arthritis through methods such as stem cell transplantation, tolerogenic dendritic cells, and antigen-based tolerogenic vaccines. Current clinical trials show promising results in terms of safety and effectiveness in restoring immune balance and improving symptoms through stem cell transplantation and tolerogenic dendritic cell therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Yi-Jin Wu, Sa-Sa Zhang, Qin Yin, Ming Lei, Qi-Hai Wang, Wen -Gang Chen, Ting -Ting Luo, Peng Zhou, Cong-Lan Ji
Summary: This study found that alpha-Mangostin (MG) can alleviate experimental arthritis, inhibit inflammatory polarization of macrophages/monocytes, and regulate PPAR-gamma and SIRT1 signals. The results showed that MG activates SIRT1 expression by binding PPAR-gamma, thereby suppressing inflammatory responses.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Endocrinology & Metabolism
Darja Andreev, Katerina Kachler, Georg Schett, Aline Bozec
Summary: Osteoimmunology is an interdisciplinary field that connects osteology with immunology. The interaction between innate and adaptive immune cells and cells involved in bone remodeling is particularly evident in rheumatoid arthritis (RA). RA not only causes inflammation in the joints, but also leads to bone loss and generalized osteoporosis. Current antirheumatic therapies effectively control joint inflammation and bone erosion, but the repair of existing bone lesions still presents a challenge.
Review
Cell Biology
Swati Chadha, Tapan Behl, Simona Bungau, Arun Kumar, Rajwinder Kaur, Thangaval Venkatachalam, Amit Gupta, Mimansa Kandhwal, Deepak Chandel
Summary: Autophagy plays a dual role in eukaryotic cells, exerting cytoprotective actions through degradation mechanisms and regulating catabolic processes. It is associated with the development and pathogenesis of autoimmune diseases like rheumatoid arthritis.
Review
Chemistry, Medicinal
Darina Bacenkova, Marianna Trebunova, Radoslav Morochovic, Erik Dosedla, Alena Findrik Balogova, Petra Gasparova, Jozef Zivcak
Summary: This review focuses on the possibility of using mesenchymal stem cells (MSCs) to modulate the immune response and suppress inflammation in rheumatoid arthritis (RA). MSCs have the ability to release bioactive molecules and directly interact with immune cells, which can suppress the inflammatory process and reduce excessive inflammation in RA.
Review
Immunology
Mengjia Tang, Lingyun Lu, Xijie Yu
Summary: The interaction between the immune and skeletal systems is crucial for maintaining skeletal homeostasis, with IL-17A playing a key role; IL-17A has dual effects on osteoclasts and osteoblasts, and is involved in immune-mediated bone diseases; Understanding the pathophysiological roles of IL-17A may offer potential strategies for treating immune-mediated bone diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
David Daikh
Summary: Rheumatoid arthritis is a prevalent autoimmune disease that has significantly contributed to the understanding and targeted therapies of immune-mediated diseases. Current research focuses on linking gene expression to cellular abnormalities for personalized medicine.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sunhee Jang, Eui-Jong Kwon, Jennifer Jooha Lee
Summary: Rheumatoid arthritis is a chronic autoimmune disease with complex pathogenesis, and recent advancements have shed light on the underlying mechanisms, providing new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Lokman Mohd Noh, Amir Hamzah Abdul Latiff, Intan Hakimah Ismail, Rahim Md Noah, Asrul Abdul Wahab, Intan Juliana Abd Hamid, Adiratna Mat Ripen, Nasuruddin B. Abdullah, Kamarul Azhar Razali, Norzila Zainudin, Florence Bakon, Long Juan Kok, Adli Ali, Bilkis Banu SAbd Aziz, Hasniah Abdul Latif, Siti Mardhiana Mohamad, Zarina Thasneem Zainudeen, Ilie Fadzilah Hashim, Iean Hamzah Sendut, Thiyagar Nadarajaw, Faizah Mohamed Jamil, David C. E. Ng, Mohd Azri Zainal Abidin
Summary: This study demonstrates the occurrence of CGD in major ethnic groups in Malaysia, possibly reflecting a similar clinical pattern in the region. C. violaceum infection is associated with higher mortality in CGD patients in Malaysia. All CGD patients with C. violaceum infection in this patient series displayed CD4+ (T helper) lymphopenia.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2021)
Article
Infectious Diseases
Nesamalar Balakrishnan, Ezura Madiana Md Monoto, Noorlaili Mohd Tohit, Asrul Abdul Wahab
Summary: This study revealed gaps in knowledge among tuberculosis patients, with negative perceptions towards treatment. Continuous counseling is helpful in reinforcing understanding of tuberculosis.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2021)
Review
Rheumatology
Rajalingham Sakthiswary, Hui Yuan Chuah, Ker Shing Chiang, Yee Shan Liew, Noor Azman Muhammad Aizat
Summary: In a pooled analysis of case reports and case series on COVID-19 in patients with systemic lupus erythematosus (SLE), lupus nephritis was found to be the only predictor of severe to critical COVID-19 in SLE patients.
Article
Infectious Diseases
Mohd Nizam Tzar, Wan Husna Barakah Meor Jamaludin, Asrul Abdul Wahab, Chuan Hun Ding
Summary: This article presents a case of a COVID-19 pneumonia patient in India who developed a 'true black fungus' infection. Despite antifungal therapy, the patient's condition deteriorated rapidly and resulted in death. The article also reviews reported cases of Exophiala dermatitidis fungemia in the past 5 years.
Article
Infectious Diseases
Nurdiyana Mohamed, Chuan Hun Ding, Asrul Abdul Wahab, Mohd Nizam Tzar, Murnihayati Hassan
Summary: Parengyodontium album is a rarely encountered opportunistic fungal pathogen. This article reports a case of fungemia caused by P. album in an 11-year-old boy undergoing elective chemotherapy.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2022)
Article
Medicine, General & Internal
Li Fen Tan, Rajalingham Sakthiswary, Uma Rajeswaran Veshaaliini, Syahrul Sazliyana Shaharir, Asrul Abdul Wahab, Suraya Aziz, Rosnah Sutan
Summary: This study suggests that elevated serum IgG4 may serve as a potential biomarker for disease activity and functional disability in rheumatoid arthritis (RA). The level of IgG4 is significantly correlated with disease activity, joint damage, and functional disability in RA patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pathology
Ting Siau Mei Valerie, Chuan Hun Ding, Asrul Abdul Wahab
Summary: A male patient with Salmonella intracranial infection was successfully treated with surgical drainage of abscess and antimicrobial therapy, resulting in clinical improvement.
MALAYSIAN JOURNAL OF PATHOLOGY
(2021)
Article
Medicine, General & Internal
Zaili Zaki, Asrul Abdul Wahab, Ramliza Ramli, Ezura Madiana Md Monoto, Chuan Hun Ding, Afaaf Esa
Summary: This study found that the prevalence of beta-hemolytic streptococcal pharyngitis was 12.2%, and positive throat culture was significantly correlated with a McIsaac score of at least 4 and the absence of cough.
GAZI MEDICAL JOURNAL
(2021)
Article
Parasitology
C. H. Ding, A. A. Wahab, Z. Marina, C. L. Leong, N. Umur, P. F. Wong
Summary: A case of nasopharyngeal diphtheria in a young adult who had received childhood vaccinations but eventually succumbed to the infection is reported.
TROPICAL BIOMEDICINE
(2021)
Review
Parasitology
H. Esa, B. Norazlah, A. A. Hameed, C. H. Ding, A. A. Wahab
Summary: The rarity of acute psychosis in typhoid fever can lead to delayed and misdiagnosis of the condition, a case of a 20-year-old man with fever and acute psychotic symptoms was successfully treated with one-week course of intravenous ceftriaxone, and subsequent tests showed no growth of Salmonella Typhi.
TROPICAL BIOMEDICINE
(2021)
Article
Medical Laboratory Technology
Afifah Aqilah Abdul Malik, Petrick Periyasamy, Najma Kori, Asrul Abdul Wahab, Chuan Hun Ding
Summary: This case study illustrates a HIV patient suffering from Cryptococcus infection. Despite initial negative tests, subsequent evaluations revealed positive Cryptococcus antigen, leading to rapid deterioration of the patient's condition.
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2021)
Article
Medicine, General & Internal
Asrul Abdul Wahab, Chuan Hun Ding, Kon Ken Wong, Husna Farhanah Ahmad, Ikmal Hisyam Bakrin
Summary: Bullous systemic lupus erythematosus (BSLE) is a rare autoimmune blistering condition that can present with generalized vesiculobullous skin eruptions, especially in children, and may be the initial manifestation of SLE. A high index of suspicion and the appropriate diagnostic tools are crucial in unmasking the true diagnosis.
GAZI MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Chuan Hun Ding, Asrul Abdul Wahab, Toh Leong Tan, Salamah Faisal Ummu
Summary: An 83-year-old woman with multiple medical conditions developed a dental abscess caused by Candida dubliniensis, but unfortunately passed away before receiving antifungal treatment despite undergoing surgical procedures.
GAZI MEDICAL JOURNAL
(2021)