Article
Chemistry, Multidisciplinary
Kazi Nadim Hossain, Md. Shafiqul Islam, Sheikh Hasibur Rahman, Subroto Sarker, Milon Mondal, Mohammad Asikur Rahman, Sadeq K. Alhag, Laila A. Al-Shuraym, Othman A. Alghamdi, Muhammad Torequl Islam, Ammar AL-Farga, Mohamed El-Shazly, Md. Jahir Alam, Heba A. S. El-Nashar
Summary: This study investigated the antioxidant, anti-inflammatory, and hepatoprotective activities of Wissadula periplocifolia. The results showed that it has strong antioxidant, anti-inflammatory, and hepatoprotective effects.
Article
Pharmacology & Pharmacy
Xianchou Xu, Qingbo Liu, Jiahao Li, Mengjie Xiao, Ting Gao, Xiaohui Zhang, Guangping Lu, Jie Wang, Yuanfang Guo, Peinan Wen, Junlian Gu
Summary: The study demonstrated that co-treatment with RES and FGF1 significantly inhibited DOX-induced hepatic inflammation and apoptosis, while also markedly suppressing DOX-induced hepatic oxidative stress via targeting the AMPK/NRF2 pathway. This combination may provide a new therapeutic strategy for limiting DOX-induced hepatotoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yeqing Hu, Qiguo Wu, Yulin Wang, Haibo Zhang, Xueying Liu, Hua Zhou, Tao Yang
Summary: This review summarizes the mechanisms of TP-induced hepatotoxicity, involving factors such as CYP450s, P-glycoprotein (P-gp), oxidative stress, excessive autophagy, apoptosis, metabolic disorders, immunity, and the gut microbiota. These new findings contribute to a comprehensive understanding of TP-induced hepatotoxicity and detoxification.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wen Su, Mingji Feng, Yuan Liu, Rong Cao, Yiao Liu, Junyao Tang, Ke Pan, Rongfeng Lan, Zhuo Mao
Summary: Deficiency of ZnT8 in mice alleviates APAP-induced liver injury by inhibiting oxidative stress and promoting hepatocyte proliferation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Sib Sankar Giri, Min Jung Kim, Sang Guen Kim, Sang Wha Kim, Jeong Woo Kang, Jun Kwon, Sung Bin Lee, Won Joon Jung, Venkatachalam Sukumaran, Se Chang Park
Summary: Curcumin, a compound found in turmeric, has been shown to have antioxidant, anti-inflammatory, and immunostimulatory effects in fish. This study demonstrated that dietary supplementation of curcumin can protect fish against lead-induced toxicity by reducing lead accumulation, improving survival rates, reversing biochemical parameter changes, and enhancing immune responses.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Food Science & Technology
Qingfeng He, Yunjing Luo, Ziqi Xie
Summary: This study demonstrated the antioxidant and anti-inflammatory effects of SFN against Cd-induced liver damage, which were associated with the modulation of the intrinsic Nrf2/ARE and NF-kappa B pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Denisa-Madalina Zalar, Cristina Pop, Elena Buzdugan, Bela Kiss, Maria-Georgia Stefan, Steliana Ghibu, Doinita Crisan, Alexandra Buruiana-Simic, Adriana Grozav, Ileana Monica Borda, Cristina Ionela Mogosan
Summary: The study evaluated the effect of colchicine in an animal model of hyperlipidemia. The results showed that colchicine reduced lipid levels, oxidative stress, and inflammation markers, and improved endothelial dysfunction. However, the use of colchicine may have adverse effects.
Article
Environmental Sciences
Annu Phogat, Jagjeet Singh, Vijay Kumar, Vinay Malik
Summary: This study aimed to investigate the toxic effects of the insecticide acetamiprid and the protective effects of the natural antioxidant berberine in rat liver tissue. The results showed that acetamiprid exposure induced oxidative stress and structural changes in liver tissue, while berberine reduced this toxicity and exhibited antioxidative and anti-inflammatory effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Demiana H. Sami, Ayman S. Soliman, Akef A. Khowailed, Reem S. Alruhaimi, Emad H. M. Hassanein, Emadeldin M. Kamel, Ayman M. Mahmoud
Summary: 7-hydroxycoumarin (7-HC) can protect against cisplatin (CIS)-induced liver injury by reducing oxidative stress and inflammation, and modulating the Nrf2/HO-1 pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Gobichettipalayam Balasubramaniam Maadurshni, Ganeshmurthy Kanniamal Tharani, Inbamani Udayakumar, Manigandan Nagarajan, Jeganathan Manivannan
Summary: Recent evidences have shown that the release of aluminum oxide nanoparticles (Al2O3-NPs) may pose a risk to the environment and cause adverse effects on living organisms. This study investigated the hepatotoxic effects of Al2O3-NPs on developing chicken embryos and cell cultures. The results revealed that exposure to Al2O3-NPs caused abnormal liver histology, increased tissue damage markers, oxidative stress, impaired antioxidant enzyme function, abnormal red blood cell morphology, and enhanced apoptosis. Additionally, novel mechanisms and prevention strategies were explored.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Linlin Qu, Rongzhan Fu, Xiaoxuan Ma, Daidi Fan
Summary: Ginsenoside Rk3 shows promising therapeutic potential in protecting against APAP-induced acute liver injury by reducing hepatotoxicity, inhibiting liver inflammation and oxidative stress, and promoting continuous activation of autophagy.
Article
Biochemistry & Molecular Biology
Alayn' Al-marddyah A. Al-khawalde, Mohammad H. Abukhalil, Muthana M. Jghef, Manal A. Alfwuaires, Fatima S. Alaryani, Saleem H. Aladaileh, Abdulmohsen Algefare, Shaik Karimulla, Fawaz Alasmari, Hammad Khalifeh Aldal'in, Abdulkareem A. Alanezi, Osama Y. Althunibat
Summary: This study investigated the effect of punicalagin on methotrexate-induced hepatotoxicity. The results showed that punicalagin can alleviate the damage caused by methotrexate, inhibit oxidative damage, inflammation, and apoptosis, and enhance antioxidant defenses. These findings suggest that punicalagin may have therapeutic potential for the prevention of methotrexate-induced hepatotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Lauren G. Poole, Anna K. Kopec, Dafna J. Groeneveld, Asmita Pant, Kevin S. Baker, Holly M. Cline-Fedewa, Matthew J. Flick, James P. Luyendyk
Summary: This study investigated the mechanisms of fibrin polymerization and cross-linking in acute liver injury induced by acetaminophen overdose. It was found that deficiency in FXIII dramatically reduced fibrin(ogen) cross-linking, while the impact on fibrin(ogen) deposition and cross-linking was less significant in Fib(AEK) mice. The presence of oxidative mediators in the injured liver was proposed as a factor affecting fibrin polymerization without affecting FXIII-mediated cross-linking.
Article
Medicine, Research & Experimental
Laiyu Zhu, Xiaoye Fan, Chunyuan Cao, Kailiang Li, Wenli Hou, Xinxin Ci
Summary: This study found that xanthohumol can exert hepatoprotective effects by inhibiting oxidative stress and mitochondrial dysfunction, and triggering the activation of Nrf2 through the AMPK/Akt/GSK3β/Nrf2 antioxidant pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Abhishek Kumar, Nikhat J. Siddiqi, Sara T. Alrashood, Haseeb A. Khan, Anchal Dubey, Bechan Sharma
Summary: The study showed that eugenol has a strong protective effect against liver damage induced by cadmium, including reversing oxidative stress and inflammation. In the experiment, eugenol effectively restored the biochemical alterations caused by Cd.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biology
Khalid M. Al-Asmari, Hisham N. Altayb, Atef M. Al-Attar, Safa H. Qahl, Saed A. Al-Thobaiti, Isam M. Abu Zeid
Summary: The study evaluated the influence of Arabica coffee oil and olive oil on MAL-induced nephrotoxicity in male rats. The oils reduced the biochemical and histopathological alterations caused by MAL intoxication.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biology
Aisha D. Alalwani, Laila A. Hummdi, Safa H. Qahl
Summary: This study evaluated the impact of Ficus carica mixture and Olea europaea leaf nano extracts, and liraglutide, on liver tissue and serum lipids in a type 2 diabetic rat model. The administration of liraglutide and nano extracts significantly reduced lipid profiles and blood glucose levels in diabetic rats and improved liver histopathological changes. Nano extracts showed significant power assays associated with hepatic histology and functional recovery compared to liraglutide treatment.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Crystallography
Reham Z. Hamza, Hatim M. Al-Yasi, Esmat F. Ali, Mustafa A. Fawzy, Tharwat G. Abdelkader, Tarek M. Galal
Summary: This study identified and evaluated the major compounds in Taif rose extract waste, showing its potential anticancer activity against HepG2 cells and its ability to alleviate hepatotoxicity induced by cadmium chloride. Taif rose extract waste could be used as a natural preventive and therapeutic agent for liver diseases and for improving redox status.
Article
Crystallography
Samy M. El-Megharbel, Eman H. Al-Thubaiti, Safa H. Qahl, Rasha A. Al-Eisa, Reham Z. Hamza
Summary: This study found that novel metal complexes of Dapg with Zn, Cr or Se can protect liver tissue from oxidative damage and pathological injury caused by diabetes, and have antibacterial activity.
Article
Biology
Reham Z. Hamza, Rasha A. Al-Eisa, Nahla S. El-Shenawy
Summary: The aim of this study was to investigate the effects of royal jelly on hepatotoxicity induced by molybdenum nanoparticles, cadmium chloride, or their combination in male rats. The results showed that royal jelly alleviated the hepatotoxicity by improving all hepatic vitality markers and acted as a potent antioxidant against the oxidative damage induced by the combination of nanoparticles and cadmium chloride.
Article
Pharmacology & Pharmacy
Raed Felimban, Hossam H. Tayeb, Adeel G. Chaudhary, Majed A. Felemban, Fuad H. Alnadwi, Sarah A. Ali, Jazia A. Alblowi, Eman ALfayez, Deena Bukhary, Mohammed Alissa, Safa H. Qahl
Summary: This study aimed to develop nanostructured lipid carriers (NLCs) containing pitavastatin (PV) combined with the essential oil of Pinus densiflora leaf (Pd oil) and assess their cytotoxicity against human gingival fibroblasts (HGF-1). The optimized PV-Pd-NLCs showed good dissolution efficiency and acceptable rheological behavior in a Carbopol 940(R) gel base, and exhibited the best cytotoxic activity against HGF-1 cells compared to other formulations. These findings suggest that the gel containing PV-Pd-NLCs has potential benefits for local treatment of gingival cancer.
Article
Pharmacology & Pharmacy
Muhammad Asim, Marriam Nazir, Zunera Chauhdary, Muhammad Irfan, Syed Haroon Khalid, Sajid Asghar, Raed I. Usra, Raed Felimban, Mohammed A. S. Majrashi, Mohannad S. Hazzazi, Mohammed Alissa, Safa H. Qahl, Ghulam Hussain, Azhar Rasul, Shahzad Ali Shahid Chatha, Ikram Ullah Khan
Summary: The current study aimed to enhance the solubility and dissolution profile of dexibuprofen (Dex) by formulating ternary solid dispersions (TSDs) through solvent evaporation. The TSD formulations showed improved solubility and dissolution, as well as gastric protection and anti-inflammatory activity.
Article
Plant Sciences
Magda I. Soliman, Nada S. Mohammed, Ghada EL-Sherbeny, Fatmah Ahmed Safhi, Salha Mesfer ALshamrani, Amal A. Alyamani, Badr Alharthi, Safa H. Qahl, Najla Amin T. Al Kashgry, Sawsan Abd-Ellatif, Amira A. Ibrahim
Summary: Green synthesis of nanoparticles is gaining attention as it is simple and environmentally friendly. This study focuses on using latex from the Cynanchum acutum L. plant as a natural stabilizer for silver nanoparticles. The characterization of the nanoparticles and their effects on a test plant, Vicia faba, were investigated. The findings showed that Cy-AgNPs had antioxidant and antibacterial activities, high levels of secondary metabolites, and low levels of chromosomal aberrations. The study suggests that Cy-AgNPs can be used in pharmaceutical applications.
Article
Plant Sciences
Husam Qanash, Abdulrahman S. Bazaid, Naif K. Binsaleh, Bandar Alharbi, Nawaf Alshammari, Safa H. Qahl, Hayaa M. Alhuthali, Abdullatiff A. Bagher
Summary: The green synthesis of silver nanoparticles (AgNPs) using the Saudi mint plant as a medicinal plant was investigated in this study. The AgNPs showed higher antimicrobial activity and antioxidant activity compared to the mint extract (ME). These findings highlight the potential of ME as a mediator for AgNPs synthesis and as natural antimicrobial and antioxidant agents.
Article
Multidisciplinary Sciences
Fawziah A. Al-Salmi, Samy M. El-Megharbel, Reham Z. Hamza
Summary: A newly synthesised mixed ligand artemisinin/zinc complex is chemically characterised and examined for its inhibitory effects against SARS-CoV-2. The complex exhibits moderate inhibitory effects without cytotoxicity on host cells, and its mode of action involves inhibiting viral replication. Molecular dynamics simulation confirms the binding of the complex to key targets of SARS-CoV-2. Further studies are recommended to investigate the biological effects of the complex in animal models and to test its clinical efficacy and safety.
Article
Multidisciplinary Sciences
Reham Z. Hamza, Khadeejah Alsolami
Summary: Obesity is associated with metabolic disorders and cardiovascular diseases, and its risk increased during the COVID-19 pandemic. This study showed the synergistic effect of ORL and Met in ameliorating hepatic functions and lipid profile, alleviating inflammation, genotoxicity, and side effects of obesity.
Article
Biochemistry & Molecular Biology
Arab Gul, Haroon Khan, Sayyed Ibrahim Shah, Khalaf F. Alsharif, Safa H. Qahl, Inayat Ur Rehman, Khang Wen Goh, Chrismawan Ardianto, Long Chiau Ming
Summary: This study aims to investigate the potential protective mechanisms of peanut methanolic crude extract and n-hexane oil fraction against gentamycin-induced nephrotoxicity. The results show that both the crude extract and the oil fraction have significant reversal effects on gentamycin-induced nephrotoxicity.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Article
Biochemistry & Molecular Biology
Samy M. El-Megharbel, Najah M. Al-Baqami, Eman H. Al-Thubaiti, Safa H. Qahl, Bander Albogami, Reham Z. Hamza
Summary: The study found that complexes of STG with Mn and Co have significant antioxidant and hepatoprotective effects, preventing hepatic biochemical alterations induced by STG alone.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)