Journal
ANTIBIOTICS-BASEL
Volume 11, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/antibiotics11030412
Keywords
antibiotic; antimicrobial resistance; delivery systems; activity enhancers; silver; polymers; lipids
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The development of effective treatments against infectious diseases requires overcoming bacteria's rapid adaptation to antibiotics. Appropriately designed activity enhancers can increase the effectiveness of current antibiotics, reduce antibiotic resistance, improve drug delivery and penetration, and decrease side effects.
The development of effective treatments against infectious diseases is an extensive and ongoing process due to the rapid adaptation of bacteria to antibiotic-based therapies. However, appropriately designed activity enhancers, including antibiotic delivery systems, can increase the effectiveness of current antibiotics, overcoming antimicrobial resistance and decreasing the chance of contributing to further bacterial resistance. The activity/delivery enhancers improve drug absorption, allow targeted antibiotic delivery, improve their tissue and biofilm penetration and reduce side effects. This review provides insights into various antibiotic activity enhancers, including polymer, lipid, and silver-based systems, designed to reduce the adverse effects of antibiotics and improve formulation stability and efficacy against multidrug-resistant bacteria.
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