Article
Neurosciences
Heba M. Tawfik, Rehab R. Desouki, Hamdi A. Singab, Sarah A. Hamza, Salma M. S. El Said
Summary: The study found that preoperative frailty in geriatric patients undergoing elective cardiac surgery may increase the incidence of postoperative complications. Comprehensive assessment using the Robinson score can accurately predict postoperative complications in elderly patients.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Oncology
Yinning Guo, Lingyu Ding, Xueyi Miao, Xiaoman Jiang, Ting Xu, Xinyi Xu, Shuqin Zhu, Qin Xu, Jieman Hu
Summary: This systematic review and meta-analysis aimed to explore the effects of prehabilitation on postoperative outcomes in frail cancer patients. Through meta-analysis, prehabilitation was found to have a positive impact on total complications, severe complications, and the average length of hospital stay, but no differences were observed in mortality and readmission rates.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Biochemistry & Molecular Biology
Chun-Yi Tsai, Keng-Hao Liu, Cheng-Chou Lai, Jun-Te Hsu, Shun -Wen Hsueh, Chia-Yen Hung, Kun-Yun Yeh, Yu-Shin Hung, Yung -Chang Lin, Wen-Chi Chou
Summary: This study aimed to investigate the association between frailty and postoperative delirium (POD) in aged cancer patients undergoing elective abdominal surgery. It found that frailty status was an independent risk factor for POD occurrence. Thus, preoperative assessment of frailty in older cancer patients is important in order to improve postoperative care.
BIOMEDICAL JOURNAL
(2023)
Article
Geriatrics & Gerontology
Janina Steenblock, Ulrike Braisch, Simone Brefka, Christine Thomas, Gerhard W. Eschweiler, Michael Rapp, Brigitte Metz, Christoph Maurer, Christine A. F. von Arnim, Matthias. L. Herrmann, Soeren Wagner, Michael Denkinger, Dhayana Dallmeier
Summary: This study aimed to analyze the association between frailty and postoperative delirium (POD) in older patients. A 30-item frailty index (FI) was developed using preoperative data, and it was found that frailty was significantly associated with POD. The preoperative 30-item FI can help identify patients at increased risk for POD.
Article
Cardiac & Cardiovascular Systems
Dashuai Wang, Sheng Le, Jia Wu, Fei Xie, Ximei Li, Hongfei Wang, Anchen Zhang, Xinling Du, Xiaofan Huang
Summary: This study aimed to explore risk factors and establish a predictive system for postoperative headache (POH) after cardiac surgery. Eight independent risk factors for POH were identified, and a nomogram model was constructed. The model may have potential application value in clinical risk assessment, decision-making, and individualized treatment associated with POH.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Caroline Baeck, Mads Hornum, Morten Buus Jorgensen, Ulver Spangsberg Lorenzen, Peter Skov Olsen, Christian H. Moller
Summary: The study aimed to evaluate the impact of frailty assessment on 1-year mortality and morbidity in patients undergoing cardiac surgery. The results showed that frail patients had a significantly increased risk of mortality and postoperative complications.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Dashuai Wang, Su Wang, Jia Wu, Sheng Le, Fei Xie, Ximei Li, Hongfei Wang, Xiaofan Huang, Xinling Du, Anchen Zhang
Summary: This study developed and validated two nomogram models for predicting postoperative hyperlactatemia in patients undergoing elective cardiac surgery. The models, including a full nomogram and a preoperative factors nomogram, showed good predictive ability and clinical utility in risk estimation, risk stratification, and targeted interventions.
FRONTIERS IN MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Chun-Qing Li, Hao Kong, Zhen-Zhen Xu, Jia-Hui Ma, Xue-Ying Li
Summary: This study compared the predictive abilities of two frailty indices (mFI and RAI-rev) in predicting life-threatening morbidity and mortality in older patients undergoing high-risk abdominal surgery. The results showed that both frailty indices displayed poor discrimination for postoperative life-threatening morbidity and mortality.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Anesthesiology
E. F. Akowuah, J. M. Wagnild, M. Bardgett, J. G. Prichard, A. Mathias, S. L. Harrison, E. O. Ogundimu, H. C. Hancock, R. H. Maier
Summary: The feasibility, safety and efficacy of prehabilitation in adult patients awaiting elective cardiac surgery were evaluated in this study. The results showed that prehabilitation did not significantly improve patients' exercise capacity and quality of life. Future research should focus on patients with sarcopenia and include inspiratory muscle strength training.
Article
Anesthesiology
Benjamin Milne, Joshua Lucas de Carvalho, Salma Ayis, Sanjay Chaubey, Habib Khan, Gudrun Kunst
Summary: Predicting postoperative disability based on preoperative frailty is crucial in cardiac surgery. Frail patients show continuous improvement in disability burden postoperatively, while non-frail patients worsen at 1 month before improving at 3 months.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Medicine, General & Internal
Enoch Akowuah, Ayesha Mathias, Michelle Bardgett, Samantha Harrison, Adetayo S. Kasim, Kirsti Loughran, Emmanuel Ogundimu, Jason Trevis, Janelle Wagnild, Pasan Witharana, Helen C. Hancock, Rebecca H. Maier
Summary: Prehabilitation prior to surgery has been shown to reduce postoperative complications, reduce length of hospital stay and improve quality of life after cancer and limb reconstruction surgery. However, there are minimal data on the impact of prehabilitation in patients undergoing cardiac surgery, despite the fact these patients are generally older and have more comorbidities and frailty. This trial will assess the feasibility and impact of a prehabilitation intervention consisting of exercise and inspiratory muscle training on preoperative functional exercise capacity in adult patients awaiting elective cardiac surgery, and determine any impact on clinical outcomes after surgery.
Article
Pharmacology & Pharmacy
Britta C. Arends, Heleen J. Blusse van Oud-Alblas, Lisette M. Vernooij, Lisa Verwijmeren, Douwe H. Biesma, Catherijne A. J. Knibbe, Peter G. Noordzij, Eric P. A. van Dongen
Summary: The use of preoperative medication, particularly polypharmacy, is associated with functional decline in elderly cardiac surgery patients. A preoperative medication review can serve as a screening tool to identify patients at risk for adverse outcomes after cardiac surgery.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dashuai Wang, Xing Chen, Jia Wu, Sheng Le, Fei Xie, Ximei Li, Hongfei Wang, Xiaofan Huang, Anchen Zhang, Xinling Du
Summary: This study identified a 6.6% incidence of postoperative pneumonia following cardiac surgery, with a mortality rate of 2.0% that significantly increased in patients with pneumonia. By developing nomogram models, it was possible to effectively predict and assess the risk of postoperative pneumonia.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Matteo Pozzi, Silvia Mariani, Margherita Scanziani, Davide Passolunghi, Adriana Bruni, Alberto Finazzi, Maddalena Lettino, Giuseppe Foti, Giuseppe Bellelli, Giovanni Marchetto
Summary: Frailty is a geriatric condition characterized by reduced homeostatic reserves, leading to poor outcomes. A multidisciplinary team is needed to assess and provide tailored care for frail patients in the perioperative period. Dedicated assessment tools are necessary to recognize frailty, as commonly used scores fail to capture it. Preoperative and postoperative interventions can reduce complications and support patient recovery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Surgery
Michelle A. Wan, James M. Clark, Miriam Nuno, David T. Cooke, Lisa M. Brown
Summary: This study demonstrates that the currently used frailty indices are not effective predictors of 30-day morbidity and mortality in patients undergoing high-risk surgery.
Article
Cardiac & Cardiovascular Systems
Rawn Salenger, Eric W. Etchill, Clifford E. Fonner, Diane Alejo, Thomas L. Matthew, Glenn J. R. Whitman, Stefano Schena, James S. Gammie, Bradley Taylor, Thomas S. Metkus, Sari D. Holmes, Niv Ad
Summary: Coronary artery bypass grafting is associated with significant interhospital variability in charges. Factors such as preoperative length of stay, operating room time, and postoperative morbidity contribute to this variability.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
James S. Gammie, Paul A. Grayburn, Rachael W. Quinn, Judy Hung, Sari D. Holmes
Summary: This study identified substantial variability in the definition and reporting of mitral regurgitation (MR) severity in contemporary clinical studies of mitral valve interventions. It is recommended to abandon the historical plus numeric grading system and use simple categories such as none or trace, mild, moderate, and severe based on US and European guidelines to improve consistency and quality in MR clinical trial design and reporting.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Niv Ad, Paul S. Massimiano, Anthony J. Rongione, Bradley Taylor, Stefano Schena, Diane Alejo, Clifford E. Fonner, Rawn Salenger, Glenn Whitman, Thomas S. Metkus, Sari D. Holmes
Summary: The study found that each additional blood product unit transfused, whether red blood cell or non-red blood cell, was associated with increased risk of complications for patients after cardiac surgery, with red blood cell transfusion carrying a greater risk compared to non-red blood cell transfusion.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Rawn Salenger, Sari D. Holmes, Amanda Rea, Jennifer Yeh, Kate Knott, Rachel Born, Michael J. Boss, Linda F. Barr
Summary: This study retrospectively analyzed the impact of cardiac Enhanced Recovery After Surgery (ERAS) care on cardiac surgical patients. The results showed that cardiac ERAS significantly decreased the use of opioids, nausea, and lightheadedness, while improving postoperative mobility for patients.
ANNALS OF THORACIC SURGERY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Sari D. Holmes, Niv Ad
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Rachael W. Quinn, Chetan Pasrija, Daniel A. Bernstein, Sari D. Holmes, James S. Gammie
Summary: The study showed that using a 1.0 or 1.5 cm translocation patch is effective for treating functional mitral regurgitation (FMR).
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2022)
Article
Anesthesiology
Nadia B. Hensley, Promise T. Ariyo, Sari D. Holmes, Marlene S. Williams, Glenn Joseph Robert Whitman, Niv Ad, Thomas Stephen Metkus
Summary: There is significant variability in the usage of DAPT within 5 days of coronary artery bypass grafting (CABG) among hospital centers. The utilization of preoperative platelet function testing may enable earlier surgery for patients on DAPT without increasing bleeding risks.
ANESTHESIA AND ANALGESIA
(2022)
Article
Cardiac & Cardiovascular Systems
Erik R. Strauss, Rachael W. Quinn, Chetan Pasrija, Reney Henderson, Sari D. Holmes, Michael N. D'Ambra, James S. Gammie
Summary: This study presents a rigorous method to analyze intraoperative echocardiographic images from the novel mitral translocation procedure and compares the data with a control group. The results demonstrate that the translocation procedure effectively eliminates mitral regurgitation and improves coaptation area and length, leading to acceptable diastolic function.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Irina Kolesnik, Sari D. Holmes, Rachael W. Quinn, Filomena Koenigsberg, James S. Gammie
Summary: This study examined the clinical outcomes and patient satisfaction of mitral valve surgery patients who had either in-person or telemedicine preoperative appointments during the COVID-19 pandemic. The study found that there were no significant differences in clinical outcomes between the two groups, and the majority of patients were satisfied with the telemedicine appointments.
JOURNAL OF CARDIAC SURGERY
(2022)
Letter
Anesthesiology
Nadia B. Hensley, Sari D. Holmes, Thomas Stephen Metkus
ANESTHESIA AND ANALGESIA
(2022)
Article
Anesthesiology
Michael A. Mazzeffi, Sari D. Holmes, Bradley Taylor, Mehrdad Ghoreishi, John S. McNeil, Miklos D. Kertai, Bruce A. Bollen, Kenichi Tanaka, Jacob Raphael, Laurent Glance
Summary: Intraoperative red blood cell (RBC) transfusion is associated with a small increase in the odds of healthcare-associated infection (HAI) in Coronary Artery Bypass Grafting (CABG) patients, with higher risk observed in patients receiving higher amounts of intraoperative RBC transfusion.
ANESTHESIA AND ANALGESIA
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Nolan M. Winicki, Isabella S. Florissi, Salman Zaheer, Sari D. Holmes, Diane E. Alejo, Clifford E. Fonner, James S. Gammie
Letter
Cardiac & Cardiovascular Systems
James S. Gammie, Rachael W. Quinn, Sari D. Holmes
ANNALS OF THORACIC SURGERY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
C. Pasrija, Z. N. Kon, A. Shah, S. D. Holmes, K. S. Rozenberg, E. Feller, S. Joseph, B. P. Griffith
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
C. Pasrija, A. Shah, S. D. Holmes, G. J. Bittle, R. Reed, V. Patel, C. Lau, A. S. Krupnick
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)