Review
Nutrition & Dietetics
Nasreddine El Omari, Saad Bakrim, Mohamed Bakha, Jose M. Lorenzo, Maksim Rebezov, Mohammad Ali Shariati, Sara Aboulaghras, Abdelaali Balahbib, Mars Khayrullin, Abdelhakim Bouyahya
Summary: Cancer is a complex disease with genetic and epigenetic disturbances playing major roles in tumor formation. Research is currently focused on the involvement of epigenetic disturbances in cancer, as well as the effects of drugs on different epigenetic pathways.
Review
Oncology
Weiyi Jiang, Tingting Xia, Cun Liu, Jie Li, Wenfeng Zhang, Changgang Sun
Summary: Epigenetics refers to physiological regulatory changes that affect gene expression without altering the DNA sequence. Flavonoids, derived from natural sources, have been shown to regulate cancer epigenetics with few side effects and significant biological activity, suggesting their potential as cancer therapeutic agents.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zahra Behroozi, Keihan Kookli, Alireza Ghadaksaz, Mahsa Motavaf, Seyedalireza Moghaddas Fazeli, Ali Motamed Nezhad, Fatemeh Ramezani, Atousa Janzadeh
Summary: This study investigated the changes in epigenetic factors after pain and PBMT. Gene and protein expression levels were evaluated using methods such as RT-qPCR and immunohistochemistry. PBMT increased the pain threshold and reduced existing pain symptoms.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qinsheng Sun, Qiuzi Dai, Cunlong Zhang, Yan Chen, Lei Zhao, Zigao Yuan, Yuyang Jiang
Summary: In this study, a series of nucleoside base hydroxamic acid derivatives were designed and synthesized as dual inhibitors of DNMT and HDAC, with compound 204 showing potent inhibitory effects against DNMT1 and HDAC1/6 and inducing cell cycle arrest in cancer cells. The findings suggest that compound 204 has potential as a lead compound for epigenetic cancer therapy.
CHINESE CHEMICAL LETTERS
(2021)
Review
Pharmacology & Pharmacy
David Rodriguez
Summary: Abusive alcohol consumption has a remarkable impact on human health, causing millions of deaths annually. Alcohol Use Disorder is a chronic disease characterized by compulsive alcohol drinking, and research on the genetic and epigenetic mechanisms behind this disease is crucial for developing new therapeutic approaches.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Microbiology
Kolathuru Puttamadaiah Ramesha, Nagabhushana Chandra Mohana, Siddaiah Chandra Nayaka, Sreedharamurthy Satish
Summary: The study found that epigenetic modification in Nigrospora sphaerica can activate new metabolites, including the induction of cryptic metabolites through the activation of potential biosynthetic gene clusters and the silencing of phomalactone in some treatments. Additionally, HDAC treatments showed a significant increase in cryptic metabolite induction, supporting the activation of cryptic metabolites with biological significance.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ignacio Silva-Llanes, Chang Hoon Shin, Jose Jimenez-Villegas, Myriam Gorospe, Isabel Lastres-Becker
Summary: The transcription factor NRF2 regulates the expression of genes encoding epigenetic regulatory factors by binding to their promoter regions containing ARE sequences. This study confirms NRF2's role in regulating histone deacetylases, DNA methyltransferases, and proteins involved in microRNA biogenesis. Additionally, NRF2 is found to be involved in the degradation of miR-155-5p through its interaction with Nfe2l2 mRNA. These findings demonstrate the epigenetic regulatory function of NRF2 and its potential implications for therapeutic strategies.
Review
Pharmacology & Pharmacy
Pengcheng Liu, Fan Yang, Lizhi Zhang, Ying Hu, Bangjie Chen, Jianpeng Wang, Lei Su, Mingyue Wu, Wenjian Chen
Summary: DNA methylation is a crucial epigenetic mechanism for gene expression regulation, and DNMTs play a vital role in this process. The abnormal function of DNMTs is closely associated with cancer development, making them an important target for cancer treatment research.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Mariana Brutt Pacheco, Vania Camilo, Nair Lopes, Filipa Moreira-Silva, Margareta P. Correia, Rui Henrique, Carmen Jeronimo
Summary: The combined treatment of DNA methylation inhibitor hydralazine and histone deacetylase inhibitors panobinostat and valproic acid showed synergistic growth inhibitory effects on prostate cancer cells, particularly in DU145 cells. This suggests that these drugs may be potential therapeutic tools to counteract the progression of prostate cancer.
Article
Nutrition & Dietetics
Afshin Zand, Sodbuyan Enkhbilguun, John M. Macharia, Ferenc Budan, Zoltan Gyongyi, Timea Varjas
Summary: In recent years, synthetic food colorants have shown wider properties compared to natural equivalents, but their health impact is still not well understood. This study aimed to determine the long-term effects of tartrazine, a commonly used artificial food colorant, on NMRI mice. The results showed significant upregulation of genes in various organs following tartrazine intake, suggesting possible associations with carcinogenesis and neurological disorders.
Article
Medicine, General & Internal
Nicolas A. Fraunhoffer, Aura I. Moreno Vega, Anala Meilerman Abuelafia, Marie Morvan, Emilie Lebarbier, Tristan Mary-Huard, Michael Zimmermann, Gwen Lomberk, Raul Urrutia, Nelson Dusetti, Yuna Blum, Remy Nicolle, Juan Iovanna
Summary: Using epigenomic inhibitors to reset gene expression patterns in pancreatic tumors shows promise in developing new therapies for pancreatic cancer.
Review
Oncology
Huey-Miin Chen, Ana Nikolic, Divya Singhal, Marco Gallo
Summary: This review explores the relationship between cancer stem cells (CSCs) and treatment resistance in glioblastoma (GBM), as well as the intrinsic and extrinsic factors that contribute to epigenomic heterogeneity and therapy resistance. Understanding these mechanisms can provide promising applications for epigenetic treatment approaches in treating GBM.
Review
Pharmacology & Pharmacy
Fahad Hussain Mohammed, Franz Cemic, Joergen Hemberger, Shibashish Giri
Summary: Epigenetic regions such as VEGF, EGFR, TGFb, DNMTs, HDAC1/2, and miRNA are innovative druggable targets for building a novel platform of drugs for preventive and regenerative skin health care. Clinical and preclinical trials are being conducted for skin regeneration using epigenetic-based small molecules. Epigenetic writers, eraser targets, and epigenetic readers will play a crucial role in skin regenerative therapy in the near future.
DRUG DISCOVERY TODAY
(2023)
Review
Cell Biology
Elena G. Pasyukova, Alexander Symonenko, Olga Y. Rybina, Alexander M. Vaiserman
Summary: Developing interventions to improve healthspan is a priority for academic and public health authorities. Geroscience focuses on targeting aging as an effective way to combat age-related disorders. Epigenome-targeted interventions in geroscience research show promise in preventing and treating various aging-related conditions.
AGEING RESEARCH REVIEWS
(2021)
Review
Oncology
Catarina Macedo-Silva, Rosaria Benedetti, Fortunato Ciardiello, Salvatore Cappabianca, Carmen Jeronimo, Lucia Altucci
Summary: Radiotherapy is a key treatment for prostate cancer, but some patients develop resistance. Epigenetic alterations play a crucial role in overcoming and predicting this resistance in PCa.
CLINICAL EPIGENETICS
(2021)
Review
Food Science & Technology
Mohamad Fawzi Mahomoodally, Dilmar Aniisah Sanaa, Gokhan Zengin, Monica Gallo, Domenico Montesano
Summary: This study systematically reviewed scientific literature from the past 10 years and highlighted the therapeutic uses of marine animals and animal products globally. It was found that a single aquatic animal could be used for treating multiple ailments, while an ailment could be addressed by several marine animals and animal-derived products. However, there is a lack of validated pharmacological studies to support these traditional uses.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Food Science & Technology
Mohammed Saber, Naoual El Menyiy, Saoulajan Charfi, Hanae Naceiri Mrabti, Omar Belmehdi, Hamza El Moudden, Douae Taha, Nasreddine El Omari, Abdelaali Balahbib, Gokhan Zengin, Mohamed Bakha, Mohamed Tabyaoui, Hicham Harhar, Monica Gallo, Domenico Montesano, Abdelhakim Bouyahya
Summary: This article reports previous investigations on Tetraclinis articulata, including its taxonomy, distribution, traditional use, phytochemistry, biological effects, toxicology, nutritional value, and economic interest. The plant exhibits various biological activities and shows no toxicity. However, further research is needed to validate its pharmacological use and toxicity.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Neurosciences
Aziz Unnisa, Nigel H. H. Greig, Mohammad Amjad Kamal
Summary: Traumatic brain injury (TBI) is a major cause of death and morbidity, and is the focus of translational research. Apoptosis is important in the pathophysiology of TBI, and inhibiting it may improve functional recovery. Caspases, such as Caspase-3 and Caspase-9, are key mediators of cell death due to apoptosis in TBI. Understanding these apoptotic pathways and finding ways to inhibit Caspases may have significant treatment implications for TBI.
CURRENT NEUROPHARMACOLOGY
(2023)
Review
Neurosciences
Aziz Unnisa, Kamal Dua, Mohammad Amjad Kamal
Summary: Parkinson's disease is a prevalent neurodegenerative disorder that affects the basal nuclei and impairs motor and cognitive functions. The disease is characterized by a loss of dopaminergic neurons and the aggregation of Lewy bodies. Current medications only relieve symptoms and do not cure the disease, highlighting the need for therapies that can effectively stop or reverse degeneration. Cell-based therapies using mesenchymal stem cells (MSCs) have gained attention for their abundance in the body, proliferation ability, and immunomodulation, showing promise in repairing dopaminergic neurons in Parkinson's patients.
CURRENT NEUROPHARMACOLOGY
(2023)
Review
Food Science & Technology
Omar Belmehdia, Naoual El Menyiy, Abdelhakim Bouyahya, Aicha El Baaboua, Nasreddine El Omari, Monica Gallo, Domenico Montesano, Daniele Naviglio, Gokhan Zengin, Nadia Skali Senhaji, Bey Hing Goh, Jamal Abrini
Summary: This review discusses the recent advances in the chemical composition and biological activities of propolis. It highlights the various important bioactive properties of propolis, including antibacterial, antioxidant, and anticancer effects. Data shows that propolis has low toxicity even at high doses, making it a promising source of bioactive compounds for drug development.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Food Science & Technology
Fatema R. Saber, Shaza H. Aly, Moustafa Ali Khallaf, Heba A. S. El-Nashar, Nouran M. Fahmy, Mohamed El-Shazly, Radha Radha, Suraj Prakash, Manoj Kumar, Doaue Taha, Abdelhakim Bouyahya, Javad Sharifi-Rad
Summary: This review highlights the phytochemical composition of doum plant and describes its active constituents. It summarizes the extraction methods and reports the different applications of doum in functional food, animal feeding, and pharmaceuticals. Doum is considered a promising dietary and therapeutic candidate.
FOOD ANALYTICAL METHODS
(2023)
Review
Pharmacology & Pharmacy
Hanae Naceiri Mrabti, Imane Jaouadi, Ikrame Zeouk, Rokia Ghchime, Naoual El Menyiy, Nasreddine El Omari, Abdelaali Balahbib, Samiah H. Al-Mijalli, Emad M. Abdallah, Mohamed El-Shazly, Gokhan Zengin, Abdelhakim Bouyahya
Summary: Myrtenol is a volatile compound belonging to the terpenoid family of monocyclic monoterpenes. It is found in various aromatic plants and exhibits antioxidant, antibacterial, antifungal, antidiabetic, anxiolytic, and gastroprotective activities. This review provides insights into the pharmacological activities, cellular and molecular mechanisms, and potential medicinal applications of myrtenol.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Behavioral Sciences
Mehboob Hoque, Arijit Samanta, Syed Sahajada Mahafujul Alam, Torki A. Zughaibi, Mohammad Amjad Kamal, Shams Tabrez
Summary: Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by the accumulation of amyloid beta (A beta) plaques and hyperphosphorylated tau protein neurofibrillary tangles (NFT). Current AD treatments have limited success and focus on improving cognitive and behavioral symptoms. Developing novel treatment approaches to control/inhibit AD progression, especially in the elderly, is crucial. Immunotherapy, which boosts the patient's immune system, shows promise as a safe treatment option. However, delivering therapeutics to the brain poses a challenge due to the minimal immune surveillance in the brain. The review discusses the use of different nano-formulations to enhance AD immunotherapy.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Editorial Material
Chemistry, Multidisciplinary
Mohammad Khursheed Alam, Mohammad Amjad Kamal, Kumar Chandan Srivastava
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Paola Ganugi, Andrea Fiorini, Vincenzo Tabaglio, Federico Capra, Gokhan Zengin, Paolo Bonini, Tito Caffi, Edoardo Puglisi, Marco Trevisan, Luigi Lucini
Summary: The application of microbial biostimulants to plants has positive effects on various aspects, but little information is available on their synergistic effects on the functional quality of yields. This study investigated the combined action of biostimulants and found that the coupling of arbuscular mycorrhiza (AMF) and Trichoderma fungal inoculations had a synergistic biostimulant effect on tomato fruits under sub-optimal fertility. This resulted in improved concentrations of carotenoid compounds and increased values for various functional quality parameters.
Article
Biochemistry & Molecular Biology
Francesco Cairone, Caterina Fraschetti, Luigi Menghini, Gokhan Zengin, Antonello Filippi, Maria Antonietta Casadei, Stefania Cesa
Summary: Based on analysis and color analysis, it was found that the harvest year, freezing, homogenization, and thermic treatments have an impact on the bioactive components of sour cherries. The main polyphenolic components are anthocyanin compounds, primarily cyanidin-3-glucosyl-rutinoside, and immediate post-harvest freezing is the best way to preserve the bioactive content, color expression, and anti-radical activity.
Article
Plant Sciences
Marco Armando De Gregorio, Gokhan Zengin, Fatma Nur Alp-Turgut, Fevzi Elbasan, Ceyda Ozfidan-Konakci, Busra Arikan, Evren Yildiztugay, Leilei Zhang, Luigi Lucini
Summary: This study investigated the impact of glutamic acid (GA), humic acid (HA), and their combination (GA+HA) on the polyphenolic profile of lettuce using a metabolomics approach. The results showed that GA and HA treatments significantly affected the biosynthesis of flavonoids, lignans, low molecular weight phenolics, phenolic acids, and stilbene in lettuce. Moreover, the combination of GA+HA exhibited strong antioxidant abilities and enzyme inhibition activities. These findings provide valuable insights for enhancing the functional properties of lettuce using plant elicitors.
Article
Biochemistry & Molecular Biology
Samiah Hamad Al-Mijalli, Hanae Naceiri Mrabti, Naoufal El Hachlafi, Taha El Kamili, Amine Elbouzidi, Emad M. Abdallah, Rachid Flouchi, Hamza Assaggaf, Ahmed Qasem, Gokhan Zengin, Abdelhakim Bouyahya, Fouad Ouazzani Chahdi
Summary: This study investigated the chemical composition and antimicrobial and antioxidant properties of cinnamon essential oil. The results showed that it exhibited broad-spectrum antimicrobial activity and significant antioxidant activity. Molecular docking and ADMET analysis provided valuable information about its binding modes and pharmacokinetic properties. In conclusion, cinnamon essential oil is a valuable source of natural preservatives and antimicrobial and antioxidant agents.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Naoufal El Hachlafi, Hanae Naceiri Mrabti, Samiah Hamad Al-Mijalli, Mohamed Jeddi, Emad M. Abdallah, Nesrine Benkhaira, Hanine Hadni, Hamza Assaggaf, Ahmed Qasem, Khang Wen Goh, Ammar AL-Farga, Abdelhakim Bouyahya, Kawtar Fikri-Benbrahim
Summary: This study investigated the volatile compounds of Cedrus atlantica essential oils (CAEOs) and examined their in vitro antimicrobial, antioxidant, anti-inflammatory, and dermatoprotective properties. The results showed that CAEO has significant antibacterial, antioxidant, and anti-inflammatory activities, and favorable pharmacokinetic properties. These findings provide scientific validation of the traditional uses of this plant and suggest its potential application as natural drugs.
Review
Biotechnology & Applied Microbiology
Javad Sharifi-Rad, Naoual El Menyiy, Alibek Ydyrys, Naoufal El Hachlafi, Nasreddine El Omari, Afaf A. Aldahish, Farukh Sharopov, Abdelhakim Bouyahya, Jelena Zivkovic, Charles O. Adetunji, Olugbemi T. Olaniyan, Miguel Martorell, Eda Sonmez Gurer, Christophe Hano, Daniela Calina
Summary: "Oxidative Stress and Inflammation Modulators: Prosopis Plants" provides up-to-date information on the use of Prosopis plants as herbal remedies for regulating oxidative stress and inflammation. These plants have been traditionally used and have shown anti-inflammatory and antioxidant effects. The review collected relevant information from scientific databases and emphasized the studies using validated markers of oxidative stress, antioxidant capacity, and inflammation.
MINERVA BIOTECHNOLOGY AND BIOMOLECULAR RESEARCH
(2023)