Letter
Oncology
Carla Isabelly Rodrigues-Fernandes, Lady Paola Aristizabal Arboleda, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Alan Roger Santos-Silva
Summary: This report describes an uncommon case of verrucous carcinoma in the oral cavity with a unique presentation of proliferative verrucous leukoplakia. It highlights the importance of considering verrucous carcinoma in the differential diagnosis of multiple leukoplakias, especially in elderly patients.
Article
Medicine, General & Internal
Houda Tebcherany, Anupama Grandhi, Ahmed Khocht
Summary: This report reviews a case of a likely HPV-related oral disease presenting as a squamous cell papilloma. Early diagnosis and treatment are crucial for preventing serious complications.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Akash N. Naik, Dustin A. Silverman, Chandler J. Rygalski, Songzhu Zhao, Guy Brock, Chen Lin, Sidharth V. Puram, James W. Rocco, Sujith Baliga, Kyle K. VanKoevering, Matthew O. Old, Nolan B. Seim, Stephen Y. Kang
Summary: This study investigates the factors associated with the use of postoperative radiation therapy (PORT) and its effect on overall survival (OS) for patients with oral cavity verrucous carcinoma (VC). The results suggest that closer distance to the hospital and stage III-IV disease are associated with the use of PORT, but there is no clear survival benefit with PORT compared to surgery alone.
Article
Dentistry, Oral Surgery & Medicine
Sebastian Blatt, Andreas Pabst, Stefanie Zimmer, Christian Walter, Bilal Al-Nawas, Maximilian Kruger
Summary: This study investigated a new rapid test for L1 antibody detection in HPV-16 associated oral squamous cell carcinoma (OSCC) and validated its diagnostic performance. The results showed that the rapid test for L1 antibodies demonstrated high sensitivity and specificity.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Otorhinolaryngology
Dasa Gluvajic, Lea Hosnjak, Vida Stegel, Srdjan Novakovic, Nina Gale, Mario Poljak, Irena Hocevar Boltezar
Summary: This study assessed the incidence and risk factors for HG-D and LSCC in patients with LSP, revealing that older age and lack of HPV infection are risk factors for the development of HG-D and LSCC. The presence of HG-D was associated with progression to LSCC, and host gene mutations may play a role in LSCC transformation.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Ian Ganly, Yuhan Hao, Matthew Rosenthal, Hongmei Wang, Jocelyn Migliacci, Bin Huang, Nora Katabi, Stuart Brown, Yi-Wei Tang, Zhiheng Pei, Liying Yang
Summary: The taxonomic composition and functional potential of the oral metagenome in nonsmokers with oral cavity squamous cell carcinoma (OC-SCC) were studied using metagenomic shotgun sequencing (MSS). The study found that three bacterial phyla, one genus, and one species were enriched in OC-SCC, while two phyla, five genera, and 18 species were enriched in controls. Pathways related to metabolism of flavin, biotin, thiamine, heme, sugars, fatty acids, peptidoglycans, and tRNA were more abundant in OC-SCC while those related to metabolism of nucleotides and essential amino acids were more abundant in controls.
Article
Oncology
Kendrick Koo, Dmitri Mouradov, Christopher M. Angel, Tim A. Iseli, David Wiesenfeld, Michael J. McCullough, Antony W. Burgess, Oliver M. Sieber
Summary: A distinct cohort of non-smoking non-drinking patients with oral cavity squamous cell carcinomas have been identified, showing specific genomic profiles different from patients who smoke and/or drink, with associations to mutations in TP53, CDKN2A, EGFR, and BRCA2 genes. Further exploration is needed to elucidate the molecular aetiology in these patients.
Review
Virology
Malgorzata Wierzbicka, Michel R. M. San Giorgi, Frederik G. Dikkers
Summary: This article examines the prevalence and routes of transmission of human papillomavirus (HPV) through a narrative review of the literature. The study suggests that HPV is mainly transmitted to the oral cavity and oropharynx through sexual contact, while transmission through saliva and daily activities is not a significant source of infection. Survivors of oropharyngeal HPV-related cancer and their partners do not have an increased risk of infection during sexual intercourse.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Medicine, Research & Experimental
Stephanus Christianto, Kar Yan Li, Ting Hsiang Huang, Yu-Xiong Su
Summary: The meta-analysis showed that HPV-positive OSCC patients have a significantly shorter overall survival and lower distant control compared to HPV-negative OSCC patients. There were no significant differences in disease-free survival, disease-specific survival, local control, and regional control between HPV-positive and negative OSCC patients. Sensitivity analysis confirmed these findings.
Article
Oncology
Matthew Uzelac, Armon Barakchi, Varsha Beldona, Daniel John, Jaideep Chakladar, Wei Tse Li, Weg M. M. Ongkeko
Summary: This study examines genomic mutations in HPV-infected HNSCC patients and finds that high expression of E6 and E7 oncoproteins is associated with an increase in point mutations and specific chromosomal alterations.
Review
Radiology, Nuclear Medicine & Medical Imaging
Philip Touska, Steve Connor
Summary: The clinical behavior and outcomes of patients with oropharyngeal cancer can be classified based on their association with HPV infection. Patients with HPV-associated disease have distinct characteristics and show better responses to treatment. Imaging techniques, such as CT and MRI, play a crucial role in staging and treatment strategies for these patients.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Vinodh Bhoopathi, Pradeep Bhagavatula, Maharaj Singh
Summary: This study examined the association between health literacy levels and receipt of at least one dose of HPV vaccination. The results showed that higher levels of health literacy were associated with a higher likelihood of receiving the vaccine. Age, gender, marital status, race/ethnicity, insurance status, and having regular access to a personal doctor were predictors of HPV vaccination status.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Alejandro Herreros-Pomares, David Hervas, Leticia Bagan-Debon, Alex Proano, Diana Garcia, Juan Sandoval, Jose Bagan
Summary: This study investigated the pathophysiologic differences between proliferative verrucous leukoplakia-associated oral squamous cell carcinoma (PVL-OSCC) and non-PVL-OSCC through transcriptomic and DNA methylation analyses. The results showed that PVL-OSCC patients had lower expression of cancer-related genes and hypermethylation of the promoter region of many genes, suggesting that DNA methylation could be a regulatory mechanism.
Article
Medicine, General & Internal
Annalisa Palmieri, Dorina Lauritano, Agnese Pellati, Luca Scapoli, Claudio Arcuri, Luigi Baggi, Roberto Gatto, Francesco Carinci
Summary: Oral cavity and oropharynx cancer associated with human papilloma virus infection is a serious public health problem, especially in young people continuously exposed to the virus. Studies showed newly acquired oral oncogenic HPV infections in healthy population are rare, but more research is needed to clarify HPV infection prevalence and guide prevention efforts.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Tsegaw Biyazin, Aynalem Yetwale, Belete Fenta
Summary: This study aimed to assess the willingness to receive HPV vaccination among female high school students in Jimma town, Ethiopia. The study found that factors such as mother's education level, having an older sister, owning a smartphone, having good knowledge, and a positive attitude were significantly associated with willingness to accept HPV vaccine.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)