Journal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume 142, Issue 9, Pages 1883-1895Publisher
SPRINGER
DOI: 10.1007/s00432-016-2118-3
Keywords
Breast cancer; Disseminated tumor cells; Bone marrow; Circulating tumor cells; Detection Enrichment; Characterization; Targets
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Advances in immunocytochemical methods have enabled the enrichment and visualization of those disseminated tumor cells in bone marrow (DTC-BM) or circulating tumor cells (CTC) in blood. Many studies could demonstrate prognostic significance of the detection of DTC-BM or CTC in different stages of breast cancer. Further characterization of those cells by immunocytochemical stainings, fluorescence in situ hybridizations, or PCR-based molecular methods will help to understand the biology of tumor cell dissemination and metastasis formation, as well as to define potential drug targets.
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