Towards Development of a Non-Toxigenic Clostridioides difficile Oral Spore Vaccine against Toxigenic C. difficile

Colonisation Factor CD0873, an Attractive Oral Vaccine Candidate against Clostridioides difficile

(2021) Cansu Karyal et al.   Microorganisms

Mimicking Native Display of CD0873 on Liposomes Augments Its Potency as an Oral Vaccine against Clostridioides difficile

(2021) Cansu Karyal et al.   Vaccines

A Revised Understanding of Clostridioides difficile Spore Germination

(2020) Amelia J. Lawler et al.   TRENDS IN MICROBIOLOGY

Comparison of polysaccharide glycoconjugates as candidate vaccines to combat Clostridiodes (Clostridium) difficile

(2020) A.D. Cox et al.   GLYCOCONJUGATE JOURNAL

Safety, immunogenicity, and efficacy of a Clostridioides difficile toxoid vaccine candidate: a phase 3 multicentre, observer-blind, randomised, controlled trial

(2020) Guy de Bruyn et al.   LANCET INFECTIOUS DISEASES

Current and future trends in clostridioides (clostridium) difficile infection management

(2019) Sahil Khanna et al.   ANAEROBE

Clostridium difficile infection: review

(2019) Jacek Czepiel et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

A Novel Conjugal Donor Strain for Improved DNA transfer into Clostridium spp.

(2019) Craig Woods et al.   ANAEROBE

Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogen Clostridioides difficile

(2019) William J. Bradshaw et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variant Signal Peptides of Vaccine Antigen, FHbp, Impair Processing Affecting Surface Localization and Antibody-Mediated Killing in Most Meningococcal Isolates

(2019) Ronni A. G. da Silva et al.   Frontiers in Microbiology

Development of vaccine for Clostridium difficile infection using membrane fraction of nontoxigenic Clostridium difficile

(2018) Mitsutoshi Senoh et al.   MICROBIAL PATHOGENESIS

Oral immunization with non-toxic C. difficile strains expressing chimeric fragments of TcdA and TcdB elicits protective immunity against C. difficile infection in both mice and hamsters

(2018) Yuanguo Wang et al.   INFECTION AND IMMUNITY

Non-toxigenic Clostridioides (Formerly Clostridium) difficile for Prevention of C. difficile Infection: From Bench to Bedside Back to Bench and Back to Bedside

(2018) Dale N. Gerding et al.   Frontiers in Microbiology

Germinant Synergy Facilitates Clostridium difficile Spore Germination under Physiological Conditions

(2018) Travis J. Kochan et al.   mSphere

Global burden of Clostridium difficile infections: a systematic review and meta-analysis

(2018) Evelyn Balsells et al.   Journal of Global Health

Immunization with Recombinant TcdB-Encapsulated Nanocomplex Induces Protection against Clostridium difficile Challenge in a Mouse Model

(2017) Yi-Wen Liu et al.   Frontiers in Microbiology

Immunogenicity and protective efficacy of Clostridium difficile spore proteins

(2016) Chandrabali Ghose et al.   ANAEROBE

Immunogenic properties of the surface layer precursor of Clostridium difficile and vaccination assays in animal models

(2016) J.-F. Bruxelle et al.   ANAEROBE

Virulence factors of Clostridium difficile and their role during infection

(2016) Claire Janoir   ANAEROBE

Detection of Clostridium difficile in Feces of Asymptomatic Patients Admitted to the Hospital

(2016) Elisabeth M. Terveer et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Immunogenicity and protective efficacy of recombinant Clostridium difficile flagellar protein FliC

(2016) Chandrabali Ghose et al.   Emerging Microbes & Infections

Clostridium difficile infection

(2016) Wiep Klaas Smits et al.   Nature Reviews Disease Primers

Antibiotic-Induced Alterations of the Gut Microbiota Alter Secondary Bile Acid Production and Allow for Clostridium difficile Spore Germination and Outgrowth in the Large Intestine

(2016) Casey M. Theriot et al.   mSphere

The Epidemiology of Clostridium difficile Infection Inside and Outside Health Care Institutions

(2015) Dale N. Gerding et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Clostridium difficile Infection

(2015) Daniel A. Leffler et al.   NEW ENGLAND JOURNAL OF MEDICINE

A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity againstClostridium difficileinfection in mice and hamsters

(2015) Yuan-Kai Wang et al.   Human Vaccines & Immunotherapeutics

Enterococci, Clostridium difficile and ESBL-producing bacteria: epidemiology, clinical impact and prevention in ICU patients

(2015) J Sidler et al.   SWISS MEDICAL WEEKLY

Dynamics and Establishment of Clostridium difficile Infection in the Murine Gastrointestinal Tract

(2014) Mark J. Koenigsknecht et al.   INFECTION AND IMMUNITY

Lipoprotein CD0873 Is a Novel Adhesin of Clostridium difficile

(2014) A. Kovacs-Simon et al.   JOURNAL OF INFECTIOUS DISEASES

Vaccines against Clostridium difficile

(2014) Rosanna Leuzzi et al.   Human Vaccines & Immunotherapeutics

A clinical and epidemiological review of non-toxigenic Clostridium difficile

(2013) Mukil Natarajan et al.   ANAEROBE

Nontoxigenic Clostridium difficile Protects Hamsters against Challenge with Historic and Epidemic Strains of Toxigenic BI/NAP1/027 C. difficile

(2013) Kristin J. Nagaro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Investigating the candidacy of a lipoteichoic acid-based glycoconjugate as a vaccine to combat Clostridium difficile infection

(2013) Andrew D. Cox et al.   GLYCOCONJUGATE JOURNAL

A novel approach to generate a recombinant toxoid vaccine against Clostridium difficile

(2013) R. G. K. Donald et al.   MICROBIOLOGY-SGM

Identification of a Novel Zinc Metalloprotease through a Global Analysis of Clostridium difficile Extracellular Proteins

(2013) Valeria Cafardi et al.   PLoS One

Immunization Using GroEL Decreases Clostridium difficile Intestinal Colonization

(2013) Séverine Péchiné et al.   PLoS One

Horizontal gene transfer converts non-toxigenic Clostridium difficile strains into toxin producers

(2013) Michael S.M. Brouwer et al.   Nature Communications

Efficacy of LFF571 in a Hamster Model of Clostridium difficile Infection

(2012) Anna Trzasko et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Possible Oligosaccharide-Conjugate Vaccine Candidate for Clostridium difficile Is Antigenic and Immunogenic

(2011) Matthias A. Oberli et al.   CHEMISTRY & BIOLOGY

Encapsulation of Cwp84 into pectin beads for oral vaccination against Clostridium difficile

(2011) Chiara Sandolo et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Immunization of hamsters againstClostridium difficileinfection using the Cwp84 protease as an antigen

(2011) Séverine Péchiné et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Profound Alterations of Intestinal Microbiota following a Single Dose of Clindamycin Results in Sustained Susceptibility to Clostridium difficile-Induced Colitis

(2011) Charlie G. Buffie et al.   INFECTION AND IMMUNITY

Chemical Probes of Surface Layer Biogenesis inClostridium difficile

(2010) T. H. Tam Dang et al.   ACS Chemical Biology

Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)

(2010) Stuart H. Cohen et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Metabolism of Bile Salts in Mice Influences Spore Germination in Clostridium difficile

(2010) Jennifer L. Giel et al.   PLoS One

Effect of broad- and narrow-spectrum antimicrobials on Clostridium difficile and microbial diversity in a model of the distal colon

(2010) M. C. Rea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cwp84, a Surface-associated Cysteine Protease, Plays a Role in the Maturation of the Surface Layer of Clostridium difficile

(2009) Jonathan M. Kirby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A modular system for Clostridium shuttle plasmids

(2009) John T. Heap et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Immunoreactive cell wall proteins of Clostridium difficile identified by human sera

(2008) A. Wright et al.   JOURNAL OF MEDICAL MICROBIOLOGY