Article
Immunology
Chong Shen, Wang Chai, Jingwen Han, Zhe Zhang, Xuejing Liu, Shaobo Yang, Yinlei Wang, Donghuai Wang, Fangxin Wan, Zhenqian Fan, Hailong Hu
Summary: In this study, a prognostic model based on nine TME-associated genes was developed and validated for breast cancer patients. The model accurately predicted survival outcomes, providing guidance for individualized treatment and offering new therapeutic strategies for the disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Yang Chen, Yunfei Lu, Changzhi Huang, Jingyu Wu, Yu Shao, Zhenling Wang, Hongqiang Zhang, Zan Fu
Summary: This study identified lysosome-related genes (PLRGs) associated with colon adenocarcinoma and divided the cancer into two subtypes based on these genes. Prognosis and tumor microenvironment were compared between the subtypes, and a PLRGs score was developed to quantify patient prognosis and provide treatment advice. Additionally, the study confirmed the high expression of MOGS in colon adenocarcinoma at the protein level.
FRONTIERS IN GENETICS
(2023)
Article
Immunology
Ruijun Zhao, Shuanglong Chen, Weiheng Cui, Chaoyu Xie, Aiping Zhang, Li Yang, Hongmei Dong
Summary: This study found that PTPN1 is overexpressed in multiple cancers and is associated with clinical outcomes and tumor immunity, suggesting it could be a valuable potential prognostic and immunological biomarker for pan-cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Qiu-Ping Liu, Jia-Yi Lin, Pei An, Yu-Ying Chen, Xin Luan, Hong Zhang
Summary: Abnormal expression of lncRNAs in the tumor microenvironment typically leads to increased proliferation, migration, and drug resistance of tumor cells, however, regulating the expression of lncRNAs in TME can significantly inhibit tumor progression.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Oncology
Dongsheng Zhang, Yan Zhao, Shirui Wang, Xiaowei Wang, Yueming Sun
Summary: Colon adenocarcinoma (COAD) is a common cancer with high mortality due to metastasis. This study analyzed the Cancer Genome Atlas (TCGA)-COAD dataset and GSE17536 to explore the involvement of angiogenesis and neutrophil extracellular traps (NETs) in tumor progression and metastasis. Bioinformatic methods and machine learning algorithms were used to build angiogenesis potential index (API) and NETs potential index (NPI). Survival analysis showed that high API and high NPI patients had the worst survival. Differential gene expression analysis identified a four-gene signature (TIMP1, FSL3, CALB2, and FABP4) associated with high API/NPI group. The risk model based on these genes showed significant association with immune microenvironment characteristics.
Review
Biochemistry & Molecular Biology
Hui Wang, Tian Tian, Jinhua Zhang
Summary: Colorectal cancer (CRC) is a highly prevalent and lethal malignant tumor in the digestive system. Tumor-associated macrophages (TAMs) play a crucial role in various mechanisms of CRC progression, such as promoting tumor proliferation, invasion, angiogenesis, and immunosuppression, although their exact role is still debated in clinical evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yue Zhao, Li Xu, Xinyu Wang, Shuai Niu, Hezhong Chen, ChunGuang Li
Summary: MicroRNAs (miRNAs) and their target genes play a crucial role in tumor progression, especially in esophageal cancer (EC). By analyzing differentially expressed miRNAs and mRNAs, a risk model involving three miRNAs was designed to predict prognosis in EC patients. The target genes of miRNAs were found to be significantly associated with immune infiltration, tumor microenvironment, cancer stemness properties, and tumor mutation burden in EC. Additionally, a pan-cancer analysis revealed that the miRNA target genes affected tumor immunity similarly across different cancers.
MOLECULAR ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Yabin Jin, Jianzhong Deng, Bing Luo, Yubo Zhong, Si Yu
Summary: In this study, an immune-related genes prognostic index (IRGPI) was constructed and validated, which may serve as a potential biomarker for evaluating response to immunotherapy and clinical outcome for colon cancer patients. The IRGPI model can predict the response to immunotherapy and clinical outcomes, providing guidance for personalized treatment decisions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Yufu Zheng, Didi Yuan, Fei Zhang, Renkuan Tang
Summary: This study comprehensively analyzed the contribution of the gasdermin (GSDM) family in a pan-cancer setting. The results showed that GSDM genes were highly upregulated in most tested cancers, and their expression levels were associated with prognosis, clinical characteristics, tumor microenvironment, and stemness scores. The study also found a higher expression of GSDMB, GSDMC, and GSDMD in kidney carcinomas, particularly kidney renal clear cell carcinoma, which negatively impacted patient outcomes. Additionally, the expressions of GSDM genes were correlated with the sensitivity of tumor cells to certain chemotherapy drugs.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Jiawei Rao, Wen Li, Chuangqi Chen
Summary: The study identified two PYG-mediated molecular subtypes in colon cancer, affecting the composition of the tumor microenvironment; the infiltration of immune cells was significantly different between the low and high PY-score groups; patients in the low PY-score group showed better survival advantage and were more sensitive to certain treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Lidong Xu, Peipei Wu, Aimei Rong, Kunkun Li, Xingguo Xiao, Yong Zhang, Huili Wu
Summary: In this study, the role of DLAT expression in cancer prognosis and immune response was investigated using various bioinformatics approaches. The results show that DLAT is aberrantly expressed in most malignant tumors and is associated with immune-related pathways, tumor microenvironment, and immune cell infiltration. Additionally, DLAT is correlated with tumor mutational burden and microsatellite instability. This study demonstrates that DLAT plays a crucial role in tumorigenesis and cancer immunity, potentially serving as a prognostic biomarker and target for cancer immunotherapy.
Article
Immunology
Xiao-Tian Shen, Sun-Zhe Xie, Jing Xu, Lu-Yu Yang, Lun-Xiu Qin
Summary: This study comprehensively analyzed the global NET-associated gene regulatory network and found a close association between NETs and cancer biology. NETs had diverse prognostic impacts among different cancer types, and SPP1 potentially played a key role in NET-related poor outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Guangzhen Cai, Jinghan Zhu, Deng Ning, Ganxun Li, Yuxin Zhang, Yixiao Xiong, Junnan Liang, Chengpeng Yu, Xiaoping Chen, Huifang Liang, Zeyang Ding
Summary: The role of hypoxia in hepatocellular carcinoma and its impact on the tumor microenvironment and drug sensitivity are not well understood. This study found that the Hypoxia_DEGs_Score model has excellent predictive value for survival. Hypoxia is closely related to somatic mutation, copy number variation, and DNA methylation, which affect tumor development, metastasis, and drug resistance. Aggravated hypoxic stress leads to immune exclusion phenotype and increased infiltration of immunosuppressive cells. Patients with high Hypoxia_DEGs_Score have worse immunotherapeutic outcomes and prognosis, and may benefit from drugs targeting cell cycle signaling pathways rather than those inhibiting the PI3K/mTOR pathway. Hypoxia_DEGs_Score can predict changes in the tumor microenvironment, the efficacy of immunotherapy, and drug response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Dandan Bao, Chenghao Zhang, Longlong Li, Haihong Wang, Qiuyan Li, Leilei Ni, Yinfeng Lin, Rong Huang, Zhangwei Yang, Yan Zhang, Yiren Hu
Summary: This study identified a correlation between various complements and tumor prognosis and immune infiltration in colon cancer and GC, with CD55 potentially serving as an indicator for survival prognosis in colon cancer and complements C3, CR4, and C5aR1 as potential biological targets for GC immunotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Duo Yun, Zhirong Yang, Shuman Zhang, Hai Yang, Dongxue Liu, Robert Gruetzmann, Christian Pilarsky, Nathalie Britzen-Laurent
Summary: This study investigates the prognostic role of RNA methylation in pancreatic ductal adenocarcinoma (PDAC) and identifies the m5C-score as a reliable prognostic marker, associated with unfavorable molecular subtypes and immune microenvironment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)