Article
Dermatology
Christopher L. Sudduth, Arin K. Greene
Summary: Obesity-induced lymphedema (OIL) is a secondary lymphedema that may occur once an individual's BMI exceeds 40, with patients also at risk of developing massive localized lymphedema (MLL). The relationship between obesity and lymphedema is complex, with weight loss being the fundamental treatment for OIL.
ADVANCES IN WOUND CARE
(2022)
Article
Public, Environmental & Occupational Health
Kazuya Fujihara, Mayuko Yamada Harada, Chika Horikawa, Midori Iwanaga, Hirofumi Tanaka, Hitoshi Nomura, Yasuharu Sui, Kyouhei Tanabe, Takaho Yamada, Satoru Kodama, Kiminori Kato, Hirohito Sone
Summary: This study developed a machine learning model to predict weight change over three years. It found that lifestyle had a significant impact on weight in individuals with high BMI and in young people. The model showed comparable accuracy to multiple regression, suggesting its potential for personalized weight management.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Oncology
Ling Wang, Hongbo Chen, Yuanzhen Li, Huixue Wang, Ning Liu, Miao Yu, Shaomei Shang
Summary: This study investigated the impact of obesity/overweight on the development of breast cancer-related lymphedema (BCRL) at different time points after surgery in Chinese breast cancer survivors. The results showed that patients with a preoperative BMI >= 25 kg/m(2) had a significantly higher occurrence of lymphedema compared to those with a preoperative BMI < 25 kg/m(2), especially at 6-12 and 12-18 months after surgery. Multivariable logistic regression analysis confirmed that a preoperative BMI >= 30 kg/m(2) was significantly associated with an increased risk of lymphedema. In conclusion, preoperative obesity is an independent risk factor for BCRL in Chinese breast cancer survivors.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Green & Sustainable Science & Technology
Gabriel Gonzalez-Valero, Josep Vidal-Conti, Felix Zurita-Ortega, Pere Palou-Sampol
Summary: This study examines the associations between active time during cooperative learning, quality of life, body mass index, and age in individuals with intellectual disabilities. The results demonstrate a positive correlation between active time in cooperative learning and quality of life, and a negative correlation with body mass index.
Article
Nutrition & Dietetics
Estela Blanco, Suzanna M. Martinez, Patricia East, Raquel Burrows, Paulina Correa-Burrows, Betsy Lozoff, Sheila Gahagan
Summary: This study examined the association between breastfeeding duration and body mass index (BMI) from childhood to young adulthood and found that longer breastfeeding was associated with lower BMI in early childhood, but had no significant effect on later BMI.
Article
Oncology
Marnix R. Jansen, Otis M. Vrielink, Marloes Faut, Eric A. Deckers, Lukas B. Been, Barbara L. van Leeuwen
Summary: The incidence of lymphedema is relatively high after videoscopic inguinal lymphadenectomy, but it gradually improves during follow-up, along with an improvement in quality of life.
Article
Rehabilitation
Seung Mi Yeo, Kyeong Eun Uhm, Ji Sung Yoo, Ji Hye Hwang
Summary: This study aimed to translate and validate the K-LYMQOL-leg, and the results showed that the questionnaire has good reliability and validity, and can be used to assess the Quality of Life (QOL) of patients with lymphedema.
DISABILITY AND REHABILITATION
(2023)
Article
Chemistry, Multidisciplinary
Alessandro de Sire, Nicola Fusco, Elham Sajjadi, Lorenzo Lippi, Carlo Cisari, Marco Invernizzi
Summary: This study evaluated the safety and tolerability of an instantly adjustable IC device in BCRL patients and found it to be effective in reducing BCRL volume significantly and decreasing IC application time, suggesting that IC could be considered as a safe, well-tolerated, and effective tool in the rehabilitative management of BCRL patients.
APPLIED SCIENCES-BASEL
(2021)
Article
Geriatrics & Gerontology
Marie-Theres Huemer, Alina Bauer, Agnese Petrera, Markus Scholz, Stefanie M. Hauck, Michael Drey, Annette Peters, Barbara Thorand
Summary: This study utilized proteomic profiling to identify novel biomarkers associated with low muscle mass, high fat mass, and their combination. Key findings included previously unknown biomarkers such as kallikrein-6, CCL28, and NT-proBNP as potential indicators of declining health status related to muscle and fat composition. The high-throughput proteomics approach accelerated biomarker discovery in muscle research.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Oncology
David Gomez, Paula Jimenez-Fonseca, Aranzazu Manzano Fernandez, Patricia Cruz Castellanos, Maria Valero Arbizu, Ruth Martinez Cabanes, David Lorente Estelles, Estrella Ferreira, Jorge Del Rio, Teresa Garcia Garcia, Alberto Carmona-Bayonas, Caterina Calderon
Summary: This study compared clinical-pathological and psychosocial variables between obese and nonobese individuals with colon cancer. It found that obese patients are more likely to have comorbidities, experience more pain after cancer surgery, exhibit worse coping mechanisms, and have higher rates of depression and lower perceived social support. Additionally, obese patients were more likely to discontinue chemotherapy and experience greater recurrence rates compared to nonobese patients.
Review
Health Care Sciences & Services
Maria Nieves Munoz-Alcaraz, Antonio Jose Jimenez-Vilchez, Luis Angel Perula-de Torres, Jesus Serrano-Merino, Alvaro Garcia-Bustillo, Rocio Pardo-Hernandez, Jeronimo Javier Gonzalez-Bernal, Josefa Gonzalez-Santos
Summary: Breast cancer-related lymphedema (BCRL) of the upper limb is a common condition that significantly affects patients' quality of life. Various treatments have been explored, but their effectiveness and perspectives remain controversial. This article reviews the evidence and suggests that a complex decongestive technique without manual lymphatic drainage is the most recommended intervention for improving patients' health-related quality of life (HRQoL). Further research is needed to guide therapeutic decisions in women with upper limb BCRL.
Article
Critical Care Medicine
Hang Ruan, Shu-Sheng Li, Qin Zhang, Xiao Ran
Summary: This study aimed to investigate the correlation between weight status and mortality in mechanically ventilated patients and explore potential mediators. The results showed that overweight individuals had a lower mortality rate and body mass index (BMI) was an independent protective factor. Bioinformatics analysis identified differential gene expression between overweight and underweight populations, and further studies revealed that high MMP-8 levels predicted mortality risk in underweight patients receiving mechanical ventilation.
Article
Dermatology
Julie De Smedt, Sofie Van Kelst, Laudine Janssen, Vivien Marasigan, Veerle Boecxstaens, Marguerite Stas, Dirk Vanderschueren, Ipek Guler, Kris Bogaerts, Katleen Vandenberghe, Oliver Bechter, Jaak Billen, Arjen Nikkels, Tine Strobbe, Gabriella Emri, Diether Lambrechts, Marjan Garmyn
Summary: This study aimed to confirm the well-known determinants and assess new determinants for 25-hydroxyvitamin D levels in a cutaneous melanoma population. The results showed that body mass index, seasonal time of blood sampling, vitamin D supplementation, and a specific subtype of skin and hair color had a significant effect on vitamin D status.
ACTA DERMATO-VENEREOLOGICA
(2022)
Letter
Medicine, General & Internal
David A. Gorelick
Summary: This comprehensive review of human adipose tissue fails to mention the role of the endocannabinoid system in fat metabolism. The endogenous cannabinoids and their receptors, found in both white and brown fat, have been recognized as key players in adipose tissue metabolism. Rimonabant, an inverse agonist of cannabinoid receptor type 1, has shown promising effects as a therapeutic target for obesity, dyslipidemia, and insulin resistance, although its clinical use was discontinued due to neuropsychiatric side effects.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Clinical Neurology
Adina Zeki Al Hazzouri, Eric Vittinghoff, Tina Hoang, Sherita H. Golden, Annette L. Fitzpatrick, Adina Zhang, Leslie Grasset, Kristine Yaffe
Summary: The study found that compared to women with normal BMI in early adulthood, the odds of dementia were higher among overweight and obese women, independent of mid- and late-life BMI. A similar relationship was observed in men. Therefore, efforts to reduce dementia incidence may need to focus on obesity prevention and treatment early in life.
ALZHEIMERS & DEMENTIA
(2021)
Article
Dentistry, Oral Surgery & Medicine
Martina Ferrillo, Mario Migliario, Nicola Marotta, Francesco Fortunato, Marino Bindi, Federica Pezzotti, Antonio Ammendolia, Amerigo Giudice, Pier Luigi Foglio Bonda, Alessandro de Sire
Summary: This study evaluated the association between temporomandibular disorder (TMD) and neck pain in patients with primary headaches. The results showed that migraine patients reported higher TMD and neck pain. Machine learning analysis demonstrated that TMD was correlated to migraine, while neck pain was correlated to tension-type headache (TTH) or migraine.
ACTA ODONTOLOGICA SCANDINAVICA
(2023)
Review
Biochemistry & Molecular Biology
Alessandro de Sire, Lorenzo Lippi, Nicola Marotta, Arianna Folli, Dario Calafiore, Stefano Moalli, Alessio Turco, Antonio Ammendolia, Nicola Fusco, Marco Invernizzi
Summary: This meta-analysis found that rehabilitation has significant effects on bone health biomarkers in breast cancer survivors, including a decrease in collagen type 1 cross-linked N-telopeptide (NTX) serum level and an increase in bone-specific alkaline phosphatase (BSAP) levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Mauro Nascimben, Lorenzo Lippi, Alessandro De Sire, Marco Invernizzi, Lia Rimondini
Summary: The current study employed a cohort of 294 patients to stratify the risk of breast cancer-related lymphedema (BCRL) and identify factors associated with high-risk patients. The findings of this study provide potential insight into precise risk assessment of BCRL patients, with implications in prevention strategies.
Review
Rehabilitation
Nicola Marotta, Lorenzo Lippi, Valerio Ammendolia, Dario Calafiore, Maria T. Inzitari, Monica Pinto, Marco Invernizzi, Alessandro De Sire
Summary: Background: Breast cancer-related lymphedema (BCRL) is a common disabling complication in breast cancer patients, affecting physical and psychological function and reducing health-related quality of life (HR-QoL). Rehabilitation plays a key role in the management of BCRL, with complex decongestive therapies (CDT) showing positive results. Kinesio taping (KT) is a recent therapeutic approach for BCRL, but its effectiveness is not well-characterized. Objective: This systematic review aimed to assess the role of KT in CDT for BCRL. Results: KT may have a positive effect on reducing limb volume in BCRL patients, although the included studies had low-quality evidence. Conclusion: This review suggests that KT does not significantly reduce upper limb volume in BCRL women, but it may increase flow rate during passive exercise. Further high-quality studies are needed to better understand the role of KT in the rehabilitative management of BC survivors with lymphedema.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Martina Ferrillo, Amerigo Giudice, Mario Migliario, Filippo Reno, Lorenzo Lippi, Dario Calafiore, Nicola Marotta, Roberto de Sire, Leonzio Fortunato, Antonio Ammendolia, Marco Invernizzi, Alessandro de Sire
Summary: Periodontal diseases, such as gingivitis and periodontitis, are oral inflammatory conditions that can lead to systemic inflammation. Alterations in gut and oral microbiota may be involved in the development of autoimmune and inflammatory diseases, including arthritis. Probiotics have the potential to restore microbial balance and reduce inflammation in both oral and intestinal environments, making them a possible therapeutic intervention for managing periodontal diseases and musculoskeletal disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Nicola Marotta, Lucrezia Moggio, Dario Calafiore, Emanuele Prestifilippo, Riccardo Spano, Anna Tasselli, Vera Drago Ferrante, Marco Invernizzi, Alessandro de Sire, Antonio Ammendolia
Summary: This proof-of-principle study aimed to assess the efficacy of proprioceptive mat training on plantar pressures and athletic performance in volleyball players. The results showed that the mat training group had a more uniform redistribution of loads with pressure hindfoot relief and significant increases in peak landing force and high concentric power development compared to the control group. These findings suggest a positive role of proprioceptive stimulation in improving jump performance and reducing the rates of micro-traumatisms of the heel fat pad and ankle injury in volleyball players.
Editorial Material
Chemistry, Multidisciplinary
Nicola Marotta, Alessandro de Sire, Antonio Ammendolia
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Alessandro de Sire, Antonio Ammendolia
APPLIED SCIENCES-BASEL
(2023)
Editorial Material
Chemistry, Multidisciplinary
Alessandro de Sire, Ozden Ozyemisci Taskiran
APPLIED SCIENCES-BASEL
(2023)
Review
Medicine, General & Internal
Nicola Marotta, Alessandro de Sire, Dario Calafiore, Francesco Agostini, Lorenzo Lippi, Claudio Curci, Francesco Ferraro, Andrea Bernetti, Marco Invernizzi, Antonio Ammendolia
Summary: The COVID-19 pandemic has significantly impacted the surgical intervention and rehabilitation plan for ACL injuries. This scoping review examines the potential persistent symptoms and residual effects after COVID-19 disease, focusing on fatigue and neuromuscular disorders. Undertraining and knee muscular imbalance may lead to inefficient movement strategies, lack of knee stability, and increased load in ACL injuries. Telerehabilitation approaches have shown promise in maintaining strength and range of motion during the post-surgery period of COVID-19. However, further research is needed to determine the most effective interventions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Lorenzo Lippi, Alessio Turco, Stefano Moalli, Marco Gallo, Claudio Curci, Antonio Maconi, Alessandro de Sire, Marco Invernizzi
Summary: This review provides a comprehensive overview of prehabilitation and rehabilitation strategies for thyroid cancer survivors, focusing on optimizing functional outcomes and enhancing quality of life. Physical exercise is highlighted as an important component of the rehabilitation process, improving cardiovascular fitness, muscle strength, body composition, and reducing fatigue. Scar management techniques and addressing dysphonia and dysphagia are also emphasized for functional recovery and cosmetic outcomes. Digital innovation and patient-centered approaches are suggested as effective strategies for implementing rehabilitative treatment. Valuable insights are provided for optimizing functional outcomes and enhancing quality of life for thyroid cancer survivors.
Review
Chemistry, Multidisciplinary
Lorenzo Lippi, Alessio Turco, Stefano Moalli, Mauro Nascimben, Claudio Curci, Alessandro de Sire, Lia Rimondini, Marco Invernizzi
Summary: Upper-limb lymphedema is a chronic condition characterized by lymphatic fluid accumulation, leading to swelling and impairment in the arm or hand. Various methods for volumetric assessment of upper-limb lymphedema have been proposed, but each has specific strengths and limitations. Factors such as operator experience and equipment availability also impact the accuracy and practicality of volume assessment. Precise volumetric assessment is crucial for improving rehabilitation, patient education, and research outcomes.
APPLIED SCIENCES-BASEL
(2023)
Review
Rheumatology
Alessandro de Sire, Lorenzo Lippi, Nicola Marotta, Martina Ferrillo, Arianna Folli, Alessio Turco, Antonio Ammendolia, Marco Invernizzi
Summary: Musculoskeletal disorders (MSD) have significant impacts on physical function, social, and economic costs, making them an important issue in current literature. Rehabilitation has shown positive effects in improving functional outcomes for individuals with MSD, but there are still questions about the underlying mechanisms. This review focuses on the biophysical dimensions of available treatments for MSD and highlights the potential of integrating a biophysical approach to enhance regenerative processes and improve pain management.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Review
Medicine, General & Internal
Lorenzo Lippi, Martina Ferrillo, Alessio Turco, Arianna Folli, Stefano Moalli, Fjorelo Refati, Luca Perrero, Antonio Ammendolia, Alessandro de Sire, Marco Invernizzi
Summary: The aim of this narrative review is to elucidate the multilevel benefits and synergies of integrating rehabilitation and hyaluronic acid injections in multidisciplinary osteoarthritis (OA) rehabilitation. Results show that HA injections can improve joint biomechanics, and rehabilitation can enhance muscle strength and overall function. Optimizing rehabilitation following HA injection may provide additional benefits in joint health. OA management requires a multidisciplinary approach integrating HA injections, rehabilitation, and personalized care.
MEDICINA-LITHUANIA
(2023)
Article
Rehabilitation
Alessandro de Sire, Nicola Marotta, Vera Drago Ferrante, Dario Calafiore, Antonio Ammendolia
Summary: Narrative Medicine is an important approach in clinical treatment, which provides tailored rehabilitation methods by focusing on the stories of patients and healthcare professionals, aiming to improve the quality of life of patients with chronic diseases.
DISABILITY AND REHABILITATION
(2023)