Review
Health Care Sciences & Services
Roberto Rosenfeld, Silvia Riondino, Vincenzo Formica, Francesco Torino, Eugenio Martuscelli, Mario Roselli
Summary: Breast cancer is the most common type of cancer in women, and the chemotherapy drug doxorubicin can cause heart toxicity. Early diagnosis of heart toxicity is important to prevent complications. Non-coding RNA, specifically microRNA and circular RNA, are being researched as potential biomarkers for early detection. Further studies are needed to understand the mechanisms and develop reliable detection methods.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biology
Sonali S. Shinde, Sakeel Ahmed, Jonaid Ahmad Malik, Umme Hani, Afreen Khanam, Faisal Ashraf Bhat, Suhail Ahmad Mir, Mohammed Ghazwani, Shadma Wahab, Nazima Haider, Abdulrahman A. Almehizia
Summary: Breast cancer (BC) is the most common cancer in women, posing a significant risk to their health. Factors such as miRNAs that control gene expression networks during BC progression have been found to play a crucial role. However, the development of miRNA-based therapies for BC faces challenges in delivery system stability and efficacy. This review discusses the tumor suppressor miRNAs in BC and their various delivery systems.
Review
Medicine, Research & Experimental
Kavya Anilkumar, L. P. Rema, Mithun Chacko John, T. Vanesa John, Alex George
Summary: Triple-Negative Breast Cancer (TNBC) is an aggressive and invasive type of breast cancer with limited treatment options. MiRNAs play a crucial role in TNBC progression and could serve as therapeutic or prognostic markers to unravel its complexity.
Review
Medicine, Research & Experimental
Negin Raei, Reza Safaralizadeh, Mohammadali Hesseinpourfeizi, Abbas Yazdanbod, Farhad Pourfarzi, Saeid Latifi-Navid
Summary: Gastrointestinal cancers are commonly affected by dysregulation of lncRNAs through epigenetic alterations, affecting processes such as cell division, migration, invasion, and drug resistance. Multi-drug resistance is a major challenge in chemotherapy for gastrointestinal cancers, impacting patient prognosis and diagnosis.
Review
Medicine, Research & Experimental
Mahshid Shahverdi, Khalil Hajiasgharzadeh, Amin Daei Sorkhabi, Mahdi Jafarlou, Maryam Shojaee, Neda Jalili Tabrizi, Nazila Alizadeh, Mariacarmela Santarpia, Oronzo Brunetti, Hossein Safarpour, Nicola Silvestris, Behzad Baradaran
Summary: Autophagy plays a crucial role in various diseases, and miRNAs can regulate cellular autophagy activity. Dysfunction of miRNAs is associated with the onset and drug resistance of lung cancer. Studying the interplay between miRNAs, autophagy, and drug resistance in lung cancer can lead to the development of new treatment interventions.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Hang Yan, Shengjie Tang, Shoujun Tang, Jun Zhang, Haiyang Guo, Chao Qin, Haiyang Hu, Chuan Zhong, Li Yang, Yunhe Zhu, Haining Zhou
Summary: Non-small cell lung cancer (NSCLC) is a common malignant tumor with suboptimal clinical success due to late diagnosis, limited treatment options, high recurrence rates, and drug resistance. MicroRNAs (miRNAs), small non-coding RNAs, have emerged as important players in NSCLC initiation, progression, and drug resistance. This review provides an overview of miRNA dysregulation and resistance in NSCLC and discusses their potential applications in different anti-cancer treatments.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Milena Rizzo
Summary: One of the main challenges in the treatment of metastatic prostate cancer is the development of resistance to docetaxel, the gold standard therapy. Non-coding RNA appears to play a significant role in the processes leading to docetaxel resistance.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Oncology
Monal Patel, Yinu Wang, Elizabeth T. Bartom, Rohin Dhir, Kenneth P. Nephew, Daniela Matei, Andrea E. Murmann, Ernst Lengyel, Marcus E. Peter
Summary: Research has shown that the balance of miRNAs carrying toxic and nontoxic 6mer seeds is closely related to platinum resistance in ovarian cancer. Analysis of RISC-bound miRNAs in tumors can predict treatment outcomes.
Article
Pharmacology & Pharmacy
Alejandro Velasco-Ruiz, Rocio Nunez-Torres, Guillermo Pita, Hans Wildiers, Diether Lambrechts, Sigrid Hatse, Danielle Delombaerde, Thomas Van Brussel, M. Rosario Alonso, Nuria Alvarez, Belen Herraez, Christof Vulsteke, Pilar Zamora, Teresa Lopez-Fernandez, Anna Gonzalez-Neira
Summary: A novel gene variant, rs62134260 located upstream of POLRMT, was identified through a two-stage genome-wide association study as a potential predictor of anthracycline-induced cardiotoxicity in breast cancer patients. This variant was found to regulate the expression of POLRMT, impacting mitochondrial gene expression in heart tissue and potentially leading to impaired mitochondrial maintenance in cardiomyocytes under stress conditions like epirubicin treatment. This discovery suggests a new molecular mechanism involved in AIC development and may enhance our ability to predict at-risk patients.
Review
Oncology
Ying Yang, Wen-Jian Meng, Zi-Qiang Wang
Summary: Colorectal cancer is one of the most common and lethal malignant tumors in the world. MicroRNAs have been identified as key regulators in CRC and potential targets to overcome drug resistance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yang Yang, Quanfeng Zhao, Zhe Peng, Yunjiang Zhou, Miao-Miao Niu, Lin Chen
Summary: This study introduces a GSH/CB dual-controlled nanomedicine that efficiently inhibits DOX-resistant breast cancer cells, providing a new approach for breast cancer therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Sara Peixoto da Silva, Hugo R. Caires, Rui Bergantim, Jose E. Guimaraes, M. Helena Vasconcelos
Summary: This review discusses the role of miRNAs in hematological malignancies, including their important role in drug resistance and their potential clinical applications.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Chemistry, Applied
Asif Mohd Itoo, Milan Paul, Balaram Ghosh, Swati Biswas
Summary: In this study, a chitosan/vitamin E conjugate was synthesized and used for the assembly of oxaliplatin micelles. The micelles showed promising therapeutic efficacy in breast cancer treatment, overcoming drug resistance and reducing nephrotoxicity.
CARBOHYDRATE POLYMERS
(2022)
Review
Biochemistry & Molecular Biology
Yordan Sbirkov, Bozhidar Vergov, Nikolay Mehterov, Victoria Sarafian
Summary: MicroRNAs play a significant role in the treatment outcome of lymphoid malignancies and are closely related to drug response. This article summarizes the impact of microRNAs on chemotherapy resistance in adult and pediatric acute lymphoblastic leukemia as well as chronic lymphocytic leukemia and discusses the potential of using microRNAs as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Cynthia Mark, Jin Sun Lee, Xiaojiang Cui, Yuan Yuan
Summary: Antibody drug conjugates (ADCs) combine monoclonal antibodies with cytotoxic drugs for selective delivery to cancer cells, optimizing treatment effectiveness. ADC research has significantly impacted breast cancer management, providing valuable options. However, important questions remain, such as drug sequencing and overcoming resistance mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
You Zhou, Guangmin Tang, Xiaoli Li, Weijun Sun, Yuan Liang, Dali Gan, Guangli Liu, Wenjie Son, Zhang Wang
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Medicine, General & Internal
Sze Wa Chan, Tanya T. W. Chu, Chung Shun Ho, Alice P. S. Kong, Brian Tomlinson, Weiwei Zeng
Summary: Bisoprolol effectively reduced blood pressure and heart rate in hypertensive Chinese patients. Common polymorphisms in CYP2D6 and CYP3A5 did not significantly affect plasma concentrations of bisoprolol or its antihypertensive effects.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, Research & Experimental
Weiwei Zeng, Brian Tomlinson
Summary: This prospective study aimed to examine the effects of bisoprolol, a highly P1-selective agent, on central aortic systolic pressure (CASP). The study found that bisoprolol effectively reduced CASP and this reduction was proportional to the decrease in brachial systolic blood pressure (Br-SBP). Additionally, the reduction in CASP after the first dose could predict more favorable CASP responses to long-term therapy.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Health Care Sciences & Services
Yan Zhong, Weiwei Zeng
Summary: This study revealed that NR2F1-AS1 acts as an oncogene in breast cancer by suppressing miR-641. It was found that high expression of NR2F1-AS1 was associated with lower survival time in breast cancer patients. Functional experiments showed that knockdown of NR2F1-AS1 inhibited BC cell viability, migration, and invasion, while overexpression of NR2F1-AS1 had the opposite effect. Mechanistic investigation revealed that NR2F1-AS1 competitively binds with miR-641 in BC.
JOURNAL OF HEALTHCARE ENGINEERING
(2022)
Article
Public, Environmental & Occupational Health
Sixian Lao, Tao Zhou, Ho-Chang Kuo, Guoping Zhong, Weiwei Zeng
Summary: This study aimed to investigate the impact of antibiotics on Kawasaki disease patients with coronary artery lesions (CAL) and identify independent risk factors. The results showed that neutrophil granulocyte percentage, lymphocyte percentage, and total protein were independent risk factors for CAL in KD without antibiotics use history.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Weiwei Zeng, Tanya T. W. Chu, Chung Shun Ho, Clara W. S. Lo, Alan S. L. Chan, Alice P. S. Kong, Brian Tomlinson, Sze Wa Chan
Summary: This study found no significant association between baseline PRA, PAC and Ang II concentrations and blood pressure response to bisoprolol treatment. However, all these parameters were reduced after 6 weeks of treatment with bisoprolol. The common polymorphisms in ADRB1 and the c.393C > T polymorphism in GNAS were also not significantly associated with blood pressure and heart rate response to bisoprolol.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Nutrition & Dietetics
Weiwei Zeng, Miao Hu, Hon Kit Lee, Elaine Wat, Clara Bik San Lau, Chung Shun Ho, Chun Kwok Wong, Brian Tomlinson
Summary: This study investigated the effect of green tea and soy isoflavone extracts on the pharmacokinetics of simvastatin in healthy subjects. It found that the intake of soy isoflavones reduced the systemic exposure to simvastatin acid, and this effect was dependent on the SLCO1B1 genotype. The study also showed no overall effect of green tea extract on simvastatin pharmacokinetics.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Weiwei Zeng, Miao Hu, Hon Kit Lee, Elaine Wat, Clara Bik San Lau, Chung Shun Ho, Chun Kwok Wong, Brian Tomlinson
Summary: This study found that repeated administration of green tea extract significantly reduced the systemic exposure of rosuvastatin in healthy volunteers, while soy isoflavones had no significant effect on the pharmacokinetics of the statin. The ABC transporter ABCG2 polymorphism had a significant impact on rosuvastatin exposure but did not affect the interaction with green tea.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Weiwei Zeng, Sixian Lao, Yi Guo, Yufeng Wu, Min Huang, Brian Tomlinson, Guoping Zhong
Summary: The study found that co-administration of EGCG with bisoprolol could impact the metabolism and effects of bisoprolol in rats. Specifically, gavage administration of EGCG with bisoprolol reduced peak concentration and extended time to peak, while intravenous administration of EGCG increased the distribution volume of bisoprolol.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Weiwei Zeng, Nga-man Cheng, Xia Liang, Haofeng Hu, Fulin Luo, Jia Jin, Ya-wei Li
Summary: This study utilized baicalin as an antibacterial component in hybrid nanofibrous membranes for wound dressing, demonstrating good antibacterial activity against S. aureus. The addition of Ti3C2TX and baicalin improved the hydrophilicity of the membranes and showed good compatibility with L6 cells.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Weiwei Zeng, Sixian Lao, Wenbin Jia, Xintian Shen, Lijuan Wu, Yan Zhong, Feiling Wang, Guoping Zhong
Summary: There are differences in clinical features of patients with mastitis following Corynebacterium kroppenstedtii infection. Non-granulomatous lobular mastitis (NGLM) patients have a higher incidence of pus, while granulomatous lobular mastitis (GLM) patients have higher levels of C-reactive protein (CRP). Treatment with local lavage (triamcinolone acetonide) and antibiotics (cefuroxime) has a recurrent rate of 25.9% in C. kroppenstedtii infection.
Article
Pharmacology & Pharmacy
Weiwei Zeng, Tanya T. W. Chu, Elaine Y. K. Chow, Miao Hu, Benny S. P. Fok, Juliana C. N. Chan, Bryan P. Y. Yan, Brian Tomlinson
Summary: In patients on long term aspirin therapy, a large proportion showed reduced antiplatelet response to aspirin, with higher white blood cell count appearing to be associated with increased risk of aspirin resistance.
Article
Cardiac & Cardiovascular Systems
Xu Zhao, Bowen Gu, Qiuying Li, Jiaxin Li, Weiwei Zeng, Yagang Li, Yanping Guan, Min Huang, Liming Lei, Guoping Zhong
Summary: This study analyzed multidimensional data of clinical features and outcomes in patients with LCOS after cardiac surgery and identified three clusters with different outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
