Article
Cell Biology
Tanlun Zeng, Sihan Jiang, Yichuan Wang, Guanqun Sun, Jinjin Cao, Dingtao Hu, Guang Wang, Xijun Liang, Jin Ding, Juan Du
Summary: This study identified 11 cellular senescence related lncRNAs (CSRLs) and established a risk model for predicting the prognosis of multiple myeloma (MM) patients. The risk model showed strong predictive value, especially for patients receiving three-drug combination therapy. Furthermore, down-regulation of one CSRL (ATP2A1-AS1) was found to promote cellular senescence in MM cell lines.
Article
Medicine, General & Internal
Ji Yeon Byun, Yong Koo Kang, Yong Hyun Jang, Young Kook Kim, Dai Woo Kim
Summary: This article presents a case of a 36-year-old male patient who developed bilateral steroid-induced glaucoma after prolonged immunosuppressive treatment for cutaneous pyoderma gangrenosum. While successful glaucoma valve implantation surgery was performed in the right eye, the same surgery repeatedly failed in the left eye and complicated with conjunctival necrosis and exposure of the donor scleral patch graft. Microinvasive glaucoma surgery (MIGS) with XEN (R) Gel Stent was then performed in the left eye, resulting in successful formation of a conjunctival bleb without necrosis and maintaining stable intraocular pressure. Ophthalmic surgery in patients with pyoderma gangrenosum can be challenging, and MIGS may offer advantages as a minimally invasive surgical technique.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Erika Csekes, Lucia Rackova
Summary: This article discusses the impact of skin aging and cellular senescence on the skin, as well as the role of natural polyphenols in preventing and delaying aging. It also summarizes the latest research on the anti-senescent mechanisms of polyphenols.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Andreas Domen, Christophe Deben, Jasper Verswyvel, Tal Flieswasser, Hans Prenen, Marc Peeters, Filip Lardon, An Wouters
Summary: Cellular senescence is a mechanism in which cells enter a state of stable cell-cycle arrest with secretory features in response to cellular stress. It has been historically seen as a protective mechanism against cancer by eliminating damaged cells. However, the accumulation of senescent cells can have long-term detrimental effects and contribute to age-related diseases, including cancer. The role of cellular senescence in cancer is ambiguous and controversial, and its detection and study in cancer patients present challenges. This review highlights the methods and challenges of detecting cellular senescence in cancer patients, and discusses its prognostic implications.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Cell Biology
Vivekananda Budamagunta, Thomas C. Foster, Daohong Zhou
Summary: Immunosenescence is a complex phenomenon that leads to age-related immune dysfunction, resulting in various pathologies such as decreased ability to clear senescent and cancerous cells, increased autoimmune response, reduced ability to combat pathogens, and diminished response to vaccination. Cellular senescence and immunosenescence have not been extensively explored in terms of their relationship, yet in the context of the ongoing pandemic, immunosenescence has become a topic of great importance.
Article
Genetics & Heredity
Cheng Zeng, Yu Liu, Rong He, Xiaohuan Lu, Yuyang Dai, Guoping Qi, Jingsong Liu, Jianzhong Deng, Wenbin Lu, Jianhua Jin, Qian Liu
Summary: A prognostic signature consisting of 15 cellular senescence-related lncRNAs was identified, which could predict survival outcomes for stomach adenocarcinoma patients. Patients in the low-risk group may be more sensitive to immunotherapy.
FRONTIERS IN GENETICS
(2022)
Review
Cell Biology
Jing Yang, Mengmeng Liu, Dongchun Hong, Musheng Zeng, Xing Zhang
Summary: Cellular senescence in cancer presents a dual role, acting as both a preventative measure and a promoter of tumor development. Senescent cells contribute to oncogenesis through their secretory phenotype, both inhibiting tumor growth and creating an environment conducive to tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zehuan Liao, Han Lin Yeo, Siaw Wen Wong, Yan Zhao
Summary: Cellular senescence is a complex process affecting various biological processes, with characteristics including senescence-associated phenotype and cell cycle arrest. Persistent senescence is associated with aging pathologies, while transient senescence is linked to beneficial programs.
Review
Cell Biology
Jinwei Xie, Yan Wang, Lingyun Lu, Lu Liu, Xijie Yu, Fuxing Pei
Summary: Cellular senescence plays a significant role in the onset and progression of osteoarthritis, but the link between cellular senescence and the disease remains unclear. Current evidence supports the involvement of senescent cells of different cell types in osteoarthritis, with a focus on the underlying mechanisms of senescence in chondrocytes.
AGEING RESEARCH REVIEWS
(2021)
Review
Oncology
Sofia Zanotti, Bieke Decaesteker, Suzanne Vanhauwaert, Bram De Wilde, Winnok H. De Vos, Frank Speleman
Summary: Neuroblastoma, a common tumor in children under five, has poor treatment outcomes for high-risk cases and causes long-term side effects. Cellular senescence has been considered a barrier against tumorigenesis, but recent research suggests a more complex and reversible nature for this process, which may impact treatment strategies. Neuroblastoma cells in a senescent state may escape treatment and promote relapse, but senescence could also provide opportunities for new therapies.
BRITISH JOURNAL OF CANCER
(2022)
Article
Pharmacology & Pharmacy
Yuting Zhuang, Tingting Li, Hongwen Xiao, Jiaxu Wu, Shuang Su, Xue Dong, Xiaoxi Hu, Qi Hua, Junwu Liu, Wendi Shang, Jiaming Ju, Fei Sun, Zhenwei Pan, Yanjie Lu, Mingyu Zhang
Summary: The study revealed that the long noncoding RNA H19 plays a pro-senescence role in cardiomyocytes by targeting the miR-19a/SOCS1/p53/p21 pathway. This provides a novel theoretical basis for finding new therapeutic targets for senescence-associated cardiac diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kaori Suzuki, Etsuo A. Susaki, Isao Nagaoka
Summary: This review discusses the roles of cellular senescence and bacterial infection in the pathogenesis of atherosclerosis. The study finds that bacterial infections and cellular senescence occur at the sites of atherosclerotic lesions, and lipopolysaccharide from Gram-negative bacteria can induce and enhance cellular senescence and the associated inflammatory properties, thus contributing to the development of atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Qing Liu, Hongbo Bao, Sibin Zhang, Tianjun Song, Chenlong Li, Guiyin Sun, Xiaoyang Sun, Tianjiao Fu, Yujie Wang, Peng Liang
Summary: In this study, a senescence-related lncRNA (SRlncRNA) signature was constructed to evaluate the prognosis of glioma. The results showed that the high-risk group defined by the signature had worse overall survival, and the signature had more accurate predictive power. Gene set enrichment analysis indicated the involvement of immune response to tumor cells, p53 signaling pathway, mTOR signaling pathway, and Wnt signaling pathway. Further validation confirmed the consistency of the signature in terms of immune cell infiltration.
FRONTIERS IN GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Fernanda Hernandez-Gonzalez, Rosa Faner, Mauricio Rojas, Alvar Agusti, Manuel Serrano, Jacobo Sellares
Summary: Fibrosing interstitial lung diseases are chronic and fatal lung diseases characterized by the irreversible accumulation of scar tissue in the lung tissue. Cellular senescence, defined as a cell fate decision caused by unrepairable cellular damage, plays an important role in the initiation and progression of pulmonary fibrosis, likely by promoting molecular and cellular changes in chronic fibrosing processes. Targeting cellular senescence may be a potential therapeutic approach for treating fibrosing ILDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Tanyalak Parimon, Miriam S. Hohmann, Changfu Yao
Summary: Pulmonary fibrosis is a chronic and fatal lung disease that predominantly affects the aging population globally. Understanding the mechanisms of cellular senescence may offer new pathways for treatment of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Xiayin Zhang, Kai Zhang, Duoru Lin, Yi Zhu, Chuan Chen, Lin He, Xusen Guo, Kexin Chen, Ruixin Wang, Zhenzhen Liu, Xiaohang Wu, Erping Long, Kai Huang, Zhiqiang He, Xiyang Liu, Haotian Lin
Article
Multidisciplinary Sciences
Erping Long, Jianzhi Zhang
Summary: The prevalence of myopia has increased significantly over the past few decades, likely due to lifestyle changes. Research shows that although myopia itself is selected against, mutant alleles associated with reproductive benefits contribute to over 100,000 new myopia cases per generation in the UK alone, highlighting the importance of antagonistic pleiotropy in explaining this phenomenon.
NATIONAL SCIENCE REVIEW
(2021)
Article
Ophthalmology
Yifan Xiang, Erping Long, Zhenzhen Liu, Xiaoyan Li, Zhuoling Lin, Yi Zhu, Chuan Chen, Haotian Lin
Summary: The study established norms for binocular and monocular acuity as well as interocular acuity differences in southern Chinese infants, which showed significant differences compared to northern Chinese infants. The findings revealed that visual acuity norms increase with age, and there are distinct differences in visual development patterns between infants from northern and southern China.
Article
Biotechnology & Applied Microbiology
Peixing Wan, Erping Long, Zhidong Li, Yingting Zhu, Wenru Su, Yehong Zhuo
Summary: Glaucoma, affecting over 70 million individuals worldwide, is primarily caused by circulatory disturbances of aqueous humor. A study identified GDF7 hypomethylation as a crucial factor in the onset of AH outflow disorders in glaucoma patients. GDF7 neutralization therapy was developed to inhibit TM fibrosis and significantly improve outflow facility, controlling IOP and protecting nerve fibers.
Article
Oncology
Jiewei Jiang, Liming Wang, Haoran Fu, Erping Long, Yibin Sun, Ruiyang Li, Zhongwen Li, Mingmin Zhu, Zhenzhen Liu, Jingjing Chen, Zhuoling Lin, Xiaohang Wu, Dongni Wang, Xiyang Liu, Haotian Lin
Summary: The study introduced the CCNN-Ensemble model for automatic detection of lens opacity in pediatric cataracts, demonstrating superior performance on multiple indices and verifying the model's generalizability and effectiveness across different datasets. Additionally, a website-based software was developed for pediatric cataract grading diagnosis in ophthalmology clinics.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Erping Long, Xiaohang Wu, Xiaohu Ding, Yahan Yang, Xun Wang, Chong Guo, Xiayin Zhang, Kexin Chen, Tongyong Yu, Dongxuan Wu, Xutu Zhao, Zhenzhen Liu, Yizhi Liu, Haotian Lin
Summary: This study used medical big data to determine the prevalence trends of myopia over the past 60 years and reveal developmental patterns in China. The results showed a significant increase in myopia prevalence among individuals born after the 1960s, reaching a peak of 80% in the 1980s. Additionally, developmental patterns indicated a dramatic increase in myopia prevalence from ages 5 to 11, stabilizing at age 20.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Erping Long, Montserrat Garcia-Closas, Stephen J. Chanock, M. Constanza Camargo, Nicholas E. Banovich, Jiyeon Choi
Summary: The lack of diversity in ancestry and tissue types in tissue-based functional genomics resources limits comprehensive investigation of gene regulation. Global efforts to increase tissue diversity will promote more equitable medical care.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Medicine, General & Internal
Wei Wang, Xiaoqing Gao, Yi Zhu, Erping Long
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Erping Long, Harsh Patel, Jinyoung Byun, Christopher Amos, Jiyeon Choi
Summary: This article reviews the progress of lung cancer GWAS research and emphasizes the heterogeneity of lung cancer GWAS results across histological subtypes, ancestries, and smoking status. It also highlights the importance and strategies of post-GWAS studies for lung cancer.
HUMAN MOLECULAR GENETICS
(2022)
Article
Genetics & Heredity
Jinyoung Byun, Younghun Han, Yafang Li, Jun Xia, Erping Long, Jiyeon Choi, Xiangjun Xiao, Meng Zhu, Wen Zhou, Ryan Sun, Yohan Bosse, Zhuoyi Song, Ann Schwartz, Christine Lusk, Thorunn Rafnar, Kari Stefansson, Tongwu Zhang, Wei Zhao, Rowland W. Pettit, Yanhong Liu, Xihao Li, Hufeng Zhou, Kyle M. Walsh, Ivan Gorlov, Olga Gorlova, Dakai Zhu, Susan M. Rosenberg, Susan Pinney, Joan E. Bailey-Wilson, Diptasri Mandal, Mariza de Andrade, Colette Gaba, James C. Willey, Ming You, Marshall Anderson, John K. Wiencke, Demetrius Albanes, Stephan Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig Bojeson, Hermann Brenner, Maria Teresa Landi, Stephen J. Chanock, Mattias Johansson, Thomas Muley, Angela Risch, H-Erich Wichmann, Heike Bickeboeller, David C. Christiani, Gad Rennert, Susanne Arnold, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Angeline S. Andrew, Lambertus A. Kiemeney, Hongbing Shen, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Angela Cox, Yun-Chul Hong, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Alpa Patel, Qing Lan, Nathaniel Rothman, Fiona Taylor, Linda Kachuri, John S. Witte, Lori C. Sakoda, Margaret Spitz, Paul Brennan, Xihong Lin, James McKay, Rayjean J. Hung, Christopher Amos
Summary: A genome-wide association meta-analysis of lung cancer among different populations reveals five new susceptibility loci and identifies population-specific effects of common and rare variants. The study also highlights the potential role of genes such as IRF4 and FUBP1 in promoting DNA damage in lung fibroblasts.
Article
Surgery
Ting Wang, Jun Xia, Ruiyang Li, Ruixin Wang, Nick Stanojcic, Ji-Peng Olivia Li, Erping Long, Jinghui Wang, Xiayin Zhang, Jianbin Li, Xiaohang Wu, Zhenzhen Liu, Jingjing Chen, Hui Chen, Danyao Nie, Huanqi Ni, Ruoxi Chen, Wenben Chen, Shiyi Yin, Duru Lin, Pisong Yan, Zeyang Xia, Shengzhi Lin, Kai Huang, Haotian Lin
Summary: DeepSurgery represents a potential approach to provide a real-time supervision and an objective surgical evaluation system for routine CS and to improve surgical outcomes.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Genetics & Heredity
Erping Long, Jinhu Yin, Karen M. Funderburk, Mai Xu, James Feng, Alexander Kane, Tongwu Zhang, Timothy Myers, Alyxandra Golden, Rohit Thakur, Hyunkyung Kong, Lea Jessop, Eun Young Kim, Kristine Jones, Raj Chari, Mitchell J. Machiela, Kai Yu, Mark M. Iles, Maria Teresa Landi, Matthew H. Law, Stephen J. Chanock, Kevin M. Brown, Jiyeon Choi
Summary: In this study, massively parallel reporter assays (MPRAs) and variant scoring were used to systematically prioritize functional variants and susceptibility genes from cutaneous melanoma GWAS loci. Integration of multi-layer annotation and overlaying with expression or methylation quantitative trait loci (eQTLs or meQTLs) identified candidate susceptibility genes for majority of the variants. This study also highlighted the role of cellular contexts in the functionality of susceptibility variants.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Cell Biology
Erping Long, Peixing Wan, Qingyu Chen, Zhiyong Lu, Jiyeon Choi
Summary: Genome-wide association studies have identified numerous disease-associated loci, but many of their molecular mechanisms remain unknown. Artificial intelligence has shown promise in interpreting and translating these findings, but faces challenges such as data heterogeneity, multiplicity, and high dimensionality.
Letter
Ophthalmology
Yahan Yang, Wenben Chen, Andi Xu, Lanqin Zhao, Xiaohu Ding, Jiawei Li, Yi Zhu, Chuan Chen, Erping Long, Zhenzhen Liu, Xun Wang, Xuelong Li, Xingying Zhang, Zhiyu Jiang, Huagui He, Guojun Wang, Ling Jin, Huipeng Liao, Dongyuan Yun, Patrick Yu-Wai-Man, Pisong Yan, Ruixin Wang, Zhongwen Li, Yi Xie, Yuantao Liu, Xiaodan Wang, Qingling Zhang, Jiantao Wang, Danyao Nie, Shaochong Zhang, Daniel Shu Wei Ting, Tien Yin Wong, Mingguang He, Yizhi Liu, Ian George Morgan, Haotian Lin