Discoidin Receptor 2 Controls Bone Formation and Marrow Adipogenesis

Reciprocal Control of Osteogenic and Adipogenic Differentiation by ERK/MAP Kinase Phosphorylation of Runx2 and PPARγ Transcription Factors

(2015) Chunxi Ge et al.   JOURNAL OF CELLULAR PHYSIOLOGY

DDR2 (discoidin domain receptor 2) suppresses osteoclastogenesis and is a potential therapeutic target in osteoporosis

(2015) Y. Zhang et al.   Science Signaling

DDR2 (discoidin domain receptor 2) suppresses osteoclastogenesis and is a potential therapeutic target in osteoporosis

(2015) Y. Zhang et al.   Science Signaling

Genetic Analysis Identifies DDR2 as a Novel Gene Affecting Bone Mineral Density and Osteoporotic Fractures in Chinese Population

(2015) Yan Guo et al.   PLoS One

A novel mutation in DDR2 causing spondylo-meta-epiphyseal dysplasia with short limbs and abnormal calcifications (SMED-SL) results in defective intra-cellular trafficking

(2014) Adila Al-Kindi et al.   BMC Medical Genetics

Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction

(2014) William P. Cawthorn et al.   Cell Metabolism

Discoidin Domain Receptors: Unique Receptor Tyrosine Kinases in Collagen-mediated Signaling

(2013) Hsueh-Liang Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

(2013) Kun Zhang et al.   NATURE CELL BIOLOGY

Discoidin domain receptor 2 (DDR2) regulates body size and fat metabolism in mice

(2013) Ikuma Kawai et al.   TRANSGENIC RESEARCH

Discoidin domain receptor tyrosine kinases: new players in cancer progression

(2012) Rajeshwari R. Valiathan et al.   CANCER AND METASTASIS REVIEWS

Biomechanical stimulation of osteoblast gene expression requires phosphorylation of the RUNX2 transcription factor

(2012) Yan Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Collagen I Induces Discoidin Domain Receptor (DDR) 1 Expression through DDR2 and a JAK2-ERK1/2-mediated Mechanism in Primary Human Lung Fibroblasts

(2011) Pedro A. Ruiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions between extracellular signal-regulated kinase 1/2 and P38 Map kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity

(2011) Chunxi Ge et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Altered Metabolism and Lipodystrophy in the Early B-Cell Factor 1-Deficient Mouse

(2010) Jackie A. Fretz et al.   ENDOCRINOLOGY

An essential role of discoidin domain receptor 2 (DDR2) in osteoblast differentiation and chondrocyte maturation via modulation of Runx2 activation

(2010) Yan Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

(2010) Matthew B. Greenblatt et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification and Functional Characterization of ERK/MAPK Phosphorylation Sites in the Runx2 Transcription Factor

(2009) Chunxi Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of cell cycle–arrested quiescent osteoclast precursors in vivo

(2009) Toshihide Mizoguchi et al.   JOURNAL OF CELL BIOLOGY

Extracellular Signal-Regulated Kinase 1 (ERK1) and ERK2 Play Essential Roles in Osteoblast Differentiation and in Supporting Osteoclastogenesis

(2009) T. Matsushita et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutations in DDR2 Gene Cause SMED with Short Limbs and Abnormal Calcifications

(2008) Ruth Bargal et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Novel Dwarfism with Gonadal Dysfunction Due to Loss-of-Function Allele of the Collagen Receptor Gene,Ddr2, in the Mouse

(2008) Kiyoshi Kano et al.   MOLECULAR ENDOCRINOLOGY