Journal
CELLS
Volume 11, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/cells11060980
Keywords
SLE; lupus; T cell; regulatory; interleukin-2
Categories
Ask authors/readers for more resources
The complexities of T cells in SLE and the potential role of IL-2 in the pathophysiological process of SLE are discussed in this article. Low-dose IL-2 administration shows promise as a therapeutic approach for SLE.
The phenotypic and functional complexities of T cells engender complicated and often confusing concepts as to how T cells ignite, accelerate and brake the inflammatory processes involved in systemic lupus erythematosus (SLE), let alone the plasticity of T cells that takes place under different immunological contexts. Nevertheless, being one of the prime survival factors of T cells, interleukin (IL)-2 plays a potentially critical role in many immunological scenarios during the pathophysiological process of SLE. Here, the pathophysiology of lupus T cells and current, as well as ongoing, therapeutic approaches of SLE that involve low-dose IL-2 administration will be highlighted. The mechanisms of IL-2 deficiency in SLE pathophysiology, the effects of low-dose IL-2 on T cells and restoration of lupus manifestations in murine SLE models, as well as the efficacy and safety of clinical trials that evaluated low-dose IL-2-containing regimens in patients with SLE will be discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available