Article
Orthopedics
Amy Y. Zhao, Amil R. Agarwal, Andrew B. Harris, Jordan S. Cohen, Gregory J. Golladay, Savyasachi C. Thakkar
Summary: This study aimed to investigate the association between recent fragility fractures and 8-year risks of revision THA, periprosthetic fracture, and secondary fragility fracture. The study found that patients with recent fragility fractures within 3 years prior to THA had significantly increased risks of revision THA, periprosthetic fracture, and secondary fragility fracture.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Endocrinology & Metabolism
Yufeng Ge, Yimin Chen, Gang Liu, Shiwen Zhu, Bo Li, Maoyi Tian, Jing Zhang, Xinbao Wu, Minghui Yang
Summary: This study aimed to investigate the association of hip bone mineral density with mortality risk after hip fracture. The results showed that all hip bone densities were significantly associated with mortality risks, and hip trochanter bone mineral density showed the strongest correlation.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Luis Gracia-Marco, Sheila Gonzalez-Salvatierra, Antonia Garcia-Martin, Esther Ubago-Guisado, Beatriz Garcia-Fontana, Jose Juan Gil-Cosano, Manuel Munoz-Torres
Summary: This study analyzed differences in 3D DXA parameters at the hip site among patients with acromegaly or AGHD and healthy controls. The study found cortical bone impairment in AGHD patients and highlighted the trochanter as the site with greater cortical bone differences between acromegaly patients and controls. 3D-DXA provided useful information about bone involvement in GH-related disorders, with AGHD patients showing distinct involvement of the cortical structure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Nico Sollmann, Maximilian T. Loeffler, Malek El Husseini, Anjany Sekuboyina, Michael Dieckmeyer, Sebastian Ruehling, Claus Zimmer, Bjoern Menze, Gabby B. Joseph, Thomas Baum, Jan S. Kirschke
Summary: This study compared lumbar volumetric bone mineral density (vBMD) assessed by a convolutional neural network (CNN)-based framework in routine CT to vBMD from dedicated quantitative CT (QCT). The study found that automated opportunistic osteoporosis screening in routine CT of various scanner setups is feasible and may demonstrate high diagnostic accuracy for prevalent vertebral fractures (VFs).
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Hossein Mokhtarzadeh, Dennis E. Anderson, Brett T. Allaire, Mary L. Bouxsein
Summary: Vertebral fractures (VFx) are common in older adults, especially at the mid-thoracic and thoracolumbar regions of the spine. This study aimed to determine activities that cause the largest vertebral load-to-strength ratios (LSRs) and examine patterns of LSRs along the spine for high-load activities in a sample of adult men and women. The results highlight the importance of considering a variety of activities when evaluating vertebral LSRs and provide guidance for future studies on the biomechanics of VFx.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Yandong Liu, Aihong Yu, Kai Li, Ling Wang, Pengju Huang, Jian Geng, Yong Zhang, Yang-yang Duanmu, Glen M. Blake, Xiaoguang Cheng
Summary: This study evaluated the prevalence of vertebral fractures (VF) among middle-aged and elderly Chinese men and women, and compared the lumbar spine volumetric bone mineral density (vBMD) between those with a grade 1 vertebral fracture and non-fractured individuals. The study found that the prevalence of VF increased rapidly in women after the age of 50, while it grew more slowly in men. Participants with a grade 1 VF had lower vBMD compared to non-fractured individuals, except for men under the age of 50.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Fabio Vescini, Iacopo Chiodini, Alberto Falchetti, Andrea Palermo, Antonio Stefano Salcuni, Stefania Bonadonna, Vincenzo De Geronimo, Roberto Cesareo, Luca Giovanelli, Martina Brigo, Francesco Bertoldo, Alfredo Scillitani, Luigi Gennari
Summary: Male osteoporosis is often underdiagnosed, leading to undertreatment and higher morbidity and mortality compared to female patients. Understanding the differences in bone health between genders is crucial for effective management and prevention of osteoporotic fractures in men.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Victoria L. Bland, Jennifer W. Bea, Robert M. Blew, Denise J. Roe, Vinson R. Lee, Janet L. Funk, Scott B. Going
Summary: The study indicates that changes in total body lean mass and fat mass during adolescence are associated with bone outcomes. Total body lean mass has a greater influence on bone development than total body fat mass, with lean mass being the predominant predictor of bone outcomes.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Marko T. Korhonen, Urho M. Kujala, Jyrki Kettunen, Olga V. Korhonen, Jaakko Kaprio, Seppo Sarna, Timo Tormakangas
Summary: Maintenance of vigorous exercise habits from young to old age is considered protective against hip fractures. This study found that continuing high-intensity exercise in old age is associated with a lower hazard rate of hip fractures, although this protective effect diminishes with age.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
T. Tsutsui, T. Fujiwara, Y. Matsumoto, A. Kimura, M. Kanahori, S. Arisumi, A. Oyamada, M. Ohishi, K. Ikuta, K. Tsuchiya, N. Tayama, S. Tomari, H. Miyahara, T. Mae, T. Hara, T. Saito, T. Arizono, K. Kaji, T. Mawatari, M. Fujiwara, M. Takasaki, K. Shin, K. Ninomiya, K. Nakaie, Y. Antoku, Y. Iwamoto, Y. Nakashima
Summary: This study examined the long-term survival and incidence of secondary fractures after fragility hip fractures. The 5-year survival rate was 62%, with higher mortality risk in patients with GNRI < 92. The 5-year incidence of secondary fractures was 22%, which was significantly higher in patients with a BMI < 20.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Orthopedics
Hong-Li Li, Yi Shen, Li-Hua Tan, Song-Bo Fu, Ru-Chun Dai, Ling-Qing Yuan, Zhi-Feng Sheng, Zhong-Jian Xie, Xian-Ping Wu, Er-Yuan Liao, Xu-Lei Tang, Xi-Yu Wu
Summary: This study investigated the relationship between BMD and risk of fragility fracture in native Chinese population. The findings showed that decreasing BMD measurement parameters and anthropometric indicators increased the risk of clinical fragility fracture, with variations in fracture HR based on gender and site.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Medicine, General & Internal
Sug Hun Che, Myung-Rae Cho, Patrick Michael Quinn, Suk-Kyoon Song
Summary: This study aimed to identify risk factors for hip fractures in elderly Korean patients, especially in patients with osteoporosis. The retrospective analysis of 168 patients showed that lower body weight, BMI, and BMD Z-scores were associated with a higher incidence of intertrochanteric fractures compared to femoral neck fractures. This suggests that there is a correlation between low body weight, BMI, and BMD Z-scores and an increased risk of intertrochanteric fractures in elderly Korean patients.
Review
Biochemistry & Molecular Biology
Giuseppe Rinonapoli, Valerio Pace, Carmelinda Ruggiero, Paolo Ceccarini, Michele Bisaccia, Luigi Meccariello, Auro Caraffa
Summary: Obesity leads to higher bone mineral density, but also an increased risk of fracture due to multiple factors such as metabolic issues and a higher risk of falls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yingke Xu, Yueyang Bao, Megan Wang, Qing Wu
Summary: Past research suggests that men are more likely to smoke and have a higher risk of smoking-related conditions than women. A meta-analysis was conducted to assess the association between smoking and fracture risk in men. The analysis found a significant increase in fracture risk associated with smoking in men. This highlights the importance of smoking cessation in reducing the risk of fractures in male smokers.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Maria-Jose Montoya-Garcia, Merce Giner, Rodrigo Marcos, David Garcia-Romero, Francisco-Jesus Olmo-Montes, Ma Jose Miranda, Blanca Hernandez-Cruz, Miguel-Angel Colmenero, Ma Angeles Vazquez-Gamez
Summary: Fragility fractures are a significant public health issue globally, with hip fractures being most prevalent in women aged 80 and above. Older age and recent fractures were identified as independent risk factors for further fracture events. There was a significant excess mortality rate in individuals aged 80 and above with a previous hip fracture.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Johannes M. Weller, Julius N. Meissner, Sebastian Stoesser, Franziska Dorn, Gabor C. Petzold, Felix J. Bode
Summary: The prevalence of preinterventional intracranial hemorrhage in acute ischemic stroke patients with large vessel occlusion is rare. This study shows that mechanical thrombectomy is technically feasible in these patients and can lead to good clinical outcomes.
CLINICAL NEURORADIOLOGY
(2022)
Article
Medicine, General & Internal
Arwed Elias Michael, Jan Boriesosdick, Denise Schoenbeck, Matthias Michael Woeltjen, Saher Saeed, Jan Robert Kroeger, Sebastian Horstmeier, Simon Lennartz, Jan Borggrefe, Julius Henning Niehoff
Summary: This study evaluated the image quality of different reconstruction methods in unenhanced PCCTs of the head. The results showed that the polyenergetic reconstruction was superior to virtual monoenergetic reconstructions in terms of signal-to-noise ratio and contrast-to-noise ratio. Although certain virtual monoenergetic reconstructions performed better in terms of artifacts, there is still room for improvement. This study is important for further improving the image quality of PCCT.
Article
Radiology, Nuclear Medicine & Medical Imaging
Julius Henning Niehoff, Matthias Michael Woeltjen, Saher Saeed, Arwed Elias Michael, Jan Boriesosdick, Jan Borggrefe, Jan Robert Kroeger
Summary: The study evaluated the diagnostic accuracy of virtual non-contrast images acquired with the first clinical photon counting CT scanner for the assessment of hepatic steatosis. The results showed that the spectral datasets from the PCCT scanner allowed reliable reconstruction of VNC images for accurate evaluation of hepatic steatosis. Adjusting the cut-off values improved the performance of the CT indices, offering excellent sensitivity and specificity.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Felix Sebastian Leo Thomsen, Sebastian Horstmeier, Julius Henning Niehoff, Jaime Andres Pena, Jan Borggrefe
Summary: This study evaluated the potential application of photon counting CT in bone microstructure imaging. The results showed that photon counting CT had comparable spatial resolution to HR-pQCT and significantly higher resolution compared to conventional CT, making it suitable for high-resolution bone imaging.
INVESTIGATIVE RADIOLOGY
(2022)
Article
Clinical Neurology
Helge Kniep, Lukas Meyer, Matthias Bechstein, Gabriel Broocks, Helena Guerreiro, Noel van Horn, Caspar Brekenfeld, Fabian Flottmann, Milani Deb-Chatterji, Anna Alegiani, Gotz Thomalla, Uta Hanning, Jens Fiehler, Susanne Gellissen
Summary: Early neurological status can predict the functional outcome of patients after mechanical thrombectomy. Around 54% of the improvement in functional outcome after successful recanalization can be observed at the 24-hour neurological status assessment.
Article
Medicine, General & Internal
Arwed Elias Michael, Jan Boriesosdick, Denise Schoenbeck, Ingo Lopez-Schmidt, Jan Robert Kroeger, Christoph Moenninghoff, Sebastian Horstmeier, Lenhard Pennig, Jan Borggrefe, Julius Henning Niehoff
Summary: This study evaluated the image quality differences between polyenergetic and monoenergetic reconstructions of CT angiographies (CTAs) of the head and neck. The results showed that the photon counting CT (PCCT) method provided excellent image quality, with the PER being the most favorable reconstruction method for diagnostic reporting.
Article
Medicine, General & Internal
Michele Sorleto, Hendrik Poos, Jan Borggrefe, Jan Robert Kroger, Carsten Gartung, Berthold Gerdes, Lutz Uekermann, Thomas Hass, Ulrich Klaus Fetzner
Summary: Radical esophagectomy with lymphadenectomy is the primary treatment for advanced esophagus carcinoma. Advances in surgical techniques, such as minimally invasive and robotic oesophagectomy, have improved the outcomes in the last two decades. Perioperative management, including prehabilitation, PDK application, early mobilization, and early food intake, also contribute to reducing complications. Early detection and interdisciplinary management are key to increasing the safety of esophageal surgery.
THERAPEUTISCHE UMSCHAU
(2022)
Article
Clinical Neurology
Egon Burian, Dominik Sepp, Manuel Lehm, Kathleen Bernkopf, Silke Wunderlich, Isabelle Riederer, Christian Maegerlein, Anna Alegiani, Claus Zimmer, Tobias Boeckh-Behrens
Summary: Simultaneous administration of intravenous thrombolysis during mechanical thrombectomy procedures can improve the functional and clinical outcomes for patients with acute ischemic stroke, with a similar risk of bleeding.
CLINICAL NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Lukas Goertz, Jan Borggrefe, Nuran Abdullayev, Erkan Celik, Lenhard Pennig, Marco Timmer, Jan-Christoffer Luers, Marc Schlamann, Christoph Kabbasch
Summary: This study reports the initial clinical experience with NHCA as a liquid embolic agent for neurovascular embolization. The results show that NHCA is feasible and effective, particularly for small and tortuous vessels that require low-profile catheterization and a slow and controlled polymerization. Further studies are needed to prove the benefits of NHCA over established embolic agents.
INTERVENTIONAL NEURORADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ulrike Cornelia Isabel Hoyer, Simon Lennartz, Nuran Abdullayev, Florian Fichter, Stephanie T. Juenger, Lukas Goertz, Kai Roman Laukamp, Roman Johannes Gertz, Jan-Peter Grunz, Christopher Hohmann, David Maintz, Thorsten Persigehl, Christoph Kabbasch, Jan Borggrefe, Kilian Weiss, Lenhard Pennig
Summary: This study aimed to compare a novel contrast-free and triggering-free vascular imaging technique (REACT) with CE-MRA in the detection of carotid artery stenosis and plaques, as well as image quality, in stroke patients. The results showed that REACT had comparable sensitivity and specificity to CE-MRA in detecting stenosis and plaques, and yielded similar image quality.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Neuroimaging
Laurens Winkelmeier, Tobias D. Faizy, Caspar Brekenfeld, Christian Heitkamp, Gabriel Broocks, Matthias Bechstein, Paul Steffen, Maximilian Schell, Susanne Gellissen, Helge Kniep, Goetz Thomalla, Jens Fiehler, Fabian Flottmann
Summary: This study found that in endovascular therapy for large ischemic strokes, mTICI 3 did not improve functional outcomes at 90 days compared with mTICI 2b. The study suggests that the additional maneuvers to seek for mTICI 3 in large ischemic strokes might not be warranted based on the benefit/risk ratio.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Medicine, General & Internal
Martin Bendszus, Jens Fiehler, Fabien Subtil, Susanne Bonekamp, Anne Hege Aamodt, Blanca Fuentes, Elke R. Gizewski, Michael D. Hill, Antonin Krajina, Laurent Pierot, Claus Z. Simonsen, Kamil Zelenak, Rolf A. Blauenfeldt, Bastian Cheng, Angelique Denis, Hannes Deutschmann, Franziska Dorn, Fabian Flottmann, Susanne Gellissen, Johannes C. Gerber, Mayank Goyal, Jozef Haring, Christian Herweh, Silke Hopf-Jensen, Vi Tuan Hua, Maerit Jensen, Andreas Kastrup, Christiane Fee Keil, Andrej Klepanec, Egon Kurca, Ronni Mikkelsen, Markus Moehlenbruch, Stefan Mueller-Huelsbeck, Nico Muennich, Paolo Pagano, Panagiotis Papanagiotou, Gabor C. Petzold, Mirko Pham, Volker Puetz, Jan Raupach, Gernot Reimann, Peter Arthur Ringleb, Maximilian Schell, Eckhard Schlemm, Silvia Schoenenberger, Bjorn Tennoe, Christian Ulfert, Katerina Valis, Eva Vitkova, Dominik F. Vollherbst, Wolfgang Wick, Goetz Thomalla
Summary: Endovascular thrombectomy is associated with improved functional outcome and lower mortality in patients with acute ischemic stroke from large vessel occlusion using non-contrast CT as the primary imaging modality for patient selection.
Article
Clinical Neurology
Laurens Winkelmeier, Tobias D. Faizy, Gabriel Broocks, Lukas Meyer, Christian Heitkamp, Caspar Brekenfeld, Christian Thaler, Paul Steffen, Maximilian Schell, Milani Deb-Chatterji, Uta Hanning, Helge Kniep, Mate E. Maros, Goetz Thomalla, Jens Fiehler, Fabian Alexander Flottmann
Summary: The clinical benefit of endovascular therapy in patients with large ischemic stroke is associated with the number of recanalization attempts. At least 2 recanalization attempts improve the likelihood of favorable functional outcomes, while more than 2 attempts should be carefully assessed.
Article
Neurosciences
Jan Boriesosdick, Alexey Surov, Arwed Michael, Christoph Moenninghoff, Julius Henning Niehoff, Nina Pauline Haag, Iram Shahzadi, Jan-Robert Kroeger, Peter Schellinger, Jan Borggrefe
Summary: In patients with acute ischemic stroke, the masseter muscle area is an independent predictor of mortality, making it a valuable tool for assessing outcomes and survival in these patients.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mareike Franke, Christian Saager, Jan-Robert Kroeger, Jan Borggrefe, Kersten Mueckner
Summary: This study treated 35 patients with symptomatic postoperative lymphoceles using vacuum-assisted suction drainage, with a high cure rate of 94.8%. The technical success rate was 100%, with a low complication rate of 4.6%.
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
(2022)
