Inhibition of a Mitochondrial Potassium Channel in Combination with Gemcitabine and Abraxane Drastically Reduces Pancreatic Ductal Adenocarcinoma in an Immunocompetent Orthotopic Murine Model

Preclinical Models of Pancreatic Ductal Adenocarcinoma and Their Utility in Immunotherapy Studies

(2021) Thao N. D. Pham et al.   Cancers

Pancreatic Cancer

(2021) Wungki Park et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Antitumor Activity of Sodium Selenite Alone and in Combination with Gemcitabine in Pancreatic Cancer: An In Vitro and In Vivo Study

(2021) Kevin Doello et al.   Cancers

Aldehyde dehydrogenase 3A1 confers oxidative stress resistance accompanied by altered DNA damage response in human corneal epithelial cells

(2020) Georgia-Persephoni Voulgaridou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family

(2020) Roberta Peruzzo et al.   Redox Biology

SWOG S1505: Initial findings on eligibility and neoadjuvant chemotherapy experience with mfolfirinox versus gemcitabine/nab-paclitaxel for resectable pancreatic adenocarcinoma.

(2019) Davendra Sohal et al.   JOURNAL OF CLINICAL ONCOLOGY

Cytochrome P450: genotype to phenotype

(2019) Rosemary H. Waring   XENOBIOTICA

Mitogen‑activated protein kinase inhibition enhances the antitumor effects of sporamin in human pancreatic cancer cells

(2018) Cui‑Juan Qian et al.   Oncology Letters

Moscatilin induces apoptosis of pancreatic cancer cells via reactive oxygen species and the JNK/SAPK pathway

(2017) Lei Zhang et al.   Molecular Medicine Reports

Nano albumin bound-paclitaxel in pancreatic cancer: Current evidences and future directions

(2017) Guido Giordano et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma

(2016) Angela Zaccagnino et al.   Oncotarget

Functional p38 MAPK Identified by Biomarker Profiling of Pancreatic Cancer Restrains Growth through JNK Inhibition and Correlates with Improved Survival

(2014) Y. Zhong et al.   CLINICAL CANCER RESEARCH

A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells

(2014) Xinlai Cheng et al.   Molecular Cancer

Mechanisms of Overcoming Intrinsic Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma through the Redox Modulation

(2014) H.-Q. Ju et al.   MOLECULAR CANCER THERAPEUTICS

DUSP1 Is a Novel Target for Enhancing Pancreatic Cancer Cell Sensitivity to Gemcitabine

(2014) Fang Liu et al.   PLoS One

Dimethylaminoparthenolide and gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer

(2013) Michele T Yip-Schneider et al.   BMC CANCER

A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis

(2013) Kantima Leelahavanichkul et al.   Molecular Oncology

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

The voltage-dependent K+ channels Kv1.3 and Kv1.5 in human cancer

(2013) Núria Comes et al.   Frontiers in Physiology

Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells

(2012) Luigi Leanza et al.   EMBO Molecular Medicine

Contribution of voltage-gated potassium channels to the regulation of apoptosis

(2010) Ildikò Szabò et al.   FEBS LETTERS

Ion channels and the hallmarks of cancer

(2010) Natalia Prevarskaya et al.   TRENDS IN MOLECULAR MEDICINE

Voltage-Dependent Potassium Channels Kv1.3 and Kv1.5 in Human Cancer

(2009) J. Bielanska et al.   CURRENT CANCER DRUG TARGETS

Deregulation of 2 Potassium Channels in Pancreas Adenocarcinomas

(2009) Marie Brevet et al.   PANCREAS

The Adnectin CT-322 is a novel VEGF receptor 2 inhibitor that decreases tumor burden in an orthotopic mouse model of pancreatic cancer

(2008) Sean P Dineen et al.   BMC CANCER

Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes

(2008) I. Szabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA