Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis

Lung Immune Tone via Gut-Lung Axis: Gut-derived LPS and Short-chain Fatty Acids' immunometabolic regulation of Lung IL-1β, FFAR2 and FFAR3 Expression

(2021) Qing Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways

(2021) Manon Laporte et al.   PLoS Pathogens

Cell-type-resolved quantitative proteomics map of interferon response against SARS-CoV-2

(2021) Elisa Saccon et al.   iScience

Tissues, not blood, are where immune cells function

(2021) Donna L. Farber   NATURE

Respiratory Viral Infection Alters the Gut Microbiota by Inducing Inappetence

(2020) Helen T. Groves et al.   mBio

Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production

(2020) Valentin Sencio et al.   Cell Reports

Timing of complementary feeding is associated with gut microbiota diversity and composition and short chain fatty acid concentrations over the first year of life

(2020) Moira K. Differding et al.   BMC MICROBIOLOGY

Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells

(2020) Laura Schaupp et al.   CELL

Altered gut microbiota in infants is associated with respiratory syncytial virus disease severity

(2020) Jeffrey N. Harding et al.   BMC MICROBIOLOGY

Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue

(2020) Jennifer A. Aguiar et al.   EUROPEAN RESPIRATORY JOURNAL

Respiratory syncytial virus immunisation overview

(2020) David A Foley et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection

(2020) Maximillian S. Habibi et al.   SCIENCE

Integrated-omics endotyping of infants with rhinovirus bronchiolitis and risk of childhood asthma

(2020) Yoshihiko Raita et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The syndrome we agreed to call bronchiolitis

(2019) Fernando P Polack et al.   JOURNAL OF INFECTIOUS DISEASES

Neutrophil recruitment and activation are differentially dependent on MyD88/TRIF and MAVS signaling during RSV infection

(2019) Freja C. M. Kirsebom et al.   Mucosal Immunology

Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

(2019) Krist Helen Antunes et al.   Nature Communications

Immunological Lessons from Respiratory Syncytial Virus Vaccine Development

(2019) Tracy J. Ruckwardt et al.   IMMUNITY

Differential interferon gene expression in bronchiolitis caused by respiratory syncytial virus-A genotype ON1

(2019) Alessandra Pierangeli et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Reduced Nasal Viral Load and IFN Responses in Infants with RSV Bronchiolitis and Respiratory Failure

(2018) Ryan S Thwaites et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation of type 2 innate lymphoid cell–dependent airway hyperreactivity by butyrate

(2018) Christina Li-Ping Thio et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates

(2018) Natalie I Mazur et al.   LANCET INFECTIOUS DISEASES

The Metabolic Sensor GPR43 Receptor Plays a Role in the Control of Klebsiella pneumoniae Infection in the Lung

(2018) Izabela Galvão et al.   Frontiers in Immunology

Respiratory Disease following Viral Lung Infection Alters the Murine Gut Microbiota

(2018) Helen T. Groves et al.   Frontiers in Immunology

Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling

(2018) Junsu Ban et al.   Viruses-Basel

Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota

(2017) Amanda J. McFarlane et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a–mediated T reg expansion

(2017) Jason P. Lynch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

(2017) Ting Shi et al.   LANCET

RIG-I: a multifunctional protein beyond a pattern recognition receptor

(2017) Xiao-xiao Xu et al.   Protein & Cell

The severity of acute bronchiolitis in infants was associated with quality of life nine months later

(2016) Leif Bjarte Rolfsjord et al.   ACTA PAEDIATRICA

Nasopharyngeal Microbiome in Respiratory Syncytial Virus Resembles Profile Associated with Increased Childhood Asthma Risk

(2016) Christian Rosas-Salazar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Fecal Microbiota Profile and Bronchiolitis in Infants

(2016) K. Hasegawa et al.   PEDIATRICS

Signatures of early frailty in the gut microbiota

(2016) Matthew A. Jackson et al.   Genome Medicine

RIG-I Works Double Duty

(2015) Ying Kai Chan et al.   Cell Host & Microbe

The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development

(2015) Shu Mei Teo et al.   Cell Host & Microbe

Principal findings of systematic reviews of acute asthma treatment in childhood

(2015) Jose A. Castro-Rodriguez et al.   JOURNAL OF ASTHMA

The Interferon Type I/III Response to Respiratory Syncytial Virus Infection in Airway Epithelial Cells Can Be Attenuated or Amplified by Antiviral Treatment

(2015) K. M. McCutcheon et al.   JOURNAL OF VIROLOGY

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Early Respiratory Microbiota Composition Determines Bacterial Succession Patterns and Respiratory Health in Children

(2014) Giske Biesbroek et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Viral and host factors determine innate immune responses in airway epithelial cells from children with wheeze and atopy

(2014) Kirsten M Spann et al.   THORAX

Azithromycin Therapy in Hospitalized Infants with Acute Bronchiolitis is Not Associated with Better Clinical Outcomes: A Randomized, Double-Blinded, and Placebo-Controlled Clinical Trial

(2012) Leonardo A. Pinto et al.   JOURNAL OF PEDIATRICS

Severity scoring systems: Are they internally valid, reliable and predictive of oxygen use in children with acute bronchiolitis?

(2012) Gabrielle B. McCallum et al.   PEDIATRIC PULMONOLOGY

Respiratory Syncytial Virus NS1 Protein Colocalizes with Mitochondrial Antiviral Signaling Protein MAVS following Infection

(2012) Sandhya Boyapalle et al.   PLoS One

Differential Pathogenesis of Respiratory Syncytial Virus Clinical Isolates in BALB/c Mice

(2011) K. L. Stokes et al.   JOURNAL OF VIROLOGY

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Differential cytopathogenesis of respiratory syncytial virus prototypic and clinical isolates in primary pediatric bronchial epithelial cells

(2011) Rémi Villenave et al.   Virology Journal

Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis

(2010) Harish Nair et al.   LANCET

Human Respiratory Syncytial Virus Nonstructural Protein NS2 Antagonizes the Activation of Beta Interferon Transcription by Interacting with RIG-I

(2009) Z. Ling et al.   JOURNAL OF VIROLOGY

Breastfeeding reduces the severity of respiratory syncytial virus infection among young infants: A multi-center prospective study

(2009) Tatsuo Nishimura et al.   PEDIATRICS INTERNATIONAL