Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure
Authors
Keywords
-
Journal
Science Advances
Volume 8, Issue 18, Pages -
Publisher
American Association for the Advancement of Science (AAAS)
Online
2022-05-05
DOI
10.1126/sciadv.abn2748
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- CRISPR technologies for precise epigenome editing
- (2021) Muneaki Nakamura et al. NATURE CELL BIOLOGY
- Age of first alcohol intoxication and psychiatric disorders in young adulthood – a prospective birth cohort study
- (2021) Mustonen Antti et al. ADDICTIVE BEHAVIORS
- Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing
- (2021) Mitchell L. Leibowitz et al. NATURE GENETICS
- Spt5-mediated enhancer transcription directly couples enhancer activation with physical promoter interaction
- (2020) Johanna Fitz et al. NATURE GENETICS
- In vivo locus-specific editing of the neuroepigenome
- (2020) Yun Young Yim et al. NATURE REVIEWS NEUROSCIENCE
- An efficient KRAB domain for CRISPRi applications in human cells
- (2020) Nader Alerasool et al. NATURE METHODS
- The relationship between genome structure and function
- (2020) A. Marieke Oudelaar et al. NATURE REVIEWS GENETICS
- Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
- (2020) George F. Koob PHARMACOLOGICAL REVIEWS
- Adolescent alcohol exposure epigenetically suppresses amygdala Arc enhancer RNA expression to confer adult anxiety susceptibility
- (2019) Evan J. Kyzar et al. BIOLOGICAL PSYCHIATRY
- The lncRNA BDNF-AS is an epigenetic regulator in the human amygdala in early onset alcohol use disorders
- (2019) John Peyton Bohnsack et al. Translational Psychiatry
- Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner
- (2019) Henriette O’Geen et al. Epigenetics & Chromatin
- Mechanisms of persistent neurobiological changes following adolescent alcohol exposure: NADIA Consortium findings
- (2019) Fulton T. Crews et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex
- (2019) Zachary S. Lorsch et al. NATURE NEUROSCIENCE
- Immediate and deferred epigenomic signatures of in vivo neuronal activation in mouse hippocampus
- (2019) Jordi Fernandez-Albert et al. NATURE NEUROSCIENCE
- Advances in the science and treatment of alcohol use disorder
- (2019) K. Witkiewitz et al. Science Advances
- Altered amygdala DNA methylation mechanisms after adolescent alcohol exposure contribute to adult anxiety and alcohol drinking
- (2019) Amul J. Sakharkar et al. NEUROPHARMACOLOGY
- Effects of adolescent alcohol consumption on the brain and behaviour
- (2018) Linda P. Spear NATURE REVIEWS NEUROSCIENCE
- The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility
- (2018) Mark J. Wall et al. NEURON
- Adolescent alcohol exposure epigenetically regulates CREB signaling in the adult amygdala
- (2018) Huaibo Zhang et al. Scientific Reports
- CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency
- (2018) Navneet Matharu et al. SCIENCE
- CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome
- (2017) Tyler S Klann et al. NATURE BIOTECHNOLOGY
- Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping
- (2017) Stefanie L. Morgan et al. Nature Communications
- Adolescent Alcohol Exposure: Burden of Epigenetic Reprogramming, Synaptic Remodeling, and Adult Psychopathology
- (2016) Evan J. Kyzar et al. Frontiers in Neuroscience
- 2010 National and State Costs of Excessive Alcohol Consumption
- (2015) Jeffrey J. Sacks et al. AMERICAN JOURNAL OF PREVENTIVE MEDICINE
- The Central Amygdala as an Integrative Hub for Anxiety and Alcohol Use Disorders
- (2015) Nicholas W. Gilpin et al. BIOLOGICAL PSYCHIATRY
- DNA Methylation in the Medial Prefrontal Cortex Regulates Alcohol-Induced Behavior and Plasticity
- (2015) Estelle Barbier et al. JOURNAL OF NEUROSCIENCE
- Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
- (2015) Isaac B Hilton et al. NATURE BIOTECHNOLOGY
- Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
- (2015) Pratiksha I Thakore et al. NATURE METHODS
- Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood
- (2015) Subhash C. Pandey et al. NEUROBIOLOGY OF DISEASE
- Adolescent alcohol exposure: Are there separable vulnerable periods within adolescence?
- (2015) Linda Patia Spear PHYSIOLOGY & BEHAVIOR
- The histone deacetylase inhibitor sodium butyrate decreases excessive ethanol intake in dependent animals
- (2014) Emmanuelle Simon-O'Brien et al. ADDICTION BIOLOGY
- Epigenetic Signaling in Psychiatric Disorders
- (2014) Catherine J. Peña et al. JOURNAL OF MOLECULAR BIOLOGY
- Enhancer RNA Facilitates NELF Release from Immediate Early Genes
- (2014) Katie Schaukowitch et al. MOLECULAR CELL
- Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors
- (2014) Elizabeth A Heller et al. NATURE NEUROSCIENCE
- Aberrant Histone Deacetylase2–Mediated Histone Modifications and Synaptic Plasticity in the Amygdala Predisposes to Anxiety and Alcoholism
- (2013) Sachin Moonat et al. BIOLOGICAL PSYCHIATRY
- DNA targeting specificity of RNA-guided Cas9 nucleases
- (2013) Patrick D Hsu et al. NATURE BIOTECHNOLOGY
- The Emerging Field of Neuroepigenetics
- (2013) J. David Sweatt NEURON
- Predicting enhancer transcription and activity from chromatin modifications
- (2013) Yun Zhu et al. NUCLEIC ACIDS RESEARCH
- Chromatin remodeling — a novel strategy to control excessive alcohol drinking
- (2013) V Warnault et al. Translational Psychiatry
- Arc in synaptic plasticity: from gene to behavior
- (2011) Erica Korb et al. TRENDS IN NEUROSCIENCES
- Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation
- (2010) Qihuang Jin et al. EMBO JOURNAL
- Widespread transcription at neuronal activity-regulated enhancers
- (2010) Tae-Kyung Kim et al. NATURE
- A unique chromatin signature uncovers early developmental enhancers in humans
- (2010) Alvaro Rada-Iglesias et al. NATURE
- Histone H3K27ac separates active from poised enhancers and predicts developmental state
- (2010) M. P. Creyghton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- KRAB–Zinc Finger Proteins and KAP1 Can Mediate Long-Range Transcriptional Repression through Heterochromatin Spreading
- (2010) Anna C. Groner et al. PLoS Genetics
- Neuropeptide Y Signaling in the Central Nucleus of Amygdala Regulates Alcohol-Drinking and Anxiety-Like Behaviors of Alcohol-Preferring Rats
- (2009) Huaibo Zhang et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons
- (2008) T. Kawashima et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started