Article
Hematology
Norma Maugeri, Rebecca De Lorenzo, Nicola Clementi, Roberta Antonia Diotti, Elena Criscuolo, Cosmo Godino, Cristina Tresoldi, Chiara Bonini, Massimo Clementi, Nicasio Mancini, Fabio Ciceri, Patrizia Rovere-Querini, Angelo A. Manfredi
Summary: The study found that COVID-19 patients have activated platelets at admission, characterized by expression and distribution of HMGB1 and von Willebrand factor, accumulation of platelet-derived extracellular vesicles and HMGB1(+) plt-EVs in plasma. Platelets interacting with SARS-CoV-2 in vitro underwent activation, suggesting a potential role of platelet activation in the inflammatory and hemostatic manifestations of COVID-19.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Endocrinology & Metabolism
R. Castagnoli, I. Brambilla, M. De Filippo, M. Votto, D. Montagna, L. Montagna, A. Licari, G. L. Marseglia
Summary: This review provides a comprehensive overview of COVID-19 in children until July 2021, including global infection and mortality data, as well as age-specific statistics.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Federica Di Spirito, Mario Caggiano, Maria Pia Di Palo, Maria Contaldo, Francesco D'Ambrosio, Stefano Martina, Alessandra Amato
Summary: This study aimed to assess the prevalence, characteristics, and epidemiology of oral lesions following pediatric SARS-CoV-2 infection and COVID-19 vaccine administration, revealing limited information.
APPLIED SCIENCES-BASEL
(2022)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Immunology
Rustom Antia, M. Elizabeth Halloran
Summary: The article discusses the basic concepts underlying the transition from an epidemic to an endemic state, as well as the implications of this transition for COVID-19.
Article
Multidisciplinary Sciences
Marcia C. Castro, Sun Kim, Lorena Barberia, Ana Freitas Ribeiro, Susie Gurzenda, Karina Braga Ribeiro, Erin Abbott, Jeffrey Blossom, Beatriz Rache, Burton H. Singer
Summary: The study found that COVID-19 in Brazil is spreading rapidly across municipalities with distinct spatial and temporal patterns of clustering, trajectories, and speed. Analysis shows that inadequate policy measures have led to high transmission and mortality burdens. The current surge in cases and deaths, along with the circulation of concerning variants, highlights the need for government to strengthen prevention and control measures.
Article
Infectious Diseases
Kamil Faltin, Zuzanna Lewandowska, Pawel Malecki, Krzysztof Czyz, Emilia Szafran, Agnieszka Kowalska-Tupko, Anna Mania, Katarzyna Mazur-Melewska, Katarzyna Jonczyk-Potoczna, Waldemar Bobkowski, Magdalena Figlerowicz
Summary: This article presents a case of a 17-year-old boy with Friedreich's ataxia-induced hypertrophic cardiomyopathy who contracted COVID-19. Despite mild initial symptoms, the patient's condition deteriorated rapidly, requiring antiarrhythmic treatment, pharmacological intervention, and convalescent plasma therapy.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Peter Chen, Ajay Nirula, Barry Heller, Robert L. Gottlieb, Joseph Boscia, Jason Morris, Gregory Huhn, Jose Cardona, Bharat Mocherla, Valentina Stosor, Imad Shawa, Andrew C. Adams, Jacob Van Naarden, Kenneth L. Custer, Lei Shen, Michael Durante, Gerard Oakley, Andrew E. Schade, Janelle Sabo, Dipak R. Patel, Paul Klekotka, Daniel M. Skovronsky
Summary: LY-CoV555, a neutralizing antibody, showed promising results in reducing viral load, improving symptoms, and lowering the risk of hospitalization among patients with mild or moderate Covid-19. While one of the doses appeared to accelerate the decline in viral load, others did not show significant effects by day 11.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Constantinos Kurt Wibmer, Frances Ayres, Tandile Hermanus, Mashudu Madzivhandila, Prudence Kgagudi, Brent Oosthuysen, Bronwen E. Lambson, Tulio de Oliveira, Marion Vermeulen, Karin van der Berg, Theresa Rossouw, Michael Boswell, Veronica Ueckermann, Susan Meiring, Anne von Gottberg, Cheryl Cohen, Lynn Morris, Jinal N. Bhiman, Penny L. Moore
Summary: The SARS-CoV-2 virus in the B.1.351 variant discovered in South Africa can evade neutralization by most antibodies when expressed, but does not affect binding by convalescent plasma. This suggests the potential for reinfection with antigenically distinct variants and predicts reduced efficacy of spike-based vaccines.
Article
Multidisciplinary Sciences
Emanuele Andreano, Ida Paciello, Silvia Marchese, Lorena Donnici, Giulio Pierleoni, Giulia Piccini, Noemi Manganaro, Elisa Pantano, Valentina Abbiento, Piero Pileri, Linda Benincasa, Ginevra Giglioli, Margherita Leonardi, Piet Maes, Concetta De Santi, Claudia Sala, Emanuele Montomoli, Raffaele De Francesco, Rino Rappuoli
Summary: In this study, Andreano and Paciello et al. provide insights into the functional and genetic characteristics of the Omicron BA.1 and BA.2 cross-protective antibody response. Their findings reveal that SARS-CoV-2 vaccines can induce neutralizing antibodies that cross-neutralize the Omicron variants and SARS-CoV-1 virus.
NATURE COMMUNICATIONS
(2022)
Review
Public, Environmental & Occupational Health
Sazada Siddiqui, Heba Waheeb Saeed Alhamdi, Huda Ahmed Alghamdi
Summary: COVID-19 is highly contagious and has caused major disruptions around the world. Prevention is crucial through measures such as self-isolation and vaccination.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
William R. Morgenlander, Stephanie N. Henson, Daniel R. Monaco, Athena Chen, Kirsten Littlefield, Evan M. Bloch, Eric Fujimura, Ingo Ruczinski, Andrew R. Crowley, Harini Natarajan, Savannah E. Butler, Joshua A. Weiner, Mamie Z. Li, Tania S. Bonny, Sarah E. Benner, Ashwin Balagopal, David Sullivan, Shmuel Shoham, Thomas C. Quinn, Susan H. Eshleman, Arturo Casadevall, Andrew D. Redd, Oliver Laeyendecker, Margaret E. Ackerman, Andrew Pekosz, Stephen J. Elledge, Matthew Robinson, Aaron A. R. Tobian, H. Benjamin Larman
Summary: This study found strong correlation between the functionality of COVID-19 convalescent plasma and polyclonal antibody targeting of specific peptides in the SARS-CoV-2 spike protein. Antibody responses to specific coronaviruses correlated with the development of highly neutralizing antibodies against CoV-2. Plasma donations reactive to the CoV-2 spike receptor binding domain had higher neutralizing titers.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Medicine, General & Internal
Eleonora Di Salvo, Mario Di Gioacchino, Alessandro Tonacci, Marco Casciaro, Sebastiano Gangemi
Summary: The role of alarmins in patients affected by COVID-19 disease and their relationship with commonly reported comorbidities are the focus of current research. There is limited literature on this specific topic, but preliminary evidence confirms the involvement of danger signals in amplifying the inflammatory reaction associated with SARS-CoV-2 infection.
ANNALS OF MEDICINE
(2021)
Article
Infectious Diseases
Chang-Sheng Xia, Minghua Zhan, Yudong Liu, Zhi-Hong Yue, Ying Song, Feifei Zhang, Hui Wang
Summary: This study assessed the levels of protective antibodies in SARS survivors with and without the COVID-19 vaccine, and found that SARS survivors have protective antibodies against SARS-CoV-2 even without vaccination, and generate a stronger antibody response after vaccination compared to controls.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Biotechnology & Applied Microbiology
Lauryna Dabasinskaite, Edvinas Krugly, Odeta Baniukaitiene, Darius Ciuzas, Dainius Martuzevicius, Lina Jankauskaite, Mantas Malinauskas, Arvydas Usas
Summary: An advanced therapy construct for cartilage regeneration was fabricated using cryo-electrospinning and contained the chondrogenic growth factor TGF beta-3. The construct was designed to promote chondral regeneration and subchondral bone formation by incorporating regenerated cellulose and hydroxyapatite.
BIOCHEMICAL ENGINEERING JOURNAL
(2022)
Article
Medicine, General & Internal
Ruud G. Nijman, Kate Honeyford, Ruth Farrugia, Katy Rose, Zsolt Bognar, Danilo Buonsenso, Liviana Da Dalt, Tisham De, Ian K. Maconochie, Niccolo Parri, Damian Roland, Tobias Alfven, Camille Aupiais, Michael Barrett, Romain Basmaci, Dorine Borensztajn, Susana Castanhinha, Corinne Vasilico, Sheena Durnin, Paddy Fitzpatrick, Laszlo Fodor, Borja Gomez, Susanne Greber-Platzer, Romain Guedj, Stuart Hartshorn, Florian Hey, Lina Jankauskaite, Daniela Kohlfuerst, Mojca Kolnik, Mark D. Lyttle, Patricia Macao, Maria Ines Mascarenhas, Shrouk Messahel, Esra Akyuz Ozkan, Zanda Pucuka, Sofia Reis, Alexis Rybak, Malin Ryd Rinder, Ozlem Teksam, Caner Turan, Valtyr Stefansson Thors, Roberto Velasco, Silvia Bressan, Henriette A. Moll, Rianne Oostenbrink, Luigi Titomanlio
Summary: During the early phase of the COVID-19 pandemic, there was a decrease in the number of children presenting to emergency departments in Europe. However, more severely ill children continued to seek medical attention despite the overall reduction in numbers.
Article
Pediatrics
Lina Jankauskaite, Yevgenii Grechukha, Kristin Avranden Kjaer, Marina Mamenko, Britt Nakstad, Ivanna Romankevych, Sara Schnyder, Joel Selvakumar, Sandra Trapani, Sandra Daniliaviciene, Arunas Valiulis, Corinne Wyder, Ketil Stordal
Summary: This study investigated knowledge and attitude towards medical overactivity in European countries. It found that despite cultural and economic differences, the patterns and drivers of increased investigations and medicalization are similar. The majority of doctors perceive expectations from family and patients as the most important driver for overtreatment.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Aiste Pociute, Muhammed Fazil Kottilingal Farook, Algirdas Dagys, Rimantas Kevalas, Goda Laucaityte, Lina Jankauskaite
Summary: The study analyzed the role of different platelet indices and specific secreted proteins in early febrile children, finding promising results for CXCL7 and sP-selectin in the diagnosis of early serious bacterial infections and sepsis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Mantas Malinauskas, Lina Jankauskaite, Lauryna Aukstikalne, Lauryna Dabasinskaite, Augustinas Rimkunas, Tomas Mickevicius, Alius Pockevicius, Edvinas Krugly, Dainius Martuzevicius, Darius Ciuzas, Odeta Baniukaitiene, Arvydas Usas
Summary: Polycaprolactone (PCL) is a suitable material for cartilage tissue engineering due to its mechanical strength, low immunogenicity, elasticity, and biodegradability. Enhancing the hydrophilicity of PCL scaffolds is necessary, and in this study, ozone treatment and TGF beta 3 loading were used to improve the properties of electrospun bilayer PCL scaffolds. In vitro and in vivo evaluations showed that the ozone-treated scaffold loaded with TGF beta 3 and rMDSCs demonstrated better chondrogenic potential and cartilage regeneration outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Lina Jankauskaite, Mantas Malinauskas, Ausra Snipaitiene
Summary: Since early 2020, SARS-CoV-2-induced infection has caused global pandemics with high morbidity, especially in adults. COVID-19 is associated with a highly prothrombotic condition and platelets are believed to play a crucial role in COVID-19-associated thrombosis. Platelets' role in inflammation and immunity, as well as their ability to release soluble factors and degrade pathogens, have been widely studied. This review focuses on the role of platelets in COVID-19-associated thrombosis and their involvement in the cholinergic anti-inflammatory pathway. Hyperactivated platelets have been observed in COVID-19 patients, and the presence of acetylcholine and α7nAchR on platelets suggests their involvement in platelet function. The stimulation of α7nAchR has anti-inflammatory effects and has been associated with better outcomes in COVID-19 patients. The inhibition of platelet activation and aggregation through the release of NO and blocking of the e p-38 pathway by acetylcholine may contribute to the platelet's role in COVID-19 thrombotic events. The similarity between SARS-CoV-2 proteins and neurotoxins suggests a potential mechanism for the interference with acetylcholine action.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Respiratory System
Lea Lenglart, Naim Ouldali, Kate Honeyford, Zsolt Bognar, Silvia Bressan, Danilo Buonsenso, Liviana Da Dalt, Tisham De, Ruth Farrugia, Ian K. Maconochie, Henriette A. Moll, Rianne Oostenbrink, Niccolo Parri, Damian Roland, Katy Rose, Esra Akyuz Ozkan, Francois Angoulvant, Camille Aupiais, Clarissa Barber, Michael Barrett, Romain Basmaci, Susana Castanhinha, Antonio Chiaretti, Sheena Durnin, Patrick Fitzpatrick, Laszlo Fodor, Borja Gomez, Susanne Greber-Platzer, Romain Guedj, Florian Hey, Lina Jankauskaite, Daniela Kohlfuerst, Ines Mascarenhas, Anna Maria Musolino, Zanda Pucuka, Sofia Reis, Alexis Rybak, Petra Salamon, Matthias Schaffert, Keren Shahar-Nissan, Maria Chiara Supino, Ozlem Teksam, Caner Turan, Roberto Velasco, Ruud G. Nijman, Luigi Titomanlio
Summary: This study aimed to assess the impact of non-pharmaceutical interventions on bronchiolitis outbreaks in 14 European countries. The study found that measures such as full lockdown, school closure, teleworking, and wearing masks indoors were associated with a reduction in bronchiolitis cases. These public health interventions can help alleviate the global burden of bronchiolitis.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Physiology
Andrius Rapalis, Povilas Piartli, Lina Jankauskaite, Vaidotas Marozas, Eugenijus Kaniusas
Summary: Pain is a common issue affecting one in every five adults worldwide and has a significant impact on health. This study aims to assess the significance of various biosignal parameters and their suitability as feedback in active pain therapy via auricular vagus nerve stimulation (aVNS). The results show that the targeted parameters decrease with cold stressor and increase with deep breathing, indicating their potential use as biofeedback in personalized pain therapy.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Pediatrics
Ausra Snipaitiene, Aurelija Sirataviciene, Leila Varoneckaite, Rima Sileikiene, Lina Jankauskaite
Summary: This study aimed to investigate the clinical importance of PLT count and PLT indices in predicting MIS-C severity in children. The results showed that a combination of PLT count and PLT indices can effectively predict the severity of MIS-C, providing important references for the diagnosis and clinical management of MIS-C.
FRONTIERS IN PEDIATRICS
(2023)
Review
Medicine, General & Internal
Laura Stendelyte, Mantas Malinauskas, Dovile Evalda Grinkeviciute, Lina Jankauskaite
Summary: Pain is a common issue in pediatric emergency visits and can cause anxiety and stress. It is important to explore new methods for pain diagnosis in children.
Article
Medicine, General & Internal
Algirdas Dagys, Goda Laucaityte, Augusta Volkeviciute, Silvijus Abramavicius, Rimantas Kevalas, Astra Vitkauskiene, Lina Jankauskaite
Summary: This study evaluates the role of certain cytokines and chemokines in the diagnosis of bacterial infection and sepsis in the pediatric emergency department. The results show that IL-2 is the most specific biomarker for identifying bacterial infection, and combining IL-2, IL-6, CRP, WBC, and neutrophil count improves diagnostic ability. Furthermore, IL-10 exhibits high specificity in recognizing sepsis in the early hours of disease onset.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Meeting Abstract
Critical Care Medicine
L. Jankauskaite, V. Jurgelene, M. Krutulyte, K. Bogdanaviciute, G. Gudaviciute
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
L. Jankauskaite, G. Mickeviciute, A. Daugela
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
L. Jankauskaite, E. Gelsvartaite, K. Snarskis, G. Laucaityte, M. Malinauskas
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)