Article
Medicine, General & Internal
Myungsik Nam, Sun Woong Kim
Summary: Corneal epithelial thickness (CET) was found to be smaller in patients with glaucoma receiving topical medications compared to controls. Among various factors influencing CET, the use of beta-blockers, prostaglandin, and frequency of BAK-containing instillations were significant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Mohammad Abusamak
Summary: This study investigates the mapping characteristics of corneal epithelial thickness (CET) in a Middle Eastern population and its relationship with age, sex, intraocular pressure, and keratometric power (K). The results show that the central CET is thicker than other zones of the cornea, males have thicker CET than females, and there is a positive correlation between age and CET. The findings of this study are important for refractive surgery decision-making and predicting corneal diseases.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Ophthalmology
Mengliang Wu, Laura E. Downie, Lisa J. Hill, Holly R. Chinnery
Summary: In this study, the neuroprotective and immunomodulatory effects of topical decorin in a murine model of BAK-induced corneal neuropathy were evaluated. The results showed that decorin reduced the infiltration of inflammatory cells and the decrease in corneal nerve density. This suggests that decorin can be a potential treatment for BAK-induced corneal neuropathy.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Biochemical Research Methods
Gary R. Ge, Behrouz Tavakol, David B. Usher, Desmond C. Adler, Jannick P. Rolland, Kevin J. Parker
Summary: In this study, a high-resolution elastography method in combination with a custom optical coherence tomography system was used to track the biomechanical changes in individual corneal layers. The results showed that the reverberant three-dimensional optical coherence elastography (OCE) technique can identify the elasticity changes associated with CXL treatments and provide insights into the nonlinearity of the elasticity changes.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Engineering, Environmental
Jieyi Zeng, Yaying Li, Guoping Jin, Jian-Qiang Su, Huaiying Yao
Summary: Antibiotic resistance genes (ARGs) are global pollutants that pose a potential risk to human health. This study found that benzalkonium chloride (C-12) (BC) disinfectants can affect antibiotic resistance in soil, but the impact of sulfamethazine (SMZ) is limited.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Medicine, General & Internal
Jens Julian Storp, Larissa Lahme, Sami Al-Nawaiseh, Nicole Eter, Maged Alnawaiseh
Summary: This study investigated the changes in corneal epithelial thickness before and after DMEK in FECD patients and compared them with a healthy control group. The results showed a significant decrease in corneal epithelial thickness after DMEK in FECD patients, reaching levels comparable to the healthy control group. This study emphasized the importance of distinguishing corneal layers in anterior segment pathologies and surgical procedures, as well as the structural alterations in FECD extending beyond the corneal stroma.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Ophthalmology
Dan Z. Reinstein, Timothy J. Archer, Ryan S. Vida
Summary: Corneal epithelial thickness mapping is a crucial tool for refractive surgery, used for various applications such as screening keratoconus and corneal ectasia, diagnosing irregular astigmatism, and planning treatment. Changes in epithelial thickness are predictable and can compensate for changes in stromal curvature gradient.
CURRENT OPINION IN OPHTHALMOLOGY
(2022)
Review
Medicine, General & Internal
Piotr Kanclerz, Ramin Khoramnia, Xiaogang Wang
Summary: Accurate assessment of corneal shape is crucial in cataract and refractive surgery, with corneal topography focusing on surface shape and tomography providing a three-dimensional section. Different technologies are used for these purposes, emphasizing the importance of thorough understanding for doctors involved in corneal surgery.
Article
Microbiology
Alizee Guerin, Arnaud Bridier, Patricia Le Grandois, Yann Sevellec, Federica Palma, Benjamin Felix, Sophie Roussel, Christophe Soumet
Summary: The study evaluated the antimicrobial susceptibility of 205 Listeria monocytogenes strains from different ecological niches to antibiotics and biocides, with food isolates showing higher resistance to certain compounds and acids. It was found that repeated exposure to certain compounds could affect susceptibility to antibiotics, indicating a potential link between biocide adaptation and antibiotic resistance in pathogenic bacteria such as Listeria monocytogenes.
Article
Multidisciplinary Sciences
Philipp Matten, Julius Scherer, Thomas Schlegl, Jonas Nienhaus, Heiko Stino, Michael Niederleithner, Ursula M. Schmidt-Erfurth, Rainer A. Leitgeb, Wolfgang Drexler, Andreas Pollreisz, Tilman Schmoll
Summary: Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults with diabetes mellitus, and optical coherence tomography angiography (OCTA) has shown potential as a tool for early diagnosis. We propose a multiple instance learning-based network, MIL-ResNet, capable of detecting biomarkers in OCTA images with high accuracy without pixel-level annotations. Our method outperforms previous state-of-the-art networks and is robust against adversarial attacks, making it a powerful diagnostic decision support tool for clinical ophthalmic screening.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Nathaniel J. M. Haven, Matthew T. Martell, Haoyang Li, James D. Hogan, Roger J. Zemp
Summary: Photoacoustic remote sensing is an all-optical imaging modality that can image various contrast agents without labeling. Using a high-speed camera, we further investigated the predicted reflectivity modulations caused by laser pulses and explored other potential mechanisms. We observed laser-induced motion in different samples and also non-motion-based intensity modulations, which are important for understanding the laser-pulse interactions.
SCIENTIFIC REPORTS
(2023)
Article
Dermatology
Irfan Botan Gunes, Berna Aksoy, Hakan Ozturk, Fuat Yavrum, Bediz Ozen
Summary: This study evaluated the relationship between psoriasis severity and central corneal epithelial thickness (CCET), and found a strong positive correlation between them. Measurement of CCET using spectral domain-optical coherence tomography (SD-OCT) can be an indicator of psoriasis severity.
ANAIS BRASILEIROS DE DERMATOLOGIA
(2023)
Article
Ophthalmology
Karin R. Pillunat, Johanna Orphal, Maike Haase, Lutz E. Pillunat, Robert Herber
Summary: The study found that corneal densitometry returned close to normal 6 months after trabeculectomy, with no significant difference compared to a healthy control group. The significant reduction in diurnal IOP and the decrease in pressure-lowering substances may be the main reasons for this finding.
Review
Biology
Tom Paterson, Serap Azizoglu, Moneisha Gokhale, Madeline Chambers, Cenk Suphioglu
Summary: Anti-allergy eyedrops are widely used for treating ocular allergies, but the common preservative benzalkonium chloride may damage corneal cells and increase the risk of corneal damage, especially when there is inflammation and eye rubbing action.
Article
Medicine, General & Internal
Achuth Nair, Manmohan Singh, Salavat R. Aglyamov, Kirill V. Larin
Summary: The biomechanical properties of the cornea are crucial for the health and function of the eye. This study demonstrates the combined use of two elastography techniques to measure corneal stiffness in a live rabbit model, with the ability to detect changes in stiffness after collagen crosslinking.
FRONTIERS IN MEDICINE
(2022)
Article
Engineering, Biomedical
M. Ourak, J. Smits, L. Esteveny, G. Borghesan, A. Gijbels, L. Schoevaerdts, Y. Douven, J. Scholtes, E. Lankenau, T. Eixmann, H. Schulz-Hildebrandt, G. Huettmann, M. Kozlovszky, G. Kronreif, K. Willekens, P. Stalmans, K. Faridpooya, M. Cereda, A. Giani, G. Staurenghi, D. Reynaerts, E. B. Vander Poorten
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2019)
Article
Biochemical Research Methods
Malte Casper, Hinnerk Schulz-Hildebrandt, Michael Evers, Reginald Birngruber, Dieter Manstein, Gereon Huettmann
JOURNAL OF BIOMEDICAL OPTICS
(2019)
Article
Dermatology
M. J. Casper, J. Glahn, M. Evers, H. Schulz-Hildebrandt, G. Kositratna, R. Birngruber, G. Huettmann, D. Manstein
LASERS IN SURGERY AND MEDICINE
(2020)
Article
Physiology
Mario Pieper, Hinnerk Schulz-Hildebrandt, Marcus A. Mall, Gereon Huettmann, Peter Koenig
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Article
Biochemical Research Methods
Asylkhan Rakhymzhan, Lucie Reuter, Raphael Raspe, Daniel Bremer, Robert Guenther, Ruth Leben, Judith Heidelin, Volker Andresen, Sergey Cheremukhin, Hinnerk Schulz-Hildebrandt, Maria G. Bixel, Ralf H. Adams, Helena Radbruch, Gereon Huettmann, Anja E. Hauser, Raluca A. Niesner
Article
Engineering, Biomedical
Sonja Jaeckle, Veronica Garcia-Vazquez, Tim Eixmann, Florian Matysiak, Felix von Haxthausen, Malte Maria Sieren, Hinnerk Schulz-Hildebrandt, Gereon Huettmann, Floris Ernst, Markus Kleemann, Torben Paetz
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2020)
Article
Optics
Michael Muenter, Malte vom Endt, Mario Pieper, Malte Casper, Martin Ahrens, Tabea Kohlfaerber, Ramtin Rahmanzadeh, Peter Koenig, Gereon Huettmann, Hinnerk Schulz-Hildebrandt
Article
Medicine, General & Internal
Hartmut Schneider, Martin Ahrens, Michaela Strumpski, Claudia Rueger, Matthias Haefer, Gereon Huettmann, Dirk Theisen-Kunde, Hinnerk Schulz-Hildebrandt, Rainer Haak
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Surgery
Sonja Jaeckle, Annkristin Lange, Veronica Garcia-Vazquez, Tim Eixmann, Florian Matysiak, Malte Maria Sieren, Marco Horn, Hinnerk Schulz-Hildebrandt, Gereon Huettmann, Floris Ernst, Stefan Heldmann, Torben Paetz, Tobias Preusser
Summary: Two novel approaches for obtaining three-dimensional instrument positions are introduced in this study – one tracking based and one image processing based. The tracking based method shows promising results for usage in EVAR procedures, while the image-based approach is more suitable for applications in smaller vessels.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2021)
Article
Biochemical Research Methods
Michael Muenter, Mario Pieper, Tabea Kohlfaerber, Ernst Bodenstorfer, Martin Ahrens, Christian Winter, Robert Huber, Peter Koenig, Gereon Huettmann, Hinnerk Schulz-Hildebrandt
Summary: High-speed 3D OCT imaging is achieved using a novel CMOS camera, enabling fast imaging of cellular structures and dynamic processes. This technology has the potential to play a significant role in clinical diagnosis and research applications in the future.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Physiology
Mario Pieper, Hinnerk Schulz-Hildebrandt, Inken Schmudde, Katharina M. Quell, Yves Laumonnier, Gereon Huettmann, Peter Koenig
Summary: This study investigated the role of mucus transport in asthma and the effects of saline treatment using microscopic optical coherence tomography. The results showed that hypertonic saline was more effective in mobilizing mucus, but it also induced more mucus secretion, which may explain its limited benefit in patients with asthma.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Ophthalmology
Matteo Giuseppe Cereda, Salvatore Parrulli, Y. G. M. Douven, Koorosh Faridpooya, Saskia van Romunde, Gereon Huttmann, Tim Eixmann, Hinnerk Schulz-Hildebrandt, Gernot Kronreif, Maarten Beelen, Marc D. de Smet
Summary: The study evaluated the efficacy of an instrument-integrated OCT-based distance sensor in vitreoretinal surgery, demonstrating its feasibility and accuracy in performing surgical tasks during the procedure, with successful completion of multiple tasks.
OPHTHALMOLOGY SCIENCE
(2021)
Proceedings Paper
Engineering, Biomedical
Sonja Jaeckle, Veronica Garcia-Vazquez, Felix von Haxthausen, Tim Eixmann, Malte Maria Sieren, Hinnerk Schulz-Hildebrandt, Gereon Huttmann, Floris Ernst, Markus Kleemann, Torben Paetz
Summary: A catheter prototype using a multicore fiber and three EM sensors for shape sensing and localization was developed for EVAR procedures. Evaluation showed average errors ranging from 0.99 to 2.29 mm and maximum errors from 1.73 to 2.99 mm in different shapes, indicating the feasibility and promise of accurate shape localization with this method. Future work will focus on further development for catheter guidance in EVAR procedures.
MEDICAL IMAGING 2020: IMAGE-GUIDED PROCEDURES, ROBOTIC INTERVENTIONS, AND MODELING
(2021)
Proceedings Paper
Medical Laboratory Technology
H. Schulz-Hildebrandt, N. Meyer-Schell, M. Casper, M. Evers, R. Birngruber, D. Manstein, G. Huettmann
CLINICAL AND PRECLINICAL OPTICAL DIAGNOSTICS II
(2019)