Article
Psychiatry
M. Ly, H. T. Karim, J. T. Becker, O. L. Lopez, S. J. Anderson, H. J. Aizenstein, C. F. Reynolds, M. D. Zmuda, M. A. Butters
Summary: Late-life depression (LLD) is associated with an increased risk of dementia, but individuals with a history of LLD do not necessarily experience faster cognitive decline compared to those without depression. Early-onset depression (EOD) shows baseline impairments in attention and global cognitive function but does not decline more rapidly, while late-onset depression (LOD) performs worse in all domains at baseline and experiences more rapid decline in verbal skills and delayed memory. These findings suggest that LLD may lower the threshold for dementia development, and EOD and LOD may represent distinct phenotypes of cognitive impairment with differing neural substrates.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Medicine, Research & Experimental
Aonan Zhao, Yang Jiao, Guanyu Ye, Wenyan Kang, Lan Tan, Yuanyuan Li, Yulei Deng, Jun Liu
Summary: This study found that sTREM2 may serve as a potential predictive biomarker of the conversion from MCI to AD. Low levels of CSF sTREM2 and Aβ1-42 were associated with an increased risk of MCI-to-AD conversion, while elevated CSF sTREM2 levels were associated with a decreased risk. In the NRHAD cohort, individuals in the MCI group with high plasma sTREM2 levels were more likely to progress to AD, and those with low Aβ1-42 and high plasma sTREM2 levels had a faster cognitive decline. CSF sTREM2 levels were highly correlated with plasma sTREM2 levels in the CABLE database.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medical Laboratory Technology
Wenwu Liu, Shuwei Weng, Huixing Liu, Chenghui Cao, Shuai Wang, Sha Wu, Jia He, Yang Yang, Die Hu, Yonghong Luo, Daoquan Peng
Summary: This study found that serum soluble TREM2 levels are elevated in patients with coronary heart disease (CHD) and are associated with various cardiovascular risk factors. Compared to traditional indicators, sTREM2 has better diagnostic performance in identifying CHD, suggesting that sTREM2 may serve as a potential biomarker for coronary heart disease.
CLINICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Valeri Cuciuc, Sagi Tshori, Livi Grib, Gal Sella, Ortal Tuvali, Igor Volodarsky, Michael Welt, Michael Fassler, Sara Shimoni, Jacob George
Summary: This study suggests that serum sTREM2 levels may predict cardiovascular mortality in patients with established coronary atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychiatry
Xiao-Yu He, Kevin Kuo, Liu Yang, Ya-Ru Zhang, Bang-Sheng Wu, Shi-Dong Chen, Wei Cheng, Jian-Feng Feng, Jin-Tai Yu
Summary: This study investigates the association between common serum laboratory tests and the risk of incident dementia. Results show that low vitamin D concentration, endocrine disorders, reduced liver and renal function, oxidative stress, dysregulated lipids, insulin resistance, and immune dysbiosis are associated with the onset of dementia.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Ming-Si Zhang, Jian-Hai Liang, Meng-Jia Yang, Yue-Ran Ren, Dai-Hong Cheng, Qi-Heng Wu, Yan He, Jia Yin
Summary: This study found that low serum superoxide dismutase (SOD) levels after mild acute ischemic stroke (AIS) were associated with a higher risk of cognitive impairment. This suggests that SOD may be a potential modifiable factor for post-stroke cognitive impairment (PSCI).
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Tai Anh Vu, Preeti Gupta, Felicia Z. Y. Leow, Eva K. Fenwick, Ryan E. K. Man, Yih-Chung Tham, Xin Xu, Debra Q. Y. Quek, Chaoxu Qian, Charumathi Sabanayagam, Christopher L. H. Chen, Tien Yin Wong, Ching-Yu Cheng, Ecosse L. Lamoureux
Summary: The study found that older adults with cognitive impairment had more than double the odds of developing visual impairment and poorer visual acuity over a 6-year period, with cataract and under-corrected refractive error being the leading causes of incident visual impairment.
Article
Endocrinology & Metabolism
Yanhua Xiao, Veda Devakumar, Liyan Xu, Lei Liu, Hanyou Mo, Xuezhi Hong
Summary: The present study found an association between diabetes and cognitive impairment (CI). In older diabetic patients, elevated serum creatinine (SCr) levels were significantly associated with decreased cognitive function, indicating that SCr may serve as an effective marker for screening CI in this population.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Xiaoling Liao, Lijun Zuo, Yanhong Dong, Yuesong Pan, Hongyi Yan, Xia Meng, Hao Li, Xingquan Zhao, Yilong Wang, Jiong Shi, Yongjun Wang
Summary: This study aimed to investigate the relationship between cognition and poor functional outcomes in patients with minor stroke or transient ischemic attack (TIA). The results showed that persisting cognitive impairment increased the risk of poor functional outcome after 3 months and 1 year follow-up.
Article
Clinical Neurology
Gowsaly Mahalingam, Suraj Samtani, Ben Chun Pan Lam, Darren M. Lipnicki, Maria Fernanda Lima-Costa, Sergio Luis Blay, Erico Castro-Costa, Shifu Xiao, Maelenn Guerchet, Pierre-Marie Preux, Antoine Gbessemehlan, Ingmar Skoog, Jenna Najar, Therese Rydberg Sterner, Nikolaos Scarmeas, Mary Yannakoulia, Themis Dardiotis, Ki-Woong Kim, Steffi Riedel-Heller, Susanne Roehr, Alexander Pabst, Suzana Shahar, Katya Numbers, Mary F. Ganguli, Tiffany Hughes, Chung-Chou H. Chang, Michael Crowe, Tze Pin Ng, Xinyi Gwee, Denise Qian Ling Chua, Joanna Rymaszewska, Karin Wolf-Ostermann, Anna-Karin Welmer, Jean Stafford, Rene Melis, Myrra Vernooij-Dassen, Yun-Hee Jeon, Perminder S. Sachdev, Henry Brodaty
Summary: Based on individual participant data from 13 longitudinal ageing studies, the study found that social connections are associated with lower risks of mild cognitive impairment, dementia, and mortality. Specifically, good social connection structure and quality are linked to lower risk of incident mild cognitive impairment, while social connection structure and function are related to lower risk of incident dementia and mortality. In Asian cohorts, being married/in a relationship is associated with reduced risk of dementia, and having a confidante is associated with reduced risk of dementia and mortality.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Tingting Geng, Qi Lu, Zhenzhen Wan, Jingyu Guo, Liegang Liu, An Pan, Gang Liu
Summary: This study examined the association between serum vitamin D levels and dementia risk among individuals with type 2 diabetes and found that higher concentrations of serum vitamin D were significantly associated with a lower risk of all-cause dementia, Alzheimer's disease, and vascular dementia. The findings suggest that screening for serum vitamin D levels may be useful in dementia care and prevention among patients with type 2 diabetes.
Article
Endocrinology & Metabolism
Wajd Alkabbani, Colleen J. J. Maxwell, Ruth Ann Marrie, Suzanne L. L. Tyas, Iliana C. C. Lega, John-Michael Gamble
Summary: This study reevaluates the association between insulin use and dementia risk in type 2 diabetes patients, considering confounding factors. The results showed no significant association between insulin use and all-cause dementia in patients previously treated with two noninsulin antihyperglycemic medications.
Article
Biochemistry & Molecular Biology
Kaung H. T. Salai, Liu-Yun Wu, Joyce R. R. Chong, Yuek Ling Chai, Bibek Gyanwali, Caroline Robert, Saima Hilal, Narayanaswamy Venketasubramanian, Gavin S. Dawe, Christopher P. P. Chen, Mitchell K. P. Lai
Summary: Tumor necrosis factor-receptor 1 (TNF-R1) signaling plays a critical role in regulating inflammatory responses. Elevated levels of soluble TNF-R1 (sTNF-R1) have been observed in predementia subjects, and specifically associated with cerebral small vessel disease (CSVD) and lower rates of cognitive decline. This suggests that sTNF-R1 interacts with vascular cognitive impairment in a complex manner, potentially providing protection against cognitive decline.
Article
Medicine, General & Internal
Hae Hyuk Jung
Summary: This study aimed to investigate the association between glycemic control and the progression of diabetic kidney disease. It found that intensive glucose control may not offer increased protection for the progression of established diabetic kidney disease, however, careful glycemic control could still improve overall outcomes, particularly among patients with chronic kidney disease.
Article
Clinical Neurology
Sandar Aye, Vincent Bouteloup, Ashley Tate, Anders Wimo, Ron Handels, Delphine Jean, Bengt Winblad, Linus Joensson
Summary: Health utility estimates for subjective cognitive decline (SCD) and mild cognitive impairment (MCI) are limited, especially in biomarker-confirmed populations. This study provides health utility estimates for SCD and MCI, revealing a decline in HR-QoL over time in moderate and severe dementia, and a negative association between clinical stage and VAS. Amyloid-positive patients show a faster decline in health utility, emphasizing the importance of considering biomarker status in HR-QoL assessments.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Transplantation
Yoshihisa Miyamoto, Ryoko Katagiri, Taiki Yamaji, Manami Inoue, Atsushi Goto, Motoki Iwasaki, Mitsuhiko Noda, Shoichiro Tsugane, Norie Sawada
Summary: This study investigated the association between chronic kidney disease (CKD) and cancer incidence. The findings suggest that a low estimated glomerular filtration rate (eGFR) is not significantly associated with an increased risk of total cancer incidence in patients with CKD, possibly due to the underpowered sample size and shared risk factors between CKD and cancer.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cell Biology
Makoto Kurano, Kazuhisa Tsukamoto, Shigeo Kamitsuji, Naoyuki Kamatani, Koji Hasegawa, Masumi Hara, Toshio Ishikawa, Yutaka Yatomi, Tamio Teramoto
Summary: ApoD is an anti-inflammatory apolipoprotein that can suppress inflammation by modulating lipid mediators and inflammatory factors.
INFLAMMATION RESEARCH
(2023)
Article
Nutrition & Dietetics
Takayuki Inoue, Bin Fu, Miwako Nishio, Miyako Tanaka, Hisashi Kato, Masashi Tanaka, Michiko Itoh, Hajime Yamakage, Kozue Ochi, Ayaka Ito, Yukihiro Shiraki, Satoshi Saito, Masafumi Ihara, Hideo Nishimura, Atsuhiko Kawamoto, Shian Inoue, Kumiko Saeki, Atsushi Enomoto, Takayoshi Suganami, Noriko Satoh-Asahara
Summary: The molecular pathogenesis of nonalcoholic steatohepatitis (NASH) involves metabolic stress and inflammatory stimuli. In this study, we found that Taxifolin treatment effectively prevented hepatic steatosis, chronic inflammation, and liver fibrosis in a NASH murine model. Taxifolin inhibited lipid accumulation in hepatocytes and increased brown adipose tissue activity. Furthermore, Taxifolin treatment after NASH development could prevent the development of liver tumors. These findings indicate the pleiotropic effects of Taxifolin for NASH treatment.
Article
Cardiac & Cardiovascular Systems
Syuhei Ikeda, Yoshimori An, Moritake Iguchi, Hisashi Ogawa, Yumiko Nakanishi, Kimihito Minami, Kenjiro Ishigami, Yuya Aono, Kosuke Doi, Yasuhiro Hamatani, Takashi Yoshizawa, Yuya Ide, Akiko Fujino, Mitsuru Ishii, Nobutoyo Masunaga, Masahiro Esato, Hikari Tsuji, Hiromichi Wada, Koji Hasegawa, Mitsuru Abe, Masaharu Akao
Summary: Previous studies have found that proteinuria is associated with the incidence of heart failure events in patients with atrial fibrillation. This community-based prospective study confirms that proteinuria is independently associated with heart failure events in Japanese patients with atrial fibrillation.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Endocrinology & Metabolism
Takako Miki, Akiko Nanri, Tetsuya Mizoue, Atsushi Goto, Mitsuhiko Noda, Norie Sawada, Shoichiro Tsugane
Summary: This study aimed to investigate the association between BMI and weight change over 5 years with the subsequent risk of pneumonia mortality in a Japanese population. The results showed that underweight and significant weight change were associated with an increased risk of pneumonia mortality in Japanese adults.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Nutrition & Dietetics
Masayo Iwasa, Hisashi Kato, Kaori Iwashita, Hajime Yamakage, Sayaka Kato, Satoshi Saito, Masafumi Ihara, Hideo Nishimura, Atsuhiko Kawamoto, Takayoshi Suganami, Masashi Tanaka, Noriko Satoh-Asahara
Summary: This study found that a high-glucose environment can increase intracellular reactive oxygen species (ROS) levels and trigger inflammation in microglial cells, leading to cognitive impairment in diabetes. However, taxifolin, a natural flavonoid, has been shown to reduce ROS levels and inhibit the activation of the TXNIP-NLRP3 axis, thereby suppressing inflammation and preventing cognitive impairment in diabetes.
Article
Nutrition & Dietetics
Yuto Kawase, Yoichi Sunagawa, Kana Shimizu, Masafumi Funamoto, Toshihide Hamabe-Horiike, Yasufumi Katanasaka, Satoshi Shimizu, Philip Hawke, Kiyoshi Mori, Maki Komiyama, Koji Hasegawa, Tatsuya Morimoto
Summary: Hypertrophic stress-induced cardiac remodeling is associated with heart failure. The phytochemical 6-shogaol can suppress hypertrophy and fibrosis, and ameliorate heart failure.
Article
Immunology
Takahiro Sogo, Shu Nakao, Tasuku Tsukamoto, Tomoe Ueyama, Yukihiro Harada, Dai Ihara, Tomoaki Ishida, Masato Nakahara, Koji Hasegawa, Yuka Akagi, Yasuyuki S. Kida, Osamu Nakagawa, Teruyuki Nagamune, Masahiro Kawahara, Teruhisa Kawamura
Summary: In this study, an inexpensive molecule-responsive differentiation-inducing chimeric antigen receptor (diCAR) was generated, which successfully activated Wnt3a signaling and promoted the differentiation of mouse embryonic stem cells into cardiomyocytes. This research is expected to be an economical and powerful tool for stem cell-based regeneration therapy.
INFLAMMATION AND REGENERATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Moritake Iguchi, Hiromichi Wada, Felipe Martinez, Koji Hasegawa
EUROPEAN CARDIOLOGY REVIEW
(2023)
Article
Cardiac & Cardiovascular Systems
Maki Komiyama, Gheorghe-Andrei Dan, Koji Hasegawa
Summary: Antiplatelet agents are commonly used in the treatment of chronic atherosclerotic coronary artery disease. Dual-pathway inhibition (DPI) with the addition of a low dose of rivaroxaban can reduce ischaemic events but increase bleeding risks. The balance between thrombotic and bleeding risks needs to be carefully considered when using DPI. However, the introduction of activated coagulation factor XI inhibitors, which have less bleeding effects, may expand the use of DPI in patients with atherosclerotic cardiovascular diseases.
EUROPEAN CARDIOLOGY REVIEW
(2023)
Article
Physics, Fluids & Plasmas
Koji Hasegawa, Yuya Kishimoto
Summary: The interfacial instability of a complex fluid in a multiphase flow system was experimentally investigated, focusing on the spreading and interfacial instability dynamics of a binary droplet on an immiscible pool. Fingering instability was observed at the spreading front of a 40 wt% water-isopropanol droplet on sunflower oil. The interplay among the speed, diameter, and number of fingers on the spreading front was analyzed, and the interfacial characteristics were quantified.
Article
Endocrinology & Metabolism
Dai Wakabayashi, Sayaka Kato, Masashi Tanaka, Hajime Yamakage, Hisashi Kato, Toru Kusakabe, Naoki Ozu, Shu Kasama, Masato Kasahara, Noriko Satoh-Asahara
Summary: This study aimed to investigate the association between serum uric acid (SUA) levels and cardiovascular disease (CVD) events in Japanese patients with obesity. The results showed that hyperuricemia was a significant factor for the incidence of CVD events, especially in female obese patients. Furthermore, a U-shaped association between SUA levels and CVD events was observed.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Meeting Abstract
Peripheral Vascular Disease
Toshihide Hamabe-Horiike, Yuto Kawase, Kana Shimizu, Masafumi Funamoto, Yoichi Sunagawa, Yasufumi Katanasaka, Satoshi Shimizu, Miki Komiyama, Koji Hasegawa, Tatsuya Morimoto
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Yuhi Nemoto, Kazuya Honda, Koji Hasegawa, Shigeatsu Hashimoto
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Yoichi Sunagawa, Toshihide Hamabe-Horiike, Masafumi Funamoto, Yasufumi Katanasaka, Koji Hasegawa, Tatsuya Morimoto
JOURNAL OF HYPERTENSION
(2023)
