Article
Clinical Neurology
Edith L. Graham, Jeffrey R. Clark, Zachary S. Orban, Patrick H. Lim, April L. Szymanski, Carolyn Taylor, Rebecca M. DiBiase, Dan Tong Jia, Roumen Balabanov, Sam U. Ho, Ayush Batra, Eric M. Liotta, Igor J. Koralnik
Summary: This study investigated the neurologic manifestations in non-hospitalized Covid-19 long haulers, revealing prominent symptoms such as brain fog and fatigue which negatively affect their cognition and quality of life.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Medicine, General & Internal
Amaya Jimeno-Almazan, Jesus G. Pallares, Angel Buendia-Romero, Alejandro Martinez-Cava, Javier Courel-Ibanez
Summary: This study identified that some post-COVID-19 patients may have cardiopulmonary limitations for physical exercise, leading to symptoms such as dyspnea and fatigue that persist in the long term. Additionally, a subset of patients may also experience chronotropic incompetence and other autonomic disorders, emphasizing the importance of appropriate diagnostic and therapeutic interventions for these individuals.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Anuradhaa Subramanian, Krishnarajah Nirantharakumar, Sarah Hughes, Puja Myles, Tim Williams, Krishna M. Gokhale, Tom Taverner, Joht Singh Chandan, Kirsty Brown, Nikita Simms-Williams, Anoop D. Shah, Megha Singh, Farah Kidy, Kelvin Okoth, Richard Hotham, Nasir Bashir, Neil Cockburn, Siang Ing Lee, Grace M. Turner, Georgios V. Gkoutos, Olalekan Lee Aiyegbusi, Christel McMullan, Alastair K. Denniston, Elizabeth Sapey, Janet M. Lord, David C. Wraith, Edward Leggett, Clare Iles, Tom Marshall, Malcolm J. Price, Steven Marwaha, Elin Haf Davies, Louise J. Jackson, Karen L. Matthews, Jenny Camaradou, Melanie Calvert, Shamil Haroon
Summary: A retrospective analysis of primary care records in the United Kingdom reveals individual symptoms associated with SARS-CoV-2 infections, which persisted for 12 weeks or more after infection, as well as risk factors associated with developing long COVID.
Article
Biochemistry & Molecular Biology
Evan Xu, Yan Xie, Ziyad Al-Aly
Summary: Individuals with COVID-19 have an increased risk of developing a range of neurologic disorders at 12 months, even if they were not hospitalized during the acute phase of the infection.
Article
Neurosciences
Hussam Y. Alghamdi, Abdulaziz M. Alrashed, Amjad M. Jawhari, Ahmed S. Abdel-Moneim
Summary: This study found that neuropsychiatric symptoms after SARS-CoV-2 infection were present in a significant percentage of the study participants, with up to 7.6% experiencing symptoms for more than 6 months. Disease severity and female sex may be potential determinants of the development and persistency of these symptoms.
ACTA NEUROPSYCHIATRICA
(2022)
Article
Multidisciplinary Sciences
Sofie Bliddal, Karina Banasik, Ole Birger Pedersen, Janna Nissen, Lisa Cantwell, Michael Schwinn, Morten Tulstrup, David Westergaard, Henrik Ullum, Soren Brunak, Niels Tommerup, Bjarke Feenstra, Frank Geller, Sisse Rye Ostrowski, Kirsten Gronbaek, Claus Henrik Nielsen, Susanne Dam Nielsen, Ulla Feldt-Rasmussen
Summary: Among non-hospitalized PCR-confirmed COVID-19 patients, one third were asymptomatic, while one third of symptomatic participants reported persistent symptoms. Risk factors for persistent symptoms included female sex and BMI.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Aysegul Bostanci, Umut Gazi, Ozgur Tosun, Kaya Suer, Emine Unal Evren, Hakan Evren, Tamer Sanlidag
Summary: This study aimed to determine the risk factors for long-COVID-19 symptoms in COVID-19 survivors. The research found that female gender, chronic illness, and symptomatic status at PCR testing were identified as risk factors for developing ongoing symptomatic COVID-19. Additionally, the study also found that vaccination status and viral variants did not have an impact on the persistent COVID-19 symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Cesar Fernandez-de-las-Penas, Ricardo Ortega-Santiago, Stella Fuensalida-Novo, Jose D. Martin-Guerrero, Oscar J. Pellicer-Valero, Juan Torres-Macho
Summary: This study compared the presence of post-COVID symptoms between vaccinated and non-vaccinated COVID-19 survivors after six months. The results showed no significant differences in symptoms between the two groups. This is important for understanding post-COVID symptoms in individuals infected with the Delta variant and those vaccinated with the Pfizer-BioNTech vaccine.
Article
Oncology
Jan Remsik, Jessica A. Wilcox, N. Esther Babady, Tracy A. McMillen, Behroze A. Vachha, Neil A. Halpern, Vikram Dhawan, Marc Rosenblum, Christine A. Iacobuzio-Donahue, Edward K. Avila, Bianca Santomasso, Adrienne Boire
Summary: Cancer patients with neurologic sequelae of COVID-19 have meningeal inflammatory cytokines without viral neuroinvasion, mainly driven by type II interferon and correlated with the degree of neurological dysfunction. The neuroinflammatory process persists weeks after recovery from acute respiratory infection, leading to long-term neurocognitive dysfunction. Anti-inflammatory treatments may play a role in managing neurological complications of COVID-19 infection.
Article
Infectious Diseases
Maddalena Peghin, Alvisa Palese, Margherita Venturini, Maria De Martino, Valentina Gerussi, Elena Graziano, Giulia Bontempo, Francesco Marrella, Alberto Tommasini, Martina Fabris, Francesco Curcio, Miriam Isola, Carlo Tascini
Summary: The study found a high prevalence rate of post-COVID-19 syndrome at 40.2% six months after onset, with factors associated including the presence of IgG antibodies, female gender, an increase in symptom number at onset, and ICU admission. Prospective follow-up for COVID-19 patients is recommended to identify long-term sequelae early.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Review
Medicine, General & Internal
Cesar Fernandez-de-las-Penas, Domingo Palacios-Cena, Victor Gomez-Mayordomo, Lidiane L. Florencio, Maria L. Cuadrado, Gustavo Plaza-Manzano, Marcos Navarro-Santana
Summary: This meta-analysis revealed that more than 60% of patients with SARS-CoV-2 infection experienced post-COVID-19 symptoms. Fatigue and dyspnea were the most prevalent post-COVID-19 symptoms, especially at 60 and >= 90 days after onset.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Fernando Daniel Flores-Silva, Miguel Garcia-Grimshaw, Sergio Ivan Valdes-Ferrer, Alma Poema Vigueras-Hernandez, Rogelio Dominguez-Moreno, Dioselina Panama Tristan-Samaniego, Anaclara Michel-Chavez, Alejandra Gonzalez-Duarte, Felipe A. Vega-Boada, Isael Reyes-Melo, Amado Jimenez-Ruiz, Oswaldo Alan Chavez-Martinez, Daniel Rebolledo-Garcia, Osvaldo Alexis Marche-Fernandez, Samantha Sanchez-Torres, Guillermo Garcia-Ramos, Carlos Cantu-Brito, Erwin Chiquete
Summary: The study found that 15.2% of hospitalized COVID-19 patients developed new neurologic complications, with headache, myalgia, dysgeusia, and anosmia being the most common neurologic symptoms. Age, headache at presentation, preexisting neurologic disease, invasive mechanical ventilation, and neutrophil/lymphocyte ratio >= 9 were identified as independent predictors of new in-hospital neurologic complications.
Article
Medicine, General & Internal
Magdalena Plywaczewska-Jakubowska, Michal Chudzik, Mateusz Babicki, Joanna Kapusta, Piotr Jankowski
Summary: Female sex, BMI, asthma, hypertension, nightshifts, and stress or overworking are significantly related to the severity of the acute phase of COVID-19 infection. Female sex, asthma, history of myocardial infarction, and the severity of symptoms in the acute phase of COVID-19 are the predictors of Long-COVID in non-hospitalized patients.
FRONTIERS IN MEDICINE
(2022)
Article
Virology
Cesar Fernandez-de-las-Penas, Juan Torres-Macho, Carlos Guijarro, Jose D. Martin-Guerrero, Oscar J. Pellicer-Valero, Gustavo Plaza-Manzano
Summary: This multicenter cohort study visualized the fluctuating evolution and trajectory of gastrointestinal symptoms in previously hospitalized COVID-19 survivors. The study found that the prevalence of overall gastrointestinal symptoms and diarrhea decreased over time and recovered within the first two to three years after infection.
Article
Psychiatry
Giuseppe Craparo, Valentina Lucia La Rosa, Graziella Marino, Michela Vezzoli, Gabriella Serena Cina, Morena Colombi, Giuseppe Arcoleo, Maria Severino, Giulia Costanzo, Ernesto Mangiapane
Summary: This study found that high levels of alexithymia, dissociation, anxiety, and depression statistically significantly predicted the three main clusters of PTSD symptoms (avoidance, intrusion, and hyperarousal) in individuals who have recovered from COVID-19. Furthermore, negative affectivity and psychoticism significantly predicted PTSD symptoms in our sample. Finally, individuals hospitalized by COVID-19 are more at risk of developing intrusion and hyperarousal symptoms than those who never needed hospital care.
PSYCHIATRY RESEARCH
(2022)
Review
Clinical Neurology
Jeffrey R. Clark, Nathan A. Shlobin, Ayush Batra, Eric M. Liotta
Summary: English proficiency is associated with better outcomes in stroke prevention, management, and recovery. Limited English proficiency can result in worse outcomes for stroke patients, but equitable care can be achieved with high interpreter availability. Tailored education and translated materials can benefit stroke patients with limited English proficiency.
FRONTIERS IN NEUROLOGY
(2022)
Article
Otorhinolaryngology
Alexander L. Schneider, Samuel D. Racette, Anthony K. Kang, Abhita T. Reddy, Julia H. Huang, David S. Lehmann, Caroline P. E. Price, Jacob G. Eide, Samuel R. Rodeghiero, David B. Conley, Kevin C. Welch, Robert C. Kern, Stephanie Shintani-Smith, Anju T. Peters, Atsushi Kato, Whitney S. Stevens, Robert P. Schleimer, Bruce K. Tan
Summary: This study found that patients who received hormonal mometasone-eluting stents (MES) had slightly higher pre-ESS middle meatus interleukin (IL) 13 and eosinophil cationic protein (ECP), but lower concentrations of IL-4 and IL-13 compared to those who did not receive the stents. However, these changes did not correspond to significantly different measures of symptomatic or radiographic disease severity.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2022)
Article
Geriatrics & Gerontology
Ayush Batra, Jeffrey R. Clark, Anthony K. Kang, Sareen Ali, Tulsi R. Patel, Nathan A. Shlobin, Steven C. Hoffman, Patrick H. Lim, Zachary S. Orban, Lavanya Visvabharathy, Edith L. Graham, David P. Sullivan, William A. Muller, Sherry H-Y Chou, Zoltan Ungvari, Igor J. Koralnik, Eric M. Liotta
Summary: This study assessed the persistent viral shedding in hospitalized COVID-19 patients and found that persistent viral shedding is associated with in-hospital delirium and increased six-month mortality.
Article
Clinical Neurology
Barbara A. Hanson, Lavanya Visvabharathy, Sareen T. Ali, Anthony K. Kang, Tulsi R. Patel, Jeffrey R. Clark, Patrick H. Lim, Zachary S. Orban, Soyoon S. Hwang, Dawn Mattoon, Ayush Batra, Eric M. Liotta, Igor J. Koralnik
Summary: This study aimed to investigate the mechanisms of neurologic symptoms in COVID-19 patients and their relationship with related factors. The results showed biochemical evidence of CNS injury in both hospitalized and nonhospitalized patients, and anxiety was associated with the extent of neurologic damage.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Edith L. Graham, Igor J. Koralnik, Eric M. Liotta
Summary: COVID-19 is a multisystem disease with significant and long-lasting neurologic consequences. In addition to relatively benign symptoms like headache, muscle pain, and loss of smell, COVID-19 can cause severe neurologic injuries that persist after the acute illness. Understanding the disease mechanisms and developing therapies targeting the neurologic complications are crucial for the management of COVID-19 patients.
Review
Clinical Neurology
Nathan A. Shlobin, Jeffrey R. Clark, Justin M. Campbell, Mark Bernstein, Babak S. Jahromi, Matthew B. Potts
Summary: This article outlines the application of bioethics in stroke care, discusses key ethical issues and special situations, and proposes methods to improve ethical decision-making for patients.
Review
Clinical Neurology
Kelli M. Money, T. Allen Barnett, Samuel Rapaka, Rebecca Osborn, Takashi Kitani, Daniel Fuguet, Faria Amjad, Jeffrey R. Clark, Debanjana Chakravarty, Matthew J. Copeland, Justin M. Honce, Princy N. Kumar, Rebecca N. Kumar, Fady Mousa-Ibrahim, Bilaal Sirdar, Rafal Sobota, Mengxuan Tang, Maureen K. Bolon, Eric J. Russell, Michael Wilson, Carlo Tornatore, Ayush Batra, Kenneth L. Tyler, Daniel M. Pastula
Summary: This study presents three cases of Monkeypox virus (MPXV)-associated central nervous system (CNS) disease during the 2022 outbreak, with imaging findings and treatment outcomes. The patients, previously healthy immunocompetent gay men in their 30s, developed a febrile illness followed by progressive neurologic symptoms and vesiculopustular rash. MPXV nucleic acid was detected in skin lesions of two patients, with the third patient having an epidemiological link to a confirmed case. Magnetic resonance imaging showed central spinal cord lesions and other brain abnormalities. All patients received tecovirimat treatment, and two also received immunotherapy. Good neurological recovery was observed in all cases.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Gina S. Perez S. Giraldo, Sareen T. Ali, Anthony K. Kang, Tulsi R. Patel, Shreya Budhiraja, Jordan I. Gaelen, Grace K. Lank, Jeffrey R. Clark, Shreya Mukherjee, Tracey Singer, Aditi Venkatesh, Zachary S. Orban, Patrick H. Lim, Millenia Jimenez, Janet Miller, Carolyn Taylor, April L. Szymanski, Jessica Scarpelli, Edith L. Graham, Roumen D. Balabanov, Bianca E. Barcelo, Joshua G. Cahan, Kaitlyn Ruckman, Alan G. Shepard, Marc W. Slutzky, Kathrin LaFaver, Priya U. Kumthekar, Neil K. Shetty, Katherine S. Carroll, Sam U. Ho, Rimas V. Lukas, Ayush Batra, Eric M. Liotta, Igor J. Koralnik
Summary: This study characterizes the neurological manifestations in post-hospitalization Neuro-PASC (PNP) and non-hospitalized Neuro-PASC (NNP) patients. PNP patients were older and had more comorbidities compared to NNP patients. PNP patients had a higher rate of abnormal neurological exams and worse cognitive performance compared to NNP patients.
ANNALS OF NEUROLOGY
(2023)
Review
Clinical Neurology
Archit B. Baskaran, Elena Grebenciucova, Thomas Shoemaker, Edith L. Graham
Summary: Multiple sclerosis (MS) is an immune-driven disease that affects the central nervous system and is characterized by acute-on-chronic demyelination attacks. It is a major cause of global neurological disability, and its prevalence has increased in the United States. This review provides a detailed update on the epidemiology, diagnosis, treatment advances, and major ongoing research investigations in MS.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
