A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors

Role of the intestinal microbiome and microbial-derived metabolites in immune checkpoint blockade immunotherapy of cancer

(2021) Eiko Hayase et al.   Genome Medicine

Resistance to Checkpoint Inhibition in Cancer Immunotherapy

(2020) Luisa Barrueto et al.   Translational Oncology

The Diversity Outbred Mouse Population Is an Improved Animal Model of Vaccination against Tuberculosis That Reflects Heterogeneity of Protection

(2020) Sherry L. Kurtz et al.   mSphere

Genomic mapping in outbred mice reveals overlap in genetic susceptibility for HZE ion– and γ-ray–induced tumors

(2020) E. F. Edmondson et al.   Science Advances

Diversity Outbred Mice Reveal the Quantitative Trait Locus and Regulatory Cells of HER2 Immunity

(2020) Wei-Zen Wei et al.   JOURNAL OF IMMUNOLOGY

Distinctive germline expression of class I human leukocyte antigen (HLA) alleles and DRB1 heterozygosis predict the outcome of patients with non-small cell lung cancer receiving PD-1/PD-L1 immune checkpoint blockade

(2020) Pierpaolo Correale et al.   Journal for ImmunoTherapy of Cancer

Whole Genome Sequencing and Progress Towards Full Inbreeding of the Mouse Collaborative Cross Population

(2019) John R. Shorter et al.   G3-Genes Genomes Genetics

Diverse tumour susceptibility in Collaborative Cross mice: identification of a new mouse model for human gastric tumourigenesis

(2019) Pin Wang et al.   GUT

Prolactin promotes fibrosis and pancreatic cancer progression

(2019) Manuj Tandon et al.   CANCER RESEARCH

Does Prolactin treatment trigger imunoendocrine alterations during experimental T. cruzi infection?

(2019) Marina Del Vecchio Filipin et al.   CYTOKINE

Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

(2019) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4

(2019) Shuang Qin et al.   Molecular Cancer

Prolactin signaling drives tumorigenesis in human high grade serous ovarian cancer cells and in a spontaneous fallopian tube derived model

(2018) Subbulakshmi Karthikeyan et al.   CANCER LETTERS

Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models

(2018) Katherine A. Leehy et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma

(2018) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden

(2018) Matthew D. Hellmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Silicosis and Silica-Induced Autoimmunity in the Diversity Outbred Mouse

(2018) Jessica M. Mayeux et al.   Frontiers in Immunology

Prolactin and Autoimmunity

(2018) Vânia Vieira Borba et al.   Frontiers in Immunology

R/qtl2: Software for Mapping Quantitative Trait Loci with High-Dimensional Data and Multi-parent Populations

(2018) Karl W. Broman et al.   GENETICS

Common Heritable Immunological Variations Revealed in Genetically Diverse Inbred Mouse Strains of the Collaborative Cross

(2018) Roxanne Collin et al.   JOURNAL OF IMMUNOLOGY

Comparing phenotypic variation between inbred and outbred mice

(2018) Alexander H. Tuttle et al.   NATURE METHODS

Autocrine Prolactin Stimulates Endometrial Carcinoma Growth and Metastasis and Reduces Sensitivity to Chemotherapy

(2017) Keshuo Ding et al.   ENDOCRINOLOGY

Genomes of the Mouse Collaborative Cross

(2017) Anuj Srivastava et al.   GENETICS

Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): results of an open-label, phase 1, multicohort study

(2017) Matthew D Hellmann et al.   LANCET ONCOLOGY

Tumor Mutational Burden and Response Rate to PD-1 Inhibition

(2017) Mark Yarchoan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

(2017) Diego Chowell et al.   SCIENCE

Extensive Homeostatic T Cell Phenotypic Variation within the Collaborative Cross

(2017) Jessica B. Graham et al.   Cell Reports

Genomes of the Mouse Collaborative Cross

(2017) Anuj Srivastava et al.   GENETICS

Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer

(2017) Jean M. Winter et al.   Cell Systems

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Mouse Universal Genotyping Array: From Substrains to Subspecies

(2015) Andrew P. Morgan et al.   G3-Genes Genomes Genetics

Effective Innate and Adaptive Antimelanoma Immunity through Localized TLR7/8 Activation

(2014) Manisha Singh et al.   JOURNAL OF IMMUNOLOGY

The Collaborative Cross as a Resource for Modeling Human Disease: CC011/Unc, a New Mouse Model for Spontaneous Colitis

(2014) Allison R. Rogala et al.   MAMMALIAN GENOME

Improved tests for the equality of normal coefficients of variation

(2013) K. Krishnamoorthy et al.   COMPUTATIONAL STATISTICS

Using the emerging Collaborative Cross to probe the immune system

(2013) J Phillippi et al.   GENES AND IMMUNITY

Immunogenicity of Murine Solid Tumor Models as a Defining Feature of In Vivo Behavior and Response to Immunotherapy

(2013) Melissa G. Lechner et al.   JOURNAL OF IMMUNOTHERAPY

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice

(2013) Falk Hildebrand et al.   GENOME BIOLOGY

High-Resolution Genetic Mapping Using the Mouse Diversity Outbred Population

(2012) Karen L. Svenson et al.   GENETICS

Cellular and Molecular Requirements for Rejection of B16 Melanoma in the Setting of Regulatory T Cell Depletion and Homeostatic Proliferation

(2012) J. Kline et al.   JOURNAL OF IMMUNOLOGY

The diversity outbred mouse population

(2012) Gary A. Churchill et al.   MAMMALIAN GENOME

Status and access to the Collaborative Cross population

(2012) Catherine E. Welsh et al.   MAMMALIAN GENOME

Emerging patterns of genetic overlap across autoimmune disorders

(2012) Corinne Richard-Miceli et al.   Genome Medicine

Bridging sequence diversity and tissue-specific expression by DNA methylation in genes of the mouse prolactin superfamily

(2011) Koji Hayakawa et al.   MAMMALIAN GENOME

Prolactin: Does it exert an up-modulation of the immune response in Trypanosoma cruzi-infected rats?

(2011) Marina Del Vecchio Filipin et al.   VETERINARY PARASITOLOGY

genoPlotR: comparative gene and genome visualization in R

(2010) L. Guy et al.   BIOINFORMATICS

Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors

(2010) V. Rouet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Epidemiology and Progression of Systemic Lupus Erythematosus

(2009) Guillermo J. Pons-Estel et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Genetic Regulation of the Response to Her-2 DNA Vaccination in Human Her-2 Transgenic Mice

(2008) O. Radkevich-Brown et al.   CANCER RESEARCH

Establishment of “The Gene Mine”: a resource for rapid identification of complex trait genes

(2008) Grant Morahan et al.   MAMMALIAN GENOME

The Collaborative Cross, developing a resource for mammalian systems genetics: A status report of the Wellcome Trust cohort

(2008) Fuad A. Iraqi et al.   MAMMALIAN GENOME

The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics

(2008) Elissa J. Chesler et al.   MAMMALIAN GENOME