Article
Biochemistry & Molecular Biology
Cesar Fernandez-de-las-Penas, Ignacio Cancela-Cilleruelo, Jorge Rodriguez-Jimenez, Stella Fuensalida-Novo, Jose D. Martin-Guerrero, Oscar J. Pellicer-Valero, Ana I. de-la-Llave-Rincon
Summary: This study aimed to visualize the evolution and trajectory of post-COVID fatigue and dyspnoea symptoms using Sankey plots and exponential bar plots in previously hospitalized COVID-19 survivors. The study found that the prevalence of post-COVID fatigue decreased over time, and dyspnoea decreased after the initial hospitalization. Female sex and experiencing symptoms at the first follow-up were factors associated with subsequent post-COVID fatigue and dyspnoea.
Article
Psychology, Clinical
Daniel Huth, Anne-Kathrin Braescher, Sarah Tholl, Johanna Fiess, Gunnar Birke, Christoph Herrmann, Michael Joebges, Daniela Mier, Michael Witthoeft
Summary: This study examined the feasibility and effectiveness of a cognitive-behavioral group intervention for individuals with post-COVID-19 condition in a neurological rehabilitation setting. The results support the acceptability and positive outcomes of the program in reducing fatigue and improving disease coping.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Yukichika Yamamoto, Yuki Otsuka, Naruhiko Sunada, Kazuki Tokumasu, Yasuhiro Nakano, Hiroyuki Honda, Yasue Sakurada, Hideharu Hagiya, Yoshihisa Hanayama, Fumio Otsuka
Summary: The pathogenesis and prognosis of post COVID-19 condition are still unclear. A study found a relatively high incidence of late-onset hypogonadism (LOH) in male patients, even young ones, with post COVID-19. Symptoms such as fatigue, anxiety, cough, and hair loss were more frequent in the LOH group than in the non-LOH group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Joel Selvakumar, Lise Beier Havdal, Martin Drevvatne, Elias Myrstad Brodwall, Lise Lund Berven, Tonje Stiansen-Sonerud, Gunnar Einvik, Truls Michael Leegaard, Trygve Tjade, Annika E. Michelsen, Tom Eirik Mollnes, Fridtjof Lund-Johansen, Trygve Holmoy, Henrik Zetterberg, Kaj Blennow, Carolina X. Sandler, Erin Cvejic, Andrew R. Lloyd, Vegard Bruun Bratholm Wyller
Summary: This study in Norway found that the prevalence and risk factors of post-COVID-19 condition (PCC) among young people are not directly related to SARS-CoV-2 infection. Factors such as symptom severity, low physical activity, and loneliness were found to be closely associated with PCC.
Review
Public, Environmental & Occupational Health
Simon Decary, Wouter De Groote, Chiara Arienti, Carlotte Kiekens, Paolo Boldrini, Stefano Giuseppe Lazzarini, Michele Dugas, Theo Stefan, Lea Langlois, Frederique Daigle, Florian Naye, Annie LeBlanc, Stefano Negrini
Summary: This study systematically maps the current evidence on the characteristics of health systems, providers, and patients to design rehabilitation care for post COVID-19 condition. The evidence is mostly conceptual and expert based, with key findings including the importance of multidisciplinary teams, continuity or coordination of care, people-centred care, and shared decision-making between clinicians and patients. Rehabilitation services should be integrated into all levels of the health system, and healthcare professionals such as physiotherapists, occupational therapists, and psychologists play a crucial role in delivering these services.
BULLETIN OF THE WORLD HEALTH ORGANIZATION
(2022)
Review
Health Care Sciences & Services
Krishna Mohan Surapaneni, Manmohan Singhal, Sofia Rani Saggu, Ashruti Bhatt, Priya Shunmathy, Ashish Joshi
Summary: The study reviewed 33 studies on the persistent symptoms of chronic/long COVID-19, finding that fatigue, dyspnea, headache, and depression are among the most frequently reported symptoms. Female gender and prior hospitalization were identified as risk factors for these long-term effects.
Review
Medicine, Research & Experimental
Ani Nalbandian, Amar D. Desai, Elaine Y. Wan
Summary: An estimated 10-15% of COVID-19 patients may develop post-COVID-19 condition, with common lingering symptoms such as shortness of breath, fatigue, high heart rate, and memory and cognitive dysfunction. The prevalence and duration of these symptoms remain uncertain due to heterogeneous research methods and limited patient follow-up. Risk factors may include female sex and underlying respiratory or psychiatric disease, and supportive therapies are the mainstay of treatment. Most patients experience symptom reduction within 1 year, but further research using standardized methods is needed to understand the pervasiveness and long-term consequences of this condition.
ANNUAL REVIEW OF MEDICINE
(2023)
Review
Multidisciplinary Sciences
Olga A. Sukocheva, Rebekah Maksoud, Narasimha M. Beeraka, SabbaRao V. Madhunapantula, Mikhail Sinelnikov, Vladimir N. Nikolenko, Margarita E. Neganova, Sergey G. Klochkov, Mohammad Amjad Kamal, Donald R. Staines, Sonya Marshall-Gradisnik
Summary: COVID-19 infection can lead to various pathologies and complications, exacerbating existing conditions in multiple body systems. Besides the respiratory organs, adverse effects of COVID-19 have been observed in the nervous, cardiovascular, gastrointestinal/metabolic, immune, and other systems. The post-COVID-19 condition shows overlapping symptoms with ME/CFS.
JOURNAL OF ADVANCED RESEARCH
(2022)
Review
Medicine, General & Internal
Marika Moller, Kristian Borg, Christer Janson, Maria Lerm, Johan Normark, Katarina Niward
Summary: The long-term effects of COVID-19 on cognitive function are a growing concern. Risk factors for cognitive dysfunction in post-COVID-19 condition include age, preexisting conditions, and severity of illness. The underlying mechanisms are not yet clear, but may involve neuroinflammation and hypoxia. Individual variation is large, requiring personalized assessments and treatments.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Rehabilitation
Chiara Arienti, Claudio Cordani, Stefano G. Lazzarini, Matteo J. Del Furia, Stefano Negrini, Carlotte Kiekens
Summary: This article aims to summarize the rehabilitation interventions for fatigue, post-exertional malaise, and orthostatic intolerance caused by post-COVID-19 condition based on the Cochrane evidence. The overall quality of the included evidence was low, but it can generate helpful hypotheses for clinical practice and future research.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Medicine, General & Internal
Sari Harenwall, Suzanne Heywood-Everett, Rebecca Henderson, Joanne Smith, Rachel McEnery, Amy R. Bland
Summary: This study explores the interaction between PTSS and breathlessness in exacerbating fatigue among individuals recovering from PCS. Regression analysis revealed a significant interaction between fatigue severity and both PTSS and breathlessness, and improvements in fatigue were significantly associated with improvements in PTSS. These findings highlight the importance of targeting PTSS in multidisciplinary rehabilitation for PCS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rehabilitation
Claudia B. Hentschel, Benjamin A. Abramoff, Timothy R. Dillingham, Liliana E. Pezzin
Summary: Although there are no significant racial differences in the utilization of outpatient rehabilitation services following COVID-19, African American/Black individuals are less likely to receive such services compared to their White counterparts. Hispanic individuals have higher utilization rates and a significantly higher incidence of post-COVID-19 fatigue.
Article
Medicine, Research & Experimental
N. Azcue, J. C. Gomez-Esteban, M. Acera, B. Tijero, T. Fernandez, N. Ayo-Mentxakatorre, T. Perez-Concha, A. Murueta-Goyena, J. V. Lafuente, A. Prada, A. Lopez de Munain, G. Ruiz-Irastorza, L. Ribacoba, I. Gabilondo, R. Del Pino
Summary: The symptomatology and cognitive patterns were similar in both groups, with greater impairment in ME/CFS. Physical problems and mood issues correlated with cognitive performance in post-COVID-19 patients, while anxiety symptoms and physical fatigue correlated with cognitive performance in ME/CFS patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Pediatrics
Terence Stephenson, Benjamin Allin, Manjula D. Nugawela, Natalia Rojas, Emma Dalrymple, Snehal Pinto Pereira, Manas Soni, Marian Knight, Emily Y. Cheung, Isobel Heyman, Roz Shafran
Summary: The objective of this study was to establish a research definition for 'Long COVID (post-COVID-19 condition)' in children and young people (CYP) to enable comparison of research studies. A three-phase online Delphi process and a consensus meeting were conducted. The research definition proposed includes a minimum duration of 12 weeks of persisting physical symptoms after initial testing, impacting everyday functioning and not explained by an alternative diagnosis, in young people with a history of confirmed SARS-CoV-2 infection. This is the first research definition of Long COVID in CYP and aligns with the clinical case definition proposed by the WHO.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Health Care Sciences & Services
Maha M. AlRasheed, Sinaa Al-Aqeel, Ghada I. Aboheimed, Noura M. AlRasheed, Norah Othman Abanmy, Ghadeer Abdulaziz Alhamid, Hadeel Mohammed Alnemari, Saad Alkhowaiter, Abdullah Rashed Alharbi, Fowad Khurshid, Khaled Trabelsi, Haitham A. Jahrami, Ahmed S. BaHammam
Summary: This study evaluated the impact of post-COVID-19 syndrome on individuals' quality of life, fatigue, and physical symptoms. It found that COVID-19 patients complained more frequently of weakness, muscle pain, respiratory symptoms, voice disorders, imbalance, taste and smell loss, and menstrual problems compared to noninfected individuals. COVID-19 patients scored lower on certain domains of quality of life and had higher fatigue severity.
Article
Clinical Neurology
Bach Xuan Tran, Tham Thi Nguyen, Hao Si Anh Nguyen, Laurent Boyer, Pascal Auquier, Guillaume Fond, Ha Thi Nhi Tran, Hung Manh Nguyen, Jongkwan Choi, Carl A. Latkin, Cyrus S. H. Ho, Syeda F. Husain, Roger S. McIntyre, Melvyn W. B. Zhang, Roger C. M. Ho
Summary: This study evaluated the potential of portable fNIRS as an adjunct diagnostic tool for bipolar and unipolar disorders during cognitive tasks. The study found differences in hemodynamics measured by fNIRS between bipolar and unipolar disorder patients during cognitive tasks. Therefore, assessing hemodynamics using portable fNIRS during cognitive tasks may serve as an adjunct diagnostic tool for mood disorders in low-resource environments.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Taeho Greg Rhee, Emily S. Gillissie, Andrew A. Nierenberg, Roger S. McIntyre
Summary: This study aimed to investigate the associations between current and remitted bipolar disorder and health-related quality of life. The results showed that both current BD and BD in remission were associated with lower mental HRQOL, but these associations were no longer significant when accounting for behavioral co-morbidities. Therefore, it is important to treat both the disorder and the co-morbidities to improve HRQOL in these patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Shakila Meshkat, Roger C. Ho, Bing Cao, Kayla M. Teopiz, Joshua D. Rosenblat, Taeho Greg Rhee, Joshua D. Di Vincenzo, Felicia Ceban, Muhammad Youshay Jawad, Roger S. McIntyre
Summary: Ketamine, a NMDA receptor antagonist, has rapid acting antidepressant effect with high efficacy. However, not all patients respond to ketamine and some may even experience symptom deterioration. The discovery of repeatable and mechanistically relevant biomarkers is needed for treatment response prediction.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Emily S. Gillissie, Gia Han Le, Taeho Greg Rhee, Bing Cao, Joshua D. Rosenblat, Rodrigo B. Mansur, Roger C. Ho, Roger S. McIntyre
Summary: This meta-analysis examined the relationship between anhedonia and suicidality, and found a significant and moderate correlation between the two, especially in psychiatric populations. The results suggest that anhedonia may be a core risk factor for suicidal ideation and behaviors.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Houman Rashidian, Mehala Subramaniapillai, Caroline Park, Orly Lipsitz, Hannah Zuckerman, Bing Cao, Yena Lee, Hartej Gill, Roger Nelson Rodrigues, Joshua D. Di Vincenzo, Michelle Iacobucci, Saja Jaberi, Joshua D. Rosenblat, Roger S. McIntyre, Rodrigo B. Mansur
Summary: This study assessed changes in insulin resistance (IR) after antidepressant treatment and found that exacerbation of IR mediated non-response to treatment. In contrast, responders showed a reduction in IR. These findings further elucidate the role of IR in antidepressant response.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Trisha Suppes, Suresh Durgam, Susan G. Kozauer, Richard Chen, Hassan D. Lakkis, Robert E. Davis, Andrew Satlin, Kimberly E. Vanover, Sharon Mates, Roger S. McIntyre, Mauricio Tohen
Summary: This study evaluated the efficacy and safety of Lumateperone as adjunctive therapy to lithium or valproate for patients with bipolar depression. The results showed that adjunctive Lumateperone 42mg significantly improved depression symptoms in patients with bipolar I or bipolar II disorder. The treatment was well tolerated with minimal side effects.
Article
Psychiatry
Wenyan Li, Wenjian Lai, Lan Guo, Wanxin Wang, Xiuwen Li, Liwan Zhu, Jingman Shi, Kayla M. Teopiz, Roger S. McIntyre, Ciyong Lu
Summary: This study found that childhood maltreatment is a major risk factor for adolescent depression. It also revealed that self-esteem and internalizing problems mediate the relationship between childhood maltreatment and depressive symptoms, while externalizing problems play an independent mediating role. Furthermore, sex differences need to be considered in prevention and intervention strategies.
Article
Medicine, General & Internal
Roger S. McIntyre, Lisa Bloudek, Jack Y. Timmons, Patrick Gillard, Amanda Harrington
Summary: This study assessed the cost-effectiveness of the Rapid Mood Screener (RMS) in identifying bipolar I disorder in patients with major depressive disorder. The results demonstrated that screening with the RMS can lead to cost savings and reduce misdiagnosis in patients with depressive symptoms.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Clinical Neurology
Roger S. McIntyre, Suresh Durgam, Susan G. Kozauer, Richard Chen, Jason Huo, Robert E. Davis, Andrew J. Cutler
Summary: A recent Phase 3 study showed that lumateperone 42 mg monotherapy effectively improved symptoms of depression in patients with bipolar depression. The study analyzed the change in MADRS scores and found significant improvements in individuals with bipolar I and bipolar II disorder.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Clinical Neurology
Giacomo d'Andrea, Mauro Pettorruso, Giorgio Di Lorenzo, Gianluca Mancusi, Roger S. McIntyre, Giovanni Martinotti
Summary: Ketamine and esketamine have generated significant interest as potential therapeutic agents for Treatment-Resistant Depression (TRD). This article provides a comprehensive overview of their action and highlights their effectiveness on mixed features, anxiety, dysphoric mood, and bipolar traits. The complex pharmacodynamic mechanisms of action are discussed, and further research is needed to evaluate the efficacy of esketamine nasal spray in bipolar depression and the potential role of these substances as mood stabilizers.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Keith M. Harris, Lu Wang, Guanglun M. Mu, Yanxia Lu, Cheryl So, Wei Zhang, Jing Ma, Kefei Liu, Wei Wang, Melvyn Wei-bin Zhang, Roger C. Ho
Summary: Clinicians face challenges in providing accurate and useful mental health assessments, especially in emergency situations. The development of a reliable and accessible Suicidality Scale (SS) addresses the urgent need for better suicide risk assessment tools. Through rigorous testing and validation, the SS has demonstrated strong psychometric properties and is applicable to diverse populations. This open-source scale represents a significant advancement in accurate assessment for individuals aged 13 and older.
Review
Genetics & Heredity
Jiangbo Ying, Qian Hui Chew, Roger S. McIntyre, Kang Sim
Summary: Treatment-resistant schizophrenia (TRS) is difficult to treat and has a negative impact on patients' quality of life. Clozapine is effective for TRS but has side effects. This review summarizes the current genetic factors associated with TRS, clozapine resistance, and side effects. Further research is needed to identify risk genes and understand the interactions between genes and relevant clinical factors in TRS treatment.
Review
Clinical Neurology
Dania Akbar, Taeho Greg Rhee, Felicia Ceban, Roger Ho, Kayla M. Teopiz, Bing Cao, Mehala Subramaniapillai, Angela T. H. Kwan, Joshua D. Rosenblat, Roger S. McIntyre
Summary: This systematic review assessed the efficacy, safety, and mechanisms of action of AXS-05 in adults with major depressive disorder (MDD). The results showed that AXS-05 had a significant effect in reducing depression severity and was well-tolerated. The findings also supported the role of glutamatergic and sigma 1 signaling in the pathophysiology of MDD.
