Role of E542 and E545 missense mutations of PIK3CA in breast cancer: a comparative computational approach

Biophysical aspect of phosphatidylinositol 3-kinase and role of oncogenic mutants (E542K & E545K)

(2016) Namrata Kalsi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Influence of V54M mutation in giant muscle protein titin: a computational screening and molecular dynamics approach

(2016) D. Thirumal Kumar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

DNA Repair Gene (XRCC1) Polymorphism (Arg399Gln) Associated with Schizophrenia in South Indian Population: A Genotypic and Molecular Dynamics Study

(2016) S. P. Sujitha et al.   PLoS One

Binding and molecular dynamic studies of sesquiterpenes (2R-acetoxymethyl-1,3,3-trimethyl-4t-(3-methyl-2-buten-1-yl)-1t-cyclohexanol) derived from marine Streptomyces sp. VITJS8 as potential anticancer agent

(2015) S. Jemimah Naine et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

DelPhiPKa web server: predicting pKaof proteins, RNAs and DNAs

(2015) Lin Wang et al.   BIOINFORMATICS

Deciphering the impact of somatic mutations in exon 20 and exon 9 ofPIK3CAgene in breast tumors among Indian women through molecular dynamics approach

(2015) N. Sudhakar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Abstract 4165: Differential pathway activation associated with domain-specific PIK3CA mutations

(2015) Christina Yau et al.   CANCER RESEARCH

PIK3CA Gene Amplification and PI3K p110α Protein Expression in Breast Carcinoma

(2014) Mohammad Firoozinia et al.   International Journal of Medical Sciences

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

Hotspot mutations in PIK3CA associate with first-line treatment outcome for aromatase inhibitors but not for tamoxifen

(2013) Diana E. Ramirez-Ardila et al.   BREAST CANCER RESEARCH AND TREATMENT

Akt SUMOylation Regulates Cell Proliferation and Tumorigenesis

(2013) R. Li et al.   CANCER RESEARCH

Analysis of PIK3CA Mutations in Breast Cancer Subtypes

(2013) Ruza Arsenic et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R

(2013) D S Meyer et al.   Oncogenesis

Predicting the Functional, Molecular, and Phenotypic Consequences of Amino Acid Substitutions using Hidden Markov Models

(2012) Hashem A. Shihab et al.   HUMAN MUTATION

Investigating the Structural Impacts of I64T and P311S Mutations in APE1-DNA Complex: A Molecular Dynamics Approach

(2012) C. George Priya Doss et al.   PLoS One

Predicting the Functional Effect of Amino Acid Substitutions and Indels

(2012) Yongwook Choi et al.   PLoS One

PIK3CA mutations in human solid tumors: Role in sensitivity to various therapeutic approaches

(2011) Giovanni Ligresti et al.   CELL CYCLE

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

HER3 Comes of Age: New Insights into Its Functions and Role in Signaling, Tumor Biology, and Cancer Therapy

(2010) M. R. Campbell et al.   CLINICAL CANCER RESEARCH

Characterization ofBRCA1andBRCA2deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study

(2010) Åke Borg et al.   HUMAN MUTATION

A Synonymous Single Nucleotide Polymorphism in ΔF508CFTRAlters the Secondary Structure of the mRNA and the Expression of the Mutant Protein

(2010) Rafal A. Bartoszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIK3CA Hotspot Mutation Scanning by a Novel and Highly Sensitive High-Resolution Small Amplicon Melting Analysis Method

(2010) Panagiotis A. Vorkas et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Identification of deleterious mutations within three human genomes

(2009) S. Chun et al.   GENOME RESEARCH

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Hotspot mutations of PIK3CA and AKT1 genes are absent in multiple myeloma

(2009) Said I. Ismail et al.   LEUKEMIA RESEARCH

A frequent kinase domain mutation that changes the interaction between PI3K  and the membrane

(2009) D. Mandelker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

REMO: A new protocol to refine full atomic protein models from C-alpha traces by optimizing hydrogen-bonding networks

(2009) Yunqi Li et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap

(2008) A. D. Johnson et al.   BIOINFORMATICS

The PIK3CA Gene as a Mutated Target for Cancer Therapy

(2008) John Gustin et al.   CURRENT CANCER DRUG TARGETS

PBEQ-Solver for online visualization of electrostatic potential of biomolecules

(2008) Sunhwan Jo et al.   NUCLEIC ACIDS RESEARCH

Helical domain and kinase domain mutations in p110  of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

(2008) L. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA