Article
Neurosciences
Bridget R. Mueller, Carly Ray, Alyha Benitez, Jessica Robinson-Papp
Summary: Abnormal autonomic reflexes may be associated with the development of POTS and chronic headache in patients with headache, according to a retrospective analysis of autonomic function testing data from 2018 to 2022.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Sameer M. Jamal, David B. Landers, Steven M. Hollenberg, Zoltan G. Turi, Taya Glotzer, Jana Tancredi, Joseph E. Parrillo
Summary: This study performed head-up tilt table (HUTT) testing in symptomatic patients with post-acute sequela of COVID-19 (PASC), revealing orthostatic intolerance suggestive of autonomic dysfunction in nearly all subjects. Patients with provoked orthostatic intolerance (POI) showed earlier improvement of symptoms compared to those with postural orthostatic tachycardia syndrome (POTS).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Artur Fedorowski, Monika Fagevik Olsen, Frida Nikesjo, Christer Janson, Judith Bruchfeld, Maria Lerm, Kristofer Hedman
Summary: A significant proportion of COVID-19 patients experience persistent health issues after recovering from the acute infection. This condition, known as post-COVID-19, can involve a wide range of symptoms affecting various organs and systems, leading to prolonged sick-leave and limited daily activities. This review focuses on the symptoms associated with cardiovascular and respiratory systems in adults, explores the potential underlying mechanism of chronic autonomic dysfunction, and discusses available treatment options.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Health Care Sciences & Services
C. (Linda) M. C. van Campen, Frans C. Visser
Summary: Hemodynamic abnormalities of a tilt test in long-haul COVID-19 patients change over time. Patients studied early in the disease course mainly exhibit POTS, while those studied later mainly show normHRBP or OH. Additionally, abnormal cerebral blood flow improves over time, but remains abnormal.
Review
Rehabilitation
Chiara Arienti, Claudio Cordani, Stefano G. Lazzarini, Matteo J. Del Furia, Stefano Negrini, Carlotte Kiekens
Summary: This article aims to summarize the rehabilitation interventions for fatigue, post-exertional malaise, and orthostatic intolerance caused by post-COVID-19 condition based on the Cochrane evidence. The overall quality of the included evidence was low, but it can generate helpful hypotheses for clinical practice and future research.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Medicine, Research & Experimental
N. Azcue, R. Del Pino, M. Acera, T. Fernandez-Valle, N. Ayo-Mentxakatorre, T. Perez-Concha, A. Murueta-Goyena, J. V. Lafuente, A. Prada, A. Lopez de Munain, G. Ruiz Irastorza, D. Martin-Iglesias, L. Ribacoba, I. Gabilondo, J. C. Gomez-Esteban, B. Tijero-Merino
Summary: The study compared autonomic and neuropathic symptoms in patients with post-COVID condition, ME/CFS, and healthy controls. The results showed significant differences between groups in heart rate, with the ME/CFS group having the highest rate. A high percentage of ME/CFS patients had Postural Orthostatic Tachycardia Syndrome (POTS) and pathological results in Sudoscan testing. Prolonged latencies for heat stimuli were observed in ME/CFS patients, suggesting damage to unmyelinated fibers. Lower parasympathetic activation was associated with worse cognitive performance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Alex Buoite Stella, Giovanni Furlanis, Nicolo Arjuna Frezza, Romina Valentinotti, Milos Ajcevic, Paolo Manganotti
Summary: The study revealed that dysautonomia may be a possible complication in post-COVID individuals, presenting symptoms such as orthostatic intolerance, sudomotor dysfunction, gastrointestinal issues, and pupillomotor dysfunction. Patients with neurological symptoms had a higher COMPASS-31 score due to more severe orthostatic intolerance symptoms compared to those without neurological symptoms.
JOURNAL OF NEUROLOGY
(2022)
Article
Nursing
Aubrey George, Blaine Winters
Summary: Postural orthostatic tachycardia syndrome (POTS) is a debilitating chronic illness characterized by sustained tachycardia upon standing and multisystem symptoms. Despite affecting millions, a majority of healthcare providers were unaware of POTS in 2019. Misdiagnosis with psychological conditions is common among POTS patients, leading to prolonged delays in proper diagnosis and treatment. Understanding the relationship between autonomic compensation and hemodynamic stability can aid in the recognition and management of POTS. This report aims to provide nurse practitioners with a practical guide for recognizing, diagnosing, managing, and educating patients with POTS.
JNP- THE JOURNAL FOR NURSE PRACTITIONERS
(2023)
Article
Geriatrics & Gerontology
Alexandra M. Hogan, Claire Luck, Sarah Woods, Andrea Ortu, Svet Petkov
Summary: Exacerbation or new onset orthostatic hypotension in perioperative patients may lead to post-operative complications, especially in frail and older patients. This study found that patients with pre-operative orthostatic hypotension were more likely to experience falls, dizziness, and unsteadiness post-operatively. Further research into modifiable perioperative risk factors associated with orthostatic hypotension is necessary to improve patient outcomes.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Review
Cardiac & Cardiovascular Systems
Cameron K. Ormiston, Iwona Swiatkiewicz, Pam R. Taub
Summary: Postural orthostatic tachycardia syndrome (POTS) is a complex multisystem disorder characterized by orthostatic intolerance and tachycardia that may be triggered by viral infection. Recent reports indicate that a significant number of COVID-19 survivors develop POTS or POTS-like symptoms within a few months of infection. The pathophysiological mechanisms of post-COVID-19 POTS are not well understood, but hypotheses include autoimmunity, autonomic dysfunction, and central nervous system invasion by the SARS-CoV-2 virus. Practitioners should actively assess POTS in patients with post-acute COVID-19 symptoms and consider lifestyle modifications and medication for treatment.
Article
Clinical Neurology
Brent P. Goodman, Julie A. Khoury, Janis E. Blair, Marie F. Grill
Summary: This study reported a case series of dysautonomia associated with COVID-19 infection in 6 patients. While all patients presented typical symptoms like fatigue and activity intolerance, autonomic testing results varied, with postural tachycardia, orthostatic hypotension, and postural hypertension observed in different patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Melanie Dani, Andreas Dirksen, Patricia Taraborrelli, Miriam Torocastro, Dimitrios Panagopoulos, Richard Sutton, Phang Boon Lim
Summary: The COVID-19 pandemic has caused unprecedented morbidity, mortality, and disruption, with a new syndrome known as 'long COVID' emerging among survivors. This syndrome, characterized by debilitating symptoms like breathlessness and palpitations, may be related to autonomic nervous system disruption post-infection. Physicians should recognize and support individuals with 'long COVID' symptoms, with a focus on managing the underlying impaired autonomic physiology.
Review
Cardiac & Cardiovascular Systems
Karan R. Chadda, Ellen E. Blakey, Christopher L. -H. Huang, Kamalan Jeevaratnam
Summary: While the increased arrhythmic tendency during acute COVID-19 infection is recognised, the long-term cardiac electrophysiological complications are less well known. Patients with long COVID, which refers to ongoing symptoms post-infection, may experience dysautonomia, particularly postural orthostatic tachycardia syndrome (POTS). The underlying mechanisms of these complications include hypovolaemia, neurotropism, inflammation, and autoimmunity. Limited treatment options are available for POTS and other long COVID symptoms, and future research should focus on elucidating the underlying mechanisms and developing targeted therapies. It is also important for healthcare professionals to be educated on recognizing complications and conditions arising from COVID-19, such as POTS, to enable prompt diagnosis and access to early treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Infectious Diseases
Joan Bosco, Ruwanthi Titano
Summary: Dysautonomia as a consequence of COVID-19 infection is becoming more prevalent. This case report highlights a non-hospitalized patient with mild initial presentation but severe and debilitating dysautonomia symptoms. Further research on its pathophysiology and treatment is needed.
BMC INFECTIOUS DISEASES
(2022)
Article
Physiology
Ann Monaghan, Glenn Jennings, Feng Xue, Lisa Byrne, Eoin Duggan, Roman Romero-Ortuno
Summary: In this observational cross-sectional study, predictors of orthostatic intolerance (OI) in adults with long COVID symptoms were investigated. OI was found to be associated with female sex, fatigue, depressive symptoms, inability to perform daily activities, and higher heart rate at the lowest systolic blood pressure point. However, initial orthostatic hypotension and classical orthostatic hypotension were not correlated with OI.
FRONTIERS IN PHYSIOLOGY
(2022)
Editorial Material
Infectious Diseases
Miguel Sogbe, Andres Blanco-Di Matteo, I. Madeleine Di Frisco, Jose Luis del Pozo
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2023)
Review
Microbiology
Emilio Bouza, Miguel Martin, Jose Enrique Ales, Nuria Aragones, Begona Barragan, Rafael de la Camara, Jose Luis Del Pozo, Valentin Garcia-Gutierrez, Ramon Garcia-Sanz, Diego Gracia, Vicente Guillem, Victor Jimenez-Yuste, Mari Cruz Martin-Delgado, Joaquin Martinez, Rafael Lopez, Alvaro Rodriguez-Lescure, Julian Ruiz Galiana, Ana Maria Sureda, Francisco Tejerina-Picado, Antoni Trilla, Antonio Zapatero, Esteban Palomo, Jesus San-Miguel
Summary: The exact number of solid organ tumors diagnosed each year in Spain is unknown, making it difficult to determine if the pandemic has led to a decrease in cancer diagnoses. However, indirect data suggests that the pandemic has resulted in later-stage diagnoses for some non-hematological neoplasms. Although there is a lack of strong evidence, oncology patients who contract COVID-19 appear to have poorer outcomes. The immune response to infection in cancer patients is influenced by factors such as the type of neoplasia, treatment received, and timing of treatment.
REVISTA ESPANOLA DE QUIMIOTERAPIA
(2023)
Article
Microbiology
Andres Blanco-Di Matteo, Nuria Garcia-Fernandez, Aitziber Aguinaga Perez, Francisco Carmona-Torre, Amaya C. Oteiza, Jose Leiva, Jose Luis Del Pozo
Summary: This study aimed to determine the best antimicrobial lock therapy (ALT) to eradicate coagulase-negative staphylococci (CoNS) biofilms, addressing the challenge of tunneled central venous catheter (TCVC) related infection in hemodialysis patients. The study found that daptomycin lock therapy achieved the highest eradication rate compared to the standard of care (SoC).
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Letter
Medicine, General & Internal
Miguel Sogbe, Ana Ezponda, Jose Luis del Pozo
Article
Immunology
Alejandro Fernandez-Montero, Jon Zuaznabar, Manuel Pina-Sanchez, Sheila Maestro, Loreto Martin-Navarro, Natalia Munoz-Rodriguez, Cristina Olague, Marta Pastrana, Maria Martinez-Fernandez, Gracian Camps, Jose Antonio Rodriguez, Francesco P. Marchese, Jon Zazpe, Marta Pozuelo, Jose Luis Del Pozo, Jorge Quiroga, Antonio Pineda-Lucena, Gabriel Reina, Jack Kolenda, Laura Moreno-Galarraga, Gloria Gonzalez-Aseguinolaza, Marta Rua, Cristian Smerdou, Francisco Carmona-Torre, Josepmaria Argemi
Summary: The study aimed to evaluate the efficacy of intranasal photodynamic therapy (PDT) in reducing the infectivity period in mildly symptomatic SARS-CoV-2 carriers. The study also analyzed the immune-stimulating effects and safety of PDT. The results showed that intranasal PDT reduced infectivity on day 3 post-treatment and increased the probability of PCR negativity on day 7. It also decelerated the decline of SARS-CoV-2 specific immune responses.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Marta Rua, Jon Ander Simon, Maria Collantes, Margarita Ecay, Jose Leiva, Francisco Carmona-Torre, Rocio Ramos, Felix Pareja, Krishna R. Pulagam, Jordi Llop, Jose Luis Del Pozo, Ivan Penuelas
Summary: This study tested two new radiotracers, [F-18]FDS and [F-18]FPABA, and examined their effectiveness in vitro and in an animal model. The results showed that [F-18]FDS can visualize Enterobacterales myositis infection and differentiate between yeasts with differential sorbitol assimilation. [F-18]FPABA was able to detect all tested bacteria and yeasts in vitro and distinguish between inflammation and infection in the animal model.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Surgery
Carlos Berniz, Francisco Carmona-Torre, Cristina Gomez-Martinez, Leire Fernendez-Ciriza, Jose Luis del Pozo, Bernardo Hontanilla
Summary: This study compares the differences in development and behavior of breast implant capsules among the major types and textures of implants available on the market. Implants with highly textured surfaces showed the highest levels of collagen and cellularity in the capsules. Nanotextured and microtextured implants were less susceptible to developing capsular contracture compared to smooth implants. The findings emphasize the importance of the implant surface in the development of capsule-related pathologies.
AESTHETIC PLASTIC SURGERY
(2023)
Article
Public, Environmental & Occupational Health
Fares Amer, Mario Gil-Conesa, Silvia Carlos, Arturo H. Arino, Francisco Carmona-Torre, Miguel A. Martinez-Gonzalez, Alejandro Fernandez-Montero
Summary: The aim of the study was to analyze the factors associated with increased risk of SARS-CoV-2 infection in a university environment with in-person lectures during the COVID-19 pandemic. A cohort study was conducted in a university in Navarra, Spain, involving 10,959 participants. The study found that living in college or residence, using motor transportation, having South American origin, and belonging to a specific campus were associated with increased risk of COVID-19.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Letter
Medicine, General & Internal
Miguel Sogbe, Cesar Urtasun, Jose Luis del Pozo
Article
Infectious Diseases
Federico Becerra-Aparicio, Silvia Gomez-Zorrilla, Marta Hernandez-Garcia, Desire Gijon, Ana Siverio, Damaris Berbel, Carlos Sanchez-Carrillo, Emilia Cercenado, Alba Rivera, Ana de Malet, Mariona Xercavins, Enrique Ruiz de Gopegui, Luis Canoura-Fernandez, Jose Antonio Martinez, Cristina Seral, Jose Luis Del Pozo, Manuel Cotarelo, Jazmin Diaz-Reganon, Rafael Canton, Antonio Oliver, Juan Pablo Horcajada, Patricia Ruiz-Garbajosa
Summary: This study aimed to evaluate the microbiological characteristics of Escherichia coli causing healthcare-associated bacteraemia of urinary origin (HCA-BUO) in Spain, with a focus on ESBL producers and isolates belonging to the high-risk clone ST131. ST131 HiRC was found to be the main driver of ESBL-producing E. coli in HCA-BUO in Spain, with the expansion of subclades CTX-M-15-C2/H30-Rx and CTX-M-27-C1/H30-R1. ST131 infection was associated with more complex patients and prior use of cephalosporins, but not with worse clinical outcomes.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Medicine, General & Internal
Francisco Javier Candel, Miguel Salavert, Angel Estella, Miquel Ferrer, Ricard Ferrer, Julio Javier Gamazo, Carolina Garcia-Vidal, Juan Gonzalez del Castillo, Victor Jose Gonzalez-Ramallo, Federico Gordo, Manuel Miron-Rubio, Javier Perez-Pallares, Cristina Pitart, Jose Luis del Pozo, Paula Ramirez, Pedro Rascado, Soledad Reyes, Patricia Ruiz-Garbajosa, Borja Suberviola, Pablo Vidal, Rafael Zaragoza
Summary: Nosocomial pneumonia and ventilator-associated pneumonia are significant global health problems, causing high morbidity and mortality rates. This scientific manuscript reviews important aspects of the management of these infectious respiratory syndromes, providing updates on etiological perspectives, diagnostic techniques, treatment options, and preventive strategies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alba Cristina Igual-Rouilleault, Ignacio Soriano, Paola Leonor Quan, Gabriel Reina, Jose Luis del Pozo, Alvaro Gonzalez, Leire Fernandez-Ciriza, Alejandro Fernandez-Montero, Luis Pina, Arlette Elizalde
Summary: The study aimed to investigate the association between ultrasound cortical thickness in reactive post-vaccination lymph nodes and the elicited humoral response in patients with and without a previous history of COVID-19 infection. The results showed that total antibodies were significantly higher in patients with a previous history of COVID-19 infection. Furthermore, there was a significant association between cortical thickness and effective humoral response, indicating that ultrasound cortical thickness can be used as a predictor of vaccine effectiveness.
EUROPEAN RADIOLOGY
(2023)