Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells

Virtual screening, docking, and dynamics of potential new inhibitors of dihydrofolate reductase fromYersinia pestis

(2016) Leonardo da Costa Bastos et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Quartz crystal microbalance with dissipation and microscale thermophoresis as tools for investigation of protein complex formation between thymidylate synthesis cycle enzymes

(2015) Anna Antosiewicz et al.   BIOSENSORS & BIOELECTRONICS

Substrate channeling between the human dihydrofolate reductase and thymidylate synthase

(2015) Nuo Wang et al.   PROTEIN SCIENCE

Origins of the specificity of inhibitor P218 toward wild-type and mutantPfDHFR: a molecular dynamics analysis

(2014) Sheenu Abbat et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Serine Hydroxymethyltransferase Anchorsde NovoThymidylate Synthesis Pathway to Nuclear Lamina for DNA Synthesis

(2012) Donald D. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Computational study of the effects of protein tyrosine nitrations on the catalytic activity of human thymidylate synthase

(2012) Adam Jarmuła et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Probing the structure of Leishmania major DHFR TS and structure based virtual screening of peptide library for the identification of anti-leishmanial leads

(2012) Rajalakshmi Rajasekaran et al.   JOURNAL OF MOLECULAR MODELING

On the binding affinity of macromolecular interactions: daring to ask why proteins interact

(2012) P. L. Kastritis et al.   Journal of the Royal Society Interface

Protein–protein interaction inhibitors get into the groove

(2012) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Trypanosomal Dihydrofolate Reductase Reveals Natural Antifolate Resistance

(2011) Jarunee Vanichtanankul et al.   ACS Chemical Biology

Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase fromBabesia bovis

(2011) Darren W. Begley et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Transcription factors LSF and E2Fs: Tandem cyclists driving G0 to S?

(2011) Ulla Hansen et al.   CELL CYCLE

Nuclear Localization ofde NovoThymidylate Biosynthesis Pathway Is Required to Prevent Uracil Accumulation in DNA

(2011) Amanda J. MacFarlane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of thymidylate synthase from various sources by human protein kinase CK2 and its catalytic subunits

(2010) Tomasz Frączyk et al.   BIOORGANIC CHEMISTRY

Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations

(2010) Tingjun Hou et al.   Journal of Chemical Information and Modeling

Probing the structure of Leishmania donovani chagasi DHFR-TS: comparative protein modeling and protein–ligand interaction studies

(2010) Lakshmi Maganti et al.   JOURNAL OF MOLECULAR MODELING

miR-192/miR-215 Influence 5-Fluorouracil Resistance through Cell Cycle-Mediated Mechanisms Complementary to Its Post-transcriptional Thymidilate Synthase Regulation

(2010) Valentina Boni et al.   MOLECULAR CANCER THERAPEUTICS

Achieving reliability and high accuracy in automated protein docking: Cluspro, PIPER, SDU, and stability analysis in CAPRI rounds 13-19

(2010) Dima Kozakov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Crystal Structure of Bacillus anthracis Dihydrofolate Reductase with the Dihydrophthalazine-Based Trimethoprim Derivative RAB1 Provides a Structural Explanation of Potency and Selectivity

(2009) C. R. Bourne et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Kinetic and Structural Characterization of Dihydrofolate Reductase fromStreptococcus pneumoniae

(2009) Jeeyeon Lee et al.   BIOCHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Identification of genes conferring resistance to 5-fluorouracil

(2009) B. K. Yoo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RosettaDock server for local protein-protein docking

(2008) S. Lyskov et al.   NUCLEIC ACIDS RESEARCH