Review
Pharmacology & Pharmacy
Dragan Primorac, Martin Cemerin, Vid Matisic, Vilim Molnar, Marko Strbad, Lenart Girandon, Lucija Zenic, Miomir Knezevic, Stephen Minger, Denis Polancec
Summary: The COVID-19 pandemic has had a significant impact globally and the overaggressive immune reaction in response to the virus can lead to ARDS. Mesenchymal stromal cell therapy presents a potential treatment option for severe patients.
Review
Pharmacology & Pharmacy
Elena Munoz-Perez, Ainhoa Gonzalez-Pujana, Manoli Igartua, Edorta Santos-Vizcaino, Rosa Maria Hernandez
Summary: The secretome of MSCs, composed of soluble factors and extracellular vesicles, has shown promising immunomodulatory effects for treating IMIDs by controlling inflammatory processes. Although this new therapy holds potential, there are still challenges to be addressed in its composition, production, application, and delivery methods.
Article
Immunology
Behnam Sadeghi, Olle Ringden, Britt Gustafsson, Markus Castegren
Summary: Acute respiratory distress syndrome (ARDS) is a life-threatening lung disease. Mesenchymal stromal cells (MSCs) have been evaluated as a therapy for ARDS, and the use of MSCs for ARDS induced by Covid-19 has shown positive results. Clinical and experimental studies have demonstrated the effectiveness of MSCs in treating sepsis and ARDS.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ali Hazrati, Kosar Malekpour, Sara Soudi, Seyed Mahmoud Hashemi
Summary: Liver tissue can be damaged by various factors, resulting in acute or chronic liver damage and potentially leading to serious conditions such as cirrhosis and liver carcinoma. Liver transplantation is the main treatment, but its limitations include a scarcity of donors, tissue rejection, immunosuppression, and high cost. Cell therapy, particularly using mesenchymal stem cells (MSCs), has gained attention as an alternative treatment due to their regenerative properties. However, MSC therapy also has limitations, and the use of MSC-derived extracellular vesicles (EVs) such as exosomes can provide a potential solution by promoting liver tissue repair and preventing disease progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Katia Nunes da Silva, Priscila Carvalho Guedes Pinheiro, Andre Luiz Nunes Gobatto, Rogerio da Hora Passos, Bruno Diaz Paredes, Luciana Souza de Arago Franca, Carolina Kymie Vasques Nonaka, Beatriz Barreto-Duarte, Mariana Araujo-Pereira, Rafael Tiburcio, Fernanda Ferreira Cruz, Gabriele Louise Soares Martins, Bruno B. Andrade, Hugo Caire de Castro-Faria-Neto, Patricia Rieken Macedo Rocco, Bruno Solano de Freitas Souza
Summary: This case report demonstrated the reduction of both lung inflammation and fibrosis in a critically ill COVID-19 patient after MSC therapy, leading to significant clinical improvement and discharge from the hospital.
FRONTIERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Mehdi Najar, Makram Merimi, Wissam H. Faour, Catherine A. Lombard, Douaa Moussa Agha, Yassine Ouhaddi, Etienne M. Sokal, Laurence Lagneaux, Hassan Fahmi
Summary: This study explored the application of Foreskin-derived mesenchymal stromal/stem cells (FSK-MSCs) in immunotherapy. It was found that FSK-MSCs can interact with T cells and inflammatory signals, modulating the T cell response accordingly.
Review
Cell & Tissue Engineering
Alexander Markov, Lakshmi Thangavelu, Surendar Aravindhan, Angelina Olegovna Zekiy, Mostafa Jarahian, Max Stanley Chartrand, Yashwant Pathak, Faroogh Marofi, Somayeh Shamlou, Ali Hassanzadeh
Summary: MSCs, with their various chararcteristics and ability to differentiate into multiple cell types, possess a secretome that can modulate inflammatory responses and promote tissue repair/regeneration. Their immunomodulatory effects are achieved through the harmonious interaction of released signaling molecules and immune/target cells, making them potential therapeutic candidates for immune-mediated disorders.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Immunology
Zhiheng Xu, Yongbo Huang, Jianmeng Zhou, Xiumei Deng, Weiqun He, Xiaoqing Liu, Yimin Li, Nanshan Zhong, Ling Sang
Summary: Cell-based therapy using mesenchymal stromal cells (MSCs) has shown promising potential in treating critical illnesses like sepsis and ARDS, with abilities to reduce inflammation, improve lung function, and promote repair, although limited preclinical data is available for MSCs in COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell & Tissue Engineering
Kun Lu, Shi-tao Geng, Shikai Tang, Hua Yang, Wei Xiong, Fang Xu, Qijun Yuan, Xian Xiao, Renqiang Huang, Haihui Liang, Zhipeng Chen, Chuanyun Qian, Yang Li, Songqing Wang
Summary: This article systematically summarizes the clinical efficacy of mesenchymal stromal cells (MSCs) in the treatment of COVID-19 and elaborates on the possible mechanisms, providing a reference for further studies.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Alexandria Van Grouw, Maxwell B. Colonna, Ty S. Maughon, Xunan Shen, Andrew M. Larey, Samuel G. Moore, Carolyn Yeago, Facundo M. Fernandez, Arthur S. Edison, Steven L. Stice, Annie C. Bowles-Welch, Ross A. Marklein
Summary: Mesenchymal stromal cells (MSCs) have functional heterogeneity in immunomodulatory function. Metabolic profiling of MSCs during expansion process using nuclear magnetic resonance (NMR) and mass spectrometry (MS) identified predictive metabolites for MSC immunomodulatory function. Consensus intracellular metabolites included lipid classes while consensus media metabolites included proline, phenylalanine, and pyruvate. Pathway analysis revealed metabolic pathways associated with MSC function. This study provides a framework for identifying predictive metabolites and guiding MSC manufacturing efforts.
Article
Biochemistry & Molecular Biology
Ryan A. Denu, Peiman Hematti
Summary: MSCs have great potential for cellular therapy but are limited by tissue scarcity, requiring ex vivo expansion. Expansion and aging are associated with oxidative stress, highlighting the need for strategies to reduce it.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell & Tissue Engineering
Silvia Preciado, Sandra Muntion, Fermin Sanchez-Guijo
Summary: This review summarizes the potential of mesenchymal stromal cells to improve hematopoietic function through the secretion of extracellular vesicles after allogenic hematopoietic stem cell transplantation. It also discusses the advantages of EVs over MSCs, as well as the challenges and uncertainties that need to be addressed for their clinical application.
Article
Biochemistry & Molecular Biology
Beatriz Hernaez-Estrada, Ainhoa Gonzalez-Pujana, Andoni Cuevas, Ander Izeta, Kara L. L. Spiller, Manoli Igartua, Edorta Santos-Vizcaino, Rosa Maria Hernandez
Summary: Hair follicle-derived MSCs have unique immunomodulatory capacities and are advantageous as an alternative source due to their relatively painless and minimally risky extraction procedure. These cells show minimal responsiveness to pro-inflammatory environments, effectively inhibit the proliferation of peripheral blood mononuclear cells, promote the induction of regulatory T cells, and skew macrophages towards M2 phenotypes.
Review
Cell & Tissue Engineering
Samin Shokravi, Vitaliy Borisov, Burhan Abdullah Zaman, Firoozeh Niazvand, Raheleh Hazrati, Meysam Mohammadi Khah, Lakshmi Thangavelu, Sima Marzban, Armin Sohrabi, Amir Zamani
Summary: MSCs and their exosomes have shown promising therapeutic effects in the treatment of acute liver failure (ALF), promoting liver regeneration through various mechanisms. There is a wide range of MSCs-based strategies for ALF treatment, including the use of different types of MSCs and their derivatives in combination with other therapeutic molecules or modalities.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell & Tissue Engineering
Wang Aitong, Zhang Leisheng, Yu Hao
Summary: The outbreak of COVID-19 has become a global pandemic, posing a serious threat to public health. Mesenchymal stem/stromal cell (MSC)-based therapy has shown promise as an alternative treatment for severe pneumonia-associated acute respiratory distress syndrome (ARDS). However, the characteristics of MSC-based cytotherapy and the underlying mechanism for COVID-19-associated ARDS are still unknown. In this study, visual analyses were used to provide an overview of ARDS-associated updates, core authors, and focused issues. The study also summarized the comprehensive knowledge of keywords, authors, and institutions using specific software. Additionally, the molecular mechanisms, safety, and efficacy of MSC-based therapy for ARDS were discussed based on clinical trials.
CURRENT STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Behnam Sadeghi, Myrese Witkamp, Dominik Schefberger, Anna Arbman, Olle Ringden
Summary: Human placenta-derived decidua stromal cells (DSCs) have been used in clinical trials for the treatment of acute inflammatory diseases, but the mechanisms of action and interaction with other immune cells require further exploration.
Article
Virology
Caroline Aliane de Souza Prado, Dennyson Leandro M. Fonseca, Youvika Singh, Igor Salerno Filgueiras, Gabriela Crispim Baiocchi, Desiree Rodrigues Placa, Alexandre H. C. Marques, Raquel Costa Silva Dantas-Komatsu, Julia N. Usuda, Paula Paccielli Freire, Ranieri Coelho Salgado, Sarah Maria da Silva Napoleao, Rodrigo Nalio Ramos, Vanderson Rocha, Guangyan Zhou, Rusan Catar, Guido Moll, Niels Olsen Saraiva Camara, Gustavo Cabral de Miranda, Vera Lucia Garcia Calich, Lasse M. Giil, Neha Mishra, Florian Tran, Andre Ducati Luchessi, Helder I. Nakaya, Hans D. Ochs, Igor Jurisica, Lena F. Schimke, Otavio Cabral-Marques
Summary: In this study, the authors analyzed proteome and transcriptome data to investigate the alterations in cell cycle-associated molecules in COVID-19 patients. They found that the expression of cell cycle-associated genes and proteins was changed and correlated with disease severity and trajectories. These findings provide a comprehensive understanding of the distinct alterations in cell cycle regulation in COVID-19 patients and suggest potential therapeutic pathways.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Otavio Cabral-Marques, Guido Moll, Rusan Catar, Beate Preuss, Lukas Bankamp, Ann-Christin Pecher, Joerg Henes, Reinhild Klein, A. S. Kamalanathan, Reza Akbarzadeh, Wieke van Oostveen, Bettina Hohberger, Matthias Endres, Bryan Koolmoes, Nivine Levarht, Rudmer Postma, Vincent van Duinen, Anton Jan van Zonneveld, Jeska de Vries-Bouwstra, Cynthia Fehres, Florian Tran, Fernando Yuri Nery do Vale, Kamilla Batista da Silva Souza, Igor Salerno Filgueiras, Lena F. Schimke, Gabriela Crispim Baiocchi, Gustavo Cabral de Miranda, Dennyson Leandro Mathias da Fonseca, Paula Paccielli Freire, Alexander M. Hackel, Hanna Grasshoff, Anja Stahle, Antje Mueller, Ralf Dechend, Xinhua Yu, Frank Petersen, Franziska Sotzny, Thomas P. Sakmar, Hans D. Ochs, Kai Schulze-Forster, Harald Heidecke, Carmen Scheibenbogen, Yehuda Shoenfeld, Gabriela Riemekasten
AUTOIMMUNITY REVIEWS
(2023)
Article
Immunology
Pedro S. Couto, Nada Al-Arawe, Igor S. Filgueiras, Dennyson L. M. Fonseca, Irene Hinterseher, Rusan A. Catar, Raghavan Chinnadurai, Alexey Bersenev, Otavio Cabral-Marques, Guido Moll, Frances Verter
Summary: This study summarizes 195 clinical trials of advanced cell therapies targeting COVID-19 that were registered over the two years between January 2020 to December 2021. It also analyzes the cell manufacturing and clinical delivery experience of 26 trials that published their outcomes by July 2022. The study found that MSCs provide a relative risk reduction for all-cause COVID-19 mortality and highlights the important role that cell therapy products may play as an adjunct therapy in the management of COVID-19.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Immunology
Raghavan Chinnadurai, Sowmya Viswanathan, Guido Moll
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Dorota Sikorska, Dorota Kaminska, Rusan Catar, Dashan Wu, Hongfan Zhao, Pinchao Wang, Julian Kamhieh-Milz, Miroslaw Banasik, Mariusz Kusztal, Magdalena Cielecka, Michal Zakliczynski, Rafal Rutkowski, Katarzyna Korybalska, Harald Heidecke, Guido Moll, Wlodzimierz Samborski
Summary: Early identification of allograft vasculopathy and elimination of risk factors is important for improving the prognosis of heart transplant recipients. This pilot study used nailfold video-capillaroscopy to evaluate the microcirculation in heart transplant patients and found that abnormal capillaroscopic patterns were associated with traditional cardiovascular risk factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Hematology
Julian Kamhieh-Milz, Lei Chen, Claudia Goettsch, Anna Maria Pfefferkorn, Anja Hofmann, Coy Brunssen, Gregor M. Mueller, Thomas Walther, Muhammad Imtiaz Ashraf, Guido Moll, Henning Morawietz, Janusz Witowski, Rusan Catar
Summary: This study analyzed the mechanism by which NOX2 contributes to Ang II-induced ET-1 production in human microvascular endothelial cells. The results showed that high-fat diet increased the expression of Ang II and ET-1 in wild-type mice, but not in Nox2-deficient mice. In vitro experiments revealed that Ang II promoted NOX2 expression through induction of the Oct-1 protein and increased production of superoxide anions. Inhibition of Oct-1 and superoxide attenuated Ang II-induced ET-1 production.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Virology
Victor Bastos, Vinicius Pacheco, Erika D. L. Rodrigues, Cassia N. S. Moraes, Adriel L. Nobile, Dennyson Leandro M. Fonseca, Kamilla B. S. Souza, Fernando Y. N. do Vale, Igor S. Filgueiras, Lena F. Schimke, Lasse M. Giil, Guido Moll, Gustavo Cabral-Miranda, Hans D. Ochs, Pedro F. da Costa Vasconcelos, Guilherme D. de Melo, Herve Bourhy, Livia M. N. Casseb, Otavio Cabral-Marques
Summary: Rabies is a neuroinvasive viral disease with a high fatality rate, mainly affecting developing countries in Africa and Asia. It can be prevented through vaccination, but cases still occur in European countries and the United States. Factors such as population growth, increasing income levels, and the COVID-19 pandemic have led to a rise in the animal population, calling for preventive measures, postexposure prophylaxis, and a better understanding of the disease's pathophysiology.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Guido Moll, Christian Luecht, Michael Adu Gyamfi, Dennyson L. M. da Fonseca, Pinchao Wang, Hongfan Zhao, Zexian Gong, Lei Chen, Muhamad Imtiaz Ashraf, Harald Heidecke, Alexander Maximilian Hackel, Duska Dragun, Klemens Budde, Olaf Penack, Gabriela Riemekasten, Otavio Cabral-Marques, Janusz Witowski, Rusan Catar
Summary: This study investigates the immune stimulatory effects and signaling mechanisms of immunoglobulin G (IgG) from kidney transplant patients with and without allograft vasculopathy. The findings suggest that IgG from patients with vasculopathy can activate endothelial cells and induce the secretion of tumor necrosis factor alpha (TNF-alpha), leading to immune cell activation. The PAR1-AP-1/c-FOS-miRNA-let7 axis was identified as a crucial signaling pathway in this process.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Hongfan Zhao, Dashan Wu, Michael Adu Gyamfi, Pinchao Wang, Christian Luecht, Anna Maria Pfefferkorn, Muhammad Imtiaz Ashraf, Julian Kamhieh-Milz, Janusz Witowski, Duska Dragun, Klemens Budde, Ralf Schindler, Daniel Zickler, Guido Moll, Rusan Catar
Summary: Expanded hemodialysis therapy with improved molecular cut-off dialyzers has beneficial effects in reducing uremia-associated chronic systemic microinflammation, which is a driver of endothelial dysfunction and cardiovascular disease in hemodialysis patients. The transcription factor KLF2 and its associated molecular signaling pathways are identified as key targets and regulators in uremia-induced endothelial microinflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Julia Nakanishi Usuda, Desiree Rodrigues Placa, Dennyson Leandro M. Fonseca, Alexandre H. C. Marques, Igor Salerno Filgueiras, Victor Gabriel Bastos Chaves, Anny Silva Adri, Amanda Torrentes-Carvalho, Mario Hiroyuki Hirata, Paula Paccielli Freire, Rusan Catar, Gustavo Cabral-Miranda, Lena F. Schimke, Guido Moll, Otavio Cabral-Marques
Summary: This study characterizes the landscape of the interferome signature in DENV infection, highlighting the crucial role of interferome dynamics in the anti-dengue immune response, and identifies potential biomarkers for disease severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Crystal C. Uwazie, Bonnie M. Pirlot, Tyler U. Faircloth, Mihir Patel, Rhett N. Parr, Halie M. Zastre, Peiman Hematti, Guido Moll, Devi Rajan, Raghavan Chinnadurai
Summary: Introduces the importance of mesenchymal stromal/stem cells (MSCs) in human physiology and their response to the herbicide Atrazine. Describes the use of the combinatorial assay matrix approach/technology to assess the phenotype and function of MSCs exposed to Atrazine, highlighting its relevance in studying the impact of environmental xenobiotics on human cellular subset involved in regenerative healing responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Geriatrics & Gerontology
Dennyson Leandro M. Fonseca, Igor Salerno Filgueiras, Alexandre H. C. Marques, Elroy Vojdani, Gilad Halpert, Yuri Ostrinski, Gabriela Crispim Baiocchi, Desiree Rodrigues Placa, Paula P. Freire, Shahab Zaki Pour, Guido Moll, Rusan Catar, Yael Bublil Lavi, Jonathan I. Silverberg, Jason Zimmerman, Gustavo Cabral-Miranda, Robson F. Carvalho, Taj Ali Khan, Harald Heidecke, Rodrigo J. S. Dalmolin, Andre Ducati Luchessi, Hans D. Ochs, Lena F. Schimke, Howard Amital, Gabriela Riemekasten, Israel Zyskind, Avi Z. Rosenberg, Aristo Vojdani, Yehuda Shoenfeld, Otavio Cabral-Marques
Summary: Age is a significant risk factor for the severity of COVID-19 due to immunosenescence and age-dependent medical conditions. A cross-sectional study found that the natural production of autoantibodies increases with age and is exacerbated by SARS-CoV-2 infection, particularly in severe COVID-19 patients. Analysis of these autoantibodies revealed an age-dependent stratification of severe COVID-19 patients. Additionally, anti-cardiolipin and anti-platelet glycoprotein autoantibodies were found to significantly increase the likelihood of developing a severe COVID-19 phenotype with aging.
Article
Cell & Tissue Engineering
Chasen Cottle, Amanda Paige Porter, Ariel Lipat, Caitlin Turner-Lyles, Jimmy Nguyen, Guido Moll, Raghavan Chinnadurai
Summary: This review article examines the current state of cryopreservation technology in cellular therapy and its application to different types of cells. The authors discuss strategies for optimizing the cryopreservation process to enhance the safety and efficacy of cellular therapeutics.
CURRENT STEM CELL REPORTS
(2022)
Article
Cell & Tissue Engineering
Jayeeta Giri, Guido Moll
Summary: Long-distance space travel poses health risks to astronaut crews, including musculoskeletal and immune system decline, genetic mutations, and cancer risks. Current methods such as physical training, pharmacological agents, and protective shielding have limitations, indicating a need for new countermeasures. Mesenchymal stromal/stem cell therapy shows potential in protecting space travelers against harmful effects and optimizing their therapeutic benefit during long-distance manned space travel.
CURRENT STEM CELL REPORTS
(2022)