Article
Endocrinology & Metabolism
Nanna Maria Uldall Torp, Niels Henrik Bruun, Peter Astrup Christensen, Aase Handberg, Stig Andersen, Stine Linding Andersen
Summary: This study established a pregnancy-specific cutoff for TRAb and found that TRAb-negative hyperthyroidism is predominant in early pregnancy and rarely develops into hyperthyroidism later on.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Immunology
Xuan Ren, Hui Chen
Summary: Th9 and Th17 cells along with their cytokines IL-9 and IL-17 are significantly elevated in untreated GD patients, but decrease in remission. There is a positive correlation between TRAb titer and levels of Th9, Th17, and their cytokines, suggesting these cells may play a role in GD pathogenesis and prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Beata Pyrzak, Malgorzata Ruminska, Ewelina Witkowska-Sedek, Anna Kucharska
Summary: Maternal Graves' disease can cause various thyroid dysfunctions in newborns, including hyperthyroidism and hypothyroidism. This study found that transient hyperthyroidism was the most common thyroid dysfunction in newborns with neonatal hyperthyroidism, but central hypothyroidism can also occur.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Microbiology
Ruonan Liang, Shuaiyin Chen, Yuefei Jin, Ling Tao, Wangquan Ji, Peiyu Zhu, Dong Li, Yu Zhang, Weiguo Zhang, Guangcai Duan
Summary: CVA2 infection leads to HFMD outbreaks, causing systemic inflammatory response and central nervous system inflammation. This study reveals the involvement of the CXCL10/CXCR3 axis in CVA2 immunopathogenesis, with activation of this axis contributing to apoptosis, proinflammatory cytokine expression, and inflammatory cell infiltration, which can be reversed by alpha CXCR3 therapy.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Sho Hosaka, Kazuo Imagawa, Yusuke Yano, Lisheng Lin, Junko Shiono, Miho Takahashi-Igari, Hideki Hara, Daisuke Hayashi, Hironori Imai, Atsushi Morita, Hiroko Fukushima, Hidetoshi Takada
Summary: We found that the CXCL10-CXCR3 axis plays an important role in the pathogenesis of Kawasaki disease.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Deborah J. W. Lee, Soon Kieng Phua, Yali Liang, Claire Chen, Tar-Choon Aw
Summary: We evaluated the performance of the Abbott thyroid-stimulating hormone receptor antibody chemiluminescent microparticle immunoassay (CMIA) on the Alinity i. The results showed that the Abbott CMIA met the requirements for precision, linearity, analytical measuring range, limit of blank, limit of detection, limit of quantitation and diagnostic cut offs for Graves' disease. Thus, it is suitable for clinical use.
Article
Immunology
Hector Rincon-Arevalo, Annika Wiedemann, Ana-Luisa Stefanski, Marie Lettau, Franziska Szelinski, Sebastian Fuchs, Andreas Philipp Frei, Malte Steinberg, Tony Kam-Thong, Klas Hatje, Baerbel Keller, Klaus Warnatz, Andreas Radbruch, Andreia C. Lino, Eva Schrezenmeier, Thomas Doerner
Summary: Circulating CD11c(+) B cells are increased in the blood of systemic lupus erythematosus (SLE) patients, mainly within memory subsets and enriched in distinct activation and checkpoint markers. Notably, SLE CD11c(+) B cells exhibit enhanced expression of checkpoint molecules compared to healthy donors, possibly indicating abnormalities in immune regulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Selwan Khamisi, Martin Lundqvist, Britt Eden Engstrom, Anders Larsson, F. Anders Karlsson, Osten Ljunggren
Summary: This study aimed to investigate the role of TSI in the management of GO. The results showed a high correlation between TSI and TRAb and fT3 values, but no significant difference between GO and non-GO patients. During the follow-up, levels of TSI and TRAb decreased and normalized in both groups.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2023)
Article
Endocrinology & Metabolism
J. Chen, W. Wang, Z. Guo, S. Huang, H. Lei, P. Zang, B. Lu, J. Shao, P. Gu
Summary: The study found that the gut microbiota diversity in GD patients was significantly lower than in healthy volunteers, with differences mainly at the genus level. With improvement in thyroid function, specific genus abundance also changed significantly. Spearman correlation analysis revealed positive and negative correlations between TRAb levels and certain bacterial genera.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Biology
Veethika Pandey, Alicia Fleming-Martinez, Ligia Bastea, Heike R. Doeppler, Jillian Eisenhauer, Tam Le, Brandy Edenfield, Peter Storz
Summary: This study highlights the importance of CXCL10/CXCR3 signaling in the early phase of murine pancreatic cancer, demonstrating its role in mediating chemotaxis, proliferation, and maintenance of inflammatory identity in macrophages within the pancreas. Inhibition of CXCL10/CXCR3 signaling shifts macrophage populations to a tumor-promoting phenotype, increasing fibrosis and lesion progression.
Article
Endocrinology & Metabolism
Sayid Shafi Zuhur, Ogun Bilen, Hunkar Aggul, Birol Topcu, Aliye Celikkol, Gulsah Elbuken
Summary: The study found that the levels of TRAb at the initial diagnosis of GD are differently associated with clinical and laboratory parameters. Male patients and smoking patients with GD tended to have markedly higher TRAb levels and more severe clinical hyperthyroidism.
ENDOKRYNOLOGIA POLSKA
(2021)
Article
Immunology
Xuan Wang, Mara Lennard Richard, Tomika S. Caldwell, Kamala Sundararaj, Shuzo Sato, Tamara K. Nowling, Xian K. Zhang
Summary: The transcription factor Fli-1 is involved in the pathogenesis of lupus disease by regulating the expression of CXCL10 and CXCR3, which play important roles in renal inflammation and damage. Targeting Fli-1 or the CXCL10-CXCR3 axis may provide new approaches for lupus treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Yunting Lin, Ruitao Lu, Jingmei Hou, Grace Guoying Zhou, Wenmin Fu
Summary: Radiotherapy is a common method for cancer treatment, but tumors may develop resistance to radiation due to the immune system. IFNgamma and CXCL10 play important roles in sensitizing tumor cells to ionizing radiation, and their interaction may contribute to effective killing of tumor cells in vitro.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Nathalie Silva de Morais, Trevor E. Angell, Sara Ahmadi, Erik K. Alexander, Patricia de Fatima dos Santos Teixeira, Ellen Marqusee
Summary: TSI and TBII assays showed similar performance in differentiating GD from other causes of thyrotoxicosis. In combination, both tests showed little benefit compared with the TBII assay alone. Thyrotropin receptor antibody assay results should be carefully interpreted in patients with mild GD or longstanding disease.
ENDOCRINE PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Peiyu Liang, Xinyi Zhang, Yahui Zhang, Yifan Wu, Yinghao Song, Xueyang Wang, Taoxiang Chen, Wanhong Liu, Biwen Peng, Jun Yin, Fanggang He, Yuanteng Fan, Song Han, Xiaohua He
Summary: Epilepsy is a common neurological disorder, and a new form of cell death called ferroptosis is associated with seizures. This study found that neuronal ferroptosis dependent on GPX4-GSH was detected in epileptic mice and could be attenuated by ferroptosis inhibitors. Additionally, neurotoxic A1 astrocytes activated in epilepsy facilitated seizure-related neuronal ferroptosis. Inhibiting ferroptosis blocked A1 astrocyte-induced neurotoxicity. A1 astrocyte-secreted CXCL10 enhanced STAT3 phosphorylation but suppressed SLC7A11 in neurons, leading to ferroptosis-associated lipid peroxidation in a GPX4-dependent manner. Clinical findings also showed a significant correlation between neuronal ferroptosis and A1 astrocytes in epileptic patients. In conclusion, this study reveals that A1 astrocyte-induced neuronal ferroptosis contributes to the pathogenesis of epilepsy, providing a novel therapeutic target for precision medicine.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Tiancheng Li, Yao Qin, Zhen Zhen, Hong Shen, Tiechuan Cong, Erik Schiferle, Shuifang Xiao
CELL PROLIFERATION
(2019)
Article
Medicine, Research & Experimental
Tiechuan Cong, Yuan Wu, Ying Gao, Quangui Wang, Yong Qin
Summary: A modified endoscopic dacryocystorhinostomy technique using a clubhead-shaped nasal flap combined with a posteriorly hinged lacrimal flap was developed to achieve tension-free anastomosis with the surrounding mucoperiosteum. This technique has shown satisfactory outcomes in treating cases of nasolacrimal duct obstruction.
Letter
Medicine, General & Internal
Yao Qin, Tian-Cheng Li, Tie-Chuan Cong, Yu-He Liu
CHINESE MEDICAL JOURNAL
(2017)
Article
Medicine, General & Internal
Cong Tie-chuan, Lu Zhe-ming, Li Yong, Zheng Li, Qin Yong
CHINESE MEDICAL JOURNAL
(2007)