Safety, Tolerability, and Pharmacokinetic Evaluation of Single and Multiple Doses of the Dipeptidyl Peptidase 1 Inhibitor Brensocatib in Healthy Japanese and White Adults

Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis

(2020) James D. Chalmers et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure-Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects

(2018) Robert Palmér et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis

(2018) Ravishankar Chandrasekaran et al.   BMC Pulmonary Medicine

Bronchiectasis: Treatment decisions for pulmonary exacerbations and their prevention

(2018) Scott C. Bell et al.   RESPIROLOGY

Prevalence and incidence of noncystic fibrosis bronchiectasis among US adults in 2013

(2017) Derek Weycker et al.   Chronic Respiratory Disease

Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)

(2016) Kevin Doyle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inflammatory Responses, Spirometry, and Quality of Life in Subjects With Bronchiectasis Exacerbations

(2015) W.-j. Guan et al.   Respiratory Care

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

(2010) B. Korkmaz et al.   PHARMACOLOGICAL REVIEWS

Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century

(2010) P. Goeminne et al.   POSTGRADUATE MEDICAL JOURNAL

The Role of Ethnicity in Variability in Response to Drugs: Focus on Clinical Pharmacology Studies

(2008) SU Yasuda et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS