Increased homocysteine regulated by androgen activates autophagy by suppressing the mammalian target of rapamycin pathway in the granulosa cells of polycystic ovary syndrome mice

Consecutive Low Doses of Streptozotocin Induce Polycystic Ovary Syndrome Features in Mice

(2021) Youngjae Ryu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome

(2020) Elisabet Stener-Victorin et al.   ENDOCRINE REVIEWS

NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats

(2020) Tianyi Wang et al.   Journal of Neuroinflammation

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

The role of androgen in autophagy of granulosa cells from PCOS

(2019) Xiaoxue Li et al.   GYNECOLOGICAL ENDOCRINOLOGY

Autophagy in hypoxic ovary

(2019) Anil Kumar Yadav et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Animal Models for Human Polycystic Ovary Syndrome (PCOS) Focused on the Use of Indirect Hormonal Perturbations: A Review of the Literature

(2019) Youngjae Ryu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LC3-positive structures are prominent in autophagy-deficient cells

(2019) Gautam Runwal et al.   Scientific Reports

Pleiotropic Effects of mTOR and Autophagy During Development and Aging

(2019) Kathrin Schmeisser et al.   Frontiers in Cell and Developmental Biology

Role of mTOR Signaling in Female Reproduction

(2019) Zaixin Guo et al.   Frontiers in Endocrinology

Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome

(2018) Helena J. Teede et al.   FERTILITY AND STERILITY

Hyperhomocysteinemia in polycystic ovary syndrome: decreased betaine-homocysteine methyltransferase and cystathionine β-synthase-mediated homocysteine metabolism

(2018) Da Li et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Homocysteine activates autophagy by inhibition of CFTR expression via interaction between DNA methylation and H3K27me3 in mouse liver

(2018) Anning Yang et al.   Cell Death & Disease

Dehydroepiandrosterone-induced activation of mTORC1 and inhibition of autophagy contribute to skeletal muscle insulin resistance in a mouse model of polycystic ovary syndrome

(2018) Xi Song et al.   Oncotarget

Inhibition of Mast Cell Function and Proliferation by mTOR Activator MHY1485

(2018) Valeriya Rakhmanova et al.   Immune Network

Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation

(2018) Sandra M. Hill et al.   CELL DEATH AND DIFFERENTIATION

Hyperhomocysteinemia-induced autophagy and apoptosis with downregulation of hairy enhancer of split 1/5 in cortical neurons in mice

(2017) Jing-Wen Zhang et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Tetrahydrocurcumin ameliorates homocysteine-mediated mitochondrial remodeling in brain endothelial cells

(2017) Jonathan C. Vacek et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Homocysteine and disease: Causal associations or epiphenomenons?

(2017) Luciana Hannibal et al.   MOLECULAR ASPECTS OF MEDICINE

Attenuated expression of MTR in both prenatally androgenized mice and women with the hyperandrogenic phenotype of PCOS

(2017) Lei Lei et al.   PLoS One

Autophagy is activated in the ovarian tissue of polycystic ovary syndrome

(2017) Da Li et al.   REPRODUCTION

Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation

(2016) Madhulika Tripathi et al.   Cell Death & Disease

Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries

(2016) Longfei Jia et al.   Scientific Reports

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Vaginal Cytology of the Laboratory Rat and Mouse

(2015) Michelle C. Cora et al.   TOXICOLOGIC PATHOLOGY

Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

(2015) M. Geoffrey Hayes et al.   Nature Communications

Early methyl donor deficiency produces severe gastritis in mothers and offspring through N-homocysteinylation of cytoskeleton proteins, cellular stress, and inflammation

(2013) Carine Bossenmeyer-Pourié et al.   FASEB JOURNAL

MicroRNA-181a Suppresses Mouse Granulosa Cell Proliferation by Targeting Activin Receptor IIA

(2013) Qun Zhang et al.   PLoS One

LDL S-homocysteinylation decrease in chronic kidney disease patients undergone lipid lowering therapy

(2012) Angelo Zinellu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The aging ovary—the poor granulosa cells

(2012) Carla Tatone et al.   FERTILITY AND STERILITY

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Autophagy and Heart Failure: A Possible Role for Homocysteine

(2011) Thomas P. Vacek et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Homocysteine concentrations in follicular fluid are associated with poor oocyte and embryo qualities in polycystic ovary syndrome patients undergoing assisted reproduction

(2009) B. Berker et al.   HUMAN REPRODUCTION