Article
Engineering, Biomedical
Yuanchi Zhang, Cairong Li, Wei Zhang, Junjie Deng, Yangyi Nie, Xiangfu Du, Ling Qin, Yuxiao Lai
Summary: This study presents a near-infrared-responsive and tight-contacting scaffold composed of shape memory polyurethane (SMPU) and magnesium (Mg) for bone regeneration. The scaffold, fabricated using 3D printing technology, demonstrates superior mechanical properties and stable photothermal effects, showing promising potential in robust bone regeneration.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Nevena Pounovic, Jessica Marbach, Yinyin Bao, Valentine Berger, Karina Klein, Sarah Schleich, Fergal Brian Coulter, Nicole Kleger, Andre R. Studart, Daniel Franzen, Zhi Luo, Jean-Christophe Leroux
Summary: Digital light processing (DLP) 3D printing is a promising technique for rapid manufacturing of precise customized medical devices. However, the development of suitable photopolymerizable materials is still a challenge. In this study, a multifunctional DLP printed material system based on gold nanorods and polyester copolymer is reported, demonstrating robust near-infrared responsiveness and shape transformation.
Article
Engineering, Biomedical
Liaobing Xin, Xiaowen Zheng, Jianmin Chen, Sentao Hu, Yilun Luo, Qunzi Ge, Xiaoying Jin, Lie Ma, Songying Zhang
Summary: This study explores an acellular biomaterial called SDF-1 alpha/E7-modified collagen scaffold (CES), which enables near-complete endometrium regeneration and fertility restoration by mobilizing endogenous MSCs. The results demonstrate that CES can overcome the traditional limitations of cell-based therapies and serve as a clinically feasible and cell-free strategy with high therapeutic efficiency for IUA treatment.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Cell & Tissue Engineering
Jiayue Huang, Wenwen Zhang, Jie Yu, Yating Gou, Nizhou Liu, Tingting Wang, Congcong Sun, Benyuan Wu, Changjiang Li, Xinpei Chen, Yanhua Mao, Yingfeng Zhang, Jia Wang
Summary: This study investigated the therapeutic effect of hAMSCs combined with PPCNg transplantation on promoting the regeneration of injured endometrium. The results showed that hAMSCs maintained normal cell proliferation, apoptosis and cell cycle in PPCNg. In addition, hAMSCs combined with PPCNg intrauterine transplantation facilitated the regeneration of injured endometrium and restored reproductive capacity.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Materials Science, Composites
Yan-Qin Wang, Yu Zhu, Jing-Hui Wang, Xiao-Na Li, Xiao-Gang Wu, Yi-Xian Qin, Wei-Yi Chen
Summary: A triple-network composite hydrogel with Fe3+, NIR light, and thermal responsive abilities has been developed, showing excellent mechanical properties and programmable multi-shape memory properties. This versatile hydrogel has the potential for applications in artificial intelligence.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Article
Engineering, Environmental
Xingxing Chen, Ruyue Wang, Chenhui Cui, Le An, Qiang Zhang, Yilong Cheng, Yanfeng Zhang
Summary: Fabrication of covalent adaptable networks with the combination of intrinsic photothermal responsiveness, NIR-triggered welding, multiple-shape memory, and selective shape memory recovery remains a challenge. The developed PUOUs show strong photothermal effect and can achieve rapid welding through the dynamic exchange of oxime-carbamate bonds induced by near-infrared laser. With two independent glass transition temperatures, PUOUs exhibit triple shape memory property and selective shape memory recovery in the region subjected to NIR irradiation.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Polymer Science
Yanmei Wang, Yanen Wang, Qinghua Wei, Juan Zhang
Summary: This article introduces the classification, working principles, preparation methods, and intelligent structure forming technologies of the latest light-responsive shape memory polymer composites. It also presents current applied research and future research directions.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Engineering, Biomedical
Lina Zhou, Hao Wang, Danpeng Shen, Jiangdong Xiang, Na Yu, Xiaoying He, Weiguang Zhao, Renjie Wang, Hongwei Wang, Hongliang Yu, Xueying Ding, Zhihong Liu, Yinyan He
Summary: Severe endometrial injury caused by invasive uterine operation and/or endometritis often leads to Asherman's syndrome (AS), resulting in menstrual disorders, infertility, and complications during pregnancy and delivery. Stem cells, in particular adipose-derived mesenchymal stem cells (ADMSCs), offer a promising therapeutic approach for endometrial regeneration. In this study, an ADMSCs-SF/PCL system was developed, which enhanced endometrial restoration by promoting cell proliferation, gland and blood vessel regeneration, and reversing endometrial fibrosis. Additionally, the system also remodeled the immune microenvironment, leading to NK cell infiltration and a balanced Th1/Th2 response in the endometrium.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Multidisciplinary
Ruixue Liang, Haojie Yu, Li Wang, Nan Wang, Bilal Ul Amin
Summary: The study developed NIR light-triggered SMPs with permanent shape reconfiguration capability, utilizing catechol-Fe3+ coordination for crosslinking polymer networks. These SMPs exhibit 1W-SME and 2W-SME effects, with great potential in biomedical and electronic applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Polymer Science
Ruibo Yang, Wenkai Liu, Nijia Song, Xin Li, Zhen Li, Feng Luo, Jiehua Li, Hong Tan
Summary: This study synthesized biodegradable shape memory polymers with a novel chain extender, which exhibited excellent shape memory effect and rapid photothermal response. The sequence distribution of the chain extender was found to influence the phase structure and degradation behavior of the polymer. The introduction of oxidized carbon black enhanced the phase separation degree and mechanical properties of the polymer.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Chen Wang, Bilha Willner, Itamar Willner
Summary: The synthesis and applications of redox-responsive and photoresponsive hydrogels are introduced, showcasing the reversible stiffness of hydrogels through oxidation/reduction of redox-active groups and discussing their use as shape-memory and self-healing materials. Photoresponsive hydrogels are designed with various crosslinking units and photoisomerizable bridges, demonstrating reversible stiffness through cyclic photoinduced formation/dissociation of photoresponsive bridges. Additionally, immobilization of Au nanoparticles or nanorods in hydrogels allows for light-induced thermoplasmonic melting of nucleic acid bridges and switchable stiffness, leading to applications in controlled drug release and shape-memory matrices.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Materials Science, Multidisciplinary
Shaoying Wu, Hongsheng Luo, Wei Shen, Junzhao Su, Cenhuai Ma, Jiahua Wu
Summary: In this study, a novel electrospun shape memory actuator with rapid near-infrared responsiveness was successfully fabricated. By depositing Ti3C2Tx (MXene)/cellulose nanocrystals (CNCs) hybrids onto fibril mats, the actuator exhibited enhanced mechanical properties and photothermal effects. It was capable of remote activation and could lift an object 265 times its weight by 80% extension within 10 seconds.
Review
Biochemistry & Molecular Biology
Gyuzyal Tabeeva, Denis Silachev, Polina Vishnyakova, Alexandra Asaturova, Timur Fatkhudinov, Antonina Smetnik, Madina Dumanovskaya
Summary: Disruption of endometrial regeneration, fibrosis formation, and intrauterine adhesions are common causes of thin endometrium and/or Asherman's syndrome, leading to infertility and adverse obstetric outcomes. Current methods do not restore the regenerative properties of the endometrium. Cell therapy using MMSCs has shown promising results in tissue damage repair, particularly through paracrine effects of EVs secreted by MMSCs, which stimulate progenitor cells and exert cytoprotective, antiapoptotic, and angiogenic effects. This review provides information on the regulatory mechanisms of endometrial regeneration, associated pathological conditions, and the role of MMSCs and EVs in endometrial repair and reproductive processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Liping Zou, Jin Huang, Qiaoling Zhang, Hui Mo, Wei Xia, Changhong Zhu, Meng Rao
Summary: This study aimed to investigate the therapeutic effect of humanin analogue on intrauterine adhesions in a rat model. The results showed that HNG supplementation attenuated the development of endometrial fibrosis and IUAs, improved fertility, and contributed to the regulation of endometrial fibrosis by inhibiting endometrial ferroptosis.
HUMAN REPRODUCTION
(2023)
Article
Developmental Biology
Meng Bao, Qiwen Feng, Liping Zou, Jin Huang, Changhong Zhu, Wei Xia
Summary: Intrauterine adhesion (IUA) is a common gynecological disease and a leading cause of female infertility. This study reveals that endoplasmic reticulum stress (ERS) activation upregulates the TGF-beta/SMAD pathway to induce epithelial-mesenchymal transition (EMT) and promote endometrial fibrosis in an IUA model.
Article
Multidisciplinary Sciences
Shan Lei, Jing Zhang, Nicholas Thomas Blum, Meng Li, Dong-Yang Zhang, Weimin Yin, Feng Zhao, Jing Lin, Peng Huang
Summary: The study demonstrates the use of three-dimensional multispectral photoacoustic molecular imaging to monitor cascade catalytic therapy in vivo, and shows its potential application in tumor treatment.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Hongshi Ma, Chen Yang, Zhenjiang Ma, Xiaoyue Wei, Muhammad Rizwan Younis, Hanbo Wang, Wentao Li, Zhiyong Wang, Wenhao Wang, Yongxiang Luo, Peng Huang, Jinwu Wang
Summary: This study utilizes bioinspired calcium silicate nanowires and alginate composite hydrogels as building blocks to construct multiscale hierarchical bioactive scaffolds, and successfully promotes tissue regeneration from tendon to bone.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Yumei Que, Zhaowenbin Zhang, Yanxin Zhang, Xin Li, Likai Chen, Peier Chen, Caiwen Ou, Chen Yang, Jiang Chang
Summary: Silicate ions, as soluble form of bioactive ceramics, effectively alleviate aortic aneurysm and dissection by regulating the local vascular microenvironment and reducing senescence, inflammation, and cell apoptosis. In vitro experiments show that silicate ions can alleviate senescence, inflammation, and apoptosis of vascular-related cells and regulate their interactions. In vivo studies confirm that silicate ions can effectively alleviate aortic senescence, inflammation, and cell apoptosis, leading to reduced aortic dilation and elastin degradation. This bioactive ceramic derived therapy has the potential to attenuate AAD progression.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yashi Li, Gang He, Lian-Hua Fu, Muhammad Rizwan Younis, Ting He, Yunzhi Chen, Jing Lin, Zhiming Li, Peng Huang
Summary: In this study, a self-oxygenation nanoplatform was developed for photodynamic therapy (PDT), which demonstrated enhanced therapeutic efficacy through the synergistic effect of self-supplying O2 and glutathione (GSH) depletion. The nanoplatform, encapsulated in a microneedle patch, efficiently delivered the photosensitizer to the target tumor site and enabled repeatable PDT guided by fluorescence imaging.
Review
Engineering, Biomedical
Shanshan Jiang, Jing Lin, Peng Huang
Summary: This review summarizes the recent advances in nanomaterials for photoacoustic imaging (PAI) in the second near-infrared window (NIR-II) and discusses the advantages of NIR-II PAI and its applications in the biomedical field. The nanomaterials-based PA contrast agents are categorized into organic, inorganic, and organic/inorganic hybrid nanomaterials, which are mainly used for imaging and diagnosis of tumor tissues, brain vasculature, inflammation, and other tissues, as well as for monitoring catalytic reaction processes in vivo. The opportunities and challenges of NIR-II PAI are also discussed.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Jinfeng Xu, Muhammad Rizwan Younis, Zhaowenbin Zhang, Yanping Feng, Lefeng Su, Yumei Que, Yiren Jiao, Chen Fan, Jiang Chang, Siyu Ni, Chen Yang
Summary: In this study, a polydopamine/alginate/nanoselenium composite hydrogel (Alg-PDA-Se) was proposed for the treatment of infected wounds. The composite hydrogel combines controllable near-infrared photothermal properties of polydopamine with the excellent anti-oxidation, anti-inflammatory, pro-proliferative, pro-migration, and proangiogenic performances of low-dosage selenium nanoparticles (Se NPs). The combination of mild temperature with low-dosage Se NPs showed a synergistic effect on combating bacterial infections and promoting wound healing in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Muhammad Rizwan Younis, Yaling He, Xikuang Yao, Gang He, Hengke Liu, Peng Huang, Jing Lin
Summary: In this study, researchers developed an acidity/carbon dioxide-sensitive polymer for the precise release of chemotherapeutic drugs against glioblastoma. They successfully prepared multifunctional gold vesicles that were responsive to multiple stimuli, achieving the programmed release of chemotherapy drugs.
ACTA BIOMATERIALIA
(2023)
Article
Biophysics
Pengyu Zhu, Muhammad Rizwan Younis, Guiqi Ma, Qianting Zhang, Ruibing An, Kaiqi Wang, Jian Dong
Summary: Dendritic polymer-platinum conjugates (G5-PEG-Pt) were designed as pH-responsive nanovesicles for target delivery of platinum drugs. The G5-PEG-Pt exhibited a well-defined structure, intrinsic fluorescence, and acid-responsive drug release. They were able to enter cancer cells and achieve comparable cytotoxicity to free cisplatin. Furthermore, the nanovesicles showed enhanced tumor platinum uptake compared to free cisplatin, potentially improving the therapeutic efficacy of platinum drugs.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Biomaterials
Li Deng, Lingwei Huang, Hao Pan, Qi Zhang, Yumei Que, Chen Fan, Jiang Chang, Siyu Ni, Chen Yang
Summary: In this study, single-phased strontium-zinc-phosphate (SZP) bioceramics were synthesized via solution combustion method and fabricated into SZP scaffolds using 3D printing technique. The 3D printed SZP scaffolds showed comparable physical properties but enhanced abilities of osteogenesis, angiogenesis, immunomodulation, and anti-bacterial activity compared to 3D printed beta-tricalcium phosphate (β-TCP) scaffolds.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Kai Guo, Dong Chen, Shuai Ren, Muhammad Rizwan Younis, Zhaogang Teng, Longjiang Zhang, Zhongqiu Wang, Ying Tian
Summary: Immune checkpoint blockade therapy and photothermal therapy have great potential in cancer treatment. Using MK-8628 and HPDA@MK as non-antibody methods, both PD-L1 and CD47 can be simultaneously suppressed, immune response can be activated, and the combined therapeutic effect can be enhanced, providing a feasible approach for the treatment of other solid tumors.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Ying Tian, Muhammad Rizwan Younis, Yatong Zhao, Kai Guo, Jiayingzi Wu, Longjiang Zhang, Peng Huang, Zhongqiu Wang
Summary: Researchers have developed a nanomodulator based on mesoporous polydopamine nanoparticles for combinational photothermal-immunotherapy. This nanomodulator improves immunotherapy outcomes by restoring immune suppression and providing thermal therapy for tumor treatment. The nanomodulator has excellent biocompatibility, water solubility, and imaging abilities. It can precisely deliver and release immune inhibitors at tumor sites, effectively reversing immune suppression and enhancing therapeutic efficacy.
Article
Engineering, Biomedical
Yahong Chen, Muhammad Rizwan Younis, Gang He, Zhiwei Zheng, Yun Wang, Ke Xue, Jian Sun, Kai Liu, Peng Huang, Xiansong Wang
Summary: In this study, adipose-derived-stem-cell-derived exosomes (Exos) are loaded into Ag@bovine serum albumin (BSA) nanoflowers (Exos-Ag@BSA NFs), which are further encapsulated into injectable collagen (Col) hydrogel (Exos-Ag@BSA NFs/Col) to remodel the oxidative wound microenvironment and release Exos. The Exos-Ag@BSA NFs selectively dissociate in the oxidative wound microenvironment, triggering sustained release of Ag ions (Ag+) and controlled release of Exos at the target site to protect them from denaturation. In a diabetic murine silicone-splinted excisional wound model, Exos-Ag@BSA NFs/Col significantly accelerates wound healing and regeneration by promoting blood perfusion, tissue granulation, collagen deposition, neovascularization, angiogenesis, and re-epithelization. This work is expected to inspire the development of more delicate and disease-specific therapeutic systems for clinical wound management.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Dong-Yang Zhang, Yuqin Liang, Mingcheng Wang, Muhammad Rizwan Younis, Huixi Yi, Xiaoya Zhao, Jishuo Chang, Yue Zheng, Weisheng Guo, Xiyong Yu
Summary: In this study, carrier-free self-assembled nanoparticles, GC NPs, were developed by integrating glucose transporter 1 inhibitor genistein (Gen) and photosensitizer chlorin e6 (Ce6). GC NPs effectively cut off tumor glucose uptake and reduce tumor oxygen consumption, enhancing the therapeutic effect of photodynamic therapy (PDT). In vitro and in vivo experiments demonstrated the excellent synergistic antitumor efficacy of GC NPs without apparent toxicity. Moreover, fluorescence and photoacoustic imaging showed the excellent tumor enrichment efficiency of GC NPs, providing guidance for in vivo PDT. This carrier-free self-assembled GC NPs strategy holds promising clinical prospects for starvation therapy-amplified PDT.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Nanjian Xu, Dezhi Lu, Lei Qiang, Yihao Liu, Dalin Yin, Zhiyong Wang, Yongxiang Luo, Chen Yang, Zhenjiang Ma, Hui Ma, Jinwu Wang
Summary: This study fabricated 3D-printed WES-TCP composite scaffolds with bilineage bioactivities for osteochondral regeneration. The results showed that 2% WES-TCP composite scaffolds not only improved compressive strength but also promoted the regeneration of both bone and cartilage tissue.
Article
Materials Science, Biomaterials
Cancan Zhao, Chen Yang, Qun Lou, Jiashu Yan, Xudong Wang, Jiang Chang
Summary: This study demonstrates that the enhanced osteogenic properties activated by micro/nano-structures on HA can still play a role even after removal, and the degree of activation can be regulated through stimulation time. These findings are important for the design of bone implants with biodegradable surface topography.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
